Open Access

Role of tumor‑associated neutrophils in lung cancer (Review)

  • Authors:
    • Jinhua Zhou
    • Huan Liu
    • Shulong Jiang
    • Wei Wang
  • View Affiliations

  • Published online on: November 8, 2022     https://doi.org/10.3892/ol.2022.13588
  • Article Number: 2
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Lung cancer is the most common malignancy and the leading cause of cancer mortality worldwide; therefore, it is very important to understand the mechanism of its occurrence and progression. It has reported that inflammation is linked to the incidence of various malignancies. Neutrophils not only participate in the inflammatory response, but are also involved in the composition of the tumor microenvironment. Tumor‑associated neutrophils (TANs) are infiltrating neutrophils in tumors that directly promote tumor development and progression. Moreover, they regulate the immune microenvironment and affect the therapeutic efficacy and prognosis of lung cancer. In the present review, the role of TANs in lung cancer development/progression and the underlying molecular signaling are evaluated, as well as the possibility of TANs as a potential therapeutic target for lung cancer intervention.
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January-2023
Volume 25 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou J, Liu H, Jiang S and Wang W: Role of tumor‑associated neutrophils in lung cancer (Review). Oncol Lett 25: 2, 2023
APA
Zhou, J., Liu, H., Jiang, S., & Wang, W. (2023). Role of tumor‑associated neutrophils in lung cancer (Review). Oncology Letters, 25, 2. https://doi.org/10.3892/ol.2022.13588
MLA
Zhou, J., Liu, H., Jiang, S., Wang, W."Role of tumor‑associated neutrophils in lung cancer (Review)". Oncology Letters 25.1 (2023): 2.
Chicago
Zhou, J., Liu, H., Jiang, S., Wang, W."Role of tumor‑associated neutrophils in lung cancer (Review)". Oncology Letters 25, no. 1 (2023): 2. https://doi.org/10.3892/ol.2022.13588