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Efficacy of different salvage regimens in progressive unresectable pediatric low‑grade glioma

  • Authors:
    • Ahmed El-Hemaly
    • Hala Taha
    • Amal Refaat
    • Fatima Adel
    • Mohamed Elbeltagy
    • Omar Arafah
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Oncology, Children's Cancer Hospital Egypt 57357, Cairo 11617, Egypt, Department of Pathology, National Cancer Institute, Cairo University, Cairo 11796, Egypt, Department of Radiodiagnosis, National Cancer Institute, Cairo University, Cairo 11796, Egypt, Department of Research, Children's Cancer Hospital Egypt 57357, Cairo 11617, Egypt, Department of Neurosurgery, Kasr Al‑Ainy School of Medicine, Cairo University, Cairo 11796, Egypt, Department of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo 11796, Egypt
    Copyright: © El-Hemaly et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 407
    |
    Published online on: September 26, 2022
       https://doi.org/10.3892/ol.2022.13527
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Abstract

Multiple salvage chemotherapy regimens are used in progressive low‑grade glioma (LGG), with no single regimen being more effective than any other. In the present study, different salvage therapies were compared with regard to the response rate, overall survival (OS) rate, event‑free survival (EFS) rate and visual outcome in 70 patients with pediatric LGG. Age was found to significantly affect the EFS and OS rates (P<0.001). The visual outcome was the same between the three regimens. The 2‑year EFS and OS rates of the vincristine/carboplatin, monthly carboplatin and weekly vinblastine regimens were 64.7 and 70.6%, 71.0 and 85.0%, and 56.0 and 62.7%, respectively (P=0.6 for EFS; P=0.56 for OS). Overall, the present study demonstrated that age had a significant impact on survival. The three salvage regimens used were equally effective with regard to the radiological response and visual outcome. However, further randomized controlled trials are required to detect the optimal salvage therapy.
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Copy and paste a formatted citation
Spandidos Publications style
El-Hemaly A, Taha H, Refaat A, Adel F, Elbeltagy M and Arafah O: Efficacy of different salvage regimens in progressive unresectable pediatric low‑grade glioma. Oncol Lett 24: 407, 2022.
APA
El-Hemaly, A., Taha, H., Refaat, A., Adel, F., Elbeltagy, M., & Arafah, O. (2022). Efficacy of different salvage regimens in progressive unresectable pediatric low‑grade glioma. Oncology Letters, 24, 407. https://doi.org/10.3892/ol.2022.13527
MLA
El-Hemaly, A., Taha, H., Refaat, A., Adel, F., Elbeltagy, M., Arafah, O."Efficacy of different salvage regimens in progressive unresectable pediatric low‑grade glioma". Oncology Letters 24.5 (2022): 407.
Chicago
El-Hemaly, A., Taha, H., Refaat, A., Adel, F., Elbeltagy, M., Arafah, O."Efficacy of different salvage regimens in progressive unresectable pediatric low‑grade glioma". Oncology Letters 24, no. 5 (2022): 407. https://doi.org/10.3892/ol.2022.13527
Copy and paste a formatted citation
x
Spandidos Publications style
El-Hemaly A, Taha H, Refaat A, Adel F, Elbeltagy M and Arafah O: Efficacy of different salvage regimens in progressive unresectable pediatric low‑grade glioma. Oncol Lett 24: 407, 2022.
APA
El-Hemaly, A., Taha, H., Refaat, A., Adel, F., Elbeltagy, M., & Arafah, O. (2022). Efficacy of different salvage regimens in progressive unresectable pediatric low‑grade glioma. Oncology Letters, 24, 407. https://doi.org/10.3892/ol.2022.13527
MLA
El-Hemaly, A., Taha, H., Refaat, A., Adel, F., Elbeltagy, M., Arafah, O."Efficacy of different salvage regimens in progressive unresectable pediatric low‑grade glioma". Oncology Letters 24.5 (2022): 407.
Chicago
El-Hemaly, A., Taha, H., Refaat, A., Adel, F., Elbeltagy, M., Arafah, O."Efficacy of different salvage regimens in progressive unresectable pediatric low‑grade glioma". Oncology Letters 24, no. 5 (2022): 407. https://doi.org/10.3892/ol.2022.13527
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