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Prognostic value of CD8+ tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis

  • Authors:
    • Yu-Pei Sun
    • You-Li Ke
    • Xiao Li
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Wuhan No. 1 Hospital, Wuhan, Hubei 430022, P.R. China, Department of Thoracic Surgery, Wuhan No. 1 Hospital, Wuhan, Hubei 430022, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 39
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    Published online on: December 8, 2022
       https://doi.org/10.3892/ol.2022.13625
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Abstract

CD8+ tumor‑infiltrating lymphocytes have been regarded as potential biomarkers for cancer prognosis, while the prognostic effect of CD8+ tumor‑infiltrating T cells remains controversial in breast cancer. In the present study, a meta‑analysis was performed to evaluate the prognostic value of CD8+ T cells in breast cancer and the associations between CD8+ T cells and the pathological characteristics. The PubMed, Embase and the Cochrane Library were systematically searched entries added from the establishment of the database to November 2021 and prospective or retrospective studies of patients with breast cancer were included. The Newcastle‑Ottawa Scale was used to assess the quality of evidence for each study. STATA 15.1 was used for the data analysis. A total of 14 studies comprising 22,222 patients were included in the final analysis and the pooled results suggested that a high CD8+ T‑cell infiltration level was significantly related to better overall survival [hazard ratio (HR)=0.70, 95% confidence interval (CI): 0.60‑0.82, P<0.001] and disease‑free survival (HR=0.63, 95% CI: 0.49‑0.81, P<0.001) for patients with breast cancer. In addition, a high CD8+ T‑cell infiltration level was significantly associated with decreased expression of estrogen receptor [odds ratio (OR)=1.92, 95% CI: 1.30‑2.85, P=0.001] and progesterone receptor (OR=1.66, 95% CI: 1.14‑2.42, P=0.008), and increased human epidermal growth factor receptor 2 expression (OR=0.79, 95% CI: 0.66‑0.94, P=0.010) in patients with breast cancer, while there was no significant association between CD8+ T‑cell infiltration and age, tumor size or lymph node status of patients with breast cancer (P>0.05). In conclusion, CD8+ T‑cell infiltration is of prognostic value in patients with breast cancer. High levels of CD8+ T‑cell infiltration were related to improved prognosis, including OS and DFS, in patients with breast cancer.
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View References

1 

Ghoncheh M, Pournamdar Z and Salehiniya H: Incidence and mortality and epidemiology of breast cancer in the world. Asian Pac J Cancer Prev. 17:43–46. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Emens LA: Breast cancer immunotherapy: Facts and hopes. Clin Cancer Res. 24:511–520. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Saponaro C, Vagheggini A, Scarpi E, Centonze M, Catacchio I, Popescu O, Pastena MI, Giotta F, Silvestris N and Mangia A: NHERF1 and tumor microenvironment: A new scene in invasive breast carcinoma. J Exp Clin Cancer Res. 37:962018. View Article : Google Scholar : PubMed/NCBI

5 

Shiao SL, Ganesan AP, Rugo HS and Coussens LM: Immune microenvironments in solid tumors: New targets for therapy. Genes Dev. 25:2559–2572. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Naito Y, Saito K, Shiiba K, Ohuchi A, Saigenji K, Nagura H and Ohtani H: CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res. 58:3491–3494. 1998.PubMed/NCBI

7 

Paijens ST, Vledder A, de Bruyn M and Nijman HW: Tumor-infiltrating lymphocytes in the immunotherapy era. Cell Mol Immunol. 18:842–859. 2021. View Article : Google Scholar : PubMed/NCBI

8 

Lotfinejad P, Asghari Jafarabadi M, Abdoli Shadbad M, Kazemi T, Pashazadeh F, Sandoghchian Shotorbani S, Jadidi Niaragh F, Baghbanzadeh A, Vahed N, Silvestris NJ and Baradaran B: Prognostic role and clinical significance of tumor-infiltrating lymphocyte (TIL) and programmed death ligand 1 (PD-L1) expression in triple-negative breast cancer (TNBC): A systematic review and meta-analysis study. Diagnostics (Basel). 10:7042020. View Article : Google Scholar : PubMed/NCBI

9 

Farhood B, Najafi M and Mortezaee K: CD8(+) cytotoxic T lymphocytes in cancer immunotherapy: A review. J Cell Physiol. 234:8509–8521. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Li F, Li C, Cai X, Xie Z, Zhou L, Cheng B, Zhong R, Xiong S, Li J, Chen Z, et al: The association between CD8+ tumor-infiltrating lymphocytes and the clinical outcome of cancer immunotherapy: A systematic review and meta-analysis. EClinicalMedicine. 41:1011342021. View Article : Google Scholar : PubMed/NCBI

11 

Liu S, Lachapelle J, Leung S, Gao D, Foulkes WD and Nielsen TO: CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer. Breast Cancer Res. 14:R482012. View Article : Google Scholar : PubMed/NCBI

12 

Mahmoud SM, Paish EC, Powe DG, Macmillan RD, Grainge MJ, Lee AH, Ellis IO and Green AR: Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer. J Clin Oncol. 29:1949–1955. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Baker K, Lachapelle J, Zlobec I, Bismar TA, Terracciano L and Foulkes WD: Prognostic significance of CD8+ T lymphocytes in breast cancer depends upon both oestrogen receptor status and histological grade. Histopathology. 58:1107–1116. 2011.PubMed/NCBI

14 

Liu F, Lang R, Zhao J, Zhang X, Pringle GA, Fan Y, Yin D, Gu F, Yao Z and Fu L: CD8(+) cytotoxic T cell and FOXP3(+) regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes. Breast Cancer Res Treat. 130:645–655. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Denkert C, Loibl S, Noske A, Roller M, Muller BM, Komor M, Budczies J, Darb-Esfahani S, Kronenwett R, Hanusch C, et al: Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. J Clin Oncol. 28:105–113. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Loi S, Sirtaine N, Piette F, Salgado R, Viale G, Van Eenoo F, Rouas G, Francis P, Crown JP, Hitre E, et al: Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98. J Clin Oncol. 31:860–867. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Moher D, Liberati A, Tetzlaff J and Altman DG; PRISMA Group, : Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Ann Intern Med. 151:264–269. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Margulis AV, Pladevall M, Riera-Guardia N, Varas-Lorenzo C, Hazell L, Berkman ND, Viswanathan M and Perez-Gutthann S: Quality assessment of observational studies in a drug-safety systematic review, comparison of two tools: The newcastle-ottawa scale and the RTI item bank. Clin Epidemiol. 6:359–368. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Mantel N and Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 22:719–748. 1959.PubMed/NCBI

20 

DerSimonian R and Laird N: Meta-analysis in clinical trials revisited. Contemp Clin Trials. 45:139–145. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Borenstein M, Hedges LV, Higgins JP and Rothstein HR: A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods. 1:97–111. 2010. View Article : Google Scholar : PubMed/NCBI

22 

DerSimonian R and Kacker R: Random-effects model for meta-analysis of clinical trials: An update. Contemp Clin Trials. 28:105–114. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Riley RD, Higgins JP and Deeks JJ: Interpretation of random effects meta-analyses. BMJ. 342:d5492011. View Article : Google Scholar : PubMed/NCBI

24 

Ma C, Zhang Q, Ye J, Wang F, Zhang Y, Wevers E, Schwartz T, Hunborg P, Varvares MA, Hoft DF, et al: Tumor-infiltrating γδ T lymphocytes predict clinical outcome in human breast cancer. J Immunol. 189:5029–5036. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Mohammed ZM, Going JJ, Edwards J, Elsberger B and McMillan DC: The relationship between lymphocyte subsets and clinico-pathological determinants of survival in patients with primary operable invasive ductal breast cancer. Br J Cancer. 109:1676–1684. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Kim ST, Jeong H, Woo OH, Seo JH, Kim A, Lee ES, Shin SW, Kim YH, Kim JS and Park KH: Tumor-infiltrating lymphocytes, tumor characteristics, and recurrence in patients with early breast cancer. Am J Clin Oncol. 36:224–231. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Sun S, Fei X, Mao Y, Wang X, Garfield DH, Huang O, Wang J, Yuan F, Sun L, Yu Q, et al: PD-1(+) immune cell infiltration inversely correlates with survival of operable breast cancer patients. Cancer Immunol Immunother. 63:395–406. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Chen Z, Chen X, Zhou E, Chen G, Qian K, Wu X, Miao X and Tang Z: Intratumoral CD8(+) cytotoxic lymphocyte is a favorable prognostic marker in node-negative breast cancer. PLoS One. 9:e954752014. View Article : Google Scholar : PubMed/NCBI

29 

Ali HR, Provenzano E, Dawson SJ, Blows FM, Liu B, Shah M, Earl HM, Poole CJ, Hiller L, Dunn JA, et al: Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients. Ann Oncol. 25:1536–1543. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Chung YR, Kim HJ, Jang MH and Park SY: Prognostic value of tumor infiltrating lymphocyte subsets in breast cancer depends on hormone receptor status. Breast Cancer Res Treat. 161:409–420. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Liu S, Chen B, Burugu S, Leung S, Gao D, Virk S, Kos Z, Parulekar WR, Shepherd L, Gelmon KA and Nielsen TO: Role of cytotoxic tumor-infiltrating lymphocytes in predicting outcomes in metastatic HER2-positive breast cancer: A secondary analysis of a randomized clinical trial. JAMA Oncol. 3:e1720852017. View Article : Google Scholar : PubMed/NCBI

32 

Papaioannou E, Sakellakis M, Melachrinou M, Tzoracoleftherakis E, Kalofonos H and Kourea E: A Standardized evaluation method for FOXP3+ tregs and CD8+ T-cells in breast carcinoma: Association with breast carcinoma subtypes, stage and prognosis. Anticancer Res. 39:1217–1232. 2019. View Article : Google Scholar : PubMed/NCBI

33 

de Groot AF, Blok EJ, Charehbili A, Engels CC, Smit V, Dekker-Ensink NG, Putter H, Meershoek-Klein Kranenbarg E, van de Velde CJ, Liefers GJ, et al: Strong CD8+ lymphocyte infiltration in combination with expression of HLA class I is associated with better tumor control in breast cancer patients treated with neoadjuvant chemotherapy. Breast Cancer Res Treat. 175:605–615. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Catacchio I, Silvestris N, Scarpi E, Schirosi L, Scattone A and Mangia A: Intratumoral, rather than stromal, CD8+ T cells could be a potential negative prognostic marker in invasive breast cancer patients. Transl Oncol. 12:585–595. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Galon J and Bruni D: Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Nat Rev Drug Discov. 18:197–218. 2019. View Article : Google Scholar : PubMed/NCBI

36 

van der Woude LL, Gorris MA, Halilovic A, Figdor CG and de Vries IJ: Migrating into the tumor: A roadmap for T cells. Trends Cancer. 3:797–808. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Berke G: The binding and lysis of target cells by cytotoxic lymphocytes: Molecular and cellular aspects. Annu Rev Immunol. 12:735–773. 1994. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Ke Y and Li X: Prognostic value of CD8<sup>+</sup> tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis. Oncol Lett 25: 39, 2023.
APA
Sun, Y., Ke, Y., & Li, X. (2023). Prognostic value of CD8<sup>+</sup> tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis. Oncology Letters, 25, 39. https://doi.org/10.3892/ol.2022.13625
MLA
Sun, Y., Ke, Y., Li, X."Prognostic value of CD8<sup>+</sup> tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis". Oncology Letters 25.1 (2023): 39.
Chicago
Sun, Y., Ke, Y., Li, X."Prognostic value of CD8<sup>+</sup> tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis". Oncology Letters 25, no. 1 (2023): 39. https://doi.org/10.3892/ol.2022.13625
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Ke Y and Li X: Prognostic value of CD8<sup>+</sup> tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis. Oncol Lett 25: 39, 2023.
APA
Sun, Y., Ke, Y., & Li, X. (2023). Prognostic value of CD8<sup>+</sup> tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis. Oncology Letters, 25, 39. https://doi.org/10.3892/ol.2022.13625
MLA
Sun, Y., Ke, Y., Li, X."Prognostic value of CD8<sup>+</sup> tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis". Oncology Letters 25.1 (2023): 39.
Chicago
Sun, Y., Ke, Y., Li, X."Prognostic value of CD8<sup>+</sup> tumor‑infiltrating T cells in patients with breast cancer: A systematic review and meta‑analysis". Oncology Letters 25, no. 1 (2023): 39. https://doi.org/10.3892/ol.2022.13625
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