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Hyperlipidemia as a risk factor for Trousseau syndrome‑related cerebral infarction in patients with advanced gastrointestinal cancer

  • Authors:
    • Toshimitsu Tanaka
    • Hiroyuki Suzuki
    • Keisuke Miwa
    • Tomoyuki Ushijima
    • Sachiko Nagasu
    • Masaru Fukahori
    • Kaito Ishii
    • Toru Nakamura
    • Hideki Iwamoto
    • Atsutaka Masuda
    • Takahiko Sakaue
    • Hironori Koga
    • Yoshito Akagi
    • Kenta Murotani
    • Takuji Torimura
  • View Affiliations / Copyright

    Affiliations: Multidisciplinary Treatment Cancer Center, Kurume University Hospital, Kurume, Fukuoka 830‑0011, Japan, Department of Medicine, Division of Gastroenterology, Kurume University School of Medicine, Kurume, Fukuoka 830‑0011, Japan, Department of Medicine, Division of Gastroenterology, Kurume University School of Medicine, Kurume, Fukuoka 830‑0011, Japan, Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830‑0011, Japan, Biostatistics Center, Kurume University, Kurume, Fukuoka 830‑0011, Japan
    Copyright: © Tanaka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 318
    |
    Published online on: July 19, 2022
       https://doi.org/10.3892/ol.2022.13437
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Abstract

Trousseau syndrome‑related cerebral infarction rarely occurs during chemotherapy in patients with gastrointestinal (GI) cancer, and its clinical features remain unclear. The present study aimed to examine the clinical features of Trousseau syndrome‑related cerebral infarction developed during chemotherapy for GI cancer. The present retrospective cohort study consecutively enrolled 878 patients with unresectable GI cancer who received chemotherapy at the Multidisciplinary Treatment Cancer Center, Kurume University Hospital (Kurume, Japan) between April 2014 and March 2020. Patients with colorectal cancer (n=308) were the most common, followed by those with pancreatic (n=242), gastric (n=222) and biliary tract (n=59) cancer, neuroendocrine tumors (n=34) and duodenal cancer (n=11). Among the 878 patients, Trousseau syndrome‑related cerebral infarction occurred in 8 (0.9%) patients with a median age of 70.5 years (range, 58‑75 years), and 50% of the patients were male (4/8). In total, 3 patients had gastric cancer, 3 had pancreatic cancer and 2 had biliary tract cancer. A greater percentage of patients with Trousseau syndrome‑related cerebral infarction had hyperlipidemia (38.0%) than those without (8.2%; P=0.005). Hyperlipidemia was a risk factor for occurrence of Trousseau syndrome‑related cerebral infarction with an odds ratio of 7.009 (95% confidence interval, 1.785‑27.513). Trousseau syndrome‑related cerebral infarction developed during GI chemotherapy was rare and hyperlipidemia may predict its onset.
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Copy and paste a formatted citation
Spandidos Publications style
Tanaka T, Suzuki H, Miwa K, Ushijima T, Nagasu S, Fukahori M, Ishii K, Nakamura T, Iwamoto H, Masuda A, Masuda A, et al: Hyperlipidemia as a risk factor for Trousseau syndrome‑related cerebral infarction in patients with advanced gastrointestinal cancer. Oncol Lett 24: 318, 2022.
APA
Tanaka, T., Suzuki, H., Miwa, K., Ushijima, T., Nagasu, S., Fukahori, M. ... Torimura, T. (2022). Hyperlipidemia as a risk factor for Trousseau syndrome‑related cerebral infarction in patients with advanced gastrointestinal cancer. Oncology Letters, 24, 318. https://doi.org/10.3892/ol.2022.13437
MLA
Tanaka, T., Suzuki, H., Miwa, K., Ushijima, T., Nagasu, S., Fukahori, M., Ishii, K., Nakamura, T., Iwamoto, H., Masuda, A., Sakaue, T., Koga, H., Akagi, Y., Murotani, K., Torimura, T."Hyperlipidemia as a risk factor for Trousseau syndrome‑related cerebral infarction in patients with advanced gastrointestinal cancer". Oncology Letters 24.3 (2022): 318.
Chicago
Tanaka, T., Suzuki, H., Miwa, K., Ushijima, T., Nagasu, S., Fukahori, M., Ishii, K., Nakamura, T., Iwamoto, H., Masuda, A., Sakaue, T., Koga, H., Akagi, Y., Murotani, K., Torimura, T."Hyperlipidemia as a risk factor for Trousseau syndrome‑related cerebral infarction in patients with advanced gastrointestinal cancer". Oncology Letters 24, no. 3 (2022): 318. https://doi.org/10.3892/ol.2022.13437
Copy and paste a formatted citation
x
Spandidos Publications style
Tanaka T, Suzuki H, Miwa K, Ushijima T, Nagasu S, Fukahori M, Ishii K, Nakamura T, Iwamoto H, Masuda A, Masuda A, et al: Hyperlipidemia as a risk factor for Trousseau syndrome‑related cerebral infarction in patients with advanced gastrointestinal cancer. Oncol Lett 24: 318, 2022.
APA
Tanaka, T., Suzuki, H., Miwa, K., Ushijima, T., Nagasu, S., Fukahori, M. ... Torimura, T. (2022). Hyperlipidemia as a risk factor for Trousseau syndrome‑related cerebral infarction in patients with advanced gastrointestinal cancer. Oncology Letters, 24, 318. https://doi.org/10.3892/ol.2022.13437
MLA
Tanaka, T., Suzuki, H., Miwa, K., Ushijima, T., Nagasu, S., Fukahori, M., Ishii, K., Nakamura, T., Iwamoto, H., Masuda, A., Sakaue, T., Koga, H., Akagi, Y., Murotani, K., Torimura, T."Hyperlipidemia as a risk factor for Trousseau syndrome‑related cerebral infarction in patients with advanced gastrointestinal cancer". Oncology Letters 24.3 (2022): 318.
Chicago
Tanaka, T., Suzuki, H., Miwa, K., Ushijima, T., Nagasu, S., Fukahori, M., Ishii, K., Nakamura, T., Iwamoto, H., Masuda, A., Sakaue, T., Koga, H., Akagi, Y., Murotani, K., Torimura, T."Hyperlipidemia as a risk factor for Trousseau syndrome‑related cerebral infarction in patients with advanced gastrointestinal cancer". Oncology Letters 24, no. 3 (2022): 318. https://doi.org/10.3892/ol.2022.13437
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