Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2023 Volume 25 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2023 Volume 25 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article

Prognostic and diagnostic significance of preoperative Jumonji domain‑containing 6 antibodies in colorectal cancer

  • Authors:
    • Kimihiko Yoshida
    • Takaki Hiwasa
    • Masaaki Ito
    • Mitsunori Ushigome
    • Hirotaka Takizawa
    • Shu-Yang Li
    • Bo-Shi Zhang
    • Yasuo Iwadate
    • Kimihiko Funahashi
    • Hideaki Shimada
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, School of Medicine, Toho University, Tokyo 143‑8541, Japan, Department of Gastroenterological Surgery and Clinical Oncology, Graduate School of Medicine, Toho University, Tokyo 143‑8541, Japan, Port Square Kashiwado Clinic, Kashiwado Memorial Foundation, Chiba 260‑0025, Japan, Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan
  • Article Number: 127
    |
    Published online on: February 10, 2023
       https://doi.org/10.3892/ol.2023.13713
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Jumonji domain‑containing 6 (JMJD6) protein has been reported to be upregulated in different cancer cells; however, to the best of our knowledge, no report has analyzed serum anti‑JMJD6 antibodies (s‑JMJD6‑Abs) in patients with cancer. Therefore, the present study evaluated the clinical significance of s‑JMJD6‑Abs in patients with colorectal cancer. Preoperative serum samples were analyzed from 167 patients with colorectal cancer who underwent radical surgery between April 2007 and May 2012. The pathological stages were as follows Stage I (n=47), stage II (n=56), stage III (n=49) and stage IV (n=15). In addition, 96 healthy participants were analyzed as controls. s‑JMJD6‑Abs were analyzed by amplified luminescent proximity homology assay‑linked immunosorbent assay. The cutoff value of s‑JMJD6‑Abs for detecting colorectal cancer was calculated to be 5,720 using the receiver operating characteristic curve. The positive rate of s‑JMJD6‑Abs was 37% in patients with colorectal cancer (61 of 167), independent of carcinoembryonic antigen or carbohydrate antigen 19‑9 and p53‑Abs. Clinicopathological factors and prognosis were compared between the s‑JMJD6‑Abs‑positive group and the s‑JMJD6‑Abs‑negative group. The s‑JMJD6‑Ab‑positive status was significantly associated with older age (P=0.03), but was not associated with other clinicopathological variables. Regarding recurrence‑free survival, the s‑JMJD6‑positive status was a significant poor prognostic factor in both univariate (P=0.02) and multivariate (P<0.01) analyses. Similarly, regarding overall survival, the s‑JMJD6‑Abs‑positive status was a significant poor prognostic factor in both univariate (P=0.03) and multivariate (P=0.01) analyses. In conclusion, preoperative s‑JMJD6‑Abs was positive in 37% of patients with colorectal cancer and may be considered an independent poor prognostic biomarker.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Yang J, Chen S, Yang Y, Ma X, Shao B, Yang S, Wei Y and Wei X: Jumonji domain-containing protein 6 protein and its role in cancer. Cell Prolif. 53:e127472020. View Article : Google Scholar : PubMed/NCBI

2 

Poulard C, Rambaud J, Lavergne E, Jacquemetton J, Renoir JM, Tredan O, Chabaud S, Treilleux I, Corbo L and Le Romancer M: Role of JMJD6 in breast tumourigenesis. PLoS One. 10:e01261812015. View Article : Google Scholar : PubMed/NCBI

3 

Lee YF, Miller LD, Chan XB, Black MA, Pang B, Ong CW, Salto-Tellez M, Liu ET and Desai KV: JMJD6 is a driver of cellular proliferation and motility and a marker of poor prognosis in breast cancer. Breast Cancer Res. 14:R852012. View Article : Google Scholar : PubMed/NCBI

4 

Liu X, Si W, Liu X, He L, Ren J, Yang Z, Yang J, Li W, Liu S, Pei F, et al: JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component. Mol Cancer. 16:1752017. View Article : Google Scholar : PubMed/NCBI

5 

Lee CR, Lee SH, Rigas NK, Kim RH, Kang MK, Park NH and Shin KH: Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties. Carcinogenesis. 37:119–128. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Zhang J, Ni SS, Zhao WL, Dong XC and Wang JL: High expression of JMJD6 predicts unfavorable survival in lung adenocarcinoma. Tumour Biol. 34:2397–2401. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Wan J, Liu H, Yang L, Ma L, Liu J and Ming L: JMJD6 promotes hepatocellular carcinoma carcinogenesis by targeting CDK4. Int J Cancer. 144:2489–2500. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Zheng H, Tie Y, Fang Z, Wu X, Yi T, Huang S, Liang X, Qian Y, Wang Xi, Pi R, et al: Jumonji domain-containing 6 (JMJD6) identified as a potential therapeutic target in ovarian cancer. Signal Transduct Target Ther. 4:242019. View Article : Google Scholar : PubMed/NCBI

9 

Wang F, He L, Huangyang P, Liang J, Si W, Yan R, Han X, Liu S, Gui B, Li W, et al: JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. PLoS Biol. 12:e10018192014. View Article : Google Scholar : PubMed/NCBI

10 

Miller TE, Liau BB, Wallace LC, Morton AR, Xie Q, Dixit D, Factor DC, Kim LJY, Morrow JJ, Wu Q, et al: Transcription elongation factors represent in vivo cancer dependencies in glioblastoma. Nature. 547:355–359. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Zhou DX, Zhou D, Zhan SQ, Wang P, Qin K, Gan W and Lin XF: Inhibition of JMJD6 expression reduces the proliferation, migration and invasion of neuroglioma stem cells. Neoplasma. 64:700–708. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Aprelikova O, Chen K, El Touny LH, Brignatz-Guittard C, Han J, Qiu T, Yang HH, Lee MP, Zhu M and Green JE: The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis. Clin Epigenetics. 8:382016. View Article : Google Scholar : PubMed/NCBI

13 

Zaneker P, Gray ES and Ziman MR: Autoantibody production in cancer-the humoral immune response toword autologous antigens in cancer patients. Autoimmun Rev. 15:477–483. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Ushigome M, Shimada H, Miura Y, Yoshida K, Kaneko T, Koda T, Nagashima Y, Suzuki T, Kagami S and Funahashi K: Changing pattern of tumor markers in recurrent colorectal cancer patients before surgery to recurrence: Serum p53 antibodies, CA19-9 and CEA. Int J Clin Oncol. 25:622–632. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Sumazaki M, Shimada H, Ito M, Shiratori F, Kobayashi E, Yoshida Y, Adachi A, Matsutani T, Iwadate Y, Mine S, et al: Serum anti-LRPAP1 is a common biomarker for digestive organ cancers and atherosclerotic diseases. Cancer Sci. 111:4453–4464. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Hiwasa T, Wang H, Goto K, Mine S, Machida T, Kobayashi E, Yoshida Y, Adachi A, Matsutani T, Sata M, et al: Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke. BMC Med. 19:1312021. View Article : Google Scholar : PubMed/NCBI

17 

Li SY, Yoshida Y, Kobayashi E, Kubota M, Matsutani T, Mine S, Machida T, Maezawa Y, Takemoto M, Yokote K, et al: Serum anti-AP3D1 antibodies are risk factors for acute ischemic stroke related with atherosclerosis. Sci Rep. 11:134502021. View Article : Google Scholar : PubMed/NCBI

18 

Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 48:452–458. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Maes T, Carceller E, Salas J, Ortega A and Buesa C: Advances in the development of histone lysine demethylase inhibitors. Curr Opin Pharmacol. 23:52–60. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Ran T, Xiao R, Huang Q, Yuan H, Lu T and Liu W: In silico discovery of JMJD6 inhibitors for cancer treatment. ACS Med Chem Lett. 10:1609–1613. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Ushigome M, Shimada H, Nabeya Y, Shiratori F, Soda H, Takiguchi N, Hoshino I, Kuwajima A, Kaneko T and Funahashi K: Possible predictive significance of serum RalA autoantibodies on relapse-free survival in patients with colorectal cancer. Mol Clin Oncol. 14:182021. View Article : Google Scholar : PubMed/NCBI

22 

Ushigome M, Nabeya Y, Soda H, Takiguchi N, Kuwajima A, Tagawa M, Matsushita K, Koike J, Funahashi K and Shimada H: Multi-panel assay of serum autoantibodies in colorectal cancer. Int J Clin Oncol. 23:917–923. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Takashi S, Satoshi Y, Akihiko O, Naoya Y, Yusuke T, Kentaro M, Yu O, Yasuaki N, Koichi Y, Takashi F, et al: Clinical impact of preoperative serum p53 antibody titers in 1487 patients with surgically treated esophageal squamous cell carcinoma: A multi-institutional study. Esophagus. 18:65–71. 2021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yoshida K, Hiwasa T, Ito M, Ushigome M, Takizawa H, Li S, Zhang B, Iwadate Y, Funahashi K, Shimada H, Shimada H, et al: Prognostic and diagnostic significance of preoperative Jumonji domain‑containing 6 antibodies in colorectal cancer. Oncol Lett 25: 127, 2023.
APA
Yoshida, K., Hiwasa, T., Ito, M., Ushigome, M., Takizawa, H., Li, S. ... Shimada, H. (2023). Prognostic and diagnostic significance of preoperative Jumonji domain‑containing 6 antibodies in colorectal cancer. Oncology Letters, 25, 127. https://doi.org/10.3892/ol.2023.13713
MLA
Yoshida, K., Hiwasa, T., Ito, M., Ushigome, M., Takizawa, H., Li, S., Zhang, B., Iwadate, Y., Funahashi, K., Shimada, H."Prognostic and diagnostic significance of preoperative Jumonji domain‑containing 6 antibodies in colorectal cancer". Oncology Letters 25.3 (2023): 127.
Chicago
Yoshida, K., Hiwasa, T., Ito, M., Ushigome, M., Takizawa, H., Li, S., Zhang, B., Iwadate, Y., Funahashi, K., Shimada, H."Prognostic and diagnostic significance of preoperative Jumonji domain‑containing 6 antibodies in colorectal cancer". Oncology Letters 25, no. 3 (2023): 127. https://doi.org/10.3892/ol.2023.13713
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshida K, Hiwasa T, Ito M, Ushigome M, Takizawa H, Li S, Zhang B, Iwadate Y, Funahashi K, Shimada H, Shimada H, et al: Prognostic and diagnostic significance of preoperative Jumonji domain‑containing 6 antibodies in colorectal cancer. Oncol Lett 25: 127, 2023.
APA
Yoshida, K., Hiwasa, T., Ito, M., Ushigome, M., Takizawa, H., Li, S. ... Shimada, H. (2023). Prognostic and diagnostic significance of preoperative Jumonji domain‑containing 6 antibodies in colorectal cancer. Oncology Letters, 25, 127. https://doi.org/10.3892/ol.2023.13713
MLA
Yoshida, K., Hiwasa, T., Ito, M., Ushigome, M., Takizawa, H., Li, S., Zhang, B., Iwadate, Y., Funahashi, K., Shimada, H."Prognostic and diagnostic significance of preoperative Jumonji domain‑containing 6 antibodies in colorectal cancer". Oncology Letters 25.3 (2023): 127.
Chicago
Yoshida, K., Hiwasa, T., Ito, M., Ushigome, M., Takizawa, H., Li, S., Zhang, B., Iwadate, Y., Funahashi, K., Shimada, H."Prognostic and diagnostic significance of preoperative Jumonji domain‑containing 6 antibodies in colorectal cancer". Oncology Letters 25, no. 3 (2023): 127. https://doi.org/10.3892/ol.2023.13713
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team