Open Access

Ubiquitin C‑terminal hydrolase‑L1: A new cancer marker and therapeutic target with dual effects (Review)

  • Authors:
    • Xiaowei Wang
    • Na Zhang
    • Meihua Li
    • Tao Hong
    • Wei Meng
    • Taohui Ouyang
  • View Affiliations

  • Published online on: February 8, 2023     https://doi.org/10.3892/ol.2023.13709
  • Article Number: 123
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ubiquitin C‑terminal hydrolase‑L1 (UCH‑L1), a member of the lesser‑known deubiquitinating enzyme family, has deubiquitinase and ubiquitin (Ub) ligase activity and the role of stabilizing Ub. UCH‑L1 was first discovered in the brain and is associated with regulating cell differentiation, proliferation, transcriptional regulation and numerous other biological processes. UCH‑L1 is predominantly expressed in the brain and serves a role in tumor promotion or inhibition. There is still controversy about the effect of UCH‑L1 dysregulation in cancer and its mechanisms are unknown. Extensive research to investigate the mechanism of UCH‑L1 in different types of cancer is key for the future treatment of UCH‑L1‑associated cancer. The present review details the molecular structure and function of UCH‑L1. The role of UCH‑L1 in different types of cancer is also summarized and how novel treatment targets provide a theoretical foundation in cancer research is discussed.
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March-2023
Volume 25 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang X, Zhang N, Li M, Hong T, Meng W and Ouyang T: Ubiquitin C‑terminal hydrolase‑L1: A new cancer marker and therapeutic target with dual effects (Review). Oncol Lett 25: 123, 2023
APA
Wang, X., Zhang, N., Li, M., Hong, T., Meng, W., & Ouyang, T. (2023). Ubiquitin C‑terminal hydrolase‑L1: A new cancer marker and therapeutic target with dual effects (Review). Oncology Letters, 25, 123. https://doi.org/10.3892/ol.2023.13709
MLA
Wang, X., Zhang, N., Li, M., Hong, T., Meng, W., Ouyang, T."Ubiquitin C‑terminal hydrolase‑L1: A new cancer marker and therapeutic target with dual effects (Review)". Oncology Letters 25.3 (2023): 123.
Chicago
Wang, X., Zhang, N., Li, M., Hong, T., Meng, W., Ouyang, T."Ubiquitin C‑terminal hydrolase‑L1: A new cancer marker and therapeutic target with dual effects (Review)". Oncology Letters 25, no. 3 (2023): 123. https://doi.org/10.3892/ol.2023.13709