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Prognostic nutritional index of early post‑pembrolizumab therapy predicts long‑term survival in patients with advanced urothelial carcinoma

  • Authors:
    • Susumu Kageyama
    • Tetsuya Yoshida
    • Kenichi Kobayashi
    • Akinori Wada
    • Masayuki Nagasawa
    • Shigehisa Kubota
    • Takuto Kusaba
    • Fumiyasu Jo
    • Shota Nakagawa
    • Kazuyoshi Johnin
    • Mitsuhiro Narita
    • Akihiro Kawauchi
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520‑2192, Japan
    Copyright: © Kageyama et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 49
    |
    Published online on: December 15, 2022
       https://doi.org/10.3892/ol.2022.13635
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Abstract

Pembrolizumab has been widely used to treat advanced urothelial carcinoma that has progressed after first‑line platinum‑based chemotherapy. Because its clinical benefits are limited, biomarkers that can predict a good response to pembrolizumab are required. The prognostic nutritional index (PNI), calculated using the serum albumin level and peripheral lymphocyte count, has been evaluated as a predictive biomarker in cancer immunotherapy. The present study investigated the application of PNI as a predictive biomarker for pembrolizumab response in patients with advanced urothelial cancer. A retrospective study was conducted on 34 patients treated with pembrolizumab at Shiga University of Medical Science Hospital between January 2018 and July 2022. The posttreatment PNI (post‑PNI) was calculated within 2 months of starting pembrolizumab. The present study investigated the association between post‑PNI and objective response, overall survival (OS) and progression‑free survival (PFS). The patient cohort was stratified into two categories, high and low post‑PNI groups, with a cutoff value of post‑PNI at 40. The higher post‑PNI group demonstrated a better disease control rate than the lower post‑PNI group (complete response + partial response + stable disease, 75 vs. 21%, P=0.004). Regarding median OS, the higher post‑PNI group exhibited a significantly longer survival time than the lower post‑PNI group (23.1 vs. 2.9 months, P<0.001). Similarly, the higher post‑PNI group exhibited a significantly longer PFS than the lower post‑PNI group (10.2 vs.1.9 months, P<0.001). Multivariate analysis showed that a higher post‑PNI value was an independent predictor for OS (hazard ratio, 0.04; 95% confidence interval, 0.01‑0.14; P<0.001) and PFS (hazard ratio, 0.12; 95% confidence interval, 0.04‑0.35; P<0.001). The present study indicated that the post‑PNI was a predictor of favorable clinical outcomes in patients treated with pembrolizumab for advanced urothelial carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Kageyama S, Yoshida T, Kobayashi K, Wada A, Nagasawa M, Kubota S, Kusaba T, Jo F, Nakagawa S, Johnin K, Johnin K, et al: Prognostic nutritional index of early post‑pembrolizumab therapy predicts long‑term survival in patients with advanced urothelial carcinoma. Oncol Lett 25: 49, 2023.
APA
Kageyama, S., Yoshida, T., Kobayashi, K., Wada, A., Nagasawa, M., Kubota, S. ... Kawauchi, A. (2023). Prognostic nutritional index of early post‑pembrolizumab therapy predicts long‑term survival in patients with advanced urothelial carcinoma. Oncology Letters, 25, 49. https://doi.org/10.3892/ol.2022.13635
MLA
Kageyama, S., Yoshida, T., Kobayashi, K., Wada, A., Nagasawa, M., Kubota, S., Kusaba, T., Jo, F., Nakagawa, S., Johnin, K., Narita, M., Kawauchi, A."Prognostic nutritional index of early post‑pembrolizumab therapy predicts long‑term survival in patients with advanced urothelial carcinoma". Oncology Letters 25.2 (2023): 49.
Chicago
Kageyama, S., Yoshida, T., Kobayashi, K., Wada, A., Nagasawa, M., Kubota, S., Kusaba, T., Jo, F., Nakagawa, S., Johnin, K., Narita, M., Kawauchi, A."Prognostic nutritional index of early post‑pembrolizumab therapy predicts long‑term survival in patients with advanced urothelial carcinoma". Oncology Letters 25, no. 2 (2023): 49. https://doi.org/10.3892/ol.2022.13635
Copy and paste a formatted citation
x
Spandidos Publications style
Kageyama S, Yoshida T, Kobayashi K, Wada A, Nagasawa M, Kubota S, Kusaba T, Jo F, Nakagawa S, Johnin K, Johnin K, et al: Prognostic nutritional index of early post‑pembrolizumab therapy predicts long‑term survival in patients with advanced urothelial carcinoma. Oncol Lett 25: 49, 2023.
APA
Kageyama, S., Yoshida, T., Kobayashi, K., Wada, A., Nagasawa, M., Kubota, S. ... Kawauchi, A. (2023). Prognostic nutritional index of early post‑pembrolizumab therapy predicts long‑term survival in patients with advanced urothelial carcinoma. Oncology Letters, 25, 49. https://doi.org/10.3892/ol.2022.13635
MLA
Kageyama, S., Yoshida, T., Kobayashi, K., Wada, A., Nagasawa, M., Kubota, S., Kusaba, T., Jo, F., Nakagawa, S., Johnin, K., Narita, M., Kawauchi, A."Prognostic nutritional index of early post‑pembrolizumab therapy predicts long‑term survival in patients with advanced urothelial carcinoma". Oncology Letters 25.2 (2023): 49.
Chicago
Kageyama, S., Yoshida, T., Kobayashi, K., Wada, A., Nagasawa, M., Kubota, S., Kusaba, T., Jo, F., Nakagawa, S., Johnin, K., Narita, M., Kawauchi, A."Prognostic nutritional index of early post‑pembrolizumab therapy predicts long‑term survival in patients with advanced urothelial carcinoma". Oncology Letters 25, no. 2 (2023): 49. https://doi.org/10.3892/ol.2022.13635
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