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Article Open Access

Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor

  • Authors:
    • Henglan Zhang
    • Ling Li
    • Dongqing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Jinan Third People's Hospital, Jinan, Shandong 250132, P.R. China, Department of Oncology, Xintai People's Hospital, Xintai, Shandong 271200, P.R. China, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 28
    |
    Published online on: November 24, 2022
       https://doi.org/10.3892/ol.2022.13614
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Abstract

The present study investigated how abnormal expression of hyaluronan‑mediated mobility receptor (HMMR) in renal cell carcinoma (RCC) tissue affects the growth of RCC cells and the association between expression of HMMR and pathological staging and prognosis of patients with RCC. Reverse transcription‑quantitative PCR was used to measure the expression of HMMR mRNA in RCC tissue and cell lines. For the prediction of HMMR gene expression, The Cancer Genome Atlas online database was utilized to compare differential gene expression of HMMR in normal renal and RCC tissue. Cell Counting Kit‑8 assay was used to examine cell proliferation. The expression of HMMR increased in RCC tissue and renal cancer cell lines. The expression of HMMR was an independent prognostic factor for 5‑year and disease‑free survival in patients with RCC. The silencing of HMMR expression decreased the expression of Cyclin B1 and inhibited the proliferation of RCC cells. Overexpression of HMMR promoted the expression of Cyclin B1 and cell proliferation. The present study demonstrated that the expression of HMMR was significantly upregulated in RCC and was an independent prognostic factor for RCC. HMMR may be involved in the occurrence of RCC by regulating Cyclin B1.
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1 

Terrone C, Guercio S, De Luca S, Poggio M, Castelli E, Scoffone CM, Tarabuzzi R, Scarpa RM, Fontana D and Rossetti SR: Number of nodes examined and staging accuracy in renal cell carcinoma (RCC). BJU Int. 91:37–40. 2003. View Article : Google Scholar

2 

Motzer RJ, Russo P, Nanus DM and Berg WJ: Renal-cell carcinoma. Curr Probl Cancer. 21:185–232. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Oosterwijk E, Stillebroer AB and Mulders PFA: Carbonic Anhydrase IX: Its Role as a Biomarker, Diagnostic, and Therapeutic Target in Renal Cell Carcinoma. Renal Cell Carcinoma. Figlin R, Rathmell W and Rini B: Springer; Boston, MA: 2012, View Article : Google Scholar

4 

Rini BI, Rathmell WK and Godley P: Renal cell carcinoma. Curr Opin Oncol. 20:300–306. 2008. View Article : Google Scholar

5 

Trump DL: 1. Sorafenib in advanced clear-cell renal-cell carcinoma. Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Siebels M, Negrier S, Chevreau C, Solska E, Desai AA, Rolland F, Demkow T, Hutson TE, Gore M, Freeman S, Schwartz B, Shan M, Simantov R and Bukowski RM; TARGET Study Group, : Department of Medicine, Institut Gustave Roussy; Villejuif, France: Urol Oncol Semin Orig Investig. 25. pp. 443–445. 2007

6 

Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Siebels M, Negrier S, Chevreau C, Solska E, Desai AA, et al: Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 356:125–134. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J and Ficarra V: Renal cell carcinoma. Nat Rev Dis Primers. 3:170092017. View Article : Google Scholar : PubMed/NCBI

8 

Snauwaert S, Vanhee S, Goetgeluk G, Verstichel G, Van Caeneghem Y, Velghe I, Philippé J, Berneman ZN, Plum J, Taghon T, et al: RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia. Haematologica. 97:1539–1547. 2012. View Article : Google Scholar

9 

Sohr S and Engeland K: RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53. Cell Cycle. 7:3448–3460. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Tilghman J, Wu H, Sang Y, Shi X, Guerrero-Cazares H, Quinones-Hinojosa A, Eberhart CG, Laterra J and Ying M: HMMR maintains the stemness and tumorigenicity of glioblastoma stem-like cells. Cancer Res. 74:3168–3179. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Esguerra KV, Tolg C, Akentieva N, Price M, Cho CF, Lewis JD, McCarthy JB, Turley EA and Luyt LG: Identification, design and synthesis of tubulin-derived peptides as novel hyaluronan mimetic ligands for the receptor for hyaluronan-mediated motility (RHAMM/HMMR). Integr Biol (Camb). 7:1547–1560. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Yang C, Li C, Zhang P, Wu W and Jiang X: Redox responsive hyaluronic acid nanogels for treating RHAMM (CD168) over-expressive cancer, both primary and metastatic tumors. Theranostics. 7:1719–1734. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Ahmad S, Kolli S, Li DQ, de Paiva CS, Pryzborski S, Dimmick I, Armstrong L, Figueiredo FC and Lako M: A putative role for RHAMM/HMMR as a negative marker of stem cell-containing population of human limbal epithelial cells. Stem Cells. 26:1609–1619. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Hamilton SR, Fard SF, Paiwand FF, Tolg C, Veiseh M, Wang C, McCarthy JB, Bissell MJ, Koropatnick J and Turley EA: The hyaluronan receptors CD44 AND Rhamm (CD168) form complexes with ERK1,2, that sustain high basal motility in breast cancer cells. J Biol Chem. 282:16667–16680. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Jöhrens K, Anagnostopoulos I, Dommerich S, Raguse JD, Szczepek AJ, Klauschen F and Stölzel K: Expression patterns of CD168 correlate with the stage and grade of squamous cell carcinoma of head and neck. Mol Clin Oncol. 6:597–602. 2017. View Article : Google Scholar

16 

Lin SL, Chang D, Chiang A and Ying SY: Androgen receptor regulates CD168 expression and signaling in prostate cancer. Carcinogenesis. 29:282–290. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Chen H, Connell M, Mei L, Gsd R and Maxwell CA: The nonmotor adaptor HMMR dampens Eg5-mediated forces to preserve the kinetics and integrity of chromosome segregation. Mol Biol Cell. 29:786–796. 2018. View Article : Google Scholar

18 

Greiner J, Ringhoffer M, Li L, Barth T, Wölfel T, Döhner H and Schmitt M: The receptor for hyaluronic acid mediated motility (RHAMM/CD168) is a leukemia associated antigen eliciting both humoral and cellular immune responses in patients with acute myeloid leukemia (AML). Cancer Cell Int. 4 (Suppl 1):S552004. View Article : Google Scholar

19 

Ishigami S, Ueno S, Nishizono Y, Matsumoto M, Kurahara H, Arigami T, Uchikado Y, Setoyama T, Arima H, Yoshiaki K, et al: Prognostic impact of CD168 expression in gastric cancer. BMC Cancer. 11:1062011. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Missinato MA, Tobita K, Romano N, Carroll JA and Tsang M: Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration. Cardiovasc Res. 107:487–498. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Heikinheimo K, Kurppa KJ, Laiho A, Peltonen S, Berdal A, Bouattour A, Ruhin B, Catón J, Thesleff I, Leivo I and Morgan PR: Early dental epithelial transcription factors distinguish ameloblastoma from keratocystic odontogenic tumor. J Dent Res. 94:101–111. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Bidadi B, Liu D, Kalari KR, Rubner M, Hein A, Beckmann MW, Rack B, Janni W, Fasching PA, Weinshilboum RM and Wang L: Pathway-based analysis of genome-wide association data identified SNPs in HMMR as biomarker for chemotherapy-induced neutropenia in breast cancer patients. Front Pharmacol. 9:1582018. View Article : Google Scholar

24 

Stevens LE, Zhao M, Liu Z and Nguyen D: Abstract 2269: A novel molecular subset of metastatic lung adenocarcinoma is defined by the function of the proteoglycan receptor HMMR. Cancer Res. 75 (Suppl 15):S22692015. View Article : Google Scholar

25 

Tang XH, Osei-Sarfo K, Urvalek AM, Zhang T, Scognamiglio T and Gudas LJ: Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Proc Natl Acad Sci USA. 111:8907–8912. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Pinaire N, Johnson P, Chari N, Spurgers K, Meyn R and McDonnell T: Abstract #5312: Novel transcriptional targets of p53 may inhibit cell migration. Cancer Res. 69 (Suppl):S53122009. View Article : Google Scholar

27 

Keane M, Craig T, Alföldi J, Berlin AM, Johnson J, Seluanov A, Gorbunova V, Di Palma F, Lindblad-Toh K, Church GM and de Magalhães JP: The naked mole rat genome resource: Facilitating analyses of cancer and longevity-related adaptations. Bioinformatics. 30:3558–3560. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Chu TLH, Connell M, Zhou LX, He ZC, Won J, Chen H, Rahavi SMR, Mohan P, Nemirovsky O, Fotovati A, et al: Cell Cycle-Dependent Tumor Engraftment and Migration Are Enabled by Aurora-A. Mol Cancer Res. 16:16–31. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Murphy JM, Park H and Lim STS: FAK and Pyk2 in disease. Front Biol. 11:1–9. 2016. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Li L and Wang D: Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor. Oncol Lett 25: 28, 2023.
APA
Zhang, H., Li, L., & Wang, D. (2023). Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor. Oncology Letters, 25, 28. https://doi.org/10.3892/ol.2022.13614
MLA
Zhang, H., Li, L., Wang, D."Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor". Oncology Letters 25.1 (2023): 28.
Chicago
Zhang, H., Li, L., Wang, D."Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor". Oncology Letters 25, no. 1 (2023): 28. https://doi.org/10.3892/ol.2022.13614
Copy and paste a formatted citation
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Spandidos Publications style
Zhang H, Li L and Wang D: Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor. Oncol Lett 25: 28, 2023.
APA
Zhang, H., Li, L., & Wang, D. (2023). Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor. Oncology Letters, 25, 28. https://doi.org/10.3892/ol.2022.13614
MLA
Zhang, H., Li, L., Wang, D."Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor". Oncology Letters 25.1 (2023): 28.
Chicago
Zhang, H., Li, L., Wang, D."Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor". Oncology Letters 25, no. 1 (2023): 28. https://doi.org/10.3892/ol.2022.13614
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