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Case Report Open Access

Methylation of CpG island promoters at ZNF625, LONRF2, SDC2 and WDR17 in a patient with numerous non‑granular type laterally spreading tumors and colorectal cancer: A case report

  • Authors:
    • Moriya Iwaizumi
    • Terumi Taniguchi
    • Kiyotaka Kurachi
    • Satoshi Osawa
    • Ken Sugimoto
    • Satoshi Baba
    • Haruhiko Sugimura
    • Masato Maekawa
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431‑3192, Japan, Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431‑3192, Japan, Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431‑3192, Japan, First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431‑3192, Japan, Department of Diagnostic Pathology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431‑3192, Japan, Department of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431‑3192, Japan
    Copyright: © Iwaizumi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 14
    |
    Published online on: November 17, 2022
       https://doi.org/10.3892/ol.2022.13600
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Abstract

Patients with adenomatous polyposis syndromes such as familial adenomatous polyposis are at higher risk of colorectal cancer, hence continuous management is necessary. However, little is known about the etiology of patients with numerous laterally spreading tumors (LSTs), or how genetic alterations uniquely influence LSTs in colorectal carcinogenesis. The present case report investigated a woman with >150 non‑granular type LSTs (LST‑NG) and one sigmoid colon cancer. After subtotal colectomy via ileorectal anastomosis, genetic and epigenetic analyses were conducted by comparing the profiles of the patient's normal colonic mucosa, four LST‑NG lesions and a cancer lesion. Using customized multigene panel testing, no pathogenic germline mutations were detected, including APC regulator of WNT signaling pathway, but identified a somatic pathogenic variant of APC in one LST‑NG lesion, and both TP53 and F‑box and WD repeat domain containing 7 somatic mutations in the cancer. Comprehensive genome‑wide methylation analysis showed that CpG island promoters at zinc finger protein 625, LON peptidase N‑terminal domain and ring finger 2, WD repeat domain 17 and syndecan 2 were methylated in both LST‑NG and cancer, which may contribute to colorectal tumorigenesis as early as the LST‑NG phase.
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Copy and paste a formatted citation
Spandidos Publications style
Iwaizumi M, Taniguchi T, Kurachi K, Osawa S, Sugimoto K, Baba S, Sugimura H and Maekawa M: Methylation of CpG island promoters at<em> ZNF625</em>, <em>LONRF2</em>, <em>SDC2</em> and <em>WDR17</em> in a patient with numerous non‑granular type laterally spreading tumors and colorectal cancer: A case report. Oncol Lett 25: 14, 2023.
APA
Iwaizumi, M., Taniguchi, T., Kurachi, K., Osawa, S., Sugimoto, K., Baba, S. ... Maekawa, M. (2023). Methylation of CpG island promoters at<em> ZNF625</em>, <em>LONRF2</em>, <em>SDC2</em> and <em>WDR17</em> in a patient with numerous non‑granular type laterally spreading tumors and colorectal cancer: A case report. Oncology Letters, 25, 14. https://doi.org/10.3892/ol.2022.13600
MLA
Iwaizumi, M., Taniguchi, T., Kurachi, K., Osawa, S., Sugimoto, K., Baba, S., Sugimura, H., Maekawa, M."Methylation of CpG island promoters at<em> ZNF625</em>, <em>LONRF2</em>, <em>SDC2</em> and <em>WDR17</em> in a patient with numerous non‑granular type laterally spreading tumors and colorectal cancer: A case report". Oncology Letters 25.1 (2023): 14.
Chicago
Iwaizumi, M., Taniguchi, T., Kurachi, K., Osawa, S., Sugimoto, K., Baba, S., Sugimura, H., Maekawa, M."Methylation of CpG island promoters at<em> ZNF625</em>, <em>LONRF2</em>, <em>SDC2</em> and <em>WDR17</em> in a patient with numerous non‑granular type laterally spreading tumors and colorectal cancer: A case report". Oncology Letters 25, no. 1 (2023): 14. https://doi.org/10.3892/ol.2022.13600
Copy and paste a formatted citation
x
Spandidos Publications style
Iwaizumi M, Taniguchi T, Kurachi K, Osawa S, Sugimoto K, Baba S, Sugimura H and Maekawa M: Methylation of CpG island promoters at<em> ZNF625</em>, <em>LONRF2</em>, <em>SDC2</em> and <em>WDR17</em> in a patient with numerous non‑granular type laterally spreading tumors and colorectal cancer: A case report. Oncol Lett 25: 14, 2023.
APA
Iwaizumi, M., Taniguchi, T., Kurachi, K., Osawa, S., Sugimoto, K., Baba, S. ... Maekawa, M. (2023). Methylation of CpG island promoters at<em> ZNF625</em>, <em>LONRF2</em>, <em>SDC2</em> and <em>WDR17</em> in a patient with numerous non‑granular type laterally spreading tumors and colorectal cancer: A case report. Oncology Letters, 25, 14. https://doi.org/10.3892/ol.2022.13600
MLA
Iwaizumi, M., Taniguchi, T., Kurachi, K., Osawa, S., Sugimoto, K., Baba, S., Sugimura, H., Maekawa, M."Methylation of CpG island promoters at<em> ZNF625</em>, <em>LONRF2</em>, <em>SDC2</em> and <em>WDR17</em> in a patient with numerous non‑granular type laterally spreading tumors and colorectal cancer: A case report". Oncology Letters 25.1 (2023): 14.
Chicago
Iwaizumi, M., Taniguchi, T., Kurachi, K., Osawa, S., Sugimoto, K., Baba, S., Sugimura, H., Maekawa, M."Methylation of CpG island promoters at<em> ZNF625</em>, <em>LONRF2</em>, <em>SDC2</em> and <em>WDR17</em> in a patient with numerous non‑granular type laterally spreading tumors and colorectal cancer: A case report". Oncology Letters 25, no. 1 (2023): 14. https://doi.org/10.3892/ol.2022.13600
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