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January-2023 Volume 25 Issue 1

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Case Report Open Access

Conservative treatment of glassy cell cervical cancer: A case report

  • Authors:
    • Houssein El Hajj
    • Mathilde Castel
    • Thomas Dennis
    • Camille Pasquesoone
    • Asma Sassi
    • Eric Leblanc
    • Fabrice Narducci
    • Delphine Hudry

  • View Affiliations / Copyright

    Affiliations: Department of Gynecologic Oncology, Oscar Lambret Cancer Center, BP307 Lille, France, Department of Pathology, Oscar Lambret Cancer Center, BP307 Lille, France
    Copyright: © El Hajj et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 16
    |
    Published online on: November 21, 2022
       https://doi.org/10.3892/ol.2022.13602
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Abstract

Glassy cell carcinoma (GCC) constitutes a rare yet histologically aggressive subtype of cervical cancer known for its rapid proliferation and high risk of recurrence and metastasis. Due to its low prevalence, the medical literature lacks large retrospective and prospective studies, and thus, no standardized management has been defined. The recommended treatment for GCC is radical hysterectomy with bilateral pelvic lymphadenectomy; however, since it mainly affects young women of reproductive age, data in the literature suggest conservative management, such as radical trachelectomy. The present report describes the cases of 2 young patients treated conservatively with pelvic lymphadenectomy and radical trachelectomy for early‑stage GCC of the cervix. The first patient was a 37‑year‑old patient who presented a 15‑mm GCC tumor [International Federation of Gynecology and Obstetrics (FIGO) stage IB1], and the second patient was a 23‑year‑old patient who presented a 14‑mm GCC tumor (FIGO stage IB1). The first patient presented early vaginal recurrence 3 months postoperatively, which was treated with concomitant pelvic chemoradiation (45 Gy) followed by vaginal and uterine brachytherapy (15 Gy). The second patient presented internal iliac nodal recurrence 1 year after treatment, which was treated by carboplatin‑paclitaxel‑Avastin‑based chemotherapy, followed by laparoscopic paraaortic lymph node dissection and pelvic chemoradiation (45 Gy). Both patients were tumor‑free after 5 and 6 years, respectively. Due to the aggressiveness of GCC of the cervix and its high risk of recurrence, conservative treatment should be considered cautiously and should not be the standard of care.
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Copy and paste a formatted citation
Spandidos Publications style
El Hajj H, Castel M, Dennis T, Pasquesoone C, Sassi A, Leblanc E, Narducci F and Hudry D: Conservative treatment of glassy cell cervical cancer: A case report. Oncol Lett 25: 16, 2023.
APA
El Hajj, H., Castel, M., Dennis, T., Pasquesoone, C., Sassi, A., Leblanc, E. ... Hudry, D. (2023). Conservative treatment of glassy cell cervical cancer: A case report. Oncology Letters, 25, 16. https://doi.org/10.3892/ol.2022.13602
MLA
El Hajj, H., Castel, M., Dennis, T., Pasquesoone, C., Sassi, A., Leblanc, E., Narducci, F., Hudry, D."Conservative treatment of glassy cell cervical cancer: A case report". Oncology Letters 25.1 (2023): 16.
Chicago
El Hajj, H., Castel, M., Dennis, T., Pasquesoone, C., Sassi, A., Leblanc, E., Narducci, F., Hudry, D."Conservative treatment of glassy cell cervical cancer: A case report". Oncology Letters 25, no. 1 (2023): 16. https://doi.org/10.3892/ol.2022.13602
Copy and paste a formatted citation
x
Spandidos Publications style
El Hajj H, Castel M, Dennis T, Pasquesoone C, Sassi A, Leblanc E, Narducci F and Hudry D: Conservative treatment of glassy cell cervical cancer: A case report. Oncol Lett 25: 16, 2023.
APA
El Hajj, H., Castel, M., Dennis, T., Pasquesoone, C., Sassi, A., Leblanc, E. ... Hudry, D. (2023). Conservative treatment of glassy cell cervical cancer: A case report. Oncology Letters, 25, 16. https://doi.org/10.3892/ol.2022.13602
MLA
El Hajj, H., Castel, M., Dennis, T., Pasquesoone, C., Sassi, A., Leblanc, E., Narducci, F., Hudry, D."Conservative treatment of glassy cell cervical cancer: A case report". Oncology Letters 25.1 (2023): 16.
Chicago
El Hajj, H., Castel, M., Dennis, T., Pasquesoone, C., Sassi, A., Leblanc, E., Narducci, F., Hudry, D."Conservative treatment of glassy cell cervical cancer: A case report". Oncology Letters 25, no. 1 (2023): 16. https://doi.org/10.3892/ol.2022.13602
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