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Worst pattern of invasion and other histopathological features in oral cancer as determinants of prognosis and survival rate: A retrospective cohort analysis

  • Authors:
    • Hani Z. Marzouki
    • Afnan F. Bukhari
    • Doaa A. Al‑Ghamdi
    • Reem M. Abdullah
    • Marwan Al‑Hajeili
    • Shadi Khayyat
    • Reem M. Alzahrani
    • Yara R. Alotaibi
    • Rolina Al‑Wassia
    • Hatim Al‑Marzouki
    • Mazin Merdad
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology‑Head and Neck Surgery, King Abdulaziz University, Jeddah 23624, Kingdom of Saudi Arabia, Department of Anatomical Pathology and Laboratory Medicine, King Fahad Medical City, Riyadh 12231, Kingdom of Saudi Arabia, Department of Medicine, King Abdulaziz University, Jeddah 23624, Kingdom of Saudi Arabia, Department of Internal Medicine, King Abdulaziz University, Jeddah 23624, Kingdom of Saudi Arabia, Department of Otolaryngology‑Head and Neck Surgery, King Fahad General Hospital, Jeddah 23325, Kingdom of Saudi Arabia, Department of Radiation Oncology, King Abdulaziz University, Jeddah 23624, Kingdom of Saudi Arabia, Department of Radiology, King Abdulaziz University, Jeddah 23624, Kingdom of Saudi Arabia
    Copyright: © Marzouki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 75
    |
    Published online on: January 4, 2023
       https://doi.org/10.3892/ol.2023.13661
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Abstract

Oral cavity squamous cell carcinoma (OCSCC) is a well‑recognized malignancy of the head and neck. Studies on patients with early‑stage oral cancer have shown that they develop locally recurring and/or regional lymph node metastasis, which results in disease‑associated mortality. Thus, early‑stage oral cancer does not always present good prognoses. The present study aimed to determine the efficacy of using worst pattern of invasion (WPOI) and other histopathological features, such as prognostic factors in OCSCC, and analyze the impact of resection margin status and histopathological prognostic indicators on local recurrence (LR) and overall survival (OS) in patients with OCSCC. A retrospective cohort study was conducted by reviewing the charts of 63 patients with OCSCC treated with primary surgery at King Abdulaziz University Hospital between 2012 and 2019. An author and an experienced pathologist reviewed pathology slides. Associations of histopathological factors, including differentiation, stage, lymphovascular invasion, extracapsular extension, perineural invasion (PNI), WPOI and surgical margins, with LR or disease‑free survival (DFS) were evaluated. Univariate analysis identified WPOI and PNI, and multivariate analysis identified the WPOI as predictive factors for LR and DFS. Kaplan‑Meier analysis identified the WPOI and PNI as predictive factors for OS and WPOI as a predictive factor for DFS. Therefore, it may be concluded that WPOI and PNI are significant independent prognostic factors for local tumor control and DFS in patients with OCSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Marzouki HZ, Bukhari AF, Al‑Ghamdi DA, Abdullah RM, Al‑Hajeili M, Khayyat S, Alzahrani RM, Alotaibi YR, Al‑Wassia R, Al‑Marzouki H, Al‑Marzouki H, et al: Worst pattern of invasion and other histopathological features in oral cancer as determinants of prognosis and survival rate: A retrospective cohort analysis. Oncol Lett 25: 75, 2023.
APA
Marzouki, H.Z., Bukhari, A.F., Al‑Ghamdi, D.A., Abdullah, R.M., Al‑Hajeili, M., Khayyat, S. ... Merdad, M. (2023). Worst pattern of invasion and other histopathological features in oral cancer as determinants of prognosis and survival rate: A retrospective cohort analysis. Oncology Letters, 25, 75. https://doi.org/10.3892/ol.2023.13661
MLA
Marzouki, H. Z., Bukhari, A. F., Al‑Ghamdi, D. A., Abdullah, R. M., Al‑Hajeili, M., Khayyat, S., Alzahrani, R. M., Alotaibi, Y. R., Al‑Wassia, R., Al‑Marzouki, H., Merdad, M."Worst pattern of invasion and other histopathological features in oral cancer as determinants of prognosis and survival rate: A retrospective cohort analysis". Oncology Letters 25.2 (2023): 75.
Chicago
Marzouki, H. Z., Bukhari, A. F., Al‑Ghamdi, D. A., Abdullah, R. M., Al‑Hajeili, M., Khayyat, S., Alzahrani, R. M., Alotaibi, Y. R., Al‑Wassia, R., Al‑Marzouki, H., Merdad, M."Worst pattern of invasion and other histopathological features in oral cancer as determinants of prognosis and survival rate: A retrospective cohort analysis". Oncology Letters 25, no. 2 (2023): 75. https://doi.org/10.3892/ol.2023.13661
Copy and paste a formatted citation
x
Spandidos Publications style
Marzouki HZ, Bukhari AF, Al‑Ghamdi DA, Abdullah RM, Al‑Hajeili M, Khayyat S, Alzahrani RM, Alotaibi YR, Al‑Wassia R, Al‑Marzouki H, Al‑Marzouki H, et al: Worst pattern of invasion and other histopathological features in oral cancer as determinants of prognosis and survival rate: A retrospective cohort analysis. Oncol Lett 25: 75, 2023.
APA
Marzouki, H.Z., Bukhari, A.F., Al‑Ghamdi, D.A., Abdullah, R.M., Al‑Hajeili, M., Khayyat, S. ... Merdad, M. (2023). Worst pattern of invasion and other histopathological features in oral cancer as determinants of prognosis and survival rate: A retrospective cohort analysis. Oncology Letters, 25, 75. https://doi.org/10.3892/ol.2023.13661
MLA
Marzouki, H. Z., Bukhari, A. F., Al‑Ghamdi, D. A., Abdullah, R. M., Al‑Hajeili, M., Khayyat, S., Alzahrani, R. M., Alotaibi, Y. R., Al‑Wassia, R., Al‑Marzouki, H., Merdad, M."Worst pattern of invasion and other histopathological features in oral cancer as determinants of prognosis and survival rate: A retrospective cohort analysis". Oncology Letters 25.2 (2023): 75.
Chicago
Marzouki, H. Z., Bukhari, A. F., Al‑Ghamdi, D. A., Abdullah, R. M., Al‑Hajeili, M., Khayyat, S., Alzahrani, R. M., Alotaibi, Y. R., Al‑Wassia, R., Al‑Marzouki, H., Merdad, M."Worst pattern of invasion and other histopathological features in oral cancer as determinants of prognosis and survival rate: A retrospective cohort analysis". Oncology Letters 25, no. 2 (2023): 75. https://doi.org/10.3892/ol.2023.13661
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