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Review Open Access

Role of tumor‑associated neutrophils in lung cancer (Review)

  • Authors:
    • Jinhua Zhou
    • Huan Liu
    • Shulong Jiang
    • Wei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Department of Emergency Internal Medicine, Jining First People's Hospital, Jining, Shandong 272000, P.R. China, Clinical Medical Laboratory Center, Jining First People's Hospital, Jinning, Shandong 272000, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 2
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    Published online on: November 8, 2022
       https://doi.org/10.3892/ol.2022.13588
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Abstract

Lung cancer is the most common malignancy and the leading cause of cancer mortality worldwide; therefore, it is very important to understand the mechanism of its occurrence and progression. It has reported that inflammation is linked to the incidence of various malignancies. Neutrophils not only participate in the inflammatory response, but are also involved in the composition of the tumor microenvironment. Tumor‑associated neutrophils (TANs) are infiltrating neutrophils in tumors that directly promote tumor development and progression. Moreover, they regulate the immune microenvironment and affect the therapeutic efficacy and prognosis of lung cancer. In the present review, the role of TANs in lung cancer development/progression and the underlying molecular signaling are evaluated, as well as the possibility of TANs as a potential therapeutic target for lung cancer intervention.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Liu H, Jiang S and Wang W: Role of tumor‑associated neutrophils in lung cancer (Review). Oncol Lett 25: 2, 2023.
APA
Zhou, J., Liu, H., Jiang, S., & Wang, W. (2023). Role of tumor‑associated neutrophils in lung cancer (Review). Oncology Letters, 25, 2. https://doi.org/10.3892/ol.2022.13588
MLA
Zhou, J., Liu, H., Jiang, S., Wang, W."Role of tumor‑associated neutrophils in lung cancer (Review)". Oncology Letters 25.1 (2023): 2.
Chicago
Zhou, J., Liu, H., Jiang, S., Wang, W."Role of tumor‑associated neutrophils in lung cancer (Review)". Oncology Letters 25, no. 1 (2023): 2. https://doi.org/10.3892/ol.2022.13588
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Liu H, Jiang S and Wang W: Role of tumor‑associated neutrophils in lung cancer (Review). Oncol Lett 25: 2, 2023.
APA
Zhou, J., Liu, H., Jiang, S., & Wang, W. (2023). Role of tumor‑associated neutrophils in lung cancer (Review). Oncology Letters, 25, 2. https://doi.org/10.3892/ol.2022.13588
MLA
Zhou, J., Liu, H., Jiang, S., Wang, W."Role of tumor‑associated neutrophils in lung cancer (Review)". Oncology Letters 25.1 (2023): 2.
Chicago
Zhou, J., Liu, H., Jiang, S., Wang, W."Role of tumor‑associated neutrophils in lung cancer (Review)". Oncology Letters 25, no. 1 (2023): 2. https://doi.org/10.3892/ol.2022.13588
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