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Article Open Access

Intermittent administration of atezolizumab with combined carboplatin and etoposide therapy for patients with extensive‑disease small cell lung cancer

  • Authors:
    • Takeshi Tsuda
    • Hisao Imai
    • Yoshiaki Nagai
    • Yukihiro Umeda
    • Ayako Shiono
    • Jun Shiihara
    • Ou Yamaguchi
    • Atsuto Mouri
    • Kyoichi Kaira
    • Tamotsu Ishizuka
    • Hirokazu Taniguchi
    • Hiroshi Kagamu
  • View Affiliations / Copyright

    Affiliations: Division of Respiratory Medicine, Toyama Prefectural Central Hospital, Toyama, Toyama 930‑8550, Japan, Department of Respiratory Medicine, International Medical Center, Saitama Medical University, Hidaka, Saitama 350‑1298, Japan, Department of Respiratory Medicine, Jichi Medical University, Saitama Medical Center, Saitama, Saitama 330‑8503, Japan, Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui 910‑1193, Japan
    Copyright: © Tsuda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 111
    |
    Published online on: February 2, 2023
       https://doi.org/10.3892/ol.2023.13696
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Abstract

To the best of our knowledge, no published reports have examined the significance of additional immune checkpoint inhibitors in treating malignancies, including lung cancer. Therefore, the present study aimed to examine the efficacy and feasibility of adding atezolizumab to carboplatin and etoposide combination chemotherapy for small cell lung cancer with extensive disease (ED‑SCLC). The present retrospective analysis examined 16 patients with ED‑SCLC who received the addition of atezolizumab to carboplatin and etoposide therapy during treatment at four institutions between August 2019 and September 2020. The effectiveness of treatment was evaluated based on tumor response, survival time and adverse events. Within the study cohort, there were 14 males (87.5%) and 2 females (12.5%), with a median age of 73.5 years (range, 62‑79 years); 7 patients had a performance status (PS) of 0‑1 (43.8%) and 9 had a PS of 2‑3 (56.3%). The median follow‑up period was 12.1 months. The overall response rate, median progression‑free survival time and median overall survival time were 75.0%, 5.3 and 13.0 months, respectively. Regarding the frequency of hematological adverse events, the occurrence of grade ≥3 adverse events was observed, including decreased neutrophil (56.3%), white blood cell (50.0%) and platelet (43.8%) counts, as well as febrile neutropenia (12.5%). Although 1 patient developed grade 3 pneumonitis as a serious adverse event, no treatment‑related deaths were observed. Despite the aforementioned hematological toxicities, the addition of atezolizumab to carboplatin and etoposide therapy during treatment demonstrated favorable efficacy and acceptable toxicity in ED‑SCLC. Thus, adding atezolizumab to carboplatin and etoposide combination chemotherapy may be a treatment option for ED‑SCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Tsuda T, Imai H, Nagai Y, Umeda Y, Shiono A, Shiihara J, Yamaguchi O, Mouri A, Kaira K, Ishizuka T, Ishizuka T, et al: Intermittent administration of atezolizumab with combined carboplatin and etoposide therapy for patients with extensive‑disease small cell lung cancer. Oncol Lett 25: 111, 2023.
APA
Tsuda, T., Imai, H., Nagai, Y., Umeda, Y., Shiono, A., Shiihara, J. ... Kagamu, H. (2023). Intermittent administration of atezolizumab with combined carboplatin and etoposide therapy for patients with extensive‑disease small cell lung cancer. Oncology Letters, 25, 111. https://doi.org/10.3892/ol.2023.13696
MLA
Tsuda, T., Imai, H., Nagai, Y., Umeda, Y., Shiono, A., Shiihara, J., Yamaguchi, O., Mouri, A., Kaira, K., Ishizuka, T., Taniguchi, H., Kagamu, H."Intermittent administration of atezolizumab with combined carboplatin and etoposide therapy for patients with extensive‑disease small cell lung cancer". Oncology Letters 25.3 (2023): 111.
Chicago
Tsuda, T., Imai, H., Nagai, Y., Umeda, Y., Shiono, A., Shiihara, J., Yamaguchi, O., Mouri, A., Kaira, K., Ishizuka, T., Taniguchi, H., Kagamu, H."Intermittent administration of atezolizumab with combined carboplatin and etoposide therapy for patients with extensive‑disease small cell lung cancer". Oncology Letters 25, no. 3 (2023): 111. https://doi.org/10.3892/ol.2023.13696
Copy and paste a formatted citation
x
Spandidos Publications style
Tsuda T, Imai H, Nagai Y, Umeda Y, Shiono A, Shiihara J, Yamaguchi O, Mouri A, Kaira K, Ishizuka T, Ishizuka T, et al: Intermittent administration of atezolizumab with combined carboplatin and etoposide therapy for patients with extensive‑disease small cell lung cancer. Oncol Lett 25: 111, 2023.
APA
Tsuda, T., Imai, H., Nagai, Y., Umeda, Y., Shiono, A., Shiihara, J. ... Kagamu, H. (2023). Intermittent administration of atezolizumab with combined carboplatin and etoposide therapy for patients with extensive‑disease small cell lung cancer. Oncology Letters, 25, 111. https://doi.org/10.3892/ol.2023.13696
MLA
Tsuda, T., Imai, H., Nagai, Y., Umeda, Y., Shiono, A., Shiihara, J., Yamaguchi, O., Mouri, A., Kaira, K., Ishizuka, T., Taniguchi, H., Kagamu, H."Intermittent administration of atezolizumab with combined carboplatin and etoposide therapy for patients with extensive‑disease small cell lung cancer". Oncology Letters 25.3 (2023): 111.
Chicago
Tsuda, T., Imai, H., Nagai, Y., Umeda, Y., Shiono, A., Shiihara, J., Yamaguchi, O., Mouri, A., Kaira, K., Ishizuka, T., Taniguchi, H., Kagamu, H."Intermittent administration of atezolizumab with combined carboplatin and etoposide therapy for patients with extensive‑disease small cell lung cancer". Oncology Letters 25, no. 3 (2023): 111. https://doi.org/10.3892/ol.2023.13696
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