Superficial soft tissue sarcomas: 10‑year survival outcomes

Tolia,Maria; Gkantaifi,Areti; Hayward,Larry; Gupta,Girish; Kyriazoglou,Anastasios; Mauri,Davide; Nixon,Ioanna

doi:10.3892/ol.2023.13682

Superficial soft tissue sarcomas: 10‑year survival outcomes

Authors:
- Maria Tolia
- Areti Gkantaifi
- Larry Hayward
- Girish Gupta
- Anastasios Kyriazoglou
- Davide Mauri
- Ioanna Nixon
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Affiliations: Department of Radiotherapy, University Hospital/Medical School, University of Crete, Vassilika, 71110 Crete, Greece, Radiotherapy Department, Theageneio Cancer Hospital, 54639 Thessaloniki, Greece, Edinburgh Cancer Research UK Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK, Department of Dermatology, NHS Lothian Hospital, EH3 9EN Edinburgh, UK, 2nd Propaedeutic Department of Medicine, Attikon University Hospital, 12462 Athens, Greece, Department of Medical Oncology, University Hospital of Ioannina, 45500 Ioannina, Greece, Department of Clinical Oncology, Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK
Published online on: January 27, 2023 https://doi.org/10.3892/ol.2023.13682
Article Number: 96

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Abstract

Cutaneous sarcomas comprise a broad group of rare, heterogeneous mesenchymal tumours. The present report describes a single centre experience regarding the management and the outcomes of patients with superficial soft tissue sarcomas (SSTS). Key prognostic factors in predicting overall survival (OS) and local relapse‑free survival were determined. Data from 66 patients with SSTS treated surgically within Edinburgh and Lothian were collected in the context of a service evaluation. Patient demographics, tumour specifics and treatment, as well as 5‑year OS and local recurrence, were analysed. Kaplan‑Meier analysis was applied for survival curves, and mortality rate estimation and Cox regression were used to establish independent predictors. The mean estimated OS time was 57.2 months, with a 95% CI between 55.0 and 59.5 months. The median OS time could not be estimated because there is no time point during which the survival function has a value <50%. The death risk for a person with SSTS was increased by 7.3% (odds ratio, 1.073; 95% CI, 1.012‑1.138) for every additional year of life. The estimated mean local relapse time was 58.5 months, with a 95% CI between 56 and 61 months. The median local relapse time could not be estimated since there is no time point during which the local recurrence function has a value <50%. In conclusion, out of all independent variables considered, none could statistically significantly explicate local relapse recurrence time. It is important that these rare tumours are treated in the context of a multidisciplinary team with consensus guidelines to assist decision‑making.

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