Open Access

EML4‑ALK fusion gene in non‑small cell lung cancer (Review)

  • Authors:
    • Yu Lei
    • Yan Lei
    • Xiang Shi
    • Jingjing Wang
  • View Affiliations

  • Published online on: June 24, 2022     https://doi.org/10.3892/ol.2022.13397
  • Article Number: 277
  • Copyright: © Lei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non‑small cell lung cancer (NSCLC) is a malignant tumor with a high morbidity and mortality rate that is a threat to human health. With the development of molecular targeted research, breakthroughs have been made on the molecular mechanism of lung cancer. The echinoderm microtubule‑associated protein‑like 4‑anaplastic lymphoma kinase (EML4‑ALK) fusion gene is one of the most important pathogenic driver genes of NSCLC discovered thus far. Four generations of targeted drugs for EML4‑ALK have been developed, with patients benefiting significantly from these drugs. Therefore, EML4‑ALK has become a research hotspot in NSCLC. The aim of the present study is to introduce the current research progress of EML4‑ALK and its association with NSCLC.
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August-2022
Volume 24 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Lei Y, Lei Y, Shi X and Wang J: EML4‑ALK fusion gene in non‑small cell lung cancer (Review). Oncol Lett 24: 277, 2022
APA
Lei, Y., Lei, Y., Shi, X., & Wang, J. (2022). EML4‑ALK fusion gene in non‑small cell lung cancer (Review). Oncology Letters, 24, 277. https://doi.org/10.3892/ol.2022.13397
MLA
Lei, Y., Lei, Y., Shi, X., Wang, J."EML4‑ALK fusion gene in non‑small cell lung cancer (Review)". Oncology Letters 24.2 (2022): 277.
Chicago
Lei, Y., Lei, Y., Shi, X., Wang, J."EML4‑ALK fusion gene in non‑small cell lung cancer (Review)". Oncology Letters 24, no. 2 (2022): 277. https://doi.org/10.3892/ol.2022.13397