Open Access

Hedgehog signaling regulates the development and treatment of glioblastoma (Review)

  • Authors:
    • Hongping Wang
    • Qun Lai
    • Dayong Wang
    • Jian Pei
    • Baogang Tian
    • Yunhe Gao
    • Zhaoguo Gao
    • Xiang Xu
  • View Affiliations

  • Published online on: July 5, 2022     https://doi.org/10.3892/ol.2022.13414
  • Article Number: 294
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioblastoma (GBM) is the most common and fatal malignant tumor type of the central nervous system. GBM affects public health and it is important to identify biomarkers to improve diagnosis, reduce drug resistance and improve prognosis (e.g., personalized targeted therapies). Hedgehog (HH) signaling has an important role in embryonic development, tissue regeneration and stem cell renewal. A large amount of evidence indicates that both normative and non‑normative HH signals have an important role in GBM. The present study reviewed the role of the HH signaling pathway in the occurrence and progression of GBM. Furthermore, the effectiveness of drugs that target different components of the HH pathway was also examined. The HH pathway has an important role in reversing drug resistance after GBM conventional treatment. The present review highlighted the relevance of HH signaling in GBM and outlined that this pathway has a key role in the occurrence, development and treatment of GBM.
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September-2022
Volume 24 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang H, Lai Q, Wang D, Pei J, Tian B, Gao Y, Gao Z and Xu X: Hedgehog signaling regulates the development and treatment of glioblastoma (Review). Oncol Lett 24: 294, 2022
APA
Wang, H., Lai, Q., Wang, D., Pei, J., Tian, B., Gao, Y. ... Xu, X. (2022). Hedgehog signaling regulates the development and treatment of glioblastoma (Review). Oncology Letters, 24, 294. https://doi.org/10.3892/ol.2022.13414
MLA
Wang, H., Lai, Q., Wang, D., Pei, J., Tian, B., Gao, Y., Gao, Z., Xu, X."Hedgehog signaling regulates the development and treatment of glioblastoma (Review)". Oncology Letters 24.3 (2022): 294.
Chicago
Wang, H., Lai, Q., Wang, D., Pei, J., Tian, B., Gao, Y., Gao, Z., Xu, X."Hedgehog signaling regulates the development and treatment of glioblastoma (Review)". Oncology Letters 24, no. 3 (2022): 294. https://doi.org/10.3892/ol.2022.13414