Open Access

Prognostic value of CD8+ tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis

  • Authors:
    • Yu-Pei Sun
    • You-Li Ke
    • Xiao Li
  • View Affiliations

  • Published online on: December 8, 2022     https://doi.org/10.3892/ol.2022.13625
  • Article Number: 39
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

CD8+ tumor‑infiltrating lymphocytes have been regarded as potential biomarkers for cancer prognosis, while the prognostic effect of CD8+ tumor‑infiltrating T cells remains controversial in breast cancer. In the present study, a meta‑analysis was performed to evaluate the prognostic value of CD8+ T cells in breast cancer and the associations between CD8+ T cells and the pathological characteristics. The PubMed, Embase and the Cochrane Library were systematically searched entries added from the establishment of the database to November 2021 and prospective or retrospective studies of patients with breast cancer were included. The Newcastle‑Ottawa Scale was used to assess the quality of evidence for each study. STATA 15.1 was used for the data analysis. A total of 14 studies comprising 22,222 patients were included in the final analysis and the pooled results suggested that a high CD8+ T‑cell infiltration level was significantly related to better overall survival [hazard ratio (HR)=0.70, 95% confidence interval (CI): 0.60‑0.82, P<0.001] and disease‑free survival (HR=0.63, 95% CI: 0.49‑0.81, P<0.001) for patients with breast cancer. In addition, a high CD8+ T‑cell infiltration level was significantly associated with decreased expression of estrogen receptor [odds ratio (OR)=1.92, 95% CI: 1.30‑2.85, P=0.001] and progesterone receptor (OR=1.66, 95% CI: 1.14‑2.42, P=0.008), and increased human epidermal growth factor receptor 2 expression (OR=0.79, 95% CI: 0.66‑0.94, P=0.010) in patients with breast cancer, while there was no significant association between CD8+ T‑cell infiltration and age, tumor size or lymph node status of patients with breast cancer (P>0.05). In conclusion, CD8+ T‑cell infiltration is of prognostic value in patients with breast cancer. High levels of CD8+ T‑cell infiltration were related to improved prognosis, including OS and DFS, in patients with breast cancer.
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January-2023
Volume 25 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Sun Y, Ke Y and Li X: Prognostic value of CD8<sup>+</sup> tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis. Oncol Lett 25: 39, 2023
APA
Sun, Y., Ke, Y., & Li, X. (2023). Prognostic value of CD8<sup>+</sup> tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis. Oncology Letters, 25, 39. https://doi.org/10.3892/ol.2022.13625
MLA
Sun, Y., Ke, Y., Li, X."Prognostic value of CD8<sup>+</sup> tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis". Oncology Letters 25.1 (2023): 39.
Chicago
Sun, Y., Ke, Y., Li, X."Prognostic value of CD8<sup>+</sup> tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis". Oncology Letters 25, no. 1 (2023): 39. https://doi.org/10.3892/ol.2022.13625