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Review Open Access

Hydroxychavicol as a potential anticancer agent (Review)

  • Authors:
    • Noor Azleen Mohamad
    • Amirah Abdul Rahman
    • Siti Hamimah Sheikh Abdul Kadir
  • View Affiliations / Copyright

    Affiliations: Institute of Medical and Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA, Universiti Teknologi MARA, Cawangan Selangor, Kampus Sungai Buloh, Sungai Buloh, Selangor 47000, Malaysia, Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA, Universiti Teknologi MARA, Cawangan Selangor, Kampus Sungai Buloh, Sungai Buloh, Selangor 47000, Malaysia
    Copyright: © Mohamad et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 34
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    Published online on: December 5, 2022
       https://doi.org/10.3892/ol.2022.13620
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Abstract

Piper betle leaves are widely cultivated in Malaysia, India, Indonesia and Thailand. They have been used as a traditional medicine for centuries due to their medicinal properties, including antioxidant, antiproliferative, antibacterial, antifungal and anti‑inflammatory properties, which are attributable to their high phenolic contents. Hydroxychavicol (HC), a primary constituent of P. betle leaves, is known to possess antiproliferative activity at micromolar doses on various cancer cell lines of different origins while leaving normal cells unharmed. The present review summarises the mechanisms of action of HC reported in the literature, reviews the scope of work done thus far and outlines the direction of future research on the potential of HC as an anticancer agent. PubMed, Scopus and Web of Science were searched using the keywords (hydroxychavicol OR 4‑allylpyrocatechol OR 4‑allylcatechol) AND (cancer OR carcinogenesis OR tumour OR carcinoma) to acquire research articles. In vitro studies reported several possible mechanisms for the chemopreventive effects of HC against cancer cell lines, including chronic myelogenous leukaemia (CML), prostate, glioma, breast and colorectal cancers, while in vivo studies encompassed investigations on Ehrlich ascites carcinoma cells in Swiss albino mice and a CML mouse model. These studies suggest that HC exerts its anticancer effect via the modulation of mitochondrial membrane potential and the c‑Jun N‑terminal kinase, mitogen‑activated protein kinase and endoplasmic reticulum‑unfolded protein responses pathways and the generation of reactive oxygen species. In summary, future research should focus on combinations of HC with other anticancer drugs and testing in animal models to evaluate its bioavailability, potency and tissue and dose selectivity.
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Copy and paste a formatted citation
Spandidos Publications style
Mohamad NA, Rahman AA and Sheikh Abdul Kadir S: Hydroxychavicol as a potential anticancer agent (Review). Oncol Lett 25: 34, 2023.
APA
Mohamad, N.A., Rahman, A.A., & Sheikh Abdul Kadir, S. (2023). Hydroxychavicol as a potential anticancer agent (Review). Oncology Letters, 25, 34. https://doi.org/10.3892/ol.2022.13620
MLA
Mohamad, N. A., Rahman, A. A., Sheikh Abdul Kadir, S."Hydroxychavicol as a potential anticancer agent (Review)". Oncology Letters 25.1 (2023): 34.
Chicago
Mohamad, N. A., Rahman, A. A., Sheikh Abdul Kadir, S."Hydroxychavicol as a potential anticancer agent (Review)". Oncology Letters 25, no. 1 (2023): 34. https://doi.org/10.3892/ol.2022.13620
Copy and paste a formatted citation
x
Spandidos Publications style
Mohamad NA, Rahman AA and Sheikh Abdul Kadir S: Hydroxychavicol as a potential anticancer agent (Review). Oncol Lett 25: 34, 2023.
APA
Mohamad, N.A., Rahman, A.A., & Sheikh Abdul Kadir, S. (2023). Hydroxychavicol as a potential anticancer agent (Review). Oncology Letters, 25, 34. https://doi.org/10.3892/ol.2022.13620
MLA
Mohamad, N. A., Rahman, A. A., Sheikh Abdul Kadir, S."Hydroxychavicol as a potential anticancer agent (Review)". Oncology Letters 25.1 (2023): 34.
Chicago
Mohamad, N. A., Rahman, A. A., Sheikh Abdul Kadir, S."Hydroxychavicol as a potential anticancer agent (Review)". Oncology Letters 25, no. 1 (2023): 34. https://doi.org/10.3892/ol.2022.13620
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