Hydroxychavicol as a potential anticancer agent (Review)
- Authors:
- Noor Azleen Mohamad
- Amirah Abdul Rahman
- Siti Hamimah Sheikh Abdul Kadir
-
Affiliations: Institute of Medical and Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA, Universiti Teknologi MARA, Cawangan Selangor, Kampus Sungai Buloh, Sungai Buloh, Selangor 47000, Malaysia, Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA, Universiti Teknologi MARA, Cawangan Selangor, Kampus Sungai Buloh, Sungai Buloh, Selangor 47000, Malaysia - Published online on: December 5, 2022 https://doi.org/10.3892/ol.2022.13620
- Article Number: 34
-
Copyright: © Mohamad et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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 |
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|
Pan SY, Litscher G, Gao SH, Zhou SF, Yu ZL, Chen HQ, Zhang SF, Tang MK, Sun JN and Ko KM: Historical perspective of traditional indigenous medical practices: The current renaissance and conservation of herbal resources. Evid Based Complement Alternat Med. 2014:5253402014. View Article : Google Scholar : PubMed/NCBI | |
|
World Health Organization (WHO), . WHO Global Report on Traditional and Complementary Medicine 2019. WHO; Geneva: 2019 | |
|
Ismail SF, Azmi IMAG, Daud M, Jalil JA and Safuan S: Regulatory control of herbal and traditional medicines in malaysia: Issues and concerns. Int J Business Society. 21:192–204. 2020. | |
|
Shehzad A, Islam SU, AL-Suhaimi EA and Lee YS: Pleiotropic effects of bioactive phytochemicals (Polyphenols and Terpenes). Functional Foods, Nutraceuticals and Natural Products. DEStech Publications Inc.; 2018 | |
|
Nishino H, Tokuda H, Satomi Y, Masuda M, Onozuka M, Yamaguchi S, Takayasu J, Tsuruta J, Takemura M, Ii T, et al: Cancer chemoprevention by phytochemicals and their related compounds. Asian Pac J Cancer Prev. 1:49–55. 2000.PubMed/NCBI | |
|
Amin ARMR, Kucuk O, Khuri FR and Shin DM: Perspectives for cancer prevention with natural compounds. J Clin Oncol. 27:2712–2725. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Nisar B, Sultan A and Rubab SL: Comparison of medicinally important natural products versus synthetic drugs-a short commentary. Nat Prod Chem Res. 6:22018. View Article : Google Scholar | |
|
Gao Q, Feng J, Liu W, Wen C, Wu Y, Liao Q, Zou L, Sui X, Xie T, Zhang J and Hu Y: Opportunities and challenges for co-delivery nanomedicines based on combination of phytochemicals with chemotherapeutic drugs in cancer treatment. Adv Drug Deliv Rev. 188:1144452022. View Article : Google Scholar : PubMed/NCBI | |
|
Bode AM and Dong Z: Toxic phytochemicals and their potential risks for human cancer. Cancer Prev Res (Phila). 8:1–8. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Kudva AK, Rao S, Rao P, Periera R, Bhandari G, Mathew JM, Ashwini K, Pais M, Swamy MK and Baliga M: Piper betle Linn, in cancer: Past, present, and future. Anticancer plants: Properties and Application. Vol 1. Springer; Singapore: pp. 327–347. 2018 | |
|
Guha P: Betel leaf: The neglected green gold of india. J Hum Ecol. 19:87–93. 2006. View Article : Google Scholar | |
|
Amonkar AJ, Nagabhushan M, D'Souza AV and Bhide SV: Hydroxychavicol: A new phenolic antimutagen from betel leaf. Food Chem Toxicol. 24:1321–1324. 1986. View Article : Google Scholar : PubMed/NCBI | |
|
Amonkar AJ, Padma PR and Bhide SV: Protective effect of hydroxychavicol, a phenolic component of betel leaf, against the tobacco-specific carcinogens. Mutat Res. 210:249–253. 1989. View Article : Google Scholar : PubMed/NCBI | |
|
Chaveerach A, Mokkamul P, Sudmoon R and Tanee T: Ethnobotany of the Genus Piper (Piperaceae) in Thailand. Ethnobotany Research Applications. 4:2232006. View Article : Google Scholar | |
|
Shah GA, Shah TI, Telang S, Science G, Nehru J and Hospital C: Anti-proliferative efficacy of piper betle leaf extracts against B16F10 melanoma in an in vivo. World J Pharm Pharm Sci. 5:835–843. 2016. | |
|
Haslan H, Suhaimi FH, Thent ZC and Das S: The underlying mechanism of action for various medicinal properties of Piper betle (betel). Clin Ter. 166:208–214. 2015.PubMed/NCBI | |
|
Agarwal T, Singh R, Shukla AD, Waris I and Gujrati A: Comparative analysis of antibacterial activity of four Piper betel varieties. Adv Appl Sci Res. 3:698–705. 2012. | |
|
Chakraborty D and Shah B: Antimicrobial, anti-oxidative and anti-hemolytic activity of Piper betel leaf extracts. Int J Pharm Pharm Sci. 3:192–199. 2011. | |
|
Kumar N, Misra P, Dube A, Bhattacharya S, Dikshit M and Ranade S: Piper betle Linn. A maligned pan-asiatic plant with an array of pharmacological activities and prospects for drug discovery. Curr Sci. 99:922–932. 2010. | |
|
Punuri JB, Sharma P, Sibyala S, Tamuli R and Bora U: Piper betle-mediated green synthesis of biocompatible gold nanoparticles. Int Nano Lett. 2:182012. View Article : Google Scholar | |
|
Sharma S, Khan IA, Ali I, Ali F, Kumar M, Kumar A, Johri RK, Abdullah ST, Bani S, Pandey A, et al: Evaluation of the antimicrobial, antioxidant, and anti-inflammatory activities of hydroxychavicol for its potential use as an oral care agent. Antimicrob Agents Chemother. 53:216–222. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Madhumita M, Guha P and Nag A: Bio-actives of betel leaf (Piper betle L.): A comprehensive review on extraction, isolation, characterization, and biological activity. Phytother Res. 34:2609–2627. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Das S, Parida R, Sandeep IS, Nayak S and Mohanty S: Biotechnological intervention in betelvine (Piper betle L.): A review on recent advances and future prospects. Asian Pac J Trop Med. 9:938–946. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Rahman AA, Mokhtar NM, Harun R, Jamal R and Ngah WZ: Transcriptome analysis reveals the molecular mechanisms of combined gamma-tocotrienol and hydroxychavicol in preventing the proliferation of 1321N1, SW1783, and LN18 glioma cancer cells. J Physiol Biochem. 75:499–517. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chakraborty JB, Mahato SK, Joshi K, Shinde V, Rakshit S, Biswas N, Mukherjee IC, Mandal L, Ganguly D, Chowdhury AA, et al: Hydroxychavicol, a Piper betle leaf component, induces apoptosis of CML cells through mitochondrial reactive oxygen species-dependent JNK and endothelial nitric oxide synthase activation and overrides imatinib resistance. Cancer Sci. 103:88–99. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Prabhu MS, Platel K, Saraswathi G and Srinivasan K: Effect of orally administered betel leaf (Piper betle Linn.) on digestive enzymes of pancreas and intestinal mucosa and on bile production in rats. Indian J Exp Biol. 33:752–756. 1995.PubMed/NCBI | |
|
Majumdar AG and Subramanian M: Hydroxychavicol from Piper betle induces apoptosis, cell cycle arrest, and inhibits epithelial-mesenchymal transition in pancreatic cancer cells. Biochem Pharmacol. 166:274–291. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Lee-Chen SF, Chen CL, Ho LY, Hsu PC, Chang JT, Sun CM, Chi CW and Liu TY: Role of oxidative DNA damage in hydroxychavicol-induced genotoxicity. Mutagenesis. 11:519–523. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Tang DW, Lin SC, Chang KW, Chi CW, Chang CS and Liu TY: Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma-evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. J Oral Pathol Med. 32:522–529. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Chang MC, Uang BJ, Tsai CY, Wu HL, Lin BR, Lee CS, Chen YJ, Chang CH, Tsai YL, Kao CJ and Jeng JH: Hydroxychavicol, a novel betel leaf component, inhibits platelet aggregation by suppression of cyclooxygenase, thromboxane production and calcium mobilization. Br J Pharmacol. 152:73–82. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Chang MC, Uang BJ, Wu HL, Lee JJ, Hahn LJ and Jeng JH: Inducing the cell cycle arrest and apoptosis of oral KB carcinoma cells by hydroxychavicol: Roles of glutathione and reactive oxygen species. Br J Pharmacol. 135:619–130. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Arksey H and O'Malley L: Scoping studies: Towards a methodological framework. International J Social Research Methodology: Theory and Practice. 8:19–32. 2005. View Article : Google Scholar | |
|
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J and Moher D: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. J Clin Epidemiol. 62:e1–e34. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Thi Truc Nguyen L, Thi Nguyen T, Ngoc Nguyen H and Thi Phuong Bui Q: Simultaneous determination of active compounds in Piper betle Linn. leaf extract and effect of extracting solvents on bioactivity. Eng Reps. 2:e122462020. | |
|
Ali A, Lim XY, Chong CH, Mah SH and Chua BL: Optimization of ultrasound-assisted extraction of natural antioxidants from Piper betle using response surface methodology. LWT. 89:681–688. 2018. View Article : Google Scholar | |
|
Pin KY, Chuah AL, Rashih AA, Mazura MP, Fadzureena J, Vimala S and Rasadah MA: Antioxidant and anti-inflammatory activities of extracts of betel leaves (Piper betle) from solvents with different polarities. J Tropical Forest Sci. 22:448–455. 2010. | |
|
Zamakshshari N, Ahmed IA and Nasharuddin MNA: Effect of extraction procedure on the yield and biological activities of hydroxychavicol from Piper betle L. leaves. J Appl Res Med Aromat Plants. 24:1003202021. | |
|
Ali A, Chong CH, Mah SH, Abdullah LC, Choong TSY and Chua BL: Impact of storage conditions on the stability of predominant phenolic constituents and antioxidant activity of dried piper betle extracts. Molecules. 23:4842018. View Article : Google Scholar : PubMed/NCBI | |
|
Gundala SR and Aneja R: Piper betel leaf: A reservoir of potential xenohormetic nutraceuticals with cancer-fighting properties. Cancer Prev Res (Phila). 7:477–486. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Mira L, Fernandez MT, Santos M, Rocha R, Florêncio MH and Jennings KR: Interactions of flavonoids with iron and copper ions: A mechanism for their antioxidant activity. Free Radic Res. 36:1199–1208. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Halliwell B: Biochemistry of oxidative stress. Biochem Soc Trans. 35:1147–1150. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Chen X, Song M, Zhang B and Zhang Y: Reactive oxygen species regulate T cell immune response in the tumor microenvironment. Oxid Med Cell Longev. 2016:15809672016. View Article : Google Scholar : PubMed/NCBI | |
|
Juan CA, de la Lastra JM, Plou FJ and Pérez-Lebeña E: The chemistry of reactive oxygen species (ROS) revisited: Outlining their role in biological macromolecules (DNA, Lipids and Proteins) and induced pathologies. Int J Mol Sci. 22:46422021. View Article : Google Scholar : PubMed/NCBI | |
|
Hayes JD, Dinkova-Kostova AT and Tew KD: Oxidative stress in cancer. Cancer Cell. 38:167–197. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Kim SJ, Kim HS and Seo YR: Understanding of ROS-inducing strategy in anticancer therapy. Oxid Med Cell Longev. 2019:53816922019. View Article : Google Scholar : PubMed/NCBI | |
|
Ureshino H, Shindo T and Kimura S: Role of cancer immunology in chronic myelogenous leukemia. Leuk Res. 88:1062732020. View Article : Google Scholar : PubMed/NCBI | |
|
Hochhaus A, Larson RA, Guilhot F, Radich JP, Branford S, Hughes TP, Baccarani M, Deininger MW, Cervantes F, Fujihara S, et al: Long-term outcomes of imatinib treatment for chronic myeloid leukemia. N Engl J Med. 376:917–927. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Paul T, Banerjee A, Reddy SVB, Mahato SK and Biswas N: Hydroxychavicol sensitizes imatinib-resistant chronic myelogenous leukemia cells to TRAIL-induced apoptosis by ROS-mediated IAP downregulation. Anticancer Drugs. 30:167–178. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chowdhury AA, Chaudhuri J, Biswas N, Manna A, Chatterjee S, Mahato SK, Chaudhuri U, Jaisankar P and Bandyopadhyay S: Synergistic apoptosis of CML cells by buthionine sulfoximine and hydroxychavicol correlates with activation of AIF and GSH-ROS-JNK-ERK-iNOS pathway. PLoS One. 8:e736722013. View Article : Google Scholar : PubMed/NCBI | |
|
Chaudhuri J, Chowdhury AA, Biswas N, Manna A, Chatterjee S, Mukherjee T, Chaudhuri U, Jaisankar P and Bandyopadhyay S: Superoxide activates mTOR-eIF4E-Bax route to induce enhanced apoptosis in leukemic cells. Apoptosis. 19:135–148. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
World Health Organization (WHO), . GLOBOCAN 2020. WHO; Geneva: 2020 | |
|
Perou CM, Sørile T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Cazzaniga M and Bonanni B: Breast cancer chemoprevention: Old and new approaches. J Biomed Biotechnol. 2012:985620S2012. View Article : Google Scholar : PubMed/NCBI | |
|
Neven P, Jongen L, Lintermans A, Van Asten K, Blomme C, Lambrechts D, Poppe A, Wildiers H, Dieudonné AS, Brouckaert O, et al: Tamoxifen metabolism and efficacy in breast cancer: A prospective multicenter trial. Clin Cancer Res. 24:2312–2318. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Waters EA, McNeel TS, Stevens WM and Freedman AN: Use of tamoxifen and raloxifene for breast cancer chemoprevention in 2010. Breast Cancer Res Treat. 134:875–880. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Chumsri S, Howes T, Bao T, Sabnis G and Brodie A: Aromatase, aromatase inhibitors, and breast cancer. J Steroid Mol Biol. 125:13–22. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Tong CWS, Wu M, Cho WCS and To KKW: Recent advances in the treatment of breast cancer. Front Oncol. 8:2272018. View Article : Google Scholar : PubMed/NCBI | |
|
Kreutzfeldt J, Rozeboom B, Dey N and De P: The trastuzumab era: Current and upcoming targeted HER2+ breast cancer therapies. Am J Cancer Res. 10:1045–1067. 2020.PubMed/NCBI | |
|
Sinha D, Biswas J, Sung B, Aggarwal BB and Bishayee A: Chemopreventive and chemotherapeutic potential of curcumin in breast cancer. Curr Drug Targets. 13:1799–1819. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Hemamalini V, Velayutham DPM, Lakshmanan L, Muthusamy K, Sivaramakrishnan S and Premkumar K: Inhibitory potential of Hydroxychavicol on Ehrlich ascites carcinoma model and in silico interaction on cancer targets. Nat Prod Res. 34:1591–1596. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG and McCain RS: Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes. World J Gastroenterol. 24:4846–4861. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Burris HA III, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P, et al: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol. 15:2403–2413. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Conroy T, Hammel P, Hebbar M, Abdelghani MB, Wei AC, Raoul JL, Choné L, Francois E, Artru P, Biagi JJ, et al: FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer. N Eng J Med. 379:2395–2406. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Neuzillet C, Gaujoux S, Williet N, Bachet JB, Bauguion L, Durand LC, Conroy T, Dahan L, Gilabert M, Huguet F, et al: Pancreatic cancer: French clinical practice guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, AFC). Dig Liver Dis. 50:1257–1271. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Hamdy FC, Donovan JL, Lane JA, Mason M, Metcalfe C, Holding P, Davis M, Peters TJ, Turner EL, Martin RM, et al: 10-year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer. N Eng J Med. 375:1415–1424. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Armstrong CM and Gao AC: Adaptive pathways and emerging strategies overcoming treatment resistance in castration resistant prostate cancer. Asian J Urol. 3:185–194. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Gundala SR, Yang C, Mukkavilli R, Paranjpe R, Brahmbhatt M, Pannu V, Cheng A, Reid MD and Aneja R: Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis. Toxicol Appl Pharmacol. 280:86–96. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kuipers EJ, Grady WM, Lieberman D, Seufferlein T, Sung JJ, Boelens PG, van de Velde CJH and Watanabe T: Colorectal cancer. Nat Rev Dis Primers. 1:50652015. View Article : Google Scholar : PubMed/NCBI | |
|
Yalcin-Ozkat G: Molecular modeling strategies of cancer multidrug resistance. Drug Resist Updat. 59:1007892021. View Article : Google Scholar : PubMed/NCBI | |
|
Rajedadram A, Pin KY, Ling SK, Yan SW and Looi ML: Hydroxychavicol, a polyphenol from Piper betle leaf extract, induces cell cycle arrest and apoptosis in TP53-resistant HT-29 colon cancer cells. J Zhejiang Univ Sci B. 22:112–122. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Bahadur S, Sahu AK, Baghel P and Saha S: Current promising treatment strategy for glioblastoma multiform: A review. Oncol Rev. 13:4172019. View Article : Google Scholar : PubMed/NCBI | |
|
Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS and Villano JL: Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomarkers Prev. 23:1985–1996. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Koshy M, Villano JL, Dolecek TA, Howard A, Mahmood U, Chmura SJ, Weichselbaum RR and McCarthy BJ: Improved survival time trends for glioblastoma using the SEER 17 population-based registries. J Neurooncol. 107:207–212. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Rahman AA, Jamal AR, Harun R, Mokhtar NM and Ngah WZ: Gamma-tocotrienol and hydroxy-chavicol synergistically inhibits growth and induces apoptosis of human glioma cells. BMC Complement Altern Med. 14:2132014. View Article : Google Scholar : PubMed/NCBI | |
|
Rahman AA, Ngah WZ, Jamal R, Makpol S, Harun R and Mokhtar N: Inhibitory mechanism of combined hydroxychavicol with epigallocatechin-3-gallate against glioma cancer cell lines: A transcriptomic analysis. Front Pharmacol. 13:8441992022. View Article : Google Scholar : PubMed/NCBI | |
|
Center MM and Jemal A: International trends in liver cancer incidence rates. Cancer Epidemiol Biomarkers Prev. 20:2362–2368. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Anwanwan D, Singh SK, Singh S, Saikam V and Singh R: Challenges in liver cancer and possible treatment approaches. Biochim Biophys Acta Rev Cancer. 1873:1883142020. View Article : Google Scholar : PubMed/NCBI | |
|
Chen CL, Chi CW and Liu TY: Enhanced hydroxychavicol-induced cytotoxic effects in glutathione-depleted HepG2 cells. Cancer Lett. 155:29–35. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Harsha C, Banik K, Ang HL, Girisa S, Vikkurthi R, Parama D, Rana V, Shabnam B, Khatoon E, Kumar AP and Kunnumakkara AB: Targeting AKT/mTOR in oral cancer: Mechanisms and advances in clinical trials. Int J Mol Sci. 21:32852020. View Article : Google Scholar : PubMed/NCBI | |
|
Sawhney M, Rohatgi N, Kaur J, Shishodia S, Sethi G, Gupta SD, Deo SVS, Shukla NK, Aggarwal BB and Ralhan R: Expression of NF- kappaB parallels COX-2 expression in oral precancer and cancer: Association with smokeless tobacco. Int J Cancer. 120:2545–2556. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Baek SH, Ko JH, Lee H, Jung J, Kong M, Lee JW, Lee J, Chinnathambi A, Zayed ME, Alharbi SA, et al: Phytomedicine Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells. Phytomedicine. 23:566–577. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Sinha N, Panda PK, Naik PP, Das DN, Mukhopadhyay S, Maiti TK, Shanmugam MK, Chinnathambi A, Zayed ME, Alharbi SA, et al: Abrus agglutinin promotes irreparable DNA damage by triggering ROS generation followed by ATM-p73 mediated apoptosis in oral squamous cell carcinoma. Mol Carcinog. 56:2400–2413. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Monisha J, Roy NK, Padmavathi G, Banik K, Bordoloi D, Khwairakpam AD, Arfuso F, Chinnathambi A, Alahmadi TA, Alharbi SA, et al: NGAL is downregulated in oral squamous cell carcinoma and leads to increased survival, proliferation, migration and chemoresistance. Cancers (Basel). 10:2282018. View Article : Google Scholar : PubMed/NCBI | |
|
Hashim D, Genden E, Posner M, Hashibe M and Boffetta P: Head and neck cancer prevention : From primary prevention to impact of clinicians on reducing burden. Ann Oncol. 30:744–756. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Behera AK, Kumar M, Shanmugam MK, Bhattacharya A, Rao VJ, Bhat A, Vasudevan M, Gopinath KS, Mohiyuddin A, Chatterjee A, et al: Functional interplay between YY1 and CARM1 promotes oral carcinogenesis. Oncotarget. 10:3709–3724. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chang MC, Pan YH, Wu HL, Lu YJ, Liao WC, Yeh CY, Lee JJ and Jeng JH: Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-ß/Smad2-dependent and-independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin. Aging. 11:11624–11639. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Jeng JH, Wang YJ, Chang WH, Wu HL, Li CH, Uang BJ, Kang JJ, Lee JJ, Hahn LJ, Lin BR and Chang MC: Reactive oxygen species are crucial for hydroxychavicol toxicity toward KB epithelial cells. Cell Mol Life Sci. 61:83–96. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Garbe C and Leiter U: Melanoma epidemiology and trends. Clin Dermatol. 27:3–9. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Lomas A, Leonardi-Bee J and Bath-Hextall F: A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol. 166:1069–1080. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Green A, Whiteman D, Frost C and Battistutta D: Sun exposure, skin cancers and related skin conditions. J Epidemiol. 9:S7–S13. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
American Cancer Society, . Cancer Facts & Figures 2016. American Cancer Society; Atlanta, GA: 2016 | |
|
Moushumi L and Sumati B: Studies on possible protective effect of plant derived phenols and the vitamin precursors-β-carotene and α-tocopherol on 7, 12 Dimethylbenz (a) anthracene induced tumour initiation events. Phytotherapy Res. 8:237–240. 1994. View Article : Google Scholar | |
|
Vinusri S, Gnanam R, Caroline R, Santhanakrishnan VP and Kandavelmani A: Anticancer potential of hydroxychavicol derived from piper betle L: An in silico and cytotoxicity study. Nutr Cancer. 74:3701–3713. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Maeda H and Akaike T: Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry (Mosc). 63:854–865. 1998.PubMed/NCBI | |
|
Kennedy BM and Harris RE: Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer. Inflammopharmacology. 26:909–923. 2018. View Article : Google Scholar | |
|
Romano M and Clària J: Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy. FASEB J. 17:1986–1995. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Schneider C and Pozzi A: Cyclooxygenases and lipoxygenases in cancer. Cancer Metastasis Rev. 30:277–294. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Lin CF, Hwang TL, Chien CC, Tu HY and Lay HL: A new hydroxychavicol dimer from the roots of Piper betle. Molecules. 18:2563–2570. 2013. View Article : Google Scholar : PubMed/NCBI |
