Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2022 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2022 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Mechanism of action of CTRP6 in the regulation of tumorigenesis in the digestive system (Review)

  • Authors:
    • Aimin Zhang
    • Mowei Kong
    • Xiuyun Zhang
    • Zhenying Pei
  • View Affiliations / Copyright

    Affiliations: Department of Nutriology, Shijiazhuang Second Hospital, Shijiazhuang, Hebei 050000, P.R. China, Department of Cardiology, Guiqian International General Hospital, Guiyang, Guizhou 550018, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 391
    |
    Published online on: September 21, 2022
       https://doi.org/10.3892/ol.2022.13511
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tumors of the digestive system have always received attention, and their occurrence and development are regulated by various mechanisms such as inflammation and immunity, glucose and lipid metabolism, and tumor angiogenesis. Complement Clq/TNF‑related protein 6 (CTRP6) is a member of the CTRP family; it is widely expressed in various tissues and cell types, and plays a biological role in a number of mechanisms, such as glucose and lipid metabolism and inflammation. Recent studies have revealed the tumor‑promoting effect of CTRP6 in gastric cancer, liver cancer, colorectal cancer and other gastrointestinal tumors, but, to the best of our knowledge, there has been no systematic discussion on the tumor‑promoting mechanism of CTRP6. The present study reviews the role of CTRP6 in tumors of the digestive system and its possible mechanisms.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Zhang CL, Wu LL and Li L: Research progress of complement-C1q/tumor necrosis factor-related protein 3. Sheng Li Xue Bao. 69:666–676. 2017.PubMed/NCBI

2 

Schäffler A and Buechler C: CTRP family: Linking immunity to metabolism. Trends Endocrinol Metab. 23:194–204. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Han M, Wang B, Zhu M and Zhang Y: C1QTNF6 as a novel biomarker regulates cellular behaviors in A549 cells and exacerbates the outcome of lung adenocarcinoma patients. In Vitro Cell Dev Biol Anim. 55:614–621. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Lin W, Chen X, Chen T, Liu J, Ye Y, Chen L, Qiu X, Chia-Hsien Cheng J, Zhang L, Wu J and Qiu S: C1QTNF6 as a novel diagnostic and prognostic biomarker for clear cell renal cell carcinoma. DNA Cell Biol. 39:1000–1011. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Wang L, Liu Z, Duan L, Ma B and Sun Z: C1q tumor necrosis factor-related protein 6 (CTRP6) inhibits the proliferation and migration of ovarian cancer cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 31:1664–1668. 2015.(In Chinese). PubMed/NCBI

6 

Wan X, Zheng C and Dong L: Inhibition of CTRP6 prevented survival and migration in hepatocellular carcinoma through inactivating the AKT signaling pathway. J Cell Biochem. 120:17059–17066. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Qu HX, Cui L, Meng XY, Wang ZJ, Cui YX, Yu YP, Wang D and Jiang XJ: C1QTNF6 is overexpressed in gastric carcinoma and contributes to the proliferation and migration of gastric carcinoma cells. Int J Mol Med. 43:621–629. 2019.PubMed/NCBI

8 

Takeuchi T, Adachi Y and Nagayama T: Expression of a secretory protein C1qTNF6, a C1qTNF family member, in hepatocellular carcinoma. Anal Cell Pathol (Amst). 34:113–121. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Kishore U, Gaboriaud C, Waters P, Shrive AK, Greenhough TJ, Reid KB, Sim RB and Arlaud GJ: C1q and tumor necrosis factor superfamily: Modularity and versatility. Trends Immunol. 25:551–561. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, Revett T, Gimeno R and Lodish HF: Molecular, biochemical and functional characterizations of C1q/TNF family members: Adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J. 416:161–177. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Kim MJ, Lee W, Park EJ and Park SY: C1qTNF-related protein-6 increases the expression of interleukin-10 in macrophages. Mol Cells. 30:59–64. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Wong GW, Wang J, Hug C, Tsao TS and Lodish HF: A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci USA. 101:10302–10307. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Kong M, Gao Y, Guo X, Xie Y and Yu Y: Role of the CTRP family in tumor development and progression. Oncol Lett. 22:7232021. View Article : Google Scholar : PubMed/NCBI

14 

Chen L and Su G: Identification of CTRP1 as a prognostic biomarker and oncogene in human glioblastoma. Biomed Res Int. 2019:25824162019.PubMed/NCBI

15 

Maeda T, Jikko A, Abe M, Yokohama-Tamaki T, Akiyama H, Furukawa S, Takigawa M and Wakisaka S: Cartducin, a paralog of Acrp30/adiponectin, is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes. J Cell Physiol. 206:537–544. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Akiyama H, Furukawa S, Wakisaka S and Maeda T: CTRP3/cartducin promotes proliferation and migration of endothelial cells. Mol Cell Biochem. 304:243–248. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Gao J, Gu G, Lu L and Wang X: Research progress of C1q tumor necrosis factor-related protein 4. International Journal of Cardiovascular Diseases 99–101; 2016

18 

Thanasupawat T, Glogowska A, Burg M, Wong GW, Hoang-Vu C, Hombach-Klonisch S and Klonisch T: RXFP1 is targeted by complement C1q tumor necrosis factor-related factor 8 in brain cancer. Front Endocrinol (Lausanne). 6:1272015. View Article : Google Scholar : PubMed/NCBI

19 

Hano K, Hatano K, Saigo C, Kito Y, Shibata T and Takeuchi T: An adiponectin paralog protein, CTRP6 decreased the proliferation and invasion activity of oral squamous cell carcinoma cells: Possible interaction with laminin receptor pathway. Mol Biol Rep. 46:4967–4973. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Gou J, Kang S, Qu H and Cui Y: Expression of complement C1q/tumor necrosis factor-related protein 6 in colon cancer. Journal of Gastroenterology and Hepatology. 28:313–316. 2019.

21 

Kirketerp-Møller N, Bayarri-Olmos R, Krogfelt KA and Garred P: C1q/TNF-Related protein 6 is a pattern recognition molecule that recruits collectin-11 from the complement system to ligands. J Immunol. 204:1598–1606. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Lei X, Seldin MM, Little HC, Choy N, Klonisch T and Wong GW: C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance. J Biol Chem. 292:14836–14850. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Xu E, Yin C, Yi X and Liu Y: Knockdown of CTRP6 inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells through regulating the Akt/NF-kB pathway. Clin Exp Pharmacol Physiol. 47:1203–1211. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Li Y, Sun J, Gu L and Gao X: Protective effect of CTRP6 on cerebral ischemia/reperfusion injury by attenuating inflammation, oxidative stress and apoptosis in PC12 cells. Mol Med Rep. 22:344–352. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Altomare DA and Testa JR: Perturbations of the AKT signaling pathway in human cancer. Oncogene. 24:7455–7464. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Pintha K, Chaiwangyen W, Yodkeeree S, Suttajit M and Tantipaiboonwong P: Suppressive effects of rosmarinic acid rich fraction from perilla on oxidative stress, inflammation and metastasis ability in A549 cells exposed to PM via C-Jun, P-65-Nf-kb and Akt signaling pathways. Biomolecules. 11:10902021. View Article : Google Scholar : PubMed/NCBI

27 

Bou Malhab LJ and Abdel-Rahman WM: Obesity and inflammation: Colorectal cancer engines. Curr Mol Pharmacol. 15:620–646. 2022. View Article : Google Scholar : PubMed/NCBI

28 

Liu X, Yao L, Qu J, Liu L, Lu N, Wang J and Zhang J: Cancer-associated fibroblast infiltration in gastric cancer: The discrepancy in subtypes pathways and immunosuppression. J Transl Med. 19:3252021. View Article : Google Scholar : PubMed/NCBI

29 

Zhai J, Shen J, Xie G, Wu J, He M, Gao L, Zhang Y, Yao X and Shen L: Cancer-associated fibroblasts-derived IL-8 mediates resistance to cisplatin in human gastric cancer. Cancer Lett. 454:37–43. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Chi X, Liu Z, Wei W, Hu X, Wang Y, Wang H and Xu B: Selenium-rich royal jelly inhibits hepatocellular carcinoma through PI3K/AKT and VEGF pathways in H22 tumor-bearing mice. Food Funct. 12:9111–9127. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Zhao H, Wu L, Yan G, Chen Y, Zhou M, Wu Y and Li Y: Inflammation and tumor progression: signaling pathways and targeted intervention. Signal Transduct Target Ther. 6:2632021. View Article : Google Scholar : PubMed/NCBI

32 

Li Z, Chi H, Zhu W, Yang G, Song J, Mo L, Zhang Y, Deng Y, Xu F, Yang J, et al: Cadmium induces renal inflammation by activating the NLRP3 inflammasome through ROS/MAPK/NF-kB pathway in vitro and in vivo. Arch Toxicol. 95:3497–3513. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Eyre S, Hinks A, Bowes J, Flynn E, Martin P, Wilson AG, Morgan AW, Emery P, Steer S, Hocking LJ, et al: Overlapping genetic susceptibility variants between three autoimmune disorders: Rheumatoid arthritis, type 1 diabetes and coeliac disease. Arthritis Res Ther. 12:R1752010. View Article : Google Scholar : PubMed/NCBI

34 

Ray AL, Berggren KL, Restrepo Cruz S, Gan GN and Beswick EJ: Inhibition of MK2 suppresses IL-1β, IL-6, and TNF-α-dependent colorectal cancer growth. Int J Cancer. 142:1702–1711. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Yang T, Zhang J, Zhou J, Zhu M, Wang L and Yan L: Resveratrol inhibits Interleukin-6 induced invasion of human gastric cancer cells. Biomed Pharmacother. 99:766–773. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Xia Y, Khoi PN, Yoon HJ, Lian S, Joo YE, Chay KO, Kim KK and Jung YD: Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells. Mol Cell Biochem. 398:147–156. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Shokrzadeh M, Mohammadpour A, Hoseini V, Abediankenari S, Ghassemi-Barghi N and Tabari YS: Serum cytokine OF IL-2, IL-10 and IL-12 levels in patients with stomach adenocarcinoma. Arq Gastroenterol. 55:385–389. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Mohamed EA, Bassiouny K, Alshambky AA and Khalil H: Anticancer properties of N,N-dibenzylasparagine as an Asparagine (Asp) analog, using colon cancer caco-2 cell line. Asian Pac J Cancer Prev. 23:2531–2540. 2022. View Article : Google Scholar : PubMed/NCBI

39 

Neurath MF: IL-23 in inflammatory bowel diseases and colon cancer. Cytokine Growth Factor Rev. 45:1–8. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Kern L, Mittenbühler MJ, Vesting AJ, Ostermann AL, Wunderlich CM and Wunderlich FT: Obesity-Induced TNFα and IL-6 signaling: The missing link between obesity and inflammation-driven liver and colorectal cancers. Cancers (Basel). 11:242018. View Article : Google Scholar : PubMed/NCBI

41 

Pu X and Chen D: Targeting adipokines in obesity-related tumors. Front Oncol. 11:6859232021. View Article : Google Scholar : PubMed/NCBI

42 

Sadeghi A, Fadaei R, Moradi N, Fouani FZ, Roozbehkia M, Zandieh Z, Ansaripour S, Vatannejad A and Doustimotlagh AH: Circulating levels of C1q/TNF-α-related protein 6 (CTRP6) in polycystic ovary syndrome. IUBMB Life. 72:1449–1459. 2020. View Article : Google Scholar : PubMed/NCBI

43 

Wu W, Xu K, Li M, Zhang J and Wang Y: MicroRNA-29b/29c targeting CTRP6 influences porcine adipogenesis via the AKT/PKA/MAPK Signalling pathway. Adipocyte. 10:264–274. 2021. View Article : Google Scholar : PubMed/NCBI

44 

Wu W, Ji M, Xu K, Zhang D, Yin Y, Huang X, Peng Y and Zhang J: Knockdown of CTRP6 reduces the deposition of intramuscular and subcutaneous fat in pigs via different signaling pathways. Biochim Biophys Acta Mol Cell Biol Lipids. 1865:1587292020. View Article : Google Scholar : PubMed/NCBI

45 

Wu WJ, Mo DL, Zhao CZ, Zhao C, Chen YS, Pang WJ and Yang GS: Knockdown of CTRP6 inhibits adipogenesis via lipogenic marker genes and Erk1/2 signalling pathway. Cell Biol Int. 39:554–562. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Wang M, Tang X, Li L, Liu D, Liu H, Zheng H, Deng W, Zhao X and Yang G: C1q/TNF-related protein-6 is associated with insulin resistance and the development of diabetes in Chinese population. Acta Diabetol. 55:1221–1229. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Chen HY, Yang MD, Chou YC, Ma YS, Peng SF, Liao CL, Chen PY, Hsia TC, Lien JC and Chen CH: Ouabain Suppresses Cell Migration and Invasion in Human Gastric Cancer AGS Cells Through the Inhibition of MMP Signaling Pathways. Anticancer Res. 41:4365–4375. 2021. View Article : Google Scholar : PubMed/NCBI

48 

Kasprzak A: Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer. Int J Mol Sci. 22:64342021. View Article : Google Scholar : PubMed/NCBI

49 

Kruszyna Ł, Murawa D, Jagodziński PP, Oszkinis G and Krasiński Z: The expression and prognostic significance of VEGF and CXCR4 in gastric cancer: Correlation with Angiogenesis, Lymphangiogenesis and Progression. Curr Issues Mol Biol. 44:3075–3088. 2022. View Article : Google Scholar : PubMed/NCBI

50 

Batzorig U, Wei PL, Wang W, Huang CY and Chang YJ: Glucose-Regulated Protein 94 Mediates the Proliferation and Metastasis through the Regulation of ETV1 and MAPK Pathway in Colorectal Cancer. Int J Med Sci. 18:2251–2261. 2021. View Article : Google Scholar : PubMed/NCBI

51 

Wiśniewska W, Kopka M, Siemiątkowska K, Fudalej MM, Sobiborowicz A and Badowska-Kozakiewicz AM: The complexity of tumour angiogenesis based on recently described molecules. Contemp Oncol (Pozn). 25:33–44. 2021.PubMed/NCBI

52 

Phung TL, Ziv K, Dabydeen D, Eyiah-Mensah G, Riveros M, Perruzzi C, Sun J, Monahan-Earley RA, Shiojima I, Nagy JA, et al: Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell. 10:159–170. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Si Y, Fan W and Sun L: A review of the relationship between CTRP family and coronary artery disease. Curr Atheroscler Rep. 22:222020. View Article : Google Scholar : PubMed/NCBI

54 

Yamaguchi S, Shibata R, Ohashi K, Enomoto T, Ogawa H, Otaka N, Hiramatsu-Ito M, Masutomi T, Kawanishi H, Murohara T and Ouchi N: C1q/TNF-Related protein 9 promotes revascularization in response to ischemia via an eNOS-Dependent manner. Front Pharmacol. 11:13132020. View Article : Google Scholar : PubMed/NCBI

55 

He L, Wang W, Shi H, Jiang C, Yao H, Zhang Y, Qian W and Lin R: THBS4/integrin α2 axis mediates BM-MSCs to promote angiogenesis in gastric cancer associated with chronic Helicobacter pylori infection. Aging (Albany NY). 13:19375–19396. 2021. View Article : Google Scholar : PubMed/NCBI

56 

Auyeung KK and Ko JK: Angiogenesis and oxidative stress in metastatic tumor progression: Pathogenesis and novel therapeutic approach of colon cancer. Curr Pharm Des. 23:3952–3961. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Zhao Z, Gao J, Li C, Xu X, Hu Y and Huang S: Reactive oxygen species induce endothelial differentiation of liver cancer stem-like sphere cells through the activation of Akt/IKK signaling pathway. Oxid Med Cell Longev. 2020:16216872020. View Article : Google Scholar : PubMed/NCBI

58 

Lin JX, Weng XF, Xie XS, Lian NZ, Qiu SL, Wang JB, Lu J, Chen QY, Cao LL, Lin M, et al: CDK5RAP3 inhibits angiogenesis in gastric neuroendocrine carcinoma by modulating AKT/HIF-1α/VEGFA signaling. Cancer Cell Int. 19:2822019. View Article : Google Scholar : PubMed/NCBI

59 

Chung SY, Chao TC and Su Y: The stemness-high human colorectal cancer cells promote angiogenesis by producing higher amounts of angiogenic cytokines via activation of the Egfr/Akt/Nf-kB pathway. Int J Mol Sci. 22:13552021. View Article : Google Scholar : PubMed/NCBI

60 

Li HY, Li M, Luo CC, Wang JQ and Zheng N: Lactoferrin exerts antitumor effects by inhibiting angiogenesis in a HT29 human colon tumor model. J Agric Food Chem. 65:10464–10472. 2017. View Article : Google Scholar : PubMed/NCBI

61 

Wang L, Yi T, Kortylewski M, Pardoll DM, Zeng D and Yu H: IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med. 206:1457–1464. 2009. View Article : Google Scholar : PubMed/NCBI

62 

Carling D: AMPK. Curr Biol. 14:R2202004. View Article : Google Scholar : PubMed/NCBI

63 

Huang H, Wang L, Qian F, Chen X, Zhu H, Yang M, Zhang C, Chu M, Wang X and Huang X: Liraglutide via activation of AMP-Activated protein kinase-hypoxia inducible factor-1α-Heme Oxygenase-1 signaling promotes wound healing by preventing endothelial dysfunction in diabetic mice. Front Physiol. 12:6602632021. View Article : Google Scholar : PubMed/NCBI

64 

Zulato E, Bergamo F, De Paoli A, Griguolo G, Esposito G, De Salvo GL, Mescoli C, Rugge M, Nardin M, Di Grazia L, et al: Prognostic significance of AMPK activation in advanced stage colorectal cancer treated with chemotherapy plus bevacizumab. Br J Cancer. 111:25–32. 2014. View Article : Google Scholar : PubMed/NCBI

65 

Dai W, Wang Y, Yang T, Wang J, Wu W and Gu J: Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals. Cell Commun Signal. 17:1132019. View Article : Google Scholar : PubMed/NCBI

66 

Wang Y, Wang B, Guerram M, Sun L, Shi W, Tian C, Zhu X, Jiang Z and Zhang L: Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activatio. Oncotarget. 6:29497–29512. 2015. View Article : Google Scholar : PubMed/NCBI

67 

Sen K, Banerjee S and Mandal M: Dual drug loaded liposome bearing apigenin and 5-Fluorouracil for synergistic therapeutic efficacy in colorectal cancer. Colloids Surf B Biointerfaces. 180:9–22. 2019. View Article : Google Scholar : PubMed/NCBI

68 

Qu LH, Hong X, Zhang Y, Cong X, Xiang RL, Mei M, Su JZ, Wu LL and Yu GY: C1q/tumor necrosis factor-related protein-6 attenuates TNF-α-induced apoptosis in salivary acinar cells via AMPK/SIRT1-modulated miR-34a-5p expression. J Cell Physiol. 236:5785–5800. 2021. View Article : Google Scholar : PubMed/NCBI

69 

Xie YH, Xiao Y, Huang Q, Hu XF, Gong ZC and Du J: Role of the CTRP6/AMPK pathway in kidney fibrosis through the promotion of fatty acid oxidation. Eur J Pharmacol. 892:1737552021. View Article : Google Scholar : PubMed/NCBI

70 

Moon HS, Liu X, Nagel JM, Chamberland JP, Diakopoulos KN, Brinkoetter MT, Hatziapostolou M, Wu Y, Robson SC, Iliopoulos D and Mantzoros CS: Salutary effects of adiponectin on colon cancer: In vivo and in vitro studies in mice. Gut. 62:561–570. 2013. View Article : Google Scholar : PubMed/NCBI

71 

Iwata Y, Yasufuku I, Saigo C, Kito Y, Takeuchi T and Yoshida K: Anti-fibrotic properties of an adiponectin paralog protein, C1q/TNF-related protein 6 (CTRP6), in diffuse gastric adenocarcinoma. J Cancer. 12:1161–1168. 2021. View Article : Google Scholar : PubMed/NCBI

72 

Murayama MA, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, Tateishi K, Ishigame H, Yabe R, Ikeda S, et al: CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis. Nat Commun. 6:84832015. View Article : Google Scholar : PubMed/NCBI

73 

Lei H, Wu D, Wang JY, Li L, Zhang CL, Feng H, Fu FY and Wu LL: C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation. Basic Res Cardiol. 110:352015. View Article : Google Scholar : PubMed/NCBI

74 

Dong X, Hu H, Fang Z, Cui J and Liu F: CTRP6 inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration. Biomed Pharmacother. 103:844–850. 2018. View Article : Google Scholar : PubMed/NCBI

75 

Li R, Du J, Yao Y, Yao G and Wang X: Adiponectin inhibits high glucose-induced angiogenesis via inhibiting autophagy in RF/6A cells. J Cell Physiol. 234:20566–20576. 2019. View Article : Google Scholar : PubMed/NCBI

76 

Shah D, Sandhu K, Das P and Bhandari V: Adiponectin ameliorates hyperoxia-induced lung endothelial dysfunction and promotes angiogenesis in neonatal mice. Pediatr Res. 91:545–555. 2022. View Article : Google Scholar : PubMed/NCBI

77 

Zhang N, Zhou J, Zhou Y and Guan F: MicroRNA-148a inhibits hepatocellular carcinoma cell growth via epithelial-to-mesenchymal transition and PI3K/AKT signaling pathways by targeting death receptor-5. Appl Biochem Biotechnol. 194:2731–2746. 2022. View Article : Google Scholar : PubMed/NCBI

78 

Sp N, Kang DY, Jo ES, Lee JM and Jang KJ: Iron metabolism as a potential mechanism for inducing TRAIL-Mediated extrinsic apoptosis using methylsulfonylmethane in embryonic cancer stem cells. Cells. 10:28472021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang A, Kong M, Zhang X and Pei Z: Mechanism of action of CTRP6 in the regulation of tumorigenesis in the digestive system (Review). Oncol Lett 24: 391, 2022.
APA
Zhang, A., Kong, M., Zhang, X., & Pei, Z. (2022). Mechanism of action of CTRP6 in the regulation of tumorigenesis in the digestive system (Review). Oncology Letters, 24, 391. https://doi.org/10.3892/ol.2022.13511
MLA
Zhang, A., Kong, M., Zhang, X., Pei, Z."Mechanism of action of CTRP6 in the regulation of tumorigenesis in the digestive system (Review)". Oncology Letters 24.5 (2022): 391.
Chicago
Zhang, A., Kong, M., Zhang, X., Pei, Z."Mechanism of action of CTRP6 in the regulation of tumorigenesis in the digestive system (Review)". Oncology Letters 24, no. 5 (2022): 391. https://doi.org/10.3892/ol.2022.13511
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang A, Kong M, Zhang X and Pei Z: Mechanism of action of CTRP6 in the regulation of tumorigenesis in the digestive system (Review). Oncol Lett 24: 391, 2022.
APA
Zhang, A., Kong, M., Zhang, X., & Pei, Z. (2022). Mechanism of action of CTRP6 in the regulation of tumorigenesis in the digestive system (Review). Oncology Letters, 24, 391. https://doi.org/10.3892/ol.2022.13511
MLA
Zhang, A., Kong, M., Zhang, X., Pei, Z."Mechanism of action of CTRP6 in the regulation of tumorigenesis in the digestive system (Review)". Oncology Letters 24.5 (2022): 391.
Chicago
Zhang, A., Kong, M., Zhang, X., Pei, Z."Mechanism of action of CTRP6 in the regulation of tumorigenesis in the digestive system (Review)". Oncology Letters 24, no. 5 (2022): 391. https://doi.org/10.3892/ol.2022.13511
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team