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Metabolic risk score as a predictor in a nomogram for assessing myometrial invasion for endometrial cancer

  • Authors:
    • Yan Qiang
    • Qinfen Zhang
    • Lingyan Dong
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China, Department of Obstetrics and Gynecology, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Qiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 114
    |
    Published online on: February 6, 2023
       https://doi.org/10.3892/ol.2023.13700
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Abstract

The purpose of the present study was to investigate the predictive value of metabolic syndrome in evaluating myometrial invasion (MI) in patients with endometrial cancer (EC). The study retrospectively included patients with EC who were diagnosed between January 2006 and December 2020 at the Department of Gynecology of Nanjing First Hospital (Nanjing, China). The metabolic risk score (MRS) was calculated using multiple metabolic indicators. Univariate and multivariate logistic regression analyses were performed to determine significant predictive factors for MI. A nomogram was then constructed based on the independent risk factors identified. A calibration curve, a receiver operating characteristic (ROC) curve and decision curve analysis (DCA) were used to evaluate the effectiveness of the nomogram. A total of 549 patients were randomly assigned to a training or validation cohort, with a 2:1 ratio. Data was then gathered on significant predictors of MI in the training cohort, including MRS [odds ratio (OR), 1.06; 95% confidence interval (CI), 1.01‑1.11; P=0.023], histological type (OR, 1.98; 95% CI, 1.11‑3.53; P=0.023), lymph node metastasis (OR, 3.15; 95% CI, 1.61‑6.15; P<0.001) and tumor grade (grade 2: OR, 1.71; 95% CI, 1.23‑2.39; P=0.002; Grade 3: OR, 2.10; 95% CI, 1.53‑2.88; P<0.001). Multivariate analysis indicated that MRS was an independent risk factor for MI in both cohorts. A nomogram was generated to predict a patient's probability of MI based on the four independent risk factors. ROC curve analysis showed that, compared with the clinical model (model 1), the combined model with MRS (model 2) significantly improved the diagnostic accuracy of MI in patients with EC (area under the curve in model 1 vs. model 2: 0.737 vs. 0.828 in the training cohort and 0.713 vs. 0.759 in the validation cohort). Calibration plots showed that the training and validation cohorts were well calibrated. DCA showed that a net benefit is obtained from the application of the nomogram. Overall, the present study developed and validated a MRS‑based nomogram predicting MI in patients with EC preoperatively. The establishment of this model may promote the use of precision medicine and targeted therapy in EC and has the potential to improve the prognosis of patients affected by EC.
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1 

Zhang S, Gong TT, Liu FH, Jiang YT, Sun H, Ma XX, Zhao YH and Wu QJ: Global, regional, and national burden of endometrial cancer, 1990–2017: Results from the global burden of disease study, 2017. Front Oncol. 9:14402019. View Article : Google Scholar : PubMed/NCBI

2 

Morice P, Leary A, Creutzberg C, Abu-Rustum N and Darai E: Endometrial cancer. Lancet. 387:1094–1108. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Yang XG, Feng JT, Wang F, He X, Zhang H, Yang L, Zhang HR and Hu YC: Development and validation of a prognostic nomogram for the overall survival of patients living with spinal metastases. J Neurooncol. 145:167–176. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Wu J, Zhang H, Li L, Hu M, Chen L, Xu B and Song Q: A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis. Cancer Commun (Lond). 40:301–312. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Dong Y, Cheng Y, Tian W, Zhang H, Wang Z, Li X, Shan B, Ren Y, Wei L, Wang H and Wang J: An Externally validated nomogram for predicting lymph node metastasis of presumed Stage I and II endometrial cancer. Front Oncol. 9:12182019. View Article : Google Scholar : PubMed/NCBI

6 

Li X, Cheng Y, Dong Y, Zhou J, Wang Z, Li X and Wang J: Development and validation of predictive model for lymph node metastasis in endometrial cancer: A SEER analysis. Ann Transl Med. 9:5382021. View Article : Google Scholar : PubMed/NCBI

7 

Wang Y, Bi Q, Deng Y, Yang Z, Song Y, Wu Y and Wu K: Development and validation of an MRI-based radiomics nomogram for assessing deep myometrial invasion in early stage endometrial adenocarcinoma. Acad Radiol. Jun 28–2022.doi: 10.1016/j.acra.2022.05.017 (Epub ahead of print). View Article : Google Scholar

8 

Esposito K, Chiodini P, Colao A, Lenzi A and Giugliano D: Metabolic syndrome and risk of cancer: A systematic review and meta-analysis. Diabetes Care. 35:2402–2411. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Sha H, Hu D, Wu S, Peng F, Xu G, Fan G, Lin X, Chen G, Liang B, Chen Y, et al: Baseline metabolic risk score and postsurgical esophageal cancer-specific mortality: The fujian prospective investigation of cancer (FIESTA) study. J Cancer. 9:1173–1181. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Yang X, Li X, Dong Y, Fan Y, Cheng Y, Zhai L, Zhang S, Zhou J and Wang J: Effects of metabolic syndrome and its components on the prognosis of endometrial cancer. Front Endocrinol (Lausanne). 12:7807692021. View Article : Google Scholar : PubMed/NCBI

11 

Tibshirani R: The lasso method for variable selection in the Cox model. Stat Med. 16:385–395. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Ruz-Caracuel I, Ramon-Patino JL, Lopez-Janeiro A, Yebenes L, Berjon A, Hernandez A, Gallego A, Heredia-Soto V, Mendiola M, Redondo A, et al: Myoinvasive pattern as a prognostic marker in Low-grade, early-stage endometrioid endometrial carcinoma. Cancers (Basel). 11:18452019. View Article : Google Scholar : PubMed/NCBI

13 

Shou H, Yan K, Song J, Zhao L, Zhang Y and Ni J: Metabolic syndrome affects the long-term survival of patients with non-endometrioid carcinoma of the uterine corpus. Int J Gynaecol Obstet. 148:96–101. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Matoba Y, Yamagami W, Chiyoda T, Kobayashi Y, Tominaga E, Banno K and Aoki D: Characteristics and clinicopathological features of patients with ovarian metastasis of endometrial cancer: A retrospective study. J Obstet Gynaecol. 42:2456–2462. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Maire M, Bourdon A, Soubeyran I, Lucchesi C, Guyon F, Babin G, Floquet A, Petit A, Baud J, Velasco V, et al: Biomarkers associated with lymph nodal metastasis in endometrioid endometrial carcinoma. Cancers (Basel). 14:21882022. View Article : Google Scholar : PubMed/NCBI

16 

Omiyale W, Allen NE and Sweetland S: Body size, body composition and endometrial cancer risk among postmenopausal women in UK Biobank. Int J Cancer. 147:2405–2415. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Zhao M, Wen F, Shi J, Song J, Zhao J, Song Q, Lai Q, Luo Y, Yu T, Jiang X, et al: MRI-based radiomics nomogram for the preoperative prediction of deep myometrial invasion of FIGO stage I endometrial carcinoma. Med Phys. 49:6505–6516. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Tong Y, Huang M, Chen L, Lei H, Lin H, Mao X and Sun P: ERRgamma, a novel biomarker, associates with pathoglycemia of endometrial cancer to predict myometrial invasion. J Oncol. 2022:52833882022. View Article : Google Scholar : PubMed/NCBI

19 

Luo YZ, Yang Z, Qiu YL, Li XH, Qin LQ, Su QS and Mo WN: Pretreatment triglycerides-to-high density lipoprotein cholesterol ratio in postmenopausal women with endometrial cancer. Kaohsiung J Med Sci. 35:303–309. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Borden LE, Locklear TM, Grider DJ, Osborne JL, Saks EJ, Valea FA and Iglesias DA: Endometrial Cancer Characteristics and Risk of Recurrence. Am J Clin Pathol. 157:90–97. 2022. View Article : Google Scholar : PubMed/NCBI

21 

Bacalbasa N, Diaconu C, Iliescu L, Savu C, Savu C, Balalau C, Dimitriu M, Filipescu A, Bratu OG, Neacsu A, et al: The Influence of the metabolic syndrome on early postoperative outcomes of patients with advanced-stage endometrial cancer. In Vivo. 34:2913–2917. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Andrade Fernandes JP, da Camara AO, Frajacomo FT, Chaves CBP, Fernandes Pereira A and Chaves GV: Metabolic profile of patients with endometrial adenocarcinoma and association with tumor grade. Int J Gynecol Cancer. 32:626–632. 2022. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qiang Y, Zhang Q and Dong L: Metabolic risk score as a predictor in a nomogram for assessing myometrial invasion for endometrial cancer. Oncol Lett 25: 114, 2023.
APA
Qiang, Y., Zhang, Q., & Dong, L. (2023). Metabolic risk score as a predictor in a nomogram for assessing myometrial invasion for endometrial cancer. Oncology Letters, 25, 114. https://doi.org/10.3892/ol.2023.13700
MLA
Qiang, Y., Zhang, Q., Dong, L."Metabolic risk score as a predictor in a nomogram for assessing myometrial invasion for endometrial cancer". Oncology Letters 25.3 (2023): 114.
Chicago
Qiang, Y., Zhang, Q., Dong, L."Metabolic risk score as a predictor in a nomogram for assessing myometrial invasion for endometrial cancer". Oncology Letters 25, no. 3 (2023): 114. https://doi.org/10.3892/ol.2023.13700
Copy and paste a formatted citation
x
Spandidos Publications style
Qiang Y, Zhang Q and Dong L: Metabolic risk score as a predictor in a nomogram for assessing myometrial invasion for endometrial cancer. Oncol Lett 25: 114, 2023.
APA
Qiang, Y., Zhang, Q., & Dong, L. (2023). Metabolic risk score as a predictor in a nomogram for assessing myometrial invasion for endometrial cancer. Oncology Letters, 25, 114. https://doi.org/10.3892/ol.2023.13700
MLA
Qiang, Y., Zhang, Q., Dong, L."Metabolic risk score as a predictor in a nomogram for assessing myometrial invasion for endometrial cancer". Oncology Letters 25.3 (2023): 114.
Chicago
Qiang, Y., Zhang, Q., Dong, L."Metabolic risk score as a predictor in a nomogram for assessing myometrial invasion for endometrial cancer". Oncology Letters 25, no. 3 (2023): 114. https://doi.org/10.3892/ol.2023.13700
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