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Article

Lymph node response to neoadjuvant chemotherapy as an independent prognostic factor in gastric cancer

  • Authors:
    • Yuma Wada
    • Masaaki Nishi
    • Kozo Yoshikawa
    • Chie Takasu
    • Takuya Tokunaga
    • Toshihiro Nakao
    • Hideya Kashihara
    • Toshiaki Yoshimoto
    • Mitsuo Shimada
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokushima University, Tokushima 770‑8503, Japan
  • Article Number: 415
    |
    Published online on: September 28, 2022
       https://doi.org/10.3892/ol.2022.13535
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Abstract

Previous studies have revealed the usefulness of neoadjuvant chemotherapy (NAC) followed by surgery for clinical stage III gastric cancer (GC). The tumor volume at the primary tumor site (PT) is sometimes difficult to measure because of the luminal structure; therefore, evaluation of the lymph node (LN) response to NAC may help to more accurately predict survival outcomes. The present study therefore evaluated the LN response to NAC for prediction of survival outcomes in patients with GC. The study involved 160 patients with clinical stage III GC who underwent NAC (n=14) and upfront surgery (n=146). PT and LN responses to NAC were evaluated, various clinicopathological factors were evaluated and Cox proportional hazard regression analyses were performed to determine survival outcomes. Overall survival (OS) and disease‑free survival (DFS) were not significantly different between patients who underwent NAC and those who underwent upfront surgery (OS, P=0.71; DFS, P=0.50). However, although there were no significant differences in PT responses, patients classified as LN non‑responders to NAC had a significantly worse prognosis compared with patients classified as LN responders in terms of DFS (PT, P=0.93; LN, P<0.01) and OS (PT, P=0.84; LN, P<0.01). Moreover, a higher neutrophil‑lymphocyte ratio tended to be associated with poor DFS [univariate: hazard ratio (HR)=4.23, P=0.06; multivariate: HR=6.45, P=0.04]. Finally, an LN response to NAC was significantly better for prediction of recurrence (univariate, HR=7.79, 95% confidence interval=1.16‑63.51, P=0.02; multivariate, HR=7.44, P=0.01). Overall, the current study revealed the clinical importance of the LN response to NAC for predicting survival outcomes in patients with GC. These findings highlight the potential clinical impact of optimizing treatment strategies to improve the selection and management of patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wada Y, Nishi M, Yoshikawa K, Takasu C, Tokunaga T, Nakao T, Kashihara H, Yoshimoto T and Shimada M: Lymph node response to neoadjuvant chemotherapy as an independent prognostic factor in gastric cancer. Oncol Lett 24: 415, 2022.
APA
Wada, Y., Nishi, M., Yoshikawa, K., Takasu, C., Tokunaga, T., Nakao, T. ... Shimada, M. (2022). Lymph node response to neoadjuvant chemotherapy as an independent prognostic factor in gastric cancer. Oncology Letters, 24, 415. https://doi.org/10.3892/ol.2022.13535
MLA
Wada, Y., Nishi, M., Yoshikawa, K., Takasu, C., Tokunaga, T., Nakao, T., Kashihara, H., Yoshimoto, T., Shimada, M."Lymph node response to neoadjuvant chemotherapy as an independent prognostic factor in gastric cancer". Oncology Letters 24.5 (2022): 415.
Chicago
Wada, Y., Nishi, M., Yoshikawa, K., Takasu, C., Tokunaga, T., Nakao, T., Kashihara, H., Yoshimoto, T., Shimada, M."Lymph node response to neoadjuvant chemotherapy as an independent prognostic factor in gastric cancer". Oncology Letters 24, no. 5 (2022): 415. https://doi.org/10.3892/ol.2022.13535
Copy and paste a formatted citation
x
Spandidos Publications style
Wada Y, Nishi M, Yoshikawa K, Takasu C, Tokunaga T, Nakao T, Kashihara H, Yoshimoto T and Shimada M: Lymph node response to neoadjuvant chemotherapy as an independent prognostic factor in gastric cancer. Oncol Lett 24: 415, 2022.
APA
Wada, Y., Nishi, M., Yoshikawa, K., Takasu, C., Tokunaga, T., Nakao, T. ... Shimada, M. (2022). Lymph node response to neoadjuvant chemotherapy as an independent prognostic factor in gastric cancer. Oncology Letters, 24, 415. https://doi.org/10.3892/ol.2022.13535
MLA
Wada, Y., Nishi, M., Yoshikawa, K., Takasu, C., Tokunaga, T., Nakao, T., Kashihara, H., Yoshimoto, T., Shimada, M."Lymph node response to neoadjuvant chemotherapy as an independent prognostic factor in gastric cancer". Oncology Letters 24.5 (2022): 415.
Chicago
Wada, Y., Nishi, M., Yoshikawa, K., Takasu, C., Tokunaga, T., Nakao, T., Kashihara, H., Yoshimoto, T., Shimada, M."Lymph node response to neoadjuvant chemotherapy as an independent prognostic factor in gastric cancer". Oncology Letters 24, no. 5 (2022): 415. https://doi.org/10.3892/ol.2022.13535
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