Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2023 Volume 25 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2023 Volume 25 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Statin use improves the prognosis of ovarian cancer: An updated and comprehensive meta‑analysis

  • Authors:
    • Qingxue Wang
    • Zheng Zhi
    • Hua Han
    • Qingtao Zhao
    • Xing Wang
    • Shumin Cao
    • Jing Zhao
  • View Affiliations / Copyright

    Affiliations: Graduate School, Hebei North University, Zhangjiakou, Hebei 075000, P.R. China, Department of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China, Department of Gynecology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China, Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China, Department of Clinical Medical Research Center and Geriatric Key Laboratory, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China, Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China, Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 65
    |
    Published online on: December 23, 2022
       https://doi.org/10.3892/ol.2022.13648
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Statins are lipid‑lowering agents that have also been found to have anticancer effects. The relationship between statin use and clinical outcomes in ovarian cancer (OC) remains controversial, as previous assessments of the relationship between statin use and OC prognosis have yielded inconsistent results. Therefore, a comprehensive meta‑analysis was performed in the present study to investigate this association. Studies were systematically retrieved by searching the PubMed, Embase and Cochrane Library databases, and consulting reference lists of the related studies. The search timeframe was from database creation to September 1, 2022. Pooled hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were calculated to assess the association. In the present meta‑analysis, 16 studies with 37,660 patients with OC were included, of which 11,296 patients had been prescribed statins. The results showed that statin use markedly improved the overall survival time (OS; HR, 0.79; 95% CI, 0.73‑0.85; P<0.00001) and OC‑specific survival time (HR, 0.84; 95% CI, 0.80‑0.89; P<0.00001), especially the OS time in patients with serous OC (HR, 0.81; 95% CI, 0.74‑0.89; P<0.0001) and endometrioid OC (HR, 0.80; 95% CI, 0.66‑0.98; P=0.03). In addition, survival rate was higher in patients who used statins after OC diagnosis (HR, 0.79; 95% CI, 0.73‑0.85; P<0.00001). However, there was no statistically significant association between statin use and the prognosis of mucinous and clear cell OC. The results suggested that statin use markedly improved the OS in patients with OC, including in those with serous and endometrioid OC. Statins were also found to improve the prognosis of patients of both Asian and non‑Asian ethnicities. In addition, both lipophilic and hydrophilic statins improved the survival in patients with OC, especially in patients using statins after OC diagnosis. However, the effect may vary depending on the statin type, duration of use and cancer type, and more well‑designed studies are needed to further evaluate this.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

Figure 12

Figure 13

Figure 14

View References

1 

Momenimovahed Z, Tiznobaik A, Taheri S and Salehiniya H: Ovarian cancer in the world: Epidemiology and risk factors. Int J Womens Health. 11:287–299. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Viale PH: The American cancer society's facts & figures: 2020 Edition. J Adv Pract Oncol. 11:135–136. 2020.PubMed/NCBI

3 

Xia C, Dong X, Li H, Cao M, Sun D, He S, Yang F, Yan X, Zhang S, Li N and Chen W: Cancer statistics in China and United States, 2022: Profiles, trends, and determinants. Chin Med J (Engl). 135:584–590. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Delgado-Ortega L, González-Domínguez A, Borrás JM, Oliva-Moreno J, González-Haba E, Menjón S, Pérez P, Vicente D, Cordero L, Jiménez M, et al: The economic burden of disease of epithelial ovarian cancer in Spain: The OvarCost study. Eur J Health Econ. 20:135–147. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Orr B and Edwards RP: Diagnosis and treatment of ovarian cancer. Hematol Oncol Clin North Am. 32:943–964. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Kuroki L and Guntupalli SR: Treatment of epithelial ovarian cancer. BMJ. 371:m37732020. View Article : Google Scholar : PubMed/NCBI

7 

Purdie DM, Bain CJ, Webb PM, Whiteman DC, Pirozzo S and Green AC: Body size and ovarian cancer: Case-control study and systematic review (Australia). Cancer Causes Control. 12:855–863. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Li YC, Park MJ, Ye SK, Kim CW and Kim YN: Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents. Am J Pathol. 168:1107–1118. 1404–1405. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Dulak J and Józkowicz A: Anti-angiogenic and anti-inflammatory effects of statins: Relevance to anti-cancer therapy. Curr Cancer Drug Targets. 5:579–594. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Jakobisiak M and Golab J: Potential antitumor effects of statins (Review). Int J Oncol. 23:1055–1069. 2003.PubMed/NCBI

11 

Irvin S, Clarke MA, Trabert B and Wentzensen N: Systematic review and meta-analysis of studies assessing the relationship between statin use and risk of ovarian cancer. Cancer Causes Control. 31:869–879. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Lavie O, Pinchev M, Rennert HS, Segev Y and Rennert G: The effect of statins on risk and survival of gynecological malignancies. Gynecol Oncol. 130:615–619. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Olsen CM, Green AC, Whiteman DC, Sadeghi S, Kolahdooz F and Webb PM: Obesity and the risk of epithelial ovarian cancer: A systematic review and meta-analysis. Eur J Cancer. 43:690–709. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Mohammadian-Hafshejani A, Sherwin CMT and Heidari-Soureshjani S: Do statins play any role in reducing the incidence and mortality of ovarian cancer? A systematic review and meta-analysis. J Prev Med Hyg. 61:E331–E339. 2020.PubMed/NCBI

15 

Majidi A, Na R, Dixon-Suen S, Jordan SJ and Webb PM: Common medications and survival in women with ovarian cancer: A systematic review and meta-analysis. Gynecol Oncol. 157:678–685. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Li X and Zhou J: Impact of postdiagnostic statin use on ovarian cancer mortality: A systematic review and meta-analysis of observational studies. Br J Clin Pharmacol. 84:1109–1120. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M and Tugwell P: The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2010.Available online at:. http://www.ohri.ca/programs/clinical_epidemiology/oxford.aspSeptember 10–2022

18 

Parmar MK, Torri V and Stewart L: Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med. 17:2815–2834. 1998. View Article : Google Scholar : PubMed/NCBI

19 

Irwig L, Macaskill P, Berry G and Glasziou P: Bias in meta-analysis detected by a simple, graphical test. Graphical test is itself biased. BMJ. 316:470–471. 1998.PubMed/NCBI

20 

Elmore RG, Ioffe Y, Scoles DR, Karlan BY and Li AJ: Impact of statin therapy on survival in epithelial ovarian cancer. Gynecol Oncol. 111:102–105. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Urpilainen E, Marttila M, Hautakoski A, Arffman M, Sund R, Ilanne-Parikka P, Arima R, Kangaskokko J, Puistola U, Hinkula M and Läärä E: Prognosis of ovarian cancer in women with type 2 diabetes using metformin and other forms of antidiabetic medication or statins: A retrospective cohort study. BMC Cancer. 18:7672018. View Article : Google Scholar : PubMed/NCBI

22 

Habis M, Wroblewski K, Bradaric M, Ismail N, Yamada SD, Litchfield L, Lengyel E and Romero IL: Statin therapy is associated with improved survival in patients with non-serous-papillary epithelial ovarian cancer: A retrospective cohort analysis. PLoS One. 9:e1045212014. View Article : Google Scholar : PubMed/NCBI

23 

Vogel TJ, Goodman MT, Li AJ and Jeon CY: Statin treatment is associated with survival in a nationally representative population of elderly women with epithelial ovarian cancer. Gynecol Oncol. 146:340–345. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Verdoodt F, Kjaer Hansen M, Kjaer SK, Pottegård A, Friis S and Dehlendorff C: Statin use and mortality among ovarian cancer patients: A population-based cohort study. Int J Cancer. 141:279–286. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Majidi A, Na R, Jordan SJ, De Fazio A and Webb PM; OPAL Study Group, : Statin use and survival following a diagnosis of ovarian cancer: A prospective observational study. Int J Cancer. 148:1608–1615. 2021. View Article : Google Scholar : PubMed/NCBI

26 

Couttenier A, Lacroix O, Vaes E, Cardwell CR, De Schutter H and Robert A: Statin use is associated with improved survival in ovarian cancer: A retrospective population-based study. PLoS One. 12:e01892332017. View Article : Google Scholar : PubMed/NCBI

27 

Bar D, Lavie O, Stein N, Feferkorn I and Shai A: The effect of metabolic comorbidities and commonly used drugs on the prognosis of patients with ovarian cancer. Eur J Obstet Gynecol Reprod Biol. 207:227–231. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Harding BN, Delaney JA, Urban RR and Weiss NS: Use of statin medications following diagnosis in relation to survival among women with ovarian cancer. Cancer Epidemiol Biomarkers Prev. 28:1127–1133. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Feng JL, Dixon-Suen SC, Jordan SJ and Webb PM: Statin use and survival among women with ovarian cancer: An Australian national data-linkage study. Br J Cancer. 125:766–771. 2021. View Article : Google Scholar : PubMed/NCBI

30 

Hanley GE, Kaur P, Berchuck A, Chase A, Grout B, Deurloo CM, Pike M, Richardson J, Terry KL, Webb PM and Pearce CL: Cardiovascular medications and survival in people with ovarian cancer: A population-based cohort study from British Columbia, Canada. Gynecol Oncol. 162:461–468. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Kim DS, Ahn HS and Kim HJ: Statin use and incidence and mortality of breast and gynecology cancer: A cohort study using the national health insurance claims database. Int J Cancer. 150:1156–1165. 2022. View Article : Google Scholar : PubMed/NCBI

32 

Chen HY, Wang Q, Xu QH, Yan L, Gao XF, Lu YH and Wang L: Statin as a combined therapy for advanced-stage ovarian cancer: A propensity score matched analysis. Biomed Res Int. 2016:91252382016. View Article : Google Scholar : PubMed/NCBI

33 

Nielsen SF, Nordestgaard BG and Bojesen SE: Statin use and reduced cancer-related mortality. N Engl J Med. 367:1792–1802. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Wang A, Aragaki AK, Tang JY, Kurian AW, Manson JE, Chlebowski RT, Simon M, Desai P, Wassertheil-Smoller S, Liu S, et al: Statin use and all-cancer survival: Prospective results from the women's health initiative. Br J Cancer. 115:129–135. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Surveillance Epidemiology and End Results Program, Ovary Cancer Survival Statistics, . http://seer.cancer.gov/statfacts/html/ovary.html2021April 21–2021

36 

Kwan ML, Habel LA, Flick ED, Quesenberry CP and Caan B: Post-diagnosis statin use and breast cancer recurrence in a prospective cohort study of early stage breast cancer survivors. Breast Cancer Res Treat. 109:573–579. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Ahern TP, Pedersen L, Tarp M, Cronin-Fenton DP, Garne JP, Silliman RA, Sørensen HT and Lash TL: Statin prescriptions and breast cancer recurrence risk: A Danish nationwide prospective cohort study. J Natl Cancer Inst. 103:1461–1468. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Cruz PMR, Mo H, McConathy WJ, Sabnis N and Lacko AG: The role of cholesterol metabolism and cholesterol transport in carcinogenesis: A review of scientific findings, relevant to future cancer therapeutics. Front Pharmacol. 4:1192013. View Article : Google Scholar : PubMed/NCBI

39 

Zhao J, Zhi Z, Wang C, Xing H, Song G, Yu X, Zhu Y, Wang X, Zhang X and Di Y: Exogenous lipids promote the growth of breast cancer cells via CD36. Oncol Rep. 38:2105–2115. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, et al: Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med. 22:427–432. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Liu H, Liang SL, Kumar S, Weyman CM, Liu W and Zhou A: Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression. Cancer Chemother Pharmacol. 63:997–1005. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Niemi RJ, Braicu EI, Kulbe H, Koistinen KM, Sehouli J, Puistola U, Mäenpää JU and Hilvo M: Ovarian tumours of different histologic type and clinical stage induce similar changes in lipid metabolism. Br J Cancer. 119:847–854. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Park YH, Jung HH, Ahn JS and Im YH: Statin induces inhibition of triple negative breast cancer (TNBC) cells via PI3K pathway. Biochem Biophys Res Commun. 439:275–279. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Sassano A and Platanias LC: Statins in tumor suppression. Cancer Lett. 260:11–19. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Jiang P, Mukthavaram R, Chao Y, Nomura N, Bharati IS, Fogal V, Pastorino S, Teng D, Cong X, Pingle SC, et al: In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells. Br J Cancer. 111:1562–1571. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Campbell MJ, Esserman LJ, Zhou Y, Shoemaker M, Lobo M, Borman E, Baehner F, Kumar AS, Adduci K, Marx C, et al: Breast cancer growth prevention by statins. Cancer Res. 66:8707–8714. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Risch HA: Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. J Natl Cancer Inst. 90:1774–1786. 1998. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Q, Zhi Z, Han H, Zhao Q, Wang X, Cao S and Zhao J: Statin use improves the prognosis of ovarian cancer: An updated and comprehensive meta‑analysis. Oncol Lett 25: 65, 2023.
APA
Wang, Q., Zhi, Z., Han, H., Zhao, Q., Wang, X., Cao, S., & Zhao, J. (2023). Statin use improves the prognosis of ovarian cancer: An updated and comprehensive meta‑analysis. Oncology Letters, 25, 65. https://doi.org/10.3892/ol.2022.13648
MLA
Wang, Q., Zhi, Z., Han, H., Zhao, Q., Wang, X., Cao, S., Zhao, J."Statin use improves the prognosis of ovarian cancer: An updated and comprehensive meta‑analysis". Oncology Letters 25.2 (2023): 65.
Chicago
Wang, Q., Zhi, Z., Han, H., Zhao, Q., Wang, X., Cao, S., Zhao, J."Statin use improves the prognosis of ovarian cancer: An updated and comprehensive meta‑analysis". Oncology Letters 25, no. 2 (2023): 65. https://doi.org/10.3892/ol.2022.13648
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Q, Zhi Z, Han H, Zhao Q, Wang X, Cao S and Zhao J: Statin use improves the prognosis of ovarian cancer: An updated and comprehensive meta‑analysis. Oncol Lett 25: 65, 2023.
APA
Wang, Q., Zhi, Z., Han, H., Zhao, Q., Wang, X., Cao, S., & Zhao, J. (2023). Statin use improves the prognosis of ovarian cancer: An updated and comprehensive meta‑analysis. Oncology Letters, 25, 65. https://doi.org/10.3892/ol.2022.13648
MLA
Wang, Q., Zhi, Z., Han, H., Zhao, Q., Wang, X., Cao, S., Zhao, J."Statin use improves the prognosis of ovarian cancer: An updated and comprehensive meta‑analysis". Oncology Letters 25.2 (2023): 65.
Chicago
Wang, Q., Zhi, Z., Han, H., Zhao, Q., Wang, X., Cao, S., Zhao, J."Statin use improves the prognosis of ovarian cancer: An updated and comprehensive meta‑analysis". Oncology Letters 25, no. 2 (2023): 65. https://doi.org/10.3892/ol.2022.13648
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team