Open Access

Advances in targeting of miR‑10‑associated lncRNAs/circRNAs for the management of cancer (Review)

  • Authors:
    • Shengyu Gao
    • Shuang Liu
    • Weiwei Wei
    • Yanxiu Qi
    • Fanshi Meng
  • View Affiliations

  • Published online on: January 19, 2023     https://doi.org/10.3892/ol.2023.13675
  • Article Number: 89
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

With advancements in sequencing technologies, an increasing number of aberrantly expressed long‑non‑coding RNAs (lncRNAs) and circular RNAs (circRNAs) have been identified in various types of cancer. lncRNAs and circRNAs are now well‑established tumor‑influencing factors in cancer, driving not only tumor proliferation and invasion, but also cancer progression, drug resistance and metastatic recurrence. The majority of lncRNAs and circRNAs influence cancer progression by targeting microRNAs (miRNAs/miRs). miR‑10a and miR‑10b, key members of the miR‑10 family, have been shown to play important regulatory roles in cell proliferation, differentiation to cancer progression, and development. Manual evaluation and grouping according to different types of competing endogenous RNA and tumor was performed. The review outlined the current state of knowledge on the regulation of miR‑10 family‑related lncRNAs and circRNAs. The involvement of lncRNAs and circRNAs in the biogenesis, maturation and function of malignant tumors through the miR‑10 family, and the key gene targets and signaling cascades that lncRNAs and circRNAs regulate through the miR‑10 family were summarized. Based on the findings of this review, it can be hypothesized that lncRNAs and circRNAs targeting the miR‑10 family may serve as diagnostic/prognostic markers and/or therapeutic targets for the management of cancer.

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March-2023
Volume 25 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Gao S, Liu S, Wei W, Qi Y and Meng F: Advances in targeting of miR‑10‑associated lncRNAs/circRNAs for the management of cancer (Review). Oncol Lett 25: 89, 2023
APA
Gao, S., Liu, S., Wei, W., Qi, Y., & Meng, F. (2023). Advances in targeting of miR‑10‑associated lncRNAs/circRNAs for the management of cancer (Review). Oncology Letters, 25, 89. https://doi.org/10.3892/ol.2023.13675
MLA
Gao, S., Liu, S., Wei, W., Qi, Y., Meng, F."Advances in targeting of miR‑10‑associated lncRNAs/circRNAs for the management of cancer (Review)". Oncology Letters 25.3 (2023): 89.
Chicago
Gao, S., Liu, S., Wei, W., Qi, Y., Meng, F."Advances in targeting of miR‑10‑associated lncRNAs/circRNAs for the management of cancer (Review)". Oncology Letters 25, no. 3 (2023): 89. https://doi.org/10.3892/ol.2023.13675