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Thyroid dysfunction during PD‑1 inhibitor treatment in patients with cancer: Incidence and association with progression‑free survival

  • Authors:
    • Yanfei Wu
    • Zhi Wang
    • Hongxia Bai
    • Yan Gao
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Navy Medical Center of People Liberation Army, Naval Medical University, Shanghai 200433, P.R. China, Department of Nuclear Radiation Injury Protection and Treatment, Navy Medical Center of People Liberation Army, Naval Medical University, Shanghai 200433, P.R. China, Department of Pulmonary and Critical Care Medicine, Baotou Central Hospital, Baotou, Inner Mongolia Autonomous Region 014040, P.R. China, Department of Nuclear Medicine, Baotou Tumor Hospital, Baotou, Inner Mongolia Autonomous Region 014030, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 309
    |
    Published online on: July 13, 2022
       https://doi.org/10.3892/ol.2022.13429
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Abstract

The use of programmed cell death‑1 (PD‑1) inhibitors has recently been approved in China. As a consequence, the identification of relevant prognostic markers that can assess the efficacy of these compounds is required. Therefore, the present study aimed to explore the incidence of thyroid dysfunction and its ability to predict progression‑free survival (PFS) in Chinese patients with cancer who received PD‑1 inhibitor treatment. Data from 72 patients with cancer who received treatment with PD‑1 inhibitors alone or in combination with chemotherapy or targeted drugs were analyzed. Moreover, the expression levels of free triiodothyronine, thyroxine, and thyrotropin during treatment were assessed to evaluate thyroid dysfunction. A total of 26 (36.1%) patients who had received PD‑1 inhibitors developed thyroid dysfunction. Specifically, the incidence of thyroid dysfunction was 35.6% in patients with lung cancer, 25.0% in patients with malignant melanoma, and 46.7% in patients with other types of cancer. In addition, the median PFS was 7.0 (95% confidence interval, 4.9‑9.1) months, whereas the 1‑ and 2‑year PFS rates were 35.1 and 26.2%, respectively. Generally, patients with thyroid dysfunction exhibited longer PFS compared with those without thyroid dysfunction (P=0.001). Subgroup analyses were subsequently performed, which demonstrated that thyroid dysfunction was associated with longer PFS in patients with malignant melanoma (P=0.039) and other types of cancer (P=0.002), but not in those with lung cancer (P=0.083). These findings were noted in patients who received PD‑1 inhibitor monotherapy (P=0.003), but not PD‑1 inhibitor plus chemotherapy (P=0.172) or PD‑1 inhibitor plus targeted therapy (P=0.582). Finally, thyroid dysfunction [P=0.001; hazard ratio (HR)=0.260] and PD‑1 inhibitor monotherapy (P=0.015; HR=2.231) were identified as independent factors that could predict PFS. In conclusion, the present study demonstrated that thyroid dysfunction during PD‑1 inhibitor treatment could be used as a potential marker for the prognosis of favorable PFS in patients with cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wu Y, Wang Z, Bai H and Gao Y: Thyroid dysfunction during PD‑1 inhibitor treatment in patients with cancer: Incidence and association with progression‑free survival. Oncol Lett 24: 309, 2022.
APA
Wu, Y., Wang, Z., Bai, H., & Gao, Y. (2022). Thyroid dysfunction during PD‑1 inhibitor treatment in patients with cancer: Incidence and association with progression‑free survival. Oncology Letters, 24, 309. https://doi.org/10.3892/ol.2022.13429
MLA
Wu, Y., Wang, Z., Bai, H., Gao, Y."Thyroid dysfunction during PD‑1 inhibitor treatment in patients with cancer: Incidence and association with progression‑free survival". Oncology Letters 24.3 (2022): 309.
Chicago
Wu, Y., Wang, Z., Bai, H., Gao, Y."Thyroid dysfunction during PD‑1 inhibitor treatment in patients with cancer: Incidence and association with progression‑free survival". Oncology Letters 24, no. 3 (2022): 309. https://doi.org/10.3892/ol.2022.13429
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Y, Wang Z, Bai H and Gao Y: Thyroid dysfunction during PD‑1 inhibitor treatment in patients with cancer: Incidence and association with progression‑free survival. Oncol Lett 24: 309, 2022.
APA
Wu, Y., Wang, Z., Bai, H., & Gao, Y. (2022). Thyroid dysfunction during PD‑1 inhibitor treatment in patients with cancer: Incidence and association with progression‑free survival. Oncology Letters, 24, 309. https://doi.org/10.3892/ol.2022.13429
MLA
Wu, Y., Wang, Z., Bai, H., Gao, Y."Thyroid dysfunction during PD‑1 inhibitor treatment in patients with cancer: Incidence and association with progression‑free survival". Oncology Letters 24.3 (2022): 309.
Chicago
Wu, Y., Wang, Z., Bai, H., Gao, Y."Thyroid dysfunction during PD‑1 inhibitor treatment in patients with cancer: Incidence and association with progression‑free survival". Oncology Letters 24, no. 3 (2022): 309. https://doi.org/10.3892/ol.2022.13429
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