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Effects of primary granulocyte‑colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with germ cell tumors

  • Authors:
    • Nikola Hapakova
    • Michal Chovanec
    • Katarina Rejlekova
    • Katarina Kalavska
    • Jana Obertova
    • Patrik Palacka
    • Valentina De Angelis
    • Daniela Svetlovska
    • Zuzana Sycova-Mila
    • Jozef Mardiak
    • Michal Mego
  • View Affiliations / Copyright

    Affiliations: Second Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, 833 10 Bratislava, Slovak Republic
    Copyright: © Hapakova et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 308
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    Published online on: July 13, 2022
       https://doi.org/10.3892/ol.2022.13428
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Abstract

Testicular germ cell tumors (GCTs) are the most common solid malignancy in males aged 15‑35 years. Febrile neutropenia (FN) is a serious complication of chemotherapy that frequently occurs in patients with GCTs. The present retrospective study aimed to evaluate the effect of primary granulocyte‑colony stimulating factor (G‑CSF) prophylaxis on the incidence of FN in patients with GCTs. The present study included a review of the medical records of patients diagnosed with GCTs treated with first‑line/adjuvant chemotherapy between January 2000 and December 2017 at the National Cancer Institute (Bratislava, Slovakia). In January 2006, a decision was made to administer G‑CSF prophylaxis (filgrastim or pegfilgrastim) to patients after every cycle of chemotherapy. The present study included 385 patients, and out of these, 264 patients received primary G‑CSF prophylaxis, while 121 patients did not. A total of 71 patients (18.4%) suffered from FN events. In the subgroup that did not receive primary prophylaxis, 42 patients exhibited FN, while only 29 patients with primary prophylaxis suffered from FN (34.7 vs. 11.0%; P=0.00000003). According to the subgroup analysis, FN incidence was decreased in all groups that received primary prophylaxis, except for patients with stage I GCT receiving adjuvant chemotherapy, without affecting overall survival. Primary G‑CSF prophylaxis was associated with markedly reduced FN incidence in patients treated with first‑line chemotherapy for metastatic disease. Therefore, the results of the present study suggested that primary G‑CSF prophylaxis should be considered in patients with GCT receiving first‑line chemotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Hapakova N, Chovanec M, Rejlekova K, Kalavska K, Obertova J, Palacka P, De Angelis V, Svetlovska D, Sycova-Mila Z, Mardiak J, Mardiak J, et al: Effects of primary granulocyte‑colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with germ cell tumors. Oncol Lett 24: 308, 2022.
APA
Hapakova, N., Chovanec, M., Rejlekova, K., Kalavska, K., Obertova, J., Palacka, P. ... Mego, M. (2022). Effects of primary granulocyte‑colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with germ cell tumors. Oncology Letters, 24, 308. https://doi.org/10.3892/ol.2022.13428
MLA
Hapakova, N., Chovanec, M., Rejlekova, K., Kalavska, K., Obertova, J., Palacka, P., De Angelis, V., Svetlovska, D., Sycova-Mila, Z., Mardiak, J., Mego, M."Effects of primary granulocyte‑colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with germ cell tumors". Oncology Letters 24.3 (2022): 308.
Chicago
Hapakova, N., Chovanec, M., Rejlekova, K., Kalavska, K., Obertova, J., Palacka, P., De Angelis, V., Svetlovska, D., Sycova-Mila, Z., Mardiak, J., Mego, M."Effects of primary granulocyte‑colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with germ cell tumors". Oncology Letters 24, no. 3 (2022): 308. https://doi.org/10.3892/ol.2022.13428
Copy and paste a formatted citation
x
Spandidos Publications style
Hapakova N, Chovanec M, Rejlekova K, Kalavska K, Obertova J, Palacka P, De Angelis V, Svetlovska D, Sycova-Mila Z, Mardiak J, Mardiak J, et al: Effects of primary granulocyte‑colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with germ cell tumors. Oncol Lett 24: 308, 2022.
APA
Hapakova, N., Chovanec, M., Rejlekova, K., Kalavska, K., Obertova, J., Palacka, P. ... Mego, M. (2022). Effects of primary granulocyte‑colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with germ cell tumors. Oncology Letters, 24, 308. https://doi.org/10.3892/ol.2022.13428
MLA
Hapakova, N., Chovanec, M., Rejlekova, K., Kalavska, K., Obertova, J., Palacka, P., De Angelis, V., Svetlovska, D., Sycova-Mila, Z., Mardiak, J., Mego, M."Effects of primary granulocyte‑colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with germ cell tumors". Oncology Letters 24.3 (2022): 308.
Chicago
Hapakova, N., Chovanec, M., Rejlekova, K., Kalavska, K., Obertova, J., Palacka, P., De Angelis, V., Svetlovska, D., Sycova-Mila, Z., Mardiak, J., Mego, M."Effects of primary granulocyte‑colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with germ cell tumors". Oncology Letters 24, no. 3 (2022): 308. https://doi.org/10.3892/ol.2022.13428
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