Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2023 Volume 25 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2023 Volume 25 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Acquired hyperfibrinolysis as the presenting sign of metastatic breast cancer: A case report

  • Authors:
    • Guanyu Lu
    • Lin Jia
    • Ruohan Yang
    • Zheng Lv
    • Jiuwei Cui
  • View Affiliations / Copyright

    Affiliations: Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Article Number: 106
    |
    Published online on: February 2, 2023
       https://doi.org/10.3892/ol.2023.13692
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Abstract. Fibrinolysis is a bleeding disorder characterized by hypofibrinogenemia caused by abnormal activation of fibrinolytic system function. Patients with cancer are prone to hypercoagulable and should be vigilant for the risk of venous thrombosis. However, patients with tumors in which bleeding is the first manifestation are relatively rare. The present study reports the case of a 52‑year‑old woman with metastatic breast cancer with acquired hyperfibrinolysis as the first manifestation. Hyperfibrinolysis is an important sign and manifestation of disease progression. In this case, fibrinogen was used as a sensitive biomarker of tumor burden to specifically predict the efficacy of the antitumor therapy. Effective antitumor therapy can improve the hyperfibrinolysis of patients, and so the fibrinogen levels gradually increased. In conclusion, the present case showed acquired hyperfibrinolysis with bleeding symptoms, which is an uncommon paraneoplastic phenomenon in breast cancer, especially when combined with bone marrow metastasis, as in the present case. Timely diagnosis and treatment of the primary disease is the fundamental way to improve hyperfibrinolysis. As an effective biomarker, fibrinogen level predicts the changes in a patient's illness and guides the clinical diagnosis and treatment process.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Kolev K and Longstaff C: Bleeding related to disturbed fibrinolysis. Br J Haematol. 175:12–23. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Longstaff C and Kolev K: Basic mechanisms and regulation of fibrinolysis. J Thromb Haemost. 13 (Suppl 1):S98–S105. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Rijken DC and Lijnen HR: New insights into the molecular mechanisms of the fibrinolytic system. J Thromb Haemost. 7:4–13. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Lin H, Xu L, Yu S, Hong W, Huang M and Xu P: Therapeutics targeting the fibrinolytic system. Exp Mol Med. 52:367–379. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Chapin JC and Hajjar KA: Fibrinolysis and the control of blood coagulation. Blood Rev. 29:17–24. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Franchini M and Mannucci PM: Primary hyperfibrinolysis: Facts and fancies. Thromb Res. 166:71–75. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Rein-Smith CM and Church FC: Emerging pathophysiological roles for fibrinolysis. Curr Opin Hematol. 21:438–444. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Leebeek FW and Rijken DC: The fibrinolytic status in liver diseases. Semin Thromb Hemost. 41:474–480. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Rabizadeh E, Cherny I, Lederfein D, Sherman S, Binkovsky N, Rosenblat Y and Inbal A: The cell-membrane prothrombinase, fibrinogen-like protein 2, promotes angiogenesis and tumor development. Thromb Res. 136:118–124. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Vanel D: The American college of radiology (ACR) breast imaging and reporting data system (BI-RADS): A step towards a universal radiological language? Eur J Radiol. 61:1832007. View Article : Google Scholar : PubMed/NCBI

11 

Plichta JK, Ren Y, Thomas SM, Greenup RA, Fayanju OM, Rosenberger LH, Hyslop T and Hwang ES: Implications for breast cancer restaging based on the 8th edition AJCC staging manual. Ann Surg. 271:169–176. 2020. View Article : Google Scholar : PubMed/NCBI

12 

National Institutes of Health, National Cancer Institute, U.S. Department of Health and Human Services, . Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. https://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5×11.pdfPublished November 27, 2017. June 20–2020

13 

Pelosof LC and Gerber DE: Paraneoplastic syndromes: An approach to diagnosis and treatment. Mayo Clin Proc. 85:838–854. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Soomro Z, Youssef M, Yust-Katz S, Jalali A, Patel AJ and Mandel J: Paraneoplastic syndromes in small cell lung cancer. J Thorac Dis. 12:6253–6263. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Franchini M, Zaffanello M and Mannucci PM: Bleeding disorders in primary fibrinolysis. Int J Mol Sci. 22:70272021. View Article : Google Scholar : PubMed/NCBI

16 

Hunt BJ: Bleeding and coagulopathies in critical care. N Engl J Med. 370:21532014. View Article : Google Scholar : PubMed/NCBI

17 

Naina HVK, Patnaik MM, Ali UA, Chen D and Ashrani AA: Systemic fibrinolysis caused by tissue plasminogen activator-producing metastatic breast cancer. J Clin Oncol. 28:e167–e168. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Winther-Larsen A, Sandfeld-Paulsen B and Hvas AM: Hyperfibrinolysis in patients with solid malignant neoplasms: A systematic review. Semin Thromb Hemost. 47:581–588. 2021. View Article : Google Scholar : PubMed/NCBI

19 

Kwaan HC and Lindholm PF: Fibrin and fibrinolysis in cancer. Semin Thromb Hemost. 45:413–422. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Cesarman-Maus G and Hajjar KA: Molecular mechanisms of fibrinolysis. Br J Haematol. 129:307–321. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Sacco E, Pinto F, Sasso F, Racioppi M, Gulino G, Volpe A and Bassi P: Paraneoplastic syndromes in patients with urological malignancies. Urol Int. 83:1–11. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Look MP, van Putten WL, Duffy MJ, Harbeck N, Christensen IJ, Thomssen C, Kates R, Spyratos F, Fernö M, Eppenberger-Castori S, et al: Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients. J Natl Cancer Inst. 94:116–128. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Ruszkowska-Ciastek B, Kwiatkowska K, Bielawska S, Robakowska M, Bielawski K and Rhone P: Evaluation of the prognostic value of fibrinolytic elements in invasive breast carcinoma patients. Neoplasma. 67:1146–1156. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Wrzeszcz K, Słomka A, Zarychta E, Rhone P and Ruszkowska-Ciastek B: Tissue plasminogen activator as a possible indicator of breast cancer relapse: A preliminary, prospective study. J Clin Med. 11:23982022. View Article : Google Scholar : PubMed/NCBI

25 

Kulić A, Cvetković Z and Libek V: Primary hyperfibrinolysis as the presenting sign of prostate cancer: A case report. Vojnosanit Pregl. 73:877–880. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Stephens RW, Brünner N, Jänicke F and Schmitt M: The urokinase plasminogen activator system as a target for prognostic studies in breast cancer. Breast Cancer Res Treat. 52:99–111. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Duffy MJ, McGowan PM, Harbeck N, Thomssen C and Schmitt M: uPA and PAI-1 as biomarkers in breast cancer: validated for clinical use in level-of-evidence-1 studies. Breast Cancer Res. 16:4282014. View Article : Google Scholar : PubMed/NCBI

28 

Malmström P, Bendahl PO, Boiesen P, Brünner N, Idvall I and Fernö M; South Sweden Breast Cancer Group, : S-phase fraction and urokinase plasminogen activator are better markers for distant recurrences than nottingham prognostic index and histologic grade in a prospective study of premenopausal lymph node-negative breast cancer. J Clin Oncol. 19:2010–2019. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Duffy MJ: The urokinase plasminogen activator system: Role in malignancy. Curr Pharm Des. 10:39–49. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Kyyriäinen J, Bolkvadze T, Koivisto H, Lipponen A, Pérez LO, Ekolle Ndode-Ekane X, Tanila H and Pitkänen A: Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility. Epilepsy Res. 151:67–74. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Resnati M, Pallavicini I, Wang JM, Oppenheim J, Serhan CN, Romano M and Blasi F: The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R. Proc Natl Acad Sci USA. 99:1359–1364. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Kortlever RM, Higgins PJ and Bernards R: Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol. 8:877–884. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Kopp HG, Krauss K, Fehm T, Staebler A, Zahm J, Vogel W, Kanz L and Mayer F: Symptomatic bone marrow involvement in breast cancer-clinical presentation, treatment, and prognosis: A single institution review of 22 cases. Anticancer Res. 31:4025–4030. 2011.PubMed/NCBI

34 

Garufi G, Carbognin L, Orlandi A, Palazzo A, Tortora G and Bria E: The therapeutic challenge of disseminated bone marrow metastasis from HR-positive HER2-negative breast cancer: Case report and review of the literature. Front Oncol. 11:6517232021. View Article : Google Scholar : PubMed/NCBI

35 

Gradishar WJ, Anderson BO, Abraham J, Aft R, Agnese D, Allison KH, Blair SL, Burstein HJ, Dang C, Elias AD, et al: Breast cancer, version 3.2020, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 18:452–478. 2020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lu G, Jia L, Yang R, Lv Z and Cui J: Acquired hyperfibrinolysis as the presenting sign of metastatic breast cancer: A case report. Oncol Lett 25: 106, 2023.
APA
Lu, G., Jia, L., Yang, R., Lv, Z., & Cui, J. (2023). Acquired hyperfibrinolysis as the presenting sign of metastatic breast cancer: A case report. Oncology Letters, 25, 106. https://doi.org/10.3892/ol.2023.13692
MLA
Lu, G., Jia, L., Yang, R., Lv, Z., Cui, J."Acquired hyperfibrinolysis as the presenting sign of metastatic breast cancer: A case report". Oncology Letters 25.3 (2023): 106.
Chicago
Lu, G., Jia, L., Yang, R., Lv, Z., Cui, J."Acquired hyperfibrinolysis as the presenting sign of metastatic breast cancer: A case report". Oncology Letters 25, no. 3 (2023): 106. https://doi.org/10.3892/ol.2023.13692
Copy and paste a formatted citation
x
Spandidos Publications style
Lu G, Jia L, Yang R, Lv Z and Cui J: Acquired hyperfibrinolysis as the presenting sign of metastatic breast cancer: A case report. Oncol Lett 25: 106, 2023.
APA
Lu, G., Jia, L., Yang, R., Lv, Z., & Cui, J. (2023). Acquired hyperfibrinolysis as the presenting sign of metastatic breast cancer: A case report. Oncology Letters, 25, 106. https://doi.org/10.3892/ol.2023.13692
MLA
Lu, G., Jia, L., Yang, R., Lv, Z., Cui, J."Acquired hyperfibrinolysis as the presenting sign of metastatic breast cancer: A case report". Oncology Letters 25.3 (2023): 106.
Chicago
Lu, G., Jia, L., Yang, R., Lv, Z., Cui, J."Acquired hyperfibrinolysis as the presenting sign of metastatic breast cancer: A case report". Oncology Letters 25, no. 3 (2023): 106. https://doi.org/10.3892/ol.2023.13692
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team