Analysis of primary synchronous breast invasive ductal carcinoma and lung adenocarcinoma with next‑generation sequencing: A case report

Wu,Di; Yu,Jinyu; Guo,Liang; Wei,Xiaofei; Tian,Zhuang; Duan,Xiumei

doi:10.3892/ol.2022.13604

January-2023 Volume 25 Issue 1

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January-2023 Volume 25 Issue 1

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Case Report Open Access

Analysis of primary synchronous breast invasive ductal carcinoma and lung adenocarcinoma with next‑generation sequencing: A case report

Authors:
- Di Wu
- Jinyu Yu
- Liang Guo
- Xiaofei Wei
- Zhuang Tian
- Xiumei Duan
View Affiliations / Copyright

Affiliations: Department of Pathology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China

Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 18
|
Published online on: November 21, 2022

https://doi.org/10.3892/ol.2022.13604
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Abstract

Multiple primary cancers (MPCs) have an increasing incidence rate due to the detection of early stages of cancer and the development of effective therapeutic strategies. MPCs are less common compared with metachronous cancers. Therefore, distinguishing synchronous primary tumors from metastasis and developing an individualized treatment strategy can be challenging. In the present study, the case of a 70‑year‑old female who was referred to The First Hospital of Jilin University (Changchun, China) with an enlarged left cervical lymph node and no other clinical manifestations is reported. Radiography revealed distinct lesions in the left breast, left cervical lymph node and bilateral lungs. Subsequently, a biopsy was performed in all three lesions and then each specimen was subjected to immunohistochemistry, fluorescence in situ hybridization, amplification refractory mutation system‑PCR and next‑generation sequencing (NGS). Disease‑related enrichment of lymph node mutant genes and Gene Ontology Biological Process enrichment of breast, as well as lung, mutant genes were performed using the Database for Annotation, Visualization and Integrated Discovery. Based on the molecular assessment, the patient was finally diagnosed with breast invasive ductal carcinoma, primary lung adenocarcinoma and cervical lymph node metastatic lung adenocarcinoma. Since primary synchronous breast and lung cancer (SBLC) is rare, a molecular assessment, particularly using NGS, could provide important information for both the diagnosis and treatment of SBLC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Analysis of primary synchronous breast invasive ductal carcinoma and lung adenocarcinoma with next‑generation sequencing: A case report

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