Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2022 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2022 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Differentially expressed genes related to lymph node metastasis in advanced laryngeal squamous cell cancers

  • Authors:
    • Ömer Bayır
    • Mehmet Doğan Aşık
    • Güleser Saylam
    • Ferda Alpaslan Pınarlı
    • Emel Çadallı Tatar
    • Ünsal Han
    • Ender Şi̇mşek
    • Mehmet Hakan Korkmaz
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Head and Neck Surgery, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara 06110, Turkey, Department of Medical Biology, School of Medicine, Ankara Yıldırım Beyazıt University, Ankara 06010, Turkey, Myogen Laboratory and Health Services, Ankara 06520, Turkey, Department of Pathology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara 06110, Turkey
    Copyright: © Bayır et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 409
    |
    Published online on: September 26, 2022
       https://doi.org/10.3892/ol.2022.13529
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Understanding the molecular mechanisms and gene expression in laryngeal squamous cell carcinoma (LSCC) may explain its aggressive biological behavior and regional metastasis pathways. In the present study, patients with locally advanced LSCC tumors were examined for differential gene expression in the normal mucosa (non-tumoral mucosa), tumors and lymph node tissues. The aim was to identify possible predictive genes for lymph node metastasis. A total of 16 patients who had undergone total laryngectomy with neck dissection for advanced LSCC were randomly selected from a hospital database: Eight of the patients had lymph node metastasis (Group 1) and the other eight patients did not have metastasis (Group 2). Overall survival (OS), disease‑free survival (DFS) and disease‑specific survival (DSS) were analyzed. For each patient, paraffin‑embedded tissue samples were collected from non‑tumoral mucosa, tumoral lesions and lymph node tissues. RNA was extracted from the tissue samples and used for complementary DNA synthesis, and microarray analysis was subsequently performed on each sample. Gene expression levels were determined in each specimen, and Groups 1 and 2 were compared and statistically analyzed. The microarray results for lymph node metastasis‑positive and ‑negative groups, indicated the differential expression of 312 genes in the lymph nodes, 691 genes in the normal mucosal tissue and 93 genes in the tumor tissue. Transgelin (TAGLN) and cofilin 1 (CFL1) were identified as possible target genes and validated using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). The RT‑qPCR results for TAGLN and CFL1 supported the microarray data. OS, DFS and DSS times were longer in Group 2 than in Group 1 (P=0.002, 0.015 and 0.009, respectively). In addition, TAGLN and CFL1 were associated with DFS and DSS. On the basis of these results, it is suggested that TAGLN and CFL1 expression may play an important role in the pathogenesis of regional metastasis and poor prognosis in advanced LSCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Vigneswaran N and Williams MD: Epidemiologic trends in head and neck cancer and aids in diagnosis. Oral Maxillofac Surg Clin North Am. 26:123–141. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Argiris A, Karamouzis MV, Raben D and Ferris RL: Head and neck cancer. Lancet. 371:1695–1709. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Mifsud M, Eskander A, Irish J, Gullane P, Gilbert R, Brown D, de Almeida JR, Urbach DR and Goldstein DP: Evolving trends in head and neck cancer epidemiology: Ontario, Canada 1993–2010. Head Neck. 39:1770–1778. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Dok R and Nuyts S: HPV positive head and neck cancers: Molecular pathogenesis and evolving treatment strategies. Cancers (Basel). 8:412016. View Article : Google Scholar : PubMed/NCBI

5 

World Health Organization (WHO), . World Cancer Report 2014. WHO; Geneva: pp. 422–435. 2014

6 

Siegel RL, Miller KD and Jemal A: Cancer Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Republic of Turkey Ministry of Health, General Directorate of Public Health, . Cancer Statistics. https://hsgm.saglik.gov.tr/depo/birimler/kanser-db/istatistik/2014-RAPOR._uzuuun.pdfSeptember 3–2019

8 

Leoncini E, Vukovic V, Cadoni G, Pastorino R, Arzani D, Bosetti C, Canova C, Garavello W, La Vecchia C, Maule M, et al: Clinical features and prognostic factors in patients with head and neck cancer: Results from a multicentric study. Cancer Epidemiol. 39:367–374. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, et al: American cancer society head and neck cancer survivorship care guideline. CA Cancer J Clin. 66:203–239. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Belcher R, Hayes K, Fedewa S and Chen AY: Current treatment of head and neck squamous cell cancer. J Surg Oncol. 110:551–574. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Timmermans AJ, de Gooijer CJ, Hamming-Vrieze O, Hilgers FJ and van den Brekel MW: T3-T4 laryngeal cancer in The Netherlands cancer institute; 10-year results of the consistent application of an organ-preserving/-sacrificing protocol. Head Neck. 37:1495–1503. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Layland MK, Sessions DG and Lenox J: The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+. Laryngoscope. 115:629–639. 2005. View Article : Google Scholar : PubMed/NCBI

13 

de Miguel-Luken MJ, Chaves-Conde M and Carnero A: A genetic view of laryngeal cancer heterogeneity. Cell Cycle. 15:1202–1212. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Compton CC, Byrd DR, Garcia-Aguilar J, Kurtzman SH, Olawaiye A and Washington MK: Larynx. AJCC Cancer Staging Atlas: A companion to the seventh editions of the AJCC cancer staging manual and handbook TNM classification of malignant tumours. Springer; New York, NY: pp. 79–90. 2012, View Article : Google Scholar

15 

Ciolofan MS, Vlăescu AN, Mogoantă CA, Ioniță E, Ioniță I, Căpitănescu AN, Mitroi MR and Anghelina F: Clinical, histological and immunohistochemical evaluation of larynx cancer. Curr Health Sci J. 43:367–375. 2017.PubMed/NCBI

16 

Sanguansin S, Kosanwat T, Juengsomjit R and Poomsawat S: Diagnostic value of cytokeratin 17 during oral carcinogenesis: An immunohistochemical study. Int J Dent. 2021:40895492021. View Article : Google Scholar : PubMed/NCBI

17 

Sayar N, Karahan G, Konu O, Bozkurt B, Bozdogan O and Yulug IG: Transgelin gene is frequently downregulated by promoter DNA hypermethylation in breast cancer. Clin Epigenetics. 7:1042015. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Abbasi R, Ramroth H, Becher H, Dietz A, Schmezer P and Popanda O: Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes. Int J Cancer. 125:1431–1439. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Krikelis D, Kotoula V, Bobos M, Fountzilas E, Markou K, Karasmanis I, Angouridakis N, Vlachtsis K, Kalogeras KT, Nikolaou A and Fountzilas G: Protein and mRNA expression of notch pathway components in operable tumors of patients with laryngeal cancer. Anticancer Res. 34:6495–6503. 2014.PubMed/NCBI

21 

Demiral AN, Sarioglu S, Birlik B, Sen M and Kinay M: Prognostic significance of EGF receptor expression in early glottic cancer. Auris Nasus Larynx. 31:417–424. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Nijkamp MM, Span PN, Terhaard CHJ, DoornaertPA H, Langendijk JA, van den EndePLA, de Jong M, van der Kogel AJ, Bussink J and Kaanders JHAM: Epidermal growth factor receptor expression in laryngeal cancer predicts the effect of hypoxia modification as an additive to accelerated radiotherapy in a randomised controlled trial. Eur J Cancer. 49:3202–3209. 2013. View Article : Google Scholar : PubMed/NCBI

23 

de Miguel-Luken MJ, Chaves-Conde M, de Miguel-Luken V, Muñoz-Galván S, López-Guerra JL, Mateos JC, Pachón J, Chinchón D, Suarez V and Carnero A: MAP17 (PDZKIP1) as a novel prognostic biomarker for laryngeal cancer. Oncotarget. 6:12625–12636. 2015. View Article : Google Scholar : PubMed/NCBI

24 

de Miguel-Luken MJ, Chaves-Conde M, Quintana B, Menoyo A, Tirado I, de Miguel-Luken V, Pachón J, Chinchón D, Suarez V and Carnero A: Phosphorylation of gH2AX as a novel prognostic biomarker for laryngoesophageal dysfunction-free survival. Oncotarget. 7:31723–31737. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Choe MH, Min JW, Jeon HB, Cho DH, Oh JS, Lee HG, Hwang SG, An S, Han YH and Kim JS: ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer. Oncotarget. 6:2654–2666. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Yang J, Zhou L, Zhang Y, Zheng J, Zhou J, Wei Z and Zou J: DIAPH1 Is upregulated and inhibits cell apoptosis through ATR/p53/caspase-3 signaling pathway in laryngeal squamous cell carcinoma. Dis Markers. 2019:67164722019. View Article : Google Scholar : PubMed/NCBI

27 

Li L, Wang R, He S, Shen X, Kong F, Li S, Zhao H, Lian M and Fang J: The identification of induction chemo-sensitivity genes of laryngeal squamous cell carcinoma and their clinical utilization. Eur Arch Otorhinolaryngol. 275:2773–2781. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Li Q, Ma L, Wu Z, Wang G, Huang Q, Shen Z and Yu R: Zinc finger Ebox binding homeobox 2 functions as an oncogene in human laryngeal squamous cell carcinoma. Mol Med Rep. 19:4545–4552. 2019.PubMed/NCBI

29 

Li D, Feng J, Wu T, Wang Y, Sun Y, Ren J and Liu M: Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma. Am J Pathol. 182:64–70. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Meng W, Cui W, Zhao L, Chi W, Cao H and Wang B: Aberrant methylation and downregulation of ZNF667-AS1 and ZNF667 promote the malignant progression of laryngeal squamous cell carcinoma. J Biomed Sci. 26:132019. View Article : Google Scholar : PubMed/NCBI

31 

Shen Z, Chen X, Li Q, Zhou C, Xu Y, Yu R, Ye H, Li J and Duan S: Elevated methylation of CMTM3 promoter in the male laryngeal squamous cell carcinoma patients. Clin Biochem. 49:1278–1282. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Yang M, Li W, Liu YY, Fu S, Qiu GB, Sun KL and Fu WN: Promoter hypermethylation-induced transcriptional down-regulation of the gene MYCT1 in laryngeal squamous cell carcinoma. BMC Cancer. 12:2192012. View Article : Google Scholar : PubMed/NCBI

33 

Zhang J, Ren X, Wang B, Cao J, Tian L and Liu M: Effect of DACH1 on proliferation and invasion of laryngeal squamous cell carcinoma. Head Face Med. 14:202018. View Article : Google Scholar : PubMed/NCBI

34 

Zhang J, Hu H and Zhao Y and Zhao Y: CDR1as is overexpressed in laryngeal squamous cell carcinoma to promote the tumour's progression via miR-7 signals. Cell Prolif. 51:e125212018. View Article : Google Scholar : PubMed/NCBI

35 

Yu X and Li Z: The role of microRNAs expression in laryngeal cancer. Oncotarget. 6:23297–23305. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Li M, Zhao X, Liu Y, An J, Xiao H and Wang C: Aberrant expression of CDK8 regulates the malignant phenotype and associated with poor prognosis in human laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 274:2205–2213. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Markowski J, Oczko-Wojciechowska M, Gierek T, Jarzab M, Paluch J, Kowalska M, Wygoda Z, Pfeifer A, Tyszkiewicz T, Jarzab B, et al: Gene expression profile analysis in laryngeal cancer by high-density oligonucleotide microarrays. J Physiol Pharmacol. 60 (Suppl 1):S57–S63. 2009.PubMed/NCBI

38 

Shen Z, Li Q, Deng H, Lu D, Song H and Guo J: Long non-coding RNA profiling in laryngeal squamous cell carcinoma and its clinical significance: Potential biomarkers for LSCC. PLoS One. 9:e1082372014. View Article : Google Scholar : PubMed/NCBI

39 

Xu CZ, Shi RJ, Chen D, Sun YY, Wu QW, Wang T and Wang PH: Potential biomarkers for paclitaxel sensitivity in hypopharynx cancer cell. Int J Clin Exp Pathol. 6:2745–2756. 2013.PubMed/NCBI

40 

Chung CH, Parker JS, Karaca G, Wu J, Funkhouser WK, Moore D, Butterfoss D, Xiang D, Zanation A, Yin X, et al: Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression. Cancer Cell. 5:489–500. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Klamt F, Zdanov S, Levine RL, Pariser A, Zhang Y, Zhang B, Yu LR, Veenstra TD and Shacter E: Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin. Nat Cell Biol. 11:1241–1246. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Lu LI, Fu NI, Luo XU, Li XY and Li XP: Overexpression of cofilin 1 in prostate cancer and the corresponding clinical implications. Oncol Lett. 9:2757–2761. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Polachini GM, Sobral LM, Mercante AM, Paes-Leme AF, Xavier FCA, Henrique T, Guimarães DM, Vidotto A, Fukuyama EE, Góis-Filho JF, et al: Proteomic approaches identify members of cofilin pathway involved in oral tumorigenesis. PLoS One. 7:e505172012. View Article : Google Scholar : PubMed/NCBI

44 

Madak-Erdogan Z, Ventrella R, Petry L and Katzenellenbogen BS: Novel roles for ERK5 and cofilin as critical mediators linking ERalpha-driven transcription, actin reorganization, and invasiveness in breast cancer. Mol Cancer Res. 12:714–727. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Zhang Y, Liao R, Li H, Liu L, Chen X and Chen H: Expression of Cofilin-1 and transgelin in esophageal squamous cell carcinoma. Med Sci Monit. 21:2659–2665. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Camoretti-Mercado B, Forsythe SM, LeBeau MM, Espinosa R III, Vieira JE, Halayko AJ, Willadsen S, Kurtz B, Ober C, Evans GA, et al: Expression and cytogenetic localization of the human SM22 gene (TAGLN). Genomics. 49:452–457. 1998. View Article : Google Scholar : PubMed/NCBI

47 

Zhou H, Zhang Y, Chen Q and Lin Y: AKT and JNK signaling pathways increase the metastatic potential of colorectal cancer cells by altering transgelin expression. Dig Dis Sci. 61:1091–1097. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Zhou HM, Fang YY, Weinberger PM, Ding LL, Cowell JK, Hudson FZ, Ren M, Lee JR, Chen QK, Su H, et al: Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility. BMC Cancer. 16:552016. View Article : Google Scholar : PubMed/NCBI

49 

Xu L, Gao Y, Chen Y, Xiao Y, He Q, Qiu H and Ge W: Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with stage III colorectal cancer. Oncotarget. 7:43868–43893. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Dvorakova M, Jerabkova J, Prochazkova I, Lenco J, Nenutil R and Bouchal P: Transgelin is upregulated in stromal cells of lymph node positive breast cancer. J Proteomics. 132:103–111. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Wu X, Dong L, Zhang R, Ying K and Shen H: Transgelin overexpression in lung adenocarcinoma is associated with tumor progression. Int J Mol Med. 34:585–591. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Bu J, Bu X, Liu B, Chen F and Chen P: Increased expression of tissue/salivary transgelin mRNA predicts poor prognosis in patients with oral squamous cell carcinoma (OSCC). Med Sci Monit. 21:2275–2281. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Winer A, Adams S and Mignatti P: Matrix metalloproteinase inhibitors in cancer therapy: Turning past failures into future successes. Mol Cancer Ther. 17:1147–1155. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Yamaguchi H and Condeelis J: Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta. 1773:642–652. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Roche J: Erratum: Roche, J. The epithelial-to-mesenchymal transition in cancer. Cancers (Basel). 10:792018. View Article : Google Scholar : PubMed/NCBI

56 

Lin Y, Buckhaults PJ, Lee JR, Xiong H, Farrell C, Podolsky RH, Schade RR and Dynan WS: Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancer. Neoplasia. 11:864–873. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Bayır Ö, Aşık MD, Saylam G, Pınarlı FA, Tatar EÇ, Han Ü, Şi̇mşek E and Korkmaz MH: Differentially expressed genes related to lymph node metastasis in advanced laryngeal squamous cell cancers. Oncol Lett 24: 409, 2022.
APA
Bayır, Ö., Aşık, M.D., Saylam, G., Pınarlı, F.A., Tatar, E.Ç., Han, Ü. ... Korkmaz, M.H. (2022). Differentially expressed genes related to lymph node metastasis in advanced laryngeal squamous cell cancers. Oncology Letters, 24, 409. https://doi.org/10.3892/ol.2022.13529
MLA
Bayır, Ö., Aşık, M. D., Saylam, G., Pınarlı, F. A., Tatar, E. Ç., Han, Ü., Şi̇mşek, E., Korkmaz, M. H."Differentially expressed genes related to lymph node metastasis in advanced laryngeal squamous cell cancers". Oncology Letters 24.5 (2022): 409.
Chicago
Bayır, Ö., Aşık, M. D., Saylam, G., Pınarlı, F. A., Tatar, E. Ç., Han, Ü., Şi̇mşek, E., Korkmaz, M. H."Differentially expressed genes related to lymph node metastasis in advanced laryngeal squamous cell cancers". Oncology Letters 24, no. 5 (2022): 409. https://doi.org/10.3892/ol.2022.13529
Copy and paste a formatted citation
x
Spandidos Publications style
Bayır Ö, Aşık MD, Saylam G, Pınarlı FA, Tatar EÇ, Han Ü, Şi̇mşek E and Korkmaz MH: Differentially expressed genes related to lymph node metastasis in advanced laryngeal squamous cell cancers. Oncol Lett 24: 409, 2022.
APA
Bayır, Ö., Aşık, M.D., Saylam, G., Pınarlı, F.A., Tatar, E.Ç., Han, Ü. ... Korkmaz, M.H. (2022). Differentially expressed genes related to lymph node metastasis in advanced laryngeal squamous cell cancers. Oncology Letters, 24, 409. https://doi.org/10.3892/ol.2022.13529
MLA
Bayır, Ö., Aşık, M. D., Saylam, G., Pınarlı, F. A., Tatar, E. Ç., Han, Ü., Şi̇mşek, E., Korkmaz, M. H."Differentially expressed genes related to lymph node metastasis in advanced laryngeal squamous cell cancers". Oncology Letters 24.5 (2022): 409.
Chicago
Bayır, Ö., Aşık, M. D., Saylam, G., Pınarlı, F. A., Tatar, E. Ç., Han, Ü., Şi̇mşek, E., Korkmaz, M. H."Differentially expressed genes related to lymph node metastasis in advanced laryngeal squamous cell cancers". Oncology Letters 24, no. 5 (2022): 409. https://doi.org/10.3892/ol.2022.13529
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team