Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2023 Volume 25 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2023 Volume 25 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Is there any difference in insulin resistance status between cases of benign and malignant ovarian neoplasms? A study on surrogate markers of insulin resistance in Indonesian non‑diabetic women

  • Authors:
    • Hariyono Winarto
    • Muhammad Habiburrahman
    • Irene Shinta Febriana
    • Fitriyadi Kusuma
    • Kartiwa Hadi Nuryanto
    • Tricia Dewi Anggraeni
    • Tofan Widya Utami
    • Andi Darma Putra
  • View Affiliations / Copyright

    Affiliations: Division of Gynecologic Oncology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta 10430, Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta 10430, Indonesia
    Copyright: © Winarto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 23
    |
    Published online on: November 23, 2022
       https://doi.org/10.3892/ol.2022.13609
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The association between insulin resistance (IR) and ovarian neoplasm is little known. The present study attempted to investigate the difference in clinicopathological characteristics, metabolic parameters, and IR prevalence between benign and malignant ovarian neoplasms. The cross‑sectional study involved 52 non‑diabetic women with benign (n=27) and malignant (n=25) diagnoses in a tertiary hospital in Indonesia. Fasting insulin level (FIL), homeostatic model assessment of IR and β‑cell dysfunction (HOMA‑IR and HOMA‑β), fasting IR index (FIRI), and quantitative insulin sensitivity check index (QUICKI) were used as surrogate markers to evaluate IR. Parametric and nonparametric statistical tests were employed to analyze the different parameters between the two groups. Pearson or Spearman's rank test assessed the correlation between markers and clinical variables. Results revealed that patients with benign neoplasms were younger than those with malignant neoplasms (38.63 vs. 47.40 years; P=0.003) and had a higher median body mass index (BMI) than their counterparts (22.98 vs. 18.61 kg/m2; P=0.014). Different characteristics between benign and malignant neoplasm cases were found in menopausal status, ovary side affected, systolic blood pressure, and BMI classes. Endometrial cysts and mucinous carcinoma were the most often diagnosed benign and malignant neoplasms. Malignant neoplasms had a lower median HOMA‑β score than benign neoplasms (49.33 vs. 75.79; P=0.011), indicating more severe β‑cell dysfunction. No significant difference was observed in the prevalence of IR between benign and malignant ovarian neoplasms for the following values of each marker: FIL (25.9% vs. 12.0%), HOMA‑IR (37.0% vs. 28.0%), FIRI (51.9% vs. 48.0%) and QUICKI (81.5% vs. 92.0%). The indicators of FIL, HOMA‑IR, HOMA‑β, FIRI, and QUICKI correlated with each other and confirmed the reliability of these surrogate markers for measuring IR status in ovarian neoplasms. In brief, benign ovarian neoplasms tended to have more IR when compared with malignant ovarian neoplasms. However, this difference was not statistically significant.
View Figures

Figure 1

Figure 2

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Teng Z, Han R, Huang X, Zhou J, Yang J, Luo P and Wu M: Increase of incidence and mortality of ovarian cancer during 2003–2012 in Jiangsu Province, China. Front Public Health. 4:1462016. View Article : Google Scholar : PubMed/NCBI

3 

Winarto H, Welladatika A, Habiburrahman M, Purwoto G, Kusuma F, Utami TW, Putra AD, Anggraeni T and Nuryanto KH: Overall survival and related factors of advanced-stage epithelial ovarian cancer patients underwent debulking surgery in Jakarta, Indonesia: A single-center experience. Open Access Maced J Med Sci. 10:265–280. 2022. View Article : Google Scholar

4 

Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, Gaudet MM, Jemal A and Siegel RL: Ovarian cancer statistics, 2018. CA Cancer J Clin. 68:284–296. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Aziz MF: Gynecological cancer in Indonesia. J Gynecol Oncol. 20:8–10. 2009. View Article : Google Scholar

6 

Devouassoux-Shisheboran M and Genestie C: Pathobiology of ovarian carcinomas. Chin J Cancer. 34:50–55. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Beauchamp MC, Yasmeen A, Knafo A and Gotlieb WH: Targeting insulin and insulin-like growth factor pathways in epithelial ovarian cancer. J Oncol. 2010:2570582010. View Article : Google Scholar

8 

Kellenberger LD, Bruin JE, Greenaway J, Campbell NE, Moorehead RA, Holloway AC and Petrik J: The role of dysregulated glucose metabolism in epithelial ovarian cancer. J Oncol. 2010:5143102010. View Article : Google Scholar

9 

Uzunlulu M, Telci Caklili O and Oguz A: Association between metabolic syndrome and cancer. Ann Nutr Metab. 68:173–179. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Tseng YH, Ueki K, Kriauciunas KM and Kahn CR: Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin. J Biol Chem. 277:31601–31611. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Djiogue S, Nwabo Kamdje AH, Vecchio L, Kipanyula MJ, Farahna M, Aldebasi Y and Seke Etet PF: Insulin resistance and cancer: The role of insulin and IGFs. Endocr Relat Cancer. 20:R1–R17. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Atsumi T: Diabetes and risk of cancer. Diabetol Int. 6:190–192. 2015. View Article : Google Scholar

13 

Joung KH, Jeong JW and Ku BJ: The association between type 2 diabetes mellitus and women cancer: The epidemiological evidences and putative mechanisms. Biomed Res Int. 2015:9206182015. View Article : Google Scholar

14 

Igwe EO, Azman A, Nordin A and Mohtarrudin N: Association between HOMA-IR and Cancer in a Medical Centre in Selangor, Malaysia. IJPHCS. 2:21–34. 2015.

15 

Ekinci O, Eren T, Kurtoglu Yakici M, Gapbarov A, Aydemir MA, Saglam ZA and Alimoglu O: Relationship Between Metabolic Syndrome and Postmenopausal Breast Cancer. Cir Esp (Engl Ed). 98:540–546. 2020.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

16 

Sun W, Lu J, Wu S, Bi Y, Mu Y, Zhao J, Liu C, Chen L, Shi L, Li Q, et al: Association of insulin resistance with breast, ovarian, endometrial and cervical cancers in non-diabetic women. Am J Cancer Res. 6:2334–2344. 2016.PubMed/NCBI

17 

Nam S, Park S, Park HS, Kim S, Kim JY and Kim SI: Association between insulin resistance and luminal B subtype breast cancer in postmenopausal women. Medicine (Baltimore). 95:e28252016. View Article : Google Scholar : PubMed/NCBI

18 

Gennari A, Puntoni M, Nanni O, De Censi A, Bruzzi P, Paleari L, Freschi A, Amaducci L, Bologna A, Gianni L and Amadori D: Impact of insulin resistance (IR) on the prognosis of metastatic breast cancer (MBC) patients treated with first-line chemotherapy (CT). J Clin Oncol. 32 (Suppl 15):S5142014. View Article : Google Scholar

19 

Doğan İ, Ürün Y and Onur H: Effects of Adjuvant Chemotherapy on Insulin Resistance in Patients with Early Breast Cancer. Cam and Sakura Med J. 2:8–13. 2022. View Article : Google Scholar

20 

Alan O, Akin Telli T, Aktas B, Koca S, Ökten IN, Hasanov R, Basoglu T, Arikan R, Demircan NC, Ercelep O, et al: Is insulin resistance a predictor for complete response in breast cancer patients who underwent neoadjuvant treatment? World J Surg Oncol. 18:2422020. View Article : Google Scholar

21 

Martín-Manzo MV, Lara C, Vargas-de-Leon C, Carrero J, Queipo G, Fonseca-Sanchez M, Mejia-Dominguez NR, Kershenobich D, Mummidi S, Zentella-Dehesa A and Hernandez J: Interaction of Breast Cancer and Insulin Resistance on PD1 and TIM3 Expression in Peripheral Blood CD8 T Cells. Pathol Oncol Res. 25:1233–1243. 2019. View Article : Google Scholar

22 

Lai Y and Sun C: Association of abnormal glucose metabolism and insulin resistance in patients with atypical and typical endometrial cancer. Oncol Lett. 15:2173–2178. 2018.

23 

Momenimovahed Z, Tiznobaik A, Taheri S and Salehiniya H: Ovarian cancer in the world: Epidemiology and risk factors. Int J Womens Health. 11:287–299. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Serin IS, Tanriverdi F, Yilmaz MO, Ozcelik B and Unluhizarci K: Serum insulin-like growth factor (IGF)-I, IGF binding protein (IGFBP)-3, leptin concentrations and insulin resistance in benign and malignant epithelial ovarian tumors in postmenopausal women. Gynecol Endocrinol. 24:117–121. 2008. View Article : Google Scholar

25 

Otokozawa S, Tanaka R, Akasaka H, Ito E, Asakura S, Ohnishi H, Saito S, Miura T, Saito T and Mori M: Associations of serum isoflavone, adiponectin and insulin levels with risk for epithelial ovarian cancer: Results of a case-control study. Asian Pac J Cancer Prev. 16:4987–4991. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Lukanova A, Lundin E, Toniolo P, Micheli A, Akhmedkhanov A, Rinaldi S, Muti P, Lenner P, Biessy C, Krogh V, et al: Circulating levels of insulin-like growth factor-I and risk of ovarian cancer. Int J Cancer. 101:549–554. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Dahlan MS: Sample Size in Medical and Health Research. 5th edition. Epidemiologi Indonesia; Jakarta: 2019, (In Indonesian).

28 

Sharma SK, Mudgal SK, Thakur K and Gaur R: How to calculate sample size for observational and experiential nursing research studies? Natl J Physiol Pharm Pharmacol. 10:1–8. 2020. View Article : Google Scholar

29 

Timmerman D, Ameye L, Fischerova D, Epstein E, Melis GB, Guerriero S, Van Holsbeke C, Savelli L, Fruscio R, Lissoni AA, et al: Simple ultrasound rules to distinguish between benign and malignant adnexal masses before surgery: Prospective validation by IOTA group. BMJ. 341:c68392010. View Article : Google Scholar : PubMed/NCBI

30 

Abramowicz JS and Timmerman D: Ovarian mass-differentiating benign from malignant: The value of the International Ovarian Tumor Analysis ultrasound rules. Am J Obstet Gynecol. 217:652–660. 2017. View Article : Google Scholar

31 

Badan Pusat Statistik/BPS-Statistics Indonesia, . Concept of Population, Age, Marital Status, Children Ever Born, Children Still Alive, and Place of Birth in Indonesia. Concept. 2021.https://www.bps.go.id/subject/12/kependudukan.htmlDecember 10–2021

32 

Mulyana W: Rural-urban linkages: Indonesia case study. Working Group: Development with Territorial Cohesion. Territorial Cohesion for Development Program Rimisp. 1–36. 2014.

33 

Badan Pusat Statistik/BPS-Statistics Indonesia, . Regulation of the Head of the Central Statistics Agency Number 120 of 2020: Classification of Urban and Rural Areas in Java, Indonesia [In Indonesian]. Book Chapter Java. 2nd ed. BPS; Jakarta: pp. 1–692. 2010

34 

Badan Pusat Statistik/BPS-Statistics Indonesia, . Regulation of the Head of the Central Statistics Agency Number 120 of 2020: Classification of Urban and Rural Areas in Sumatra, Indonesia [In Indonesian]. Book Chapter Sumatera. 2nd ed. BPS; Jakarta: pp. 1–681. 2010

35 

Klar M, Hasenburg A, Hasanov M, Hilpert F, Meier W, Pfisterer J, Pujade-Lauraine E, Herrstedt J, Reuss A and du Bois A: Prognostic factors in young ovarian cancer patients: An analysis of four prospective phase III intergroup trials of the AGO Study Group, GINECO and NSGO. Eur J Cancer. 66:114–124. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Lalrinpuii E, Bhageerathy PS, Sebastian A, Jeyaseelan L, Vinotha Thomas, Thomas A, Chandy R and Peedicayil A: Ovarian Cancer in Young Women. Indian J Surg Oncol. 8:540–547. 2017. View Article : Google Scholar

37 

Encinas G, Maistro S, Pasini FS, Katayama ML, Brentani MM, Bock GH and Folgueira MA: Somatic mutations in breast and serous ovarian cancer young patients: A systematic review and meta-analysis. Rev Assoc Med Bras (1992). 61:474–483. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Bozas G, Dimopoulos MA, Kastritis E, Efstathiou E, Koutsoukou V, Rodolakis A, Vlahos G, Voulgaris Z, Papageorgiou T, Gika D, et al: Young age is associated with favorable characteristics but is not an independent prognostic factor in patients with epithelial ovarian cancer: A single institution experience. Oncology. 70:265–272. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Winarto H, Habiburrahman M, Dorothea M, Wijaya A, Nuryanto KH, Kusuma F, Utami TW and Anggraeni TD: Knowledge, attitudes, and practices among Indonesian urban communities regarding HPV infection, cervical cancer, and HPV vaccination. PLoS One. 17:e02661392022. View Article : Google Scholar : PubMed/NCBI

40 

4Berek JS, Renz M, Kehoe S, Kumar L and Friedlander M: FIGO Cancer Report 2021: Cancer of the ovary, fallopian tube, and peritoneum: 2021 update. Int J Gynaecol Obstet. 155:61–85. 2021. View Article : Google Scholar

41 

World Health Organization and International Agency for Research on Cancer, . World Health Organization: WHO Classification of Tumours: Female Genital Tumours. 5th edition. WHO; Geneva, Switzerland: pp. 31–163. 2021

42 

Matz M, Coleman MP, Sant M, Chirlaque MD, Visser O, Gore M and Allemani C; & the CONCORD Working Group, : The histology of ovarian cancer: Worldwide distribution and implications for international survival comparisons (CONCORD-2). Gynecol Oncol. 144:405–413. 2017. View Article : Google Scholar

43 

Unger T, Borghi C, Charchar F, Khan NA, Poulter NR, Prabhakaran D, Ramirez A, Schlaich M, Stergiou GS, Tomaszewski M, et al: 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension. 75:1334–1357. 2020. View Article : Google Scholar : PubMed/NCBI

44 

National Health and Nutrition Examination Survey and Center of Disease Control and Prevention, . Anthropometry Procedures Manual CDC2. 1–65. 2007.

45 

Lim JU, Lee JH, Kim JS, Hwang YI, Kim TH, Lim SY, Yoo KH, Jung KS, Kim YK and Rhee CK: Comparison of World Health Organization and Asia-Pacific body mass index classifications in COPD patients. Int J Chron Obstruct Pulmon Dis. 12:2465–2475. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Cleveland Clinic, . Fasting Blood Sugar Test. Diagnostics & Testing; 2021, https://my.clevelandclinic.org/health/diagnostics/21952-fasting-blood-sugarDecember 10–2021

47 

Gayoso-Diz P, Otero-González A, Rodriguez-Alvarez MX, Gude F, García F, De Francisco A and Quintela AG: Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: Effect of gender and age: EPIRCE cross-sectional study. BMC Endocr Disord. 13:472013. View Article : Google Scholar : PubMed/NCBI

48 

Farahani H, Mahmoudi T, Asadi A, Nobakht H, Dabiri R and Hamta A: Insulin Resistance and Colorectal Cancer Risk: The Role of Elevated Plasma Resistin Levels. J Gastrointest Cancer. 51:478–483. 2020. View Article : Google Scholar : PubMed/NCBI

49 

Gupta RK, Dholariya SJ, Kaushik S, Gupta SK, Tripathi R and Jain SL: Hyperinsulinemia and Hypoadiponectinemia are Associated with increased risk for occurrence of ovarian cancer in non-diabetic women of North Indian Population. Indian J Clin Biochem. 36:221–227. 2021. View Article : Google Scholar : PubMed/NCBI

50 

American Diabetes Association (ADA), . Diagnosis of Diabetes Mellitus. ADA; Arlington, VA: 2022

51 

Lunger F, Wildt L and Seeber B: Accurate screening for insulin resistance in PCOS women using fasting insulin concentrations. Gynecol Endocrinol. 29:541–544. 2013. View Article : Google Scholar

52 

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF and Turner RC: Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:412–419. 1985. View Article : Google Scholar

53 

Onishi Y, Hayashi T, Sato KK, Ogihara T, Kuzuya N, Anai M, Tsukuda K, Boyko EJ, Fujimoto WY and Kikuchi M: Fasting tests of insulin secretion and sensitivity predict future prediabetes in Japanese with normal glucose tolerance. J Diabetes Investig. 1:191–195. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Yamauchi K, Sato Y, Nakasone Y and Aizawa T: Comparison of HOMA-IR, HOMA-β% and disposition index between US white men and Japanese men in Japan in the ERA JUMP study: Was the calculation of disposition index legitimate? Diabetologia. 58:1679–1680. 2015. View Article : Google Scholar

55 

Imano H, Kitamura A, Yamagishi K, Kiyama M, Ohira T, Cui R, Umesawa M, Okada T and Iso H; CIRCS Investigators, : Abstract P455: Insulin Resistance, Secretion and Risk of Incident Coronary Heart Disease in Non-diabetic Japanese Population: The Circulatory Risk in Communities Study. Circulation. 129:AP4552014. View Article : Google Scholar

56 

Singh B and Saxena A: Surrogate markers of insulin resistance: A review. World J Diabetes. 1:36–47. 2010. View Article : Google Scholar : PubMed/NCBI

57 

Duncan MH, Singh BM, Wise PH, Carter G and Alaghband-Zadeh J: A simple measure of insulin resistance. Lancet. 346:120–121. 1995. View Article : Google Scholar

58 

Tsarouhas K, Tsitsimpikou C, Haliassos A, Georgoulias P, Koutsioras I, Kouretas D, Kogias J, Liosis I, Rentoukas E and Kyriakides Z: Study of insulin resistance, TNF-α, total antioxidant capacity and lipid profile in patients with chronic heart failure under exercise. In Vivo. 25:1031–1037. 2011.PubMed/NCBI

59 

Farkas GJ, Gordon PS, Trewick N, Gorgey AS, Dolbow DR, Tiozzo E, Berg AS and Gater DR Jr: Comparison of various indices in identifying insulin resistance and diabetes in chronic spinal cord injury. J Clin Med. 10:55912021. View Article : Google Scholar : PubMed/NCBI

60 

Gordon PS, Farkas GJ and Gater DR Jr: Neurogenic Obesity-Induced Insulin Resistance and Type 2 Diabetes Mellitus in Chronic Spinal Cord Injury. Top Spinal Cord Inj Rehabil. 27:36–56. 2021. View Article : Google Scholar

61 

Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G and Quon MJ: Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 85:2402–2410. 2000. View Article : Google Scholar : PubMed/NCBI

62 

Matsuda M and DeFronzo RA: Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp. Diabetes Care. 22:1462–1470. 1999. View Article : Google Scholar : PubMed/NCBI

63 

Pratisthita Livy B, Purnamasari D, Rizka A, Soewondo P, Yunir E and Tahapary DL: The Cut-off Values of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in Indonesian Rural Population. Lancet Preprint. 6:7–20. 2020.

64 

Rahman MN, Sukmawati IR, Puspitasari IM and Fattah M: Serum free zinc as a predictor for excessive function of pancreatic beta-cells in central-obese men. Indones Biomed J. 11:262–266. 2019. View Article : Google Scholar

65 

AlZadjali MA, Godfrey V, Khan F, Choy A, Doney AS, Wong AK, Petrie JR, Struthers AD and Lang CC: Insulin resistance is highly prevalent and is associated with reduced exercise tolerance in nondiabetic patients with heart failure. J Am Coll Cardiol. 53:747–753. 2009. View Article : Google Scholar

66 

Kaur N, Gitanjali, Garg R, Tapasvi C, Chawla S and Kaur N: Correlation of Surrogate Markers of Insulin Resistance with Fasting Insulin in Type 2 Diabetes Mellitus Patients: A Study of Malwa Population in Punjab, India. J Lab Physicians. 13:238–244. 2021. View Article : Google Scholar : PubMed/NCBI

67 

Diebetes.co.uk, . Blood Sugar Converter. Calculators and Tools. 2022.https://www.diabetes.co.uk/blood-sugar-converter.htmlApril 12–2022

68 

Katalin C: Surrogate Measures of Insulin Resistance in Middle-aged Non-diabetic Subjects. Acta Med Marisiensis. 59:279–284. 2014. View Article : Google Scholar

69 

Burzawa JK, Schmeler KM, Soliman PT, Meyer LA, Bevers MW, Pustilnik TL, Anderson ML, Ramondetta LM, Tortolero-Luna G, Urbauer DL, et al: Prospective evaluation of insulin resistance among endometrial cancer patients. Am J Obstet Gynecol. 204:355.e1–7. 2011. View Article : Google Scholar

70 

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC and Vandenbroucke JP: Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ. 335:806 LP–808. 2007. View Article : Google Scholar

71 

Statistic Tutor: Spearman's correlation, 2021. http://www.statstutor.ac.uk/resources/uploaded/spearmans.pdfDecember 10–2021

72 

Beavis AL, Smith AJ and Fader AN: Lifestyle changes and the risk of developing endometrial and ovarian cancers: Opportunities for prevention and management. Int J Womens Health. 8:151–167. 2016.PubMed/NCBI

73 

Szpurek D, Moszynski R, Szubert S and Sajdak S: Urban and rural differences in characteristics of ovarian cancer patients. Ann Agric Environ Med. 20:390–394. 2013.PubMed/NCBI

74 

Saccò M, Meschi M, Regolisti G, Detrenis S, Bianchi L, Bertorelli M, Pioli S, Magnano A, Spagnoli F, Giuri PG, et al: The relationship between blood pressure and pain. J Clin Hypertens (Greenwich). 15:600–605. 2013. View Article : Google Scholar

75 

El-Atat FA, Stas SN, McFarlane SI and Sowers JR: The relationship between hyperinsulinemia, hypertension and progressive renal disease. J Am Soc Nephrol. 15:2816–2827. 2004. View Article : Google Scholar

76 

Pérez-Pérez A, Sánchez-Jiménez F, Vilariño-García T and Sánchez-Margalet V: Role of Leptin in Inflammation and Vice Versa. Int J Mol Sci. 21:2020. View Article : Google Scholar

77 

Orgel E and Mittelman SD: The links between insulin resistance, diabetes, and cancer. Curr Diab Rep. 13:213–222. 2013. View Article : Google Scholar : PubMed/NCBI

78 

Kim SI, Kim HS, Kim TH, Suh DH, Kin K, No JH, Chung HH, Kim YB and Song YS: Impact of underweight after treatment on prognosis of advanced-stage ovarian cancer. J Immunol Res. 2014.1–8. 2014. View Article : Google Scholar

79 

Wright JD, Powell MA, Mutch DG, Rader JS, Gibb RK, Gao F and Herzog TJ: Relationship of ovarian neoplasms and body mass index. J Reprod Med. 50:595–602. 2005.PubMed/NCBI

80 

Leitzmann MF, Koebnick C, Danforth KN, et al: Body mass index and risk of ovarian cancer. Cancer. 115:812–822. 2009. View Article : Google Scholar : PubMed/NCBI

81 

Hernandez AV, Guarnizo M, Miranda Y, Pasupuleti V, Deshpande A, Paico S, Lenti H, Ganoza S, Montalvo L, Thota P and Lazaro H: Association between insulin resistance and breast carcinoma: A systematic review and meta-analysis. PLoS One. 9:e993172014. View Article : Google Scholar : PubMed/NCBI

82 

Kundaktepe BP, Durmus S, Cengiz M, Kundaktepe FO, Sozer V, Papila C, Gelisgen R and Uzun H: The significance of insulin resistance in nondiabetic breast cancer patients. J Endocrinol Metab. 11:42–48. 2021. View Article : Google Scholar

83 

Gómez JM, Maravall FJ, Gómez N, Navarro MA, Casamitjana R and Soler J: Interactions between serum leptin, the insulin-like growth factor-I system, and sex, age, anthropometric and body composition variables in a healthy population randomly selected. Clin Endocrinol (Oxf). 58:213–219. 2003. View Article : Google Scholar

84 

Bjørge T, Lukanova A, Tretli S, Manjer J, Ulmer H, Stocks T, Selmer R, Nagel G, Almquist M, Concin H, et al: Metabolic risk factors and ovarian cancer in the Metabolic Syndrome and Cancer project. Int J Epidemiol. 40:1667–1677. 2011. View Article : Google Scholar

85 

Craig ER, Londoño AI, Norian LA and Arend RC: Metabolic risk factors and mechanisms of disease in epithelial ovarian cancer: A review. Gynecol Oncol. 143:674–683. 2016. View Article : Google Scholar

86 

Khanlarkhani N, Azizi E, Amidi F, Khodarahmian M, Salehi E, Pazhohan A, Farhood B, Mortezae K, Goradel NH and Nashtaei MS: Metabolic risk factors of ovarian cancer: A review. JBRA Assist Reprod. 26:335–347. 2022.PubMed/NCBI

87 

Dixon SC, Nagle CM, Thrift AP, Pharoah PD, Pearce CL, Zheng W, Painter JN; AOCS Group & Australian Cancer Study (Ovarian Cancer), ; Chenevix-Trench G, Fasching PA, et al: Adult body mass index and risk of ovarian cancer by subtype: A Mendelian randomization study. Int J Epidemiol. 45:884–895. 2016. View Article : Google Scholar

88 

Zeleznik OA, Eliassen AH, Kraft P, Poole EM, Rosner BA, Jeanfavre S, Deik AA, Bullock K, Hitchcock DS, Avila-Pacheco J, et al: A prospective analysis of circulating plasma metabolites Associated with ovarian cancer risk. Cancer Res. 80:1357–1367. 2020. View Article : Google Scholar : PubMed/NCBI

89 

Lee S, Choi S, Kim HJ, Chung YS, Lee KW, Lee HC, Huh KB and Kim DJ: Cutoff values of surrogate measures of insulin resistance for metabolic syndrome in Korean non-diabetic adults. J Korean Med Sci. 21:695–700. 2006. View Article : Google Scholar

90 

Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, Monauni T and Muggeo M: Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: Studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care. 23:57–63. 2000. View Article : Google Scholar : PubMed/NCBI

91 

Robbins DC, Andersen L, Bowsher R, Chance R, Dinesen B, Frank B, Gingerich R, Goldstein D, Widemeyer HM, Haffner S, et al: Report of the American Diabetes Association's Task Force on standardization of the insulin assay. Diabetes. 45:242–256. 1996. View Article : Google Scholar : PubMed/NCBI

92 

Mack R, Skurnick B, Sterling-Jean Y, Pedra-Nobre M and Bigg D: Fasting insulin levels as a measure of insulin resistance in American blacks. J Med. 34:31–38. 2003.PubMed/NCBI

93 

Yeni-Komshian H, Carantoni M, Abbasi F and Reaven GM: Relationship between several surrogate estimates of insulin resistance and quantification of insulin-mediated glucose disposal in 490 healthy nondiabetic volunteers. Diabetes Care. 23:171–175. 2000. View Article : Google Scholar : PubMed/NCBI

94 

Buchanan TA, Watanabe RM and Xiang AH: Limitations in surrogate measures of insulin resistance. J Clin Endocrinol Metab. 95:4874–4876. 2010. View Article : Google Scholar : PubMed/NCBI

95 

Haffner SM, Miettinen H and Stern MP: The homeostasis model in the San Antonio Heart Study. Diabetes Care. 20:1087–1092. 1997. View Article : Google Scholar : PubMed/NCBI

96 

Legro RS, Finegood D and Dunaif A: A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 83:2694–2698. 1998. View Article : Google Scholar : PubMed/NCBI

97 

Jørgensen SW, Hjort L, Gillberg L, Justesen L, Madsbad S, Brøns C and Vaag AA: Impact of prolonged fasting on insulin secretion, insulin action, and hepatic versus whole body insulin secretion disposition indices in healthy young males. Am J Physiol Endocrinol Metab. 320:E281–E290. 2021. View Article : Google Scholar

98 

Habib SS, Eshki A, AlTassan B, Fatani D, Helmi H and AlSaif S: Relationship of serum novel adipokine chemerin levels with body composition, insulin resistance, dyslipidemia and diabesity in Saudi women. Eur Rev Med Pharmacol Sci. 21:1296–1302. 2017.

99 

Pavelić K, Slijepcević M, Pavelić J, Ivić J, Audy-Jurković S, Pavelić ZP and Boranić M: Growth and treatment of Ehrlich tumor in mice with alloxan-induced diabetes. Cancer Res. 39:1807–1813. 1979.

100 

Gates JR, Parpia B, Campbell TC and Chen J: Evaluation of the FIRI (Fasting Insulin Resistance Index) and selected plasma parameters associated with insulin resistance as predictors of cardiovascular mortality in rural Chinese women. Asia Pac J Clin Nutr. 6:200–202. 1997.PubMed/NCBI

101 

Mather KJ, Hunt AE, Steinberg HO, Paradisi G, Hook G, Katz A, Quon MJ and Baron AD: Repeatability characteristics of simple indices of insulin resistance: Implications for research applications. J Clin Endocrinol Metab. 86:5457–5464. 2001. View Article : Google Scholar : PubMed/NCBI

102 

Chen H, Sullivan G, Yue LQ, Katz A and Quon MJ: QUICKI is a useful index of insulin sensitivity in subjects with hypertension. Am J Physiol Endocrinol Metab. 284:E804–E812. 2003. View Article : Google Scholar : PubMed/NCBI

103 

Hettihewa LM, Palangasinghe S, Jayasinghe SS, Gunasekara SW and Weerarathna TP: Comparison of insulin resistance by indirect methods-HOMA, QUICKI and McAuley-With fasting insulin in patients with type 2 diabetes in Galle, Sri Lanka: A pilot study. Online J Health Allied Sci. 5:1–8. 2006.

104 

Scoppola A, Strigari L, Barnabei A, Petasecca P, De Galitiis F, Fulgenzi CAM, Roselli M, De Lorenzo A, Di Renzo L, Marchetti P and Torino F: Insulin resistance as a risk factor for cutaneous melanoma. A case control study and risk-assessment nomograms. Front Endocrinol (Lausanne). 10:7572019. View Article : Google Scholar : PubMed/NCBI

105 

Rutter MK, Wilson PWF, Sullivan LM, Fox CS, D'Agostino RB Sr and Meigs JB: Use of alternative thresholds defining insulin resistance to predict incident type 2 diabetes mellitus and cardiovascular disease. Circulation. 117:1003–1009. 2008. View Article : Google Scholar : PubMed/NCBI

106 

Conwell LS, Trost SG, Brown WJ and Batch JA: Indexes of insulin resistance and secretion in obese children and adolescents: A validation study. Diabetes Care. 27:314–319. 2004. View Article : Google Scholar : PubMed/NCBI

107 

Garg MK, Tandon N, Marwaha RK and Singh Y: Evaluation of surrogate markers for insulin resistance for defining metabolic syndrome in urban Indian adolescents. Indian Pediatr. 51:279–284. 2014. View Article : Google Scholar : PubMed/NCBI

108 

Rudvik A and Månsson M: Evaluation of surrogate measures of insulin sensitivity-correlation with gold standard is not enough. BMC Med Res Methodol. 18:642018. View Article : Google Scholar

109 

Coppola D, Saunders B, Fu L, Mao W and Nicosia SV: The insulin-like growth factor 1 receptor induces transformation and tumorigenicity of ovarian mesothelial cells and down-regulates their Fas-receptor expression. Cancer Res. 59:3264–3270. 1999.PubMed/NCBI

110 

Karasik A, Menczer J, Pariente C and Kanety H: Insulin-like growth factor-I (IGF-I) and IGF-binding protein-2 are increased in cyst fluids of epithelial ovarian cancer. J Clin Endocrinol Metab. 78:271–276. 1994. View Article : Google Scholar : PubMed/NCBI

111 

Holly J: Insulin-like growth factor-1 and risk of breast cancer. Lancet. 352:13881998. View Article : Google Scholar

112 

D'Esposito V, Passaretti F, Hammarstedt A, Liguoro D, Terracciano D, Molea G, Canta L, Miele C, Smith U, Beguinot F and Formisano P: Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro. Diabetologia. 55:2811–2822. 2012. View Article : Google Scholar

113 

Sanchez-Garrido MA and Tena-Sempere M: Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies. Mol Metab. 35:2020. View Article : Google Scholar

114 

Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber MT, Summer RS, Kihara S and Walsh K: Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest. 117:375–386. 2007. View Article : Google Scholar

115 

Kalli KR, Falowo OI, Bale LK, Zschunke MA, Roche PC and Conover CA: Functional insulin receptors on human epithelial ovarian carcinoma cells: Implications for IGF-II mitogenic signaling. Endocrinology. 143:3259–3267. 2002. View Article : Google Scholar : PubMed/NCBI

116 

Lutz AM, Ray P, Willmann JK, Drescher C and Gambhir SS: 2-Deoxy-2-[F-18]fluoro-D-glucose accumulation in ovarian carcinoma cell lines. Mol Imaging Biol. 9:260–266. 2007. View Article : Google Scholar

117 

Shibata K, Kajiyama H, Mizokami Y, Ino K, Nomura S, Mizutani S, Terauchi M and Kikkawa F: Placental leucine aminopeptidase (P-LAP) and glucose transporter 4 (GLUT4) expression in benign, borderline, and malignant ovarian epithelia. Gynecol Oncol. 98:11–18. 2005. View Article : Google Scholar

118 

Tsukioka M, Matsumoto Y, Noriyuki M, Yoshida C, Nobeyama H, Yoshida H, Yasui T, Sumi T, Honda K and Ishiko O: Expression of glucose transporters in epithelial ovarian carcinoma: Correlation with clinical characteristics and tumor angiogenesis. Oncol Rep. 18:361–367. 2007.PubMed/NCBI

119 

Sheetz MJ and King GL: Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA. 288:2579–2588. 2002. View Article : Google Scholar : PubMed/NCBI

120 

Yamagishi S, Nakamura K, Inoue H, Kikuchi S and Takeuchi M: Possible participation of advanced glycation end products in the pathogenesis of colorectal cancer in diabetic patients. Med Hypotheses. 64:1208–1210. 2005. View Article : Google Scholar : PubMed/NCBI

121 

Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, Tanji N, Lu Y, Lalla E, Fu C, et al: Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature. 405:354–360. 2000. View Article : Google Scholar : PubMed/NCBI

122 

Ness RB, Grisso JA, Cottreau C, Klapper J, Vergona R, Wheeler JE, Morgan M and Schlesselman JJ: Factors related to inflammation of the ovarian epithelium and risk of ovarian cancer. Epidemiology. 11:111–117. 2000. View Article : Google Scholar : PubMed/NCBI

123 

Benjamin LE: Glucose, VEGF-A, and diabetic complications. Am J Pathol. 158:1181–1184. 2001. View Article : Google Scholar

124 

Wang M, Cheng N, Zheng S, Wang D, Hu X, Ren X, Pei H, Ma H, Mu H and Bai Y: Metabolic syndrome and the risk of breast cancer among postmenopausal women in North-West China. Climacteric. 18:852–858. 2015. View Article : Google Scholar

125 

DeFronzo RA, Tobin JD and Andres R: Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol. 237:E214–E223. 1979.

126 

Alberti KG and Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 15:539–553. 1998. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Winarto H, Habiburrahman M, Febriana IS, Kusuma F, Nuryanto KH, Anggraeni TD, Utami TW and Putra AD: Is there any difference in insulin resistance status between cases of benign and malignant ovarian neoplasms? A study on surrogate markers of insulin resistance in Indonesian non‑diabetic women. Oncol Lett 25: 23, 2023.
APA
Winarto, H., Habiburrahman, M., Febriana, I.S., Kusuma, F., Nuryanto, K.H., Anggraeni, T.D. ... Putra, A.D. (2023). Is there any difference in insulin resistance status between cases of benign and malignant ovarian neoplasms? A study on surrogate markers of insulin resistance in Indonesian non‑diabetic women. Oncology Letters, 25, 23. https://doi.org/10.3892/ol.2022.13609
MLA
Winarto, H., Habiburrahman, M., Febriana, I. S., Kusuma, F., Nuryanto, K. H., Anggraeni, T. D., Utami, T. W., Putra, A. D."Is there any difference in insulin resistance status between cases of benign and malignant ovarian neoplasms? A study on surrogate markers of insulin resistance in Indonesian non‑diabetic women". Oncology Letters 25.1 (2023): 23.
Chicago
Winarto, H., Habiburrahman, M., Febriana, I. S., Kusuma, F., Nuryanto, K. H., Anggraeni, T. D., Utami, T. W., Putra, A. D."Is there any difference in insulin resistance status between cases of benign and malignant ovarian neoplasms? A study on surrogate markers of insulin resistance in Indonesian non‑diabetic women". Oncology Letters 25, no. 1 (2023): 23. https://doi.org/10.3892/ol.2022.13609
Copy and paste a formatted citation
x
Spandidos Publications style
Winarto H, Habiburrahman M, Febriana IS, Kusuma F, Nuryanto KH, Anggraeni TD, Utami TW and Putra AD: Is there any difference in insulin resistance status between cases of benign and malignant ovarian neoplasms? A study on surrogate markers of insulin resistance in Indonesian non‑diabetic women. Oncol Lett 25: 23, 2023.
APA
Winarto, H., Habiburrahman, M., Febriana, I.S., Kusuma, F., Nuryanto, K.H., Anggraeni, T.D. ... Putra, A.D. (2023). Is there any difference in insulin resistance status between cases of benign and malignant ovarian neoplasms? A study on surrogate markers of insulin resistance in Indonesian non‑diabetic women. Oncology Letters, 25, 23. https://doi.org/10.3892/ol.2022.13609
MLA
Winarto, H., Habiburrahman, M., Febriana, I. S., Kusuma, F., Nuryanto, K. H., Anggraeni, T. D., Utami, T. W., Putra, A. D."Is there any difference in insulin resistance status between cases of benign and malignant ovarian neoplasms? A study on surrogate markers of insulin resistance in Indonesian non‑diabetic women". Oncology Letters 25.1 (2023): 23.
Chicago
Winarto, H., Habiburrahman, M., Febriana, I. S., Kusuma, F., Nuryanto, K. H., Anggraeni, T. D., Utami, T. W., Putra, A. D."Is there any difference in insulin resistance status between cases of benign and malignant ovarian neoplasms? A study on surrogate markers of insulin resistance in Indonesian non‑diabetic women". Oncology Letters 25, no. 1 (2023): 23. https://doi.org/10.3892/ol.2022.13609
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team