Open Access

Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report

  • Authors:
    • Yueqing Cao
    • Lang Zou
    • Hao Zhou
    • Gan Fu
    • Xielan Zhao
  • View Affiliations

  • Published online on: July 5, 2022     https://doi.org/10.3892/ol.2022.13418
  • Article Number: 298
  • Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A 53‑year‑old male presented with a 1‑month history of hyperpyrexia. The clinical manifestations revealed hemophagocytic lymphohistiocytosis (HLH). Although a lymph node biopsy could not be obtained, a bone marrow biopsy revealed the activated B‑cell subtype of diffuse large B‑cell lymphoma (DLBCL). After being treated with HLH‑1994 (dexamethasone and etoposide), a rituximab‑containing chemotherapy and target agents involving bortezomib, the patient achieved remission. To understand the molecular profile of patient, next‑generation sequencing and MYD88 L265P mutation examinations were performed, and the patient was determined to be positive for the MYD88 L265P mutation. Reports of DLBCL with plasmacytic differentiation and a MYD88 innate immune signal transduction adaptor L265P mutation concurrent with HLH are rare. Early recognition, precise diagnosis and timely therapy are pivotal in improving patient prognosis. Furthermore, molecular profiling enables researchers to develop potential therapies aimed at the activated NF‑κB and endoplasmic reticulum stress signaling pathways. The present study highlights this pathogenesis and provides suggestions for further individualized therapeutics.
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September-2022
Volume 24 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Cao Y, Zou L, Zhou H, Fu G and Zhao X: Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report. Oncol Lett 24: 298, 2022
APA
Cao, Y., Zou, L., Zhou, H., Fu, G., & Zhao, X. (2022). Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report. Oncology Letters, 24, 298. https://doi.org/10.3892/ol.2022.13418
MLA
Cao, Y., Zou, L., Zhou, H., Fu, G., Zhao, X."Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report". Oncology Letters 24.3 (2022): 298.
Chicago
Cao, Y., Zou, L., Zhou, H., Fu, G., Zhao, X."Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report". Oncology Letters 24, no. 3 (2022): 298. https://doi.org/10.3892/ol.2022.13418