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Case Report Open Access

Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report

  • Authors:
    • Yueqing Cao
    • Lang Zou
    • Hao Zhou
    • Gan Fu
    • Xielan Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 298
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    Published online on: July 5, 2022
       https://doi.org/10.3892/ol.2022.13418
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Abstract

A 53‑year‑old male presented with a 1‑month history of hyperpyrexia. The clinical manifestations revealed hemophagocytic lymphohistiocytosis (HLH). Although a lymph node biopsy could not be obtained, a bone marrow biopsy revealed the activated B‑cell subtype of diffuse large B‑cell lymphoma (DLBCL). After being treated with HLH‑1994 (dexamethasone and etoposide), a rituximab‑containing chemotherapy and target agents involving bortezomib, the patient achieved remission. To understand the molecular profile of patient, next‑generation sequencing and MYD88 L265P mutation examinations were performed, and the patient was determined to be positive for the MYD88 L265P mutation. Reports of DLBCL with plasmacytic differentiation and a MYD88 innate immune signal transduction adaptor L265P mutation concurrent with HLH are rare. Early recognition, precise diagnosis and timely therapy are pivotal in improving patient prognosis. Furthermore, molecular profiling enables researchers to develop potential therapies aimed at the activated NF‑κB and endoplasmic reticulum stress signaling pathways. The present study highlights this pathogenesis and provides suggestions for further individualized therapeutics.
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Copy and paste a formatted citation
Spandidos Publications style
Cao Y, Zou L, Zhou H, Fu G and Zhao X: Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report. Oncol Lett 24: 298, 2022.
APA
Cao, Y., Zou, L., Zhou, H., Fu, G., & Zhao, X. (2022). Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report. Oncology Letters, 24, 298. https://doi.org/10.3892/ol.2022.13418
MLA
Cao, Y., Zou, L., Zhou, H., Fu, G., Zhao, X."Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report". Oncology Letters 24.3 (2022): 298.
Chicago
Cao, Y., Zou, L., Zhou, H., Fu, G., Zhao, X."Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report". Oncology Letters 24, no. 3 (2022): 298. https://doi.org/10.3892/ol.2022.13418
Copy and paste a formatted citation
x
Spandidos Publications style
Cao Y, Zou L, Zhou H, Fu G and Zhao X: Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report. Oncol Lett 24: 298, 2022.
APA
Cao, Y., Zou, L., Zhou, H., Fu, G., & Zhao, X. (2022). Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report. Oncology Letters, 24, 298. https://doi.org/10.3892/ol.2022.13418
MLA
Cao, Y., Zou, L., Zhou, H., Fu, G., Zhao, X."Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report". Oncology Letters 24.3 (2022): 298.
Chicago
Cao, Y., Zou, L., Zhou, H., Fu, G., Zhao, X."Hemophagocytic lymphohistiocytosis as an onset of diffuse large B‑cell lymphoma: A case report". Oncology Letters 24, no. 3 (2022): 298. https://doi.org/10.3892/ol.2022.13418
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