Effect of pelvic radiotherapy on patients with stage IB‑IIA cervical cancer after radical hysterectomy: A single‑center retrospective study

Ishizawa,Chihiro; Taguchi,Ayumi; Tanikawa,Michihiro; Honjo,Harunori; Nishijima,Akira; Eguchi,Satoko; Miyamoto,Yuichiro; Sone,Kenbun; Tsuruga,Tetsushi; Mori,Mayuyo; Osuga,Yutaka

doi:10.3892/ol.2023.13698

March-2023 Volume 25 Issue 3

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March-2023 Volume 25 Issue 3

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Article Open Access

Effect of pelvic radiotherapy on patients with stage IB‑IIA cervical cancer after radical hysterectomy: A single‑center retrospective study

Authors:
- Chihiro Ishizawa
- Ayumi Taguchi
- Michihiro Tanikawa
- Harunori Honjo
- Akira Nishijima
- Satoko Eguchi
- Yuichiro Miyamoto
- Kenbun Sone
- Tetsushi Tsuruga
- Mayuyo Mori
- Yutaka Osuga
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, The University of Tokyo Hospital, Tokyo 113‑8655, Japan

Copyright: © Ishizawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
Article Number: 112
|
Published online on: February 2, 2023

https://doi.org/10.3892/ol.2023.13698
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Abstract

The effects of post‑operative adjuvant radiotherapy (RT) on intermediate‑risk patients with cervical cancer have not been fully elucidated. Therefore, the present study aimed to investigate the impact of RT on intermediate‑risk cervical cancer. The data of 112 patients with stage IB and IIA cervical cancer treated with radical hysterectomy between January 2009 and December 2018 were retrospectively reviewed. Overall survival (OS), progression‑free survival (PFS), and the frequency of adverse events were compared between patients with and without adjuvant RT (RT⁺ and RT^‑, respectively). Subgroup analyses of PFS based on tumor size, cervical stromal invasion, lymphovascular space invasion and histology [squamous cell carcinoma (SCC) vs. non‑SCC] were performed. Among the 112 patients, 41 received adjuvant RT. Although there were no significant differences in OS or PFS between the RT+ and RT‑ groups, the frequency of adverse events was much higher in the RT⁺ group. Patients in the RT⁺ group also had more recurrent risk factors than those in the RT^‑ group. Based on the subgroup analyses, although no significant differences were observed between any of the groups, RT demonstrated a different impact on PFS between SCC and non‑SCC: No difference was observed in the SCC group, whereas patients in the RT⁺ group tended to have poorer prognoses compared to those in the RT^‑ group of the non‑SCC group. These results suggest that the impact of post‑operative RT on stage IB and IIA cervical cancer is limited and is accompanied by increased adverse events. The eligibility of patients for post‑operative RT should be carefully determined based on the therapeutic effect of RT in each subgroup.

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