Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2023 Volume 25 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2023 Volume 25 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma

  • Authors:
    • Ivana Mijatov
    • Aleksandar Kiralj
    • Miroslav P. Ilić
    • Nada Vučković
    • Aleksandar Spasić
    • Jelena Nikolić
    • Ana Tadić
    • Saša Mijatov
  • View Affiliations / Copyright

    Affiliations: Faculty of Medicine, University of Novi Sad, Novi Sad, Autonomous Province of Vojvodina 21000, Republic of Serbia, Clinic for Maxillofacial Surgery, University Clinical Center of Vojvodina, Novi Sad, Autonomous Province of Vojvodina 21000, Republic of Serbia
    Copyright: © Mijatov et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 94
    |
    Published online on: January 25, 2023
       https://doi.org/10.3892/ol.2023.13679
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oral squamous cell carcinoma (OSCC) is the eighth most common type of cancer in the world. Knowledge of prognostic factors of survival in OSCC is key. Several clinical and pathological prognostic factors have been investigated to develop a prognostic model of survival for patients with oral cancer. The present study focused on the association between pathological tumor volume (PTV) and overall survival time in patients with OSCC, regardless of cervical nodal status. The present study was a prospective study and covered 65 consecutive patients who received surgical treatment for oral cancer. The PTV was calculated according to dimensions of the postoperative specimen. Other pathological parameters as perineural and perivascular tumor spreading and extra‑nodular propagation were also determined. The data were analyzed using the IBM SPSS 25.0 software. Cox PH regression model was built to analyze association between the PTV and survival time. Survival time was defined as the period from surgery to a target event or last contact. The results of the present study showed that PTV >4.24 cm³ was significantly associated with shorter overall survival time in patients with OSCC. The PTV value was higher in patients with metastasis and in patients with higher pathological tumor and node stage. In conclusion, PTV was an important pathological prognostic factor for survival in patients with OSCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Amit M, Tam S, Takahashi H, Choi KY, Zafereo M, Bell D and Weber RS: Prognostic performance of the American joint committee on cancer 8th edition of the TNM staging system in patients with early oral tongue cancer. Head Neck. 41:1270–1276. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Conway DI, Purkayastha M and Chestnutt IG: The changing epidemiology of oral cancer: Definitions, trends, and risk factors. Br Dent J. 225:867–873. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Diz P, Meleti M, Diniz-Freitas M, Vescovi P, Warnakulasuriya S, Johnson NW and Kerr AR: Oral and pharyngeal cancer in Europe. Transl Res Oral Oncol. 2:20571782017.

4 

Wang B, Zhang S, Yue K and Wang DX: The recurrence and survival of oral squamous cell carcinoma: A report of 275 cases. Chin J Cancer. 32:614–618. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Mijatov I and Mijatov S: Application of the eighth edition of the American joint committee on cancer staging system for oral carcinoma. Med Pregl. 72:165–170. 2019. View Article : Google Scholar

6 

Tarsitano A, Ricotta F, Cercenelli L, Bortolano B, Battaglia S, Lucci E, Marchetti C and Marceli E: Pretreatment tumor volume and tumor sphericity as prognostic factors in patients with oral cavity squamous cell carcinoma. J Craniomaxillofac Surg. 47:510–515. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Nixon IJ, Palmer FL, Lakin P, Kattan MM, Lee NY and Ganly I: Pathologically determined tumor volume vs pathologic T stage in the prediction of outcome after surgical treatment of oropharyngeal squamous cell carcinoma. JAMA Otolaryngol Head Neck Surg. 139:1151–1155. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Mucoyama N, Suzuki H, Hanai N, Sone M and Hasewaga Y: Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma. Oncol Lett. 16:2471–2477. 2018.PubMed/NCBI

9 

Youden WJ: Index for rating diagnostic tests. Cancer. 3:32–35. 1950. View Article : Google Scholar : PubMed/NCBI

10 

Panarese I, Aquino G, Ronchi A, Longo F, Montella M, Cozzolino I, Roccuzzo G, Colella G, Caraglia M and Franco R: Oral and oropharyngeal squamous cell carcinoma: Prognostic and predictive parameters in the etiopathogenetic route. Expert Rev Anticancer Ther. 19:105–119. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Majumdar B, Patil S, Sarode SC, Sarode GS and Rao RS: Clinico-pathological prognosticators in oral squamous cell carcinoma: An update. Transl Res Oral Oncol. 2:1–14. 2017.

12 

Mücke T, Mitchell DA, Ritschl LM, Tannapfel A, Wolff KD, Kesting MR, Lofelbein DJ and Kanatas A: Influence of tumor volume on survival in patients with oral squamous cell carcinoma. J Cancer Res Clin Oncol. 141:1007–1011. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Fan S, Tang QL, Lin YJ, Chen WL, Li JS, Huang ZQ, Yang ZH, Wang YY, Zhang DM, Wang HJ, et al: A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma. Int J Oral Sci. 3:180–191. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Weimar EAM, Huang SH, Lu L, O'Sulivan B, Perez-Ordonez B, Weinreb I, Hope A, Tong L, Goldstein D, irish J, et al: Radiologic-pathologic correlation of tumor thickness and its prognostic importance in squamous cell carcinoma of the oral cavity: Implications for the eight edition tumor, node, metastasis classification. AJNR Am J Neuroradiol. 39:1896–1902. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Arora A, Husain N, Bansal A, Neyaz A, Jaiswal R, Jain K, Chaturvedi A, Anand N, Malhotra K and Shukla S: Development of a new outcome prediction model in early-stage squamous cell carcinoma of the oral cavity based on histopathologic parameters with multivariate analysis: The aditi-nuzhat lymph-node prediction score (ANLPS) system. Am J Surg Pathol. 41:950–60. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Po Wing Yuen A, Lam KY, Lam LK, Ho CM, Wong A, Chow TL, Yuen WF and Wei WI: Prognostic factors of clinically stage I and II oral tongue carcinoma-a comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, martinez-gimeno score, and pathologic features. Head Neck. 24:513–520. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Kuznetskov S, Yu Q, Spieler B, Hartsoug R, Zhu X, Murnan E, Hironaka M and Zaid W: Can radiographic tumor volume of oral squamous cell carcinoma help predict clinical and pathological tumor features? J Oral Maxillofac Surg. 79:2582–2592. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Strongin A, Yovino S, Taylor R, Wolf J, Cullen K, Zimrin A, Strome S, Regine W and Suntharalingam M: Primary tumor volume is an important predictor of clinical outcomes among patients with locally advanced squamous cell cancer of the head and neck treated with definitive chemoradiotherapy. Int J Radiat Oncol Biol Phys. 82:1823–1830. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Montebugnoli L, Gissi DB, Flamminio F, Gentile L, Dallera V, Leonardi E, Beccarini T and Foschini MP: Clinicopathologic parameters related to recurrence and locoregional metastasis in 180 oral squamous cell carcinomas. Int J Surg Pathol. 22:55–62. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Chen MK, Chen CM, Lee MC, Chen LS and Chen HC: Primary tumor volume is an independent predictor of outcome within pT4a-staged tongue carcinoma. Ann Surg Oncol. 18:1447–1452. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Lin NC, Su IH, Hsu JT, Tsai KY and Chen MYC: FDG-PET predicts bone invasion and prognosis in patients with oral squamous cell carcinoma. Sci Rep. 11:151532021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Mijatov I, Kiralj A, Ilić MP, Vučković N, Spasić A, Nikolić J, Tadić A and Mijatov S: Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma. Oncol Lett 25: 94, 2023.
APA
Mijatov, I., Kiralj, A., Ilić, M.P., Vučković, N., Spasić, A., Nikolić, J. ... Mijatov, S. (2023). Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma. Oncology Letters, 25, 94. https://doi.org/10.3892/ol.2023.13679
MLA
Mijatov, I., Kiralj, A., Ilić, M. P., Vučković, N., Spasić, A., Nikolić, J., Tadić, A., Mijatov, S."Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma". Oncology Letters 25.3 (2023): 94.
Chicago
Mijatov, I., Kiralj, A., Ilić, M. P., Vučković, N., Spasić, A., Nikolić, J., Tadić, A., Mijatov, S."Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma". Oncology Letters 25, no. 3 (2023): 94. https://doi.org/10.3892/ol.2023.13679
Copy and paste a formatted citation
x
Spandidos Publications style
Mijatov I, Kiralj A, Ilić MP, Vučković N, Spasić A, Nikolić J, Tadić A and Mijatov S: Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma. Oncol Lett 25: 94, 2023.
APA
Mijatov, I., Kiralj, A., Ilić, M.P., Vučković, N., Spasić, A., Nikolić, J. ... Mijatov, S. (2023). Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma. Oncology Letters, 25, 94. https://doi.org/10.3892/ol.2023.13679
MLA
Mijatov, I., Kiralj, A., Ilić, M. P., Vučković, N., Spasić, A., Nikolić, J., Tadić, A., Mijatov, S."Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma". Oncology Letters 25.3 (2023): 94.
Chicago
Mijatov, I., Kiralj, A., Ilić, M. P., Vučković, N., Spasić, A., Nikolić, J., Tadić, A., Mijatov, S."Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma". Oncology Letters 25, no. 3 (2023): 94. https://doi.org/10.3892/ol.2023.13679
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team