Open Access

Polymorphisms in the gene encoding CYP1A2 influence prostate cancer risk and progression

  • Authors:
    • Marta Vilčková
    • Mária Škereňová
    • Dušan Dobrota
    • Peter Kaplán
    • Jana Jurečeková
    • Ján Kliment
    • Márk Híveš
    • Róbert Dušenka
    • Daniel Evin
    • Martina Knoško Brožová
    • Monika Kmeťová Sivoňová
  • View Affiliations

  • Published online on: January 16, 2023     https://doi.org/10.3892/ol.2023.13671
  • Article Number: 85
  • Copyright: © Vilčková et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The role of the cytochrome P450 1A2 (CYP1A2) rs2472299, rs2470890 and rs11072508 polymorphisms in prostate cancer risk, disease progression and tumour development remains unclear. The potential associations of these three CYP1A2 polymorphisms and haplotypes with prostate cancer susceptibility and its clinicopathological characteristics were therefore investigated. The present case‑control study consisted of 522 patients with prostate cancer and 554 healthy controls. High‑resolution melting analysis was used to determine the CYP1A2 polymorphisms. No significant association in prostate cancer risk was seen for CYP1A2 rs2472299 and rs11072508. However, a significantly decreased risk of prostate cancer was found for CYP1A2 rs2470890 [odds ratio (OR), 0.67; P=0.02] in the recessive model. After analysis of the associations of clinical status and these three CYP1A2 polymorphisms, the CYP1A2 rs2470890 and rs11072508 polymorphisms showed a positive association with a higher Gleason score (rs2470890 OR, 1.36, P=0.04 in the allelic model; rs11072508 OR, 1.37, P=0.04 in the allelic model and OR, 1.60, P=0.03 in the dominant model). All three polymorphisms showed a significant positive association with pathological T stage in the additive, allelic and dominant genetic models (P<0.05). Haplotype analysis revealed that the most common haplotypes ‘GTT’ and ‘ACC’ were significantly associated with pathological T stages 3 and 4 (OR, 0.62; P=0.02 and OR, 1.54; P=0.03, respectively). A significant association was found between the ‘GTT’ haplotype and the Gleason score (OR, 0.71; P=0.03). In conclusion, these CYP1A2 polymorphisms and haplotypes have the potential to predict prostate cancer disease progression.
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February-2023
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Spandidos Publications style
Vilčková M, Škereňová M, Dobrota D, Kaplán P, Jurečeková J, Kliment J, Híveš M, Dušenka R, Evin D, Brožová MK, Brožová MK, et al: Polymorphisms in the gene encoding CYP1A2 influence prostate cancer risk and progression. Oncol Lett 25: 85, 2023
APA
Vilčková, M., Škereňová, M., Dobrota, D., Kaplán, P., Jurečeková, J., Kliment, J. ... Sivoňová, M.K. (2023). Polymorphisms in the gene encoding CYP1A2 influence prostate cancer risk and progression. Oncology Letters, 25, 85. https://doi.org/10.3892/ol.2023.13671
MLA
Vilčková, M., Škereňová, M., Dobrota, D., Kaplán, P., Jurečeková, J., Kliment, J., Híveš, M., Dušenka, R., Evin, D., Brožová, M. K., Sivoňová, M. K."Polymorphisms in the gene encoding CYP1A2 influence prostate cancer risk and progression". Oncology Letters 25.2 (2023): 85.
Chicago
Vilčková, M., Škereňová, M., Dobrota, D., Kaplán, P., Jurečeková, J., Kliment, J., Híveš, M., Dušenka, R., Evin, D., Brožová, M. K., Sivoňová, M. K."Polymorphisms in the gene encoding CYP1A2 influence prostate cancer risk and progression". Oncology Letters 25, no. 2 (2023): 85. https://doi.org/10.3892/ol.2023.13671