Low‑dose radiotherapy combined with immunotherapy for suboral adenoid cystic carcinoma with bilateral lung metastasis: <br />A case report and literature review

Li,Danyang; Pang,Xuezhou; Zhu,Xinxin; Shanzhou,Qiyue; Wen,Guo; Ma,Daiyuan

doi:10.3892/ol.2022.13399

Low‑dose radiotherapy combined with immunotherapy for suboral adenoid cystic carcinoma with bilateral lung metastasis:
A case report and literature review

Authors:
- Danyang Li
- Xuezhou Pang
- Xinxin Zhu
- Qiyue Shanzhou
- Guo Wen
- Daiyuan Ma
View Affiliations

Affiliations: Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China
Published online on: June 24, 2022 https://doi.org/10.3892/ol.2022.13399
Article Number: 279
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Adenoid cystic carcinoma (ACC) is a type of malignant tumor arising from the salivary glands. The tumor is characterized by a predilection for recurrence and metastasis. At present, there is no effective treatment for ACC complicated with lung metastasis. The present study reported on a case of suboral ACC with bilateral lung metastasis and the clinical features and treatment options were discussed based on a literature review. A 55‑year‑old female presented with suboral ACC accompanied with bilateral lung metastases. The main symptoms were masses in the right mandible and shortness of breath. Low‑dose radiotherapy (LDRT) combined with immunotherapy were administered to control lung metastases. The patient is currently in a stable condition and is receiving immunotherapy. LDRT combined with immunotherapy is a feasible treatment option for such patients. Our experience with this case and the information from the literature review provide insight into the therapeutic approach for this relatively rare entity.

View Figures

View References

1	Dodd RL and Slevin NJ: Salivary gland adenoid cystic carcinoma: A review of chemotherapy and molecular therapies. Oral Oncol. 42:759–769. 2006. View Article : Google Scholar : PubMed/NCBI
2	Bradley PJ: Adenoid cystic carcinoma evaluation and management: Progress with optimism! Curr Opin Otolaryngol Head Neck Surg. 25:147–153. 2017. View Article : Google Scholar : PubMed/NCBI
3	Patel RR, He K, Barsoumian HB, Chang JY, Tang C, Verma V, Comeaux N, Chun SG, Gandhi S, Truong MT, et al: High-dose irradiation in combination with non-ablative low-dose radiation to treat metastatic disease after progression on immunotherapy: Results of a phase II trial. Radiother Oncol. 162:60–67. 2021. View Article : Google Scholar : PubMed/NCBI
4	Menon H, Chen D, Ramapriyan R, Verma V, Barsoumian HB, Cushman TR, Younes AI, Cortez MA, Erasmus JJ, de Groot P, et al: Influence of low-dose radiation on abscopal responses in patients receiving high-dose radiation and immunotherapy. J Immunother Cancer. 7:2372019. View Article : Google Scholar : PubMed/NCBI
5	Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–2247. 2009. View Article : Google Scholar : PubMed/NCBI
6	van Weert S, Reinhard R, Bloemena E, Buter J, Witte BI, Vergeer MR and Leemans CR: Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck. Head Neck. 39:456–463. 2017. View Article : Google Scholar : PubMed/NCBI
7	Seok J, Lee DY, Kim WS, Jeong WJ, Chung EJ, Jung YH, Kwon SK, Kwon TK, Sung MW and Ahn SH: Lung metastasis in adenoid cystic carcinoma of the head and neck. Head Neck. 41:3976–3983. 2019. View Article : Google Scholar : PubMed/NCBI
8	Girelli L, Locati L, Galeone C, Scanagatta P, Duranti L, Licitra L and Pastorino U: Lung metastasectomy in adenoid cystic cancer: Is it worth it? Oral Oncol. 65:114–118. 2017. View Article : Google Scholar : PubMed/NCBI
9	Sharma VJ, Gupta A, Yaftian N, Ball D, Brown R, Barnett S and Antippa P: Low recurrence of lung adenoid cystic carcinoma with radiotherapy and resection. ANZ J Surg. 89:1051–1055. 2019. View Article : Google Scholar : PubMed/NCBI
10	Jeong IS, Roh JL, Cho KJ, Choi SH, Nam SY and Kim SY: Risk factors for survival and distant metastasis in 125 patients with head and neck adenoid cystic carcinoma undergoing primary surgery. J Cancer Res Clin Oncol. 146:1343–1350. 2020. View Article : Google Scholar : PubMed/NCBI
11	Coca-Pelaz A, Rodrigo JP, Bradley PJ, Vander Poorten V, Triantafyllou A, Hunt JL, Strojan P, Rinaldo A, Haigentz M Jr, Takes RP, et al: Adenoid cystic carcinoma of the head and neck-An update. Oral Oncol. 51:652–661. 2015. View Article : Google Scholar : PubMed/NCBI
12	Locy H, de Mey S, de Mey W, De Ridder M, Thielemans K and Maenhout SK: Immunomodulation of the tumor microenvironment: Turn foe into friend. Front Immunol. 9:29092018. View Article : Google Scholar : PubMed/NCBI
13	Bhalla N, Brooker R and Brada M: Combining immunotherapy and radiotherapy in lung cancer. J Thorac Dis. 10 (Suppl 13):S1447–S1460. 2018. View Article : Google Scholar : PubMed/NCBI
14	Theelen WS, de Jong MC and Baas P: Synergizing systemic responses by combining immunotherapy with radiotherapy in metastatic non-small cell lung cancer: The potential of the abscopal effect. Lung Cancer. 142:106–113. 2020. View Article : Google Scholar : PubMed/NCBI
15	Yin L, Xue J, Li R, Zhou L, Deng L, Chen L, Zhang Y, Li Y, Zhang X, Xiu W, et al: Effect of low-dose radiation therapy on abscopal responses to hypofractionated radiation therapy and Anti-PD1 in mice and patients with non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 108:212–224. 2020. View Article : Google Scholar : PubMed/NCBI
16	Shevtsov M, Sato H, Multhoff G and Shibata A: Novel approaches to improve the efficacy of immuno-radiotherapy. Front Oncol. 9:1562019. View Article : Google Scholar : PubMed/NCBI
17	Dhawan G, Kapoor R, Dhawan R, Singh R, Monga B, Giordano J and Calabrese EJ: Low dose radiation therapy as a potential life saving treatment for COVID-19-induced acute respiratory distress syndrome (ARDS). Radiother Oncol. 147:212–216. 2020. View Article : Google Scholar : PubMed/NCBI
18	Schalper KA, Brown J, Carvajal-Hausdorf D, McLaughlin J, Velcheti V, Syrigos KN, Herbst RS and Rimm DL: Objective measurement and clinical significance of TILs in non-small cell lung cancer. J Natl Cancer Inst. 107:dju4352015. View Article : Google Scholar : PubMed/NCBI