Open Access

Prognostic value of des‑γ‑carboxyprothrombin in patients with AFP‑negative HCC treated with TACE

  • Authors:
    • Hanyao Sun
    • Wei Yang
    • Weizhong Zhou
    • Chungao Zhou
    • Sheng Liu
    • Haibin Shi
    • Wei Tian
  • View Affiliations

  • Published online on: December 29, 2022     https://doi.org/10.3892/ol.2022.13655
  • Article Number: 69
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In patients with AFP‑negative hepatocellular carcinoma (HCC), des‑γ‑carboxyprothrombin (DCP) is an important prognostic indicator for the preoperative assessment of transarterial chemoembolization (TACE). However, the association between the serum DCP levels and the degree of progression and prognosis of patients with AFP‑negative HCC treated with TACE has not been thoroughly investigated to date, and the molecular mechanism is also unclear. The present study retrospectively analyzed the clinical data of 107 patients with AFP‑negative HCC treated with TACE and divided them into two groups based on the median serum DCP levels. The association between DCP and the clinical characteristics of the patients was analyzed, and the survival data were analyzed using Kaplan‑Meier curves and Cox regression models. The results demonstrated that the median follow‑up time was 755 days (range, 64‑1,556 days), and patients in the low‑DCP group (n=11; 20.8%) had a lower mortality rate than those in the high‑DCP group (n=20; 37.0%). Cox multivariate regression analysis suggested that preoperative lymph node metastasis [hazard ratio (HR), 3.903; 95% CI, 1.778‑8.519; P=0.001] and DCP group (HR, 2.465; 95% CI, 1.038‑5.854; P=0.041) were independent risk factors. Furthermore, the Gene Expression Omnibus database was utilized to screen differentially expressed mRNAs. Enrichment analyses were then performed, and a protein‑protein interaction (PPI) network was constructed to identify hub genes. A total of 169 differentially expressed genes were screened. Enrichment analyses revealed that cancer‑related and ribosomal pathways were significantly enriched. Furthermore, 10 hub genes were identified in the PPI network by counting the number of gene interactions, the majority of which belonged to the ribosomal protein (RPS) family, and the top three significant genes were RPS23, RPS11 and RPS3A. In patients with AFP‑negative HCC, higher serum DCP levels were associated with poor prognosis after TACE. This may be associated with genes such as those belonging to the RPS family, which may contribute to future personalized therapy for this disease.
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February-2023
Volume 25 Issue 2

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Online ISSN:1792-1082

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Spandidos Publications style
Sun H, Yang W, Zhou W, Zhou C, Liu S, Shi H and Tian W: Prognostic value of des‑γ‑carboxyprothrombin in patients with AFP‑negative HCC treated with TACE. Oncol Lett 25: 69, 2023
APA
Sun, H., Yang, W., Zhou, W., Zhou, C., Liu, S., Shi, H., & Tian, W. (2023). Prognostic value of des‑γ‑carboxyprothrombin in patients with AFP‑negative HCC treated with TACE. Oncology Letters, 25, 69. https://doi.org/10.3892/ol.2022.13655
MLA
Sun, H., Yang, W., Zhou, W., Zhou, C., Liu, S., Shi, H., Tian, W."Prognostic value of des‑γ‑carboxyprothrombin in patients with AFP‑negative HCC treated with TACE". Oncology Letters 25.2 (2023): 69.
Chicago
Sun, H., Yang, W., Zhou, W., Zhou, C., Liu, S., Shi, H., Tian, W."Prognostic value of des‑γ‑carboxyprothrombin in patients with AFP‑negative HCC treated with TACE". Oncology Letters 25, no. 2 (2023): 69. https://doi.org/10.3892/ol.2022.13655