Role of neutrophil‑lymphocyte ratio, platelet‑lymphocyte ratio, lymphocyte‑monocyte ratio and platelets in prognosis of patients with prostate cancer

Huszno,Joanna; Kołosza,Zofia; Mrochem-Kwarciak,Jolanta; Telka,Ewa; Jochymek,Bożena; Miszczyk,Leszek

doi:10.3892/ol.2022.13425

September-2022 Volume 24 Issue 3

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September-2022 Volume 24 Issue 3

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Article

Role of neutrophil‑lymphocyte ratio, platelet‑lymphocyte ratio, lymphocyte‑monocyte ratio and platelets in prognosis of patients with prostate cancer

Authors:
- Joanna Huszno
- Zofia Kołosza
- Jolanta Mrochem-Kwarciak
- Ewa Telka
- Bożena Jochymek
- Leszek Miszczyk
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Affiliations: Radiotherapy Department, Maria Sklodowska‑Curie National Research Institute of Oncology Gliwice Branch, 44‑100 Gliwice, Poland, Department of Biostatistics and Bioinformatics, Maria Sklodowska‑Curie National Research Institute of Oncology Gliwice Branch, 44‑100 Gliwice, Poland, Analytics and Clinical Biochemistry Department, Maria Sklodowska‑Curie National Research Institute of Oncology Gliwice Branch, 44‑100 Gliwice, Poland
Article Number: 305
|
Published online on: July 8, 2022

https://doi.org/10.3892/ol.2022.13425
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Abstract

The aim of the present analysis was to evaluate the platelet‑lymphocyte ratio (PLR), neutrophil‑lymphocyte ratio (NLR), lymphocyte‑monocyte ratio (LMR), platelets (PLT) and neutrophil level for their prognostic values in patients with prostate cancer who had been treated with radiotherapy. A retrospective analysis of 152 patients who were treated in the Radiotherapy Department at Maria Sklodowska‑Curie National Research Institute of Oncology (Gliwice, Poland) between January 2012 and December 2014 was performed. The prognostic value (overall survival; OS) of the pre‑treatment PLR, NLR, LMR, PLT, neutrophil level and other laboratory factors such as: leukocyte, lymphocyte, monocyte, hemoglobin, RBC, prostate‑specific antigen level (PSA), Gleason score, age, smoking and comorbid condition were assessed using univariate analysis. The cut‑off point was determined for NLR as ‘elevated’ at >4.66, LMR >3.26 and the PLR was considered ‘elevated’ at >89.6. Median follow‑up was 4.9 years. The 5 and 7‑year OS rates were 81.5 and 72.2%, respectively. In univariate analysis higher NLR (P=0.007), higher level of PLT (P=0.004), higher level of neutrophils (P=0.013), elevated level of leukocyte (P=0.043) and lymphocyte (P=0.043) were factors significantly associated with decreased OS. No difference was found for PLR (P=0.308) and LMR (P=0.109). The other factor associated with decreased OS were: higher Gleason score (>7; P=0.005), higher PSA level (>20 ng/dl; P=0.0001), smoking (P=0.003) and older age (>70 years; P=0.018). In multivariate analysis, NLR, LMR, leukocyte and RBC were independently associated with prognosis in patients with prostate cancer. Elevated pre‑treatment NLR [hazard ratio (HR)=10.83; P=0.001), LMR (HR=3.14; P=0.007) and higher leukocyte level (HR=3.14; P=0.007) were independently associated with increased mortality risk. Overall, pre‑treatment NLR, PLR, leukocyte and RBC levels were revealed to be independent prognostic factors.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Role of neutrophil‑lymphocyte ratio, platelet‑lymphocyte ratio, lymphocyte‑monocyte ratio and platelets in prognosis of patients with prostate cancer

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