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Article Open Access

Prognostic value of the sarcomatoid component in bladder cancer: A propensity score matching study

  • Authors:
    • Shuai Liu
    • Yu Yao
    • Zhan-Kun Wang
    • Li-Jiang Sun
    • Gui-Ming Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Department of Urology, Qingdao Eighth People's Hospital, Qingdao, Shandong 266121, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 103
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    Published online on: February 2, 2023
       https://doi.org/10.3892/ol.2023.13690
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Abstract

Sarcomatoid carcinoma of the bladder is rare, and little is known about the prognostic impact of the proportion of sarcomatoid components of the bladder. The present study aimed to assess the prognostic value of the proportion of sarcomatoid components with regard to death and recurrence rates in patients with bladder cancer (BC), and to validate the worse survival results of sarcomatoid carcinomas of the bladder using propensity score matching. Patients with sarcomatoid carcinoma of the bladder who were treated at the Affiliated Hospital of Qingdao University between August 2010 and May 2021 were included in the study. A 1:2 propensity score matching system based on age, sex and pathological T stage was used for sarcomatoid and non‑sarcomatoid carcinoma matching. Finally, 114 patients with BC were included. Patients with sarcomatoid carcinoma had worse 5‑year cancer‑specific survival (CSS) (69.1 vs. 86.9%; log‑rank P=0.008) and recurrence‑free survival (RFS) (64.1 vs. 83.6%; log‑rank P=0.001) rates compared with patients with non‑sarcomatoid carcinoma, as had the subgroup with muscle invasion. Multivariate analysis revealed sarcomatoid carcinoma as an independent prognostic factor. Patients with a low proportion of sarcomatoid components (1‑50%) had a better prognosis than patients with a high proportion (>50%), and no significant difference was found compared with the non‑sarcomatoid group. Overall, a proportion of sarcomatoid components >50% was a predictor of CSS and RFS. Sarcomatoid components markedly increased the risk of death and recurrence in muscle‑invasive BC, but not in non‑muscle‑invasive BC. A higher proportion of sarcomatoid components was significantly associated with poorer survival.
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Copy and paste a formatted citation
Spandidos Publications style
Liu S, Yao Y, Wang Z, Sun L and Zhang G: Prognostic value of the sarcomatoid component in bladder cancer: A propensity score matching study. Oncol Lett 25: 103, 2023.
APA
Liu, S., Yao, Y., Wang, Z., Sun, L., & Zhang, G. (2023). Prognostic value of the sarcomatoid component in bladder cancer: A propensity score matching study. Oncology Letters, 25, 103. https://doi.org/10.3892/ol.2023.13690
MLA
Liu, S., Yao, Y., Wang, Z., Sun, L., Zhang, G."Prognostic value of the sarcomatoid component in bladder cancer: A propensity score matching study". Oncology Letters 25.3 (2023): 103.
Chicago
Liu, S., Yao, Y., Wang, Z., Sun, L., Zhang, G."Prognostic value of the sarcomatoid component in bladder cancer: A propensity score matching study". Oncology Letters 25, no. 3 (2023): 103. https://doi.org/10.3892/ol.2023.13690
Copy and paste a formatted citation
x
Spandidos Publications style
Liu S, Yao Y, Wang Z, Sun L and Zhang G: Prognostic value of the sarcomatoid component in bladder cancer: A propensity score matching study. Oncol Lett 25: 103, 2023.
APA
Liu, S., Yao, Y., Wang, Z., Sun, L., & Zhang, G. (2023). Prognostic value of the sarcomatoid component in bladder cancer: A propensity score matching study. Oncology Letters, 25, 103. https://doi.org/10.3892/ol.2023.13690
MLA
Liu, S., Yao, Y., Wang, Z., Sun, L., Zhang, G."Prognostic value of the sarcomatoid component in bladder cancer: A propensity score matching study". Oncology Letters 25.3 (2023): 103.
Chicago
Liu, S., Yao, Y., Wang, Z., Sun, L., Zhang, G."Prognostic value of the sarcomatoid component in bladder cancer: A propensity score matching study". Oncology Letters 25, no. 3 (2023): 103. https://doi.org/10.3892/ol.2023.13690
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