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Article Open Access

Knockdown of lncRNA JPX suppresses IL‑1β‑stimulated injury in chondrocytes through modulating an miR‑25‑3p/PPID axis

  • Authors:
    • Zhiyong Ren
    • Liguo Tang
    • Zhonghua Ding
    • Jun Song
    • Hailiang Zheng
    • Dongzhu Li
  • View Affiliations / Copyright

    Affiliations: Orthopedic Center, Sunshine Union Hospital, Weifang, Shandong 261000, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 388
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    Published online on: September 19, 2022
       https://doi.org/10.3892/ol.2022.13508
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Abstract

The aim of this study was to investigate the potential mechanisms of long noncoding (lnc) RNA Just proximal to X‑inactive specific transcript (JPX) in interleukin (IL)‑1β‑stimulated chondrocytes. Human C28/I2 chondrocytes were treated with IL‑1β to simulate osteoarthritic (OA) injury. The expression levels of JPX, microRNA (miRNA/miR)‑25‑3p, and peptidylprolyl isomerase D (PPID) were measured using reverse transcription‑quantitative PCR or western blotting. The IL‑1β‑stimulated injury was assessed using a Cell Counting Kit‑8 assay, flow cytometry, and western blot analysis. The targeted relationship between miR‑25‑3p, JPX, and PPID was verified using a dual‑luciferase reporter and RNA immunoprecipitation (RIP) assays. The results showed that JPX expression was upregulated in OA patients and IL‑1β‑stimulated chondrocytes. JPX knockdown enhanced cell viability and suppressed apoptosis of IL‑1β‑stimulated chondrocytes. miR‑25‑3p inhibition rescued the inhibitory effect of JPX knockdown on IL‑1β‑stimulated injury. PPID overexpression eliminated the effects of JPX knockdown on IL‑1β‑stimulated chondrocytes. In conclusion, JPX knockdown increased cell viability and reduced apoptosis in IL‑1β‑stimulated chondrocytes, and this involved modulation of a miR‑25‑3p/PPID axis.
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View References

1 

Sacitharan PK: Ageing and osteoarthritis. Subcell Biochem. 91:123–159. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Zhi L, Zhao J, Zhao H, Qing Z, Liu H and Ma J: Downregulation of LncRNA OIP5-AS1 induced by IL-1β aggravates osteoarthritis via regulating miR-29b-3p/PGRN. Cartilage. 3 (2_suppl):1345S–1355S. 2020.PubMed/NCBI

3 

Bolduc JA, Collins JA and Loeser RF: Reactive oxygen species, aging and articular cartilage homeostasis. Free Radic Biol Med. 132:73–82. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Charlier E, Deroyer C, Ciregia F, Malaise O, Neuville S, Plener Z, Malaise M and de Seny D: Chondrocyte dedifferentiation and osteoarthritis (OA). Biochem Pharmacol. 165:49–65. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Pap T and Korb-Pap A: Cartilage damage in osteoarthritis and rheumatoid arthritis-two unequal siblings. Nat Rev Rheumatol. 11:606–615. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Theocharis AD, Manou D and Karamanos NK: The extracellular matrix as a multitasking player in disease. FEBS J. 286:2830–2869. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Quinn JJ and Chang HY: Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 17:47–62. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Cao L, Wang Y, Wang Q and Huang J: LncRNA FOXD2-AS1 regulates chondrocyte proliferation in osteoarthritis by acting as a sponge of miR-206 to modulate CCND1 expression. Biomed Pharmacother. 106:1220–1226. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Wawrzyniak O, Zarębska Ż, Rolle K and Gotz-Więckowska A: Circular and long non-coding RNAs and their role in ophthalmologic diseases. Acta Biochim Pol. 65:497–508. 2018.PubMed/NCBI

10 

Wei JW, Huang K, Yang C and Kang CS: Non-coding RNAs as regulators in epigenetics (Review). Oncol Rep. 37:3–9. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Zhang L, Zhang P, Sun X, Zhou L and Zhao J: Long non-coding RNA DANCR regulates proliferation and apoptosis of chondrocytes in osteoarthritis via miR-216a-5p-JAK2-STAT3 axis. Biosci Rep. 38:BSR201812282018. View Article : Google Scholar : PubMed/NCBI

12 

Mao G, Kang Y, Lin R, Hu S and Zhang Z, Li H, Liao W and Zhang Z: Long Non-coding RNA HOTTIP promotes CCL3 expression and induces cartilage degradation by sponging miR-455-3p. Front Cell Dev Biol. 7:1612019. View Article : Google Scholar : PubMed/NCBI

13 

Ye D, Jian W, Feng J and Liao X: Role of long noncoding RNA ZFAS1 in proliferation, apoptosis and migration of chondrocytes in osteoarthritis. Biomed Pharmacother. 104:825–831. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Wang G, Bu X, Zhang Y, Zhao X, Kong Y, Ma L, Niu S, Wu B and Meng C: LncRNA-UCA1 enhances MMP-13 expression by inhibiting miR-204-5p in human chondrocytes. Oncotarget. 8:91281–91290. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Ma X, Yuan T, Yang C, Wang Z, Zang Y, Wu L and Zhuang L: X-inactive-specific transcript of peripheral blood cells is regulated by exosomal Jpx and acts as a biomarker for female patients with hepatocellular carcinoma. Ther Adv Med Oncol. 9:665–677. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Khajehdehi M, Khalaj-Kondori M and Hosseinpour Feizi MA: Expression profiling of cancer-related long non-coding RNAs revealed upregulation and biomarker potential of HAR1B and JPX in colorectal cancer. Mol Biol Rep. 49:6075–6084. 2022. View Article : Google Scholar : PubMed/NCBI

17 

Pan J, Fang S, Tian H, Zhou C, Zhao X, Tian H, He J, Shen W, Meng X, Jin X and Gong Z: lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling. Mol Cancer. 19:92020. View Article : Google Scholar : PubMed/NCBI

18 

Yao Y, Chen S, Lu N, Yin Y and Liu Z: LncRNA JPX overexpressed in oral squamous cell carcinoma drives malignancy via miR-944/CDH2 axis. Oral Dis. 27:924–933. 2021. View Article : Google Scholar : PubMed/NCBI

19 

Zimta AA, Tomuleasa C, Sahnoune I, Calin GA and Berindan-Neagoe I: Long Non-coding RNAs in myeloid malignancies. Front Oncol. 9:10482019. View Article : Google Scholar : PubMed/NCBI

20 

Gál Z, Gézsi A, Semsei ÁF, Nagy A, Sultész M, Csoma Z, Tamási L, Gálffy G and Szalai C: Investigation of circulating lncRNAs as potential biomarkers in chronic respiratory diseases. J Transl Med. 18:4222020. View Article : Google Scholar : PubMed/NCBI

21 

Chen Z, Ke X, Wang X, Kang H and Hong S: LncRNA JPX contributes to Treg/Th17 imbalance in allergic rhinitis via targeting the miR-378g/CCL5 axis. Immunopharmacol Immunotoxicol. 44:519–524. 2022. View Article : Google Scholar : PubMed/NCBI

22 

Mellis D and Caporali A: MicroRNA-based therapeutics in cardiovascular disease: Screening and delivery to the target. Biochem Soc Trans. 46:11–21. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Swingler TE, Niu L, Smith P, Paddy P, Le L, Barter MJ, Young DA and Clark IM: The function of microRNAs in cartilage and osteoarthritis. Clin Exp Rheumatol. 37 (Suppl):S40–S47. 2019.PubMed/NCBI

24 

Chen K, Zhu H, Zheng MQ and Dong QR: LncRNA MEG3 inhibits the degradation of the extracellular matrix of chondrocytes in osteoarthritis via targeting miR-93/TGFBR2 axis. Cartilage. 13 (2_Suppl):1274S–1284S. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Zhang P, Sun J, Liang C, Gu B, Xu Y, Lu H, Cao B and Xu H: lncRNA IGHCγ1 Acts as a ceRNA to regulate macrophage inflammation via the miR-6891-3p/TLR4 axis in osteoarthritis. Mediators Inflamm. 2020:97430372020. View Article : Google Scholar : PubMed/NCBI

26 

Yao N, Peng S, Wu H, Liu W, Cai D and Huang D: Long noncoding RNA PVT1 promotes chondrocyte extracellular matrix degradation by acting as a sponge for miR-140 in IL-1β-stimulated chondrocytes. J Orthop Surg Res. 17:2182022. View Article : Google Scholar : PubMed/NCBI

27 

Zhang Y, Ma L, Wang C, Wang L, Guo Y and Wang G: Long noncoding RNA LINC00461 induced osteoarthritis progression by inhibiting miR-30a-5p. Aging. 12:4111–4123. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Lu J, Wu Z and Xiong Y: Knockdown of long noncoding RNA HOTAIR inhibits osteoarthritis chondrocyte injury by miR-107/CXCL12 axis. J Orthop Surg Res. 16:4102021. View Article : Google Scholar : PubMed/NCBI

29 

Kurowska W, Kuca-Warnawin E, Radzikowska A, Jakubaszek M, Maślińska M, Kwiatkowska B and Maśliński W: Monocyte-related biomarkers of rheumatoid arthritis development in undifferentiated arthritis patients-a pilot study. Reumatologia. 56:10–16. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Wang X, Ning Y, Zhou B, Yang L, Wang Y and Guo X: Integrated bioinformatics analysis of the osteoarthritis-associated microRNA expression signature. Mol Med Rep. 17:1833–1838. 2018.PubMed/NCBI

31 

He X and Deng L: Potential of miR-25-3p in protection of chondrocytes: Emphasis on osteoarthritis. Folia Histochem Cytobiol. 59:30–39. 2021. View Article : Google Scholar : PubMed/NCBI

32 

Fischer G, Berger E and Bang H: Kinetic beta-deuterium isotope effects suggest a covalent mechanism for the protein folding enzyme peptidylprolyl cis/trans-isomerase. FEBS Lett. 250:267–270. 1989. View Article : Google Scholar : PubMed/NCBI

33 

Galat A: Peptidylprolyl cis/trans isomerases (immunophilins): Biological diversity-targets-functions. Curr Top Med Chem. 3:1315–1347. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Lebedev I, Nemajerova A, Foda ZH, Kornaj M, Tong M, Moll UM and Seeliger MA: A novel in vitro CypD-Mediated p53 aggregation assay suggests a model for mitochondrial permeability transition by chaperone systems. J Mol Biol. 428:4154–4167. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Lu LQ, Tian J, Luo XJ and Peng J: Targeting the pathways of regulated necrosis: A potential strategy for alleviation of cardio-cerebrovascular injury. Cell Mol Life Sci. 78:63–78. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Gan X, Zhang L, Liu B, Zhu Z, He Y, Chen J, Zhu J and Yu H: CypD-mPTP axis regulates mitochondrial functions contributing to osteogenic dysfunction of MC3T3-E1 cells in inflammation. J Physiol Biochem. 74:395–402. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Huang Z, Lan J and Gao X: Feprazone Mitigates IL-1β-Induced cellular senescence in chondrocytes. ACS Omega. 6:9442–9448. 2021. View Article : Google Scholar : PubMed/NCBI

38 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Li JH, Liu S, Zhou H, Qu LH and Yang JH: starBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 42:(Database Issue). D92–D97. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Yang JH, Li JH, Shao P, Zhou H, Chen YQ and Qu LH: starBase: A database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res. 39:(Database Issue). D202–D209. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Pearson MJ and Jones SW: Review: Long Noncoding RNAs in the regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis. Arthritis Rheumatol. 68:2575–2583. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Cen X, Huang XQ, Sun WT, Liu Q and Liu J: Long noncoding RNAs: A new regulatory code in osteoarthritis. Am J Transl Res. 9:4747–4755. 2017.PubMed/NCBI

43 

Brooks P: Inflammation as an important feature of osteoarthritis. Bull World Health Organ. 81:689–690. 2003.PubMed/NCBI

44 

Yu T, Qu J, Wang Y and Jin H: Ligustrazine protects chondrocyte against IL-1β induced injury by regulation of SOX9/NF-κB signaling pathway. J Cell Biochem. 119:7419–7430. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Zuniga MC, Raghuraman G and Zhou W: Physiologic levels of resistin induce a shift from proliferation to apoptosis in macrophage and VSMC co-culture. Surgery. 163:906–911. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Yao C, Cao X, Fu Z, Tian J, Dong W, Xu J, An K, Zhai L and Yu J: Boschniakia rossica polysaccharide triggers laryngeal carcinoma cell apoptosis by regulating expression of Bcl-2, Caspase-3, and P53. Med Sci Monit. 23:2059–2064. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Kim JA, Kim JC, Min JS, Kang I, Oh J and Ahn JK: HSV-1 ICP27 induces apoptosis by promoting Bax translocation to mitochondria through interacting with 14-3-3θ. BMB Rep. 50:257–262. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Lin XQ, Huang ZM, Chen X, Wu F and Wu W: XIST Induced by JPX suppresses hepatocellular carcinoma by sponging miR-155-5p. Yonsei Med J. 59:816–826. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Yang H, Wang G, Liu J, Lin M, Chen J, Fang Y, Li Y, Cai W and Zhan D: LncRNA JPX regulates proliferation and apoptosis of nucleus pulposus cells by targeting the miR-18a-5p/HIF-1α/Hippo-YAP pathway. Biochem Biophys Res Commun. 566:16–23. 2021. View Article : Google Scholar : PubMed/NCBI

50 

Li R, Wen Y, Wu B, He M, Zhang P, Zhang Q and Chen Y: MicroRNA-25-3p suppresses epileptiform discharges through inhibiting oxidative stress and apoptosis via targeting OXSR1 in neurons. Biochem Biophys Res Commun. 523:859–866. 2020. View Article : Google Scholar : PubMed/NCBI

51 

Liu G, Kang X, Guo P, Shang Y, Du R, Wang X, Chen L, Yue R and Kong F: miR-25-3p promotes proliferation and inhibits autophagy of renal cells in polycystic kidney mice by regulating ATG14-Beclin 1. Ren Fail. 42:333–342. 2020. View Article : Google Scholar : PubMed/NCBI

52 

Jandova J, Janda J and Sligh JE: Cyclophilin 40 alters UVA-induced apoptosis and mitochondrial ROS generation in keratinocytes. Exp Cell Res. 319:750–760. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ren Z, Tang L, Ding Z, Song J, Zheng H and Li D: Knockdown of lncRNA JPX suppresses IL‑1β‑stimulated injury in chondrocytes through modulating an miR‑25‑3p/PPID axis. Oncol Lett 24: 388, 2022.
APA
Ren, Z., Tang, L., Ding, Z., Song, J., Zheng, H., & Li, D. (2022). Knockdown of lncRNA JPX suppresses IL‑1β‑stimulated injury in chondrocytes through modulating an miR‑25‑3p/PPID axis. Oncology Letters, 24, 388. https://doi.org/10.3892/ol.2022.13508
MLA
Ren, Z., Tang, L., Ding, Z., Song, J., Zheng, H., Li, D."Knockdown of lncRNA JPX suppresses IL‑1β‑stimulated injury in chondrocytes through modulating an miR‑25‑3p/PPID axis". Oncology Letters 24.5 (2022): 388.
Chicago
Ren, Z., Tang, L., Ding, Z., Song, J., Zheng, H., Li, D."Knockdown of lncRNA JPX suppresses IL‑1β‑stimulated injury in chondrocytes through modulating an miR‑25‑3p/PPID axis". Oncology Letters 24, no. 5 (2022): 388. https://doi.org/10.3892/ol.2022.13508
Copy and paste a formatted citation
x
Spandidos Publications style
Ren Z, Tang L, Ding Z, Song J, Zheng H and Li D: Knockdown of lncRNA JPX suppresses IL‑1β‑stimulated injury in chondrocytes through modulating an miR‑25‑3p/PPID axis. Oncol Lett 24: 388, 2022.
APA
Ren, Z., Tang, L., Ding, Z., Song, J., Zheng, H., & Li, D. (2022). Knockdown of lncRNA JPX suppresses IL‑1β‑stimulated injury in chondrocytes through modulating an miR‑25‑3p/PPID axis. Oncology Letters, 24, 388. https://doi.org/10.3892/ol.2022.13508
MLA
Ren, Z., Tang, L., Ding, Z., Song, J., Zheng, H., Li, D."Knockdown of lncRNA JPX suppresses IL‑1β‑stimulated injury in chondrocytes through modulating an miR‑25‑3p/PPID axis". Oncology Letters 24.5 (2022): 388.
Chicago
Ren, Z., Tang, L., Ding, Z., Song, J., Zheng, H., Li, D."Knockdown of lncRNA JPX suppresses IL‑1β‑stimulated injury in chondrocytes through modulating an miR‑25‑3p/PPID axis". Oncology Letters 24, no. 5 (2022): 388. https://doi.org/10.3892/ol.2022.13508
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