Open Access

Surgical and oncological outcomes of distal gastrectomy compared to total gastrectomy for middle‑third gastric cancer: A systematic review and meta‑analysis

  • Authors:
    • Yuxing Jiang
    • Fan Yang
    • Jingfu Ma
    • Ning Zhang
    • Chao Zhang
    • Gaoming Li
    • Zhengyan Li
  • View Affiliations

  • Published online on: July 4, 2022     https://doi.org/10.3892/ol.2022.13411
  • Article Number: 291
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Distal gastrectomy (DG) and total gastrectomy (TG) are the most common types of radical surgery for patients with middle‑third gastric cancer (MTGC). However, the indications and benefits of the two procedures still remain controversial. The present meta‑analysis aimed to compare the surgical and oncological outcomes of DG and TG in the treatment of MTGC. A rigorous literature review was performed in the databases of PubMed, Embase, Web of Science, China National Knowledge Infrastructure and Chinese BioMedical Literature to retrieve studies published up to February 2022. The Newcastle‑Ottawa Scale was used to assess the quality of included studies and a meta‑analysis was performed using RevMan 5.3 software. A total of 12 retrospective studies performing comparisons of DG and TG were included in the present meta‑analysis. For patients who underwent DG, a lower rate of overall post‑operative complications, anastomosis leakage and intro‑abdominal infection was determined. No significant difference was observed between DG and TG in the 5‑year overall survival when the proximal resection margin ranged from 3 to 5 cm. Although DG was associated with a higher 5‑year overall survival rate when compared to TG, there was no significant difference in the stratified analyses by TNM stage. In conclusion, the prognosis of MTGC did not depend on the extent of gastrectomy. With lower complications and acceptable oncological outcomes, DG was a safe and feasible surgical procedure for MTGC when a negative proximal margin was confirmed.
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September-2022
Volume 24 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jiang Y, Yang F, Ma J, Zhang N, Zhang C, Li G and Li Z: Surgical and oncological outcomes of distal gastrectomy compared to total gastrectomy for middle‑third gastric cancer: A systematic review and meta‑analysis. Oncol Lett 24: 291, 2022
APA
Jiang, Y., Yang, F., Ma, J., Zhang, N., Zhang, C., Li, G., & Li, Z. (2022). Surgical and oncological outcomes of distal gastrectomy compared to total gastrectomy for middle‑third gastric cancer: A systematic review and meta‑analysis. Oncology Letters, 24, 291. https://doi.org/10.3892/ol.2022.13411
MLA
Jiang, Y., Yang, F., Ma, J., Zhang, N., Zhang, C., Li, G., Li, Z."Surgical and oncological outcomes of distal gastrectomy compared to total gastrectomy for middle‑third gastric cancer: A systematic review and meta‑analysis". Oncology Letters 24.3 (2022): 291.
Chicago
Jiang, Y., Yang, F., Ma, J., Zhang, N., Zhang, C., Li, G., Li, Z."Surgical and oncological outcomes of distal gastrectomy compared to total gastrectomy for middle‑third gastric cancer: A systematic review and meta‑analysis". Oncology Letters 24, no. 3 (2022): 291. https://doi.org/10.3892/ol.2022.13411