Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer

  • Authors:
    • Shuqin Gui
    • Qinrong Wang
    • Liya Bao
    • Xiaofeng He
    • Zhengrong Wang
    • Linlin Liu
    • Lixia Wu
    • Yan Zhao
    • Jianjiang Zhou
    • Yuan Xie
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Endemic and Ethnic Minority Diseases, Ministry of Education and Key Laboratory of Molecular Biology, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Hepatitis Laboratory, Department of Infectious Diseases, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China
    Copyright: © Gui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 143
    |
    Published online on: February 28, 2023
       https://doi.org/10.3892/ol.2023.13729
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Helicobacter pylori (Hp) is a primary risk factor for gastric cancer. The fat mass and obesity‑associated (FTO) gene is associated with the development and progression of various cancer types such as glioma, leukemia, breast cancer and colorectal cancer. The aim of the present study was to investigate the effect of Hp infection on the expression of FTO and its roles in gastric cancer. It was found that the expression levels of both FTO mRNA and protein were significantly increased in Hp‑infected human gastric mucosal epithelial cells and Mongolian gerbil gastric tissues. The expression of FTO in gastric cancer tissues was higher than that in para‑cancer tissues. Data from The Cancer Genome Atlas demonstrated that FTO expression in gastric cancer tissues was significantly higher than that in normal tissues. Patient survival rate was significantly decreased in patients with high expression levels of FTO. It was also demonstrated that FTO expression was associated with several pathological parameters, such as tumor stage, metastasis stage and the American Joint Committee on Cancer stage. The FTO gene was positively correlated with 16,601 genes in gastric cancer and negatively correlated with 3,623 genes. Gene Ontology enrichment analysis demonstrated that FTO was significantly enriched in the regulation of gene expression and oxidative RNA demethylase activity, and it was associated with components such as the RNA N6‑methyladenosine methyltransferase complex and nuclear speckle. In addition, knockdown of the FTO gene inhibited the migration and invasion of Hp‑infected cells. In conclusion, the data suggests that Hp infection leads to upregulation of the FTO gene, which may be related to patient survival rate, tumor staging and other pathological parameters of patients with gastric cancer. It also suggests that FTO promotes proliferation and migration of gastric cancer cells, which may be involved in the pathogenesis of Hp‑induced gastric cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Wu C, Li M, Meng H, Liu Y, Niu W, Zhou Y, Zhao R, Duan Y, Zeng Z, Li X, et al: Analysis of status and countermeasures of cancer incidence and mortality in China. Sci China Life Sci. 62:640–647. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Li Y, Feng A, Zheng S, Chen C and Lyu J: Recent estimates and predictions of 5-year survival in patients with gastric cancer: A model-based period analysis. Cancer Control. 29:107327482210992272022. View Article : Google Scholar : PubMed/NCBI

4 

GBD 2017 Stomach Cancer Collaborators, . The global, regional, and national burden of stomach cancer in 195 countries, 1990–2017: A systematic analysis for the global burden of disease study 2017. Lancet Gastroenterol Hepatol. 5:42–54. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T and Cao X: Prevention of gastric cancer: Eradication of Helicobacter pylori and beyond. Int J Mol Sci. 18:16992017. View Article : Google Scholar : PubMed/NCBI

6 

Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG and He C: N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol. 7:885–887. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, et al: Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia. Cancer Cell. 35:677–691.e10. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Xu Y, Ye S, Zhang N, Zheng S, Liu H, Zhou K, Wang L, Cao Y, Sun P and Wang T: The FTO/miR-181b-3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer. Cancer Commun (Lond). 40:484–500. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Huang H, Wang Y, Kandpal M, Zhao G, Cardenas H, Ji Y, Chaparala A, Tanner EJ, Chen J, Davuluri RV and Matei D: FTO-Dependent N (6)-Methyladenosine modifications inhibit ovarian cancer stem cell self-renewal by blocking cAMP signaling. Cancer Res. 80:3200–3214. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Yue C, Chen J, Li Z, Li L, Chen J and Guo Y: MicroRNA-96 promotes occurrence and progression of colorectal cancer via regulation of the AMPKα2-FTO-m6A/MYC axis. J Exp Clin Cancer Res. 39:2402020. View Article : Google Scholar : PubMed/NCBI

11 

Su Y, Huang J and Hu J: M6A RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gastric cancer. Front Oncol. 9:10382019. View Article : Google Scholar : PubMed/NCBI

12 

Shimura T, Kandimalla R, Okugawa Y, Ohi M, Toiyama Y, He C and Goel A: Novel evidence for m(6)A methylation regulators as prognostic biomarkers and FTO as a potential therapeutic target in gastric cancer. Br J Cancer. 126:228–237. 2022. View Article : Google Scholar : PubMed/NCBI

13 

Zhao Y, Yan X, Wang Y, Zhou J and Yu Y: Denocarcinoma. Front Oncol. 11:7260182022. View Article : Google Scholar : PubMed/NCBI

14 

Xu D, Shao W, Jiang Y, Wang X, Liu Y and Liu X: FTO expression is associated with the occurrence of gastric cancer and prognosis. Oncol Rep. 38:2285–2292. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Niu Y, Lin Z, Wan A, Chen H, Liang H, Sun L, Wang Y, Li X, Xiong XF, Wei B, et al: RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3. Mol Cancer. 18:462019. View Article : Google Scholar : PubMed/NCBI

16 

Long NY, Xiong L, Zhao Y, Yuan H, Li YJ, Chen XS, Zhang XY, Xie Y and Zhou JJ: Sequences difference of CagA between East Asian strain and Western strain of Helicobacter pylori and its impact on the proliferation and apoptosis. Microbiology. 45:848–855. 2018.(In Chinese).

17 

Zhao Y, Xie Y, Chen X, Xu W, Wang Y and Zhou J: Establishment of Mongolian gerbil model of gastric cancer induced by Helicobacter pylori infection and its proteomics analysis. Zhonghua Bing Li Xue Za Zhi. 43:820–826. 2014.(In Chinese). PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Amin MB, Edge SB, Greene FL, Byrd DR, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR, Sullivan DC, et al: AJCC Cancer Staging Manual. 8th edition. Springer International Publishing; New York, NY: 2017, View Article : Google Scholar

20 

Amieva M and Peek RM JR: Pathobiology of Helicobacter pylori-induced gastric cancer. Gastroenterology. 150:64–78. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Correa P: Human gastric carcinogenesis: A multistep and multifactorial process-first american cancer society award lecture on cancer epidemiology and prevention. Cancer Res. 52:6735–6740. 1992.PubMed/NCBI

22 

Yang L, Ying X, Liu S, Lyu G, Xu Z, Zhang X, Li H, Li Q, Wang N and Ji J: Gastric cancer: Epidemiology, risk factors and prevention strategies. Chin J Cancer Res. 32:695–704. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Loor A and Dumitraşcu DL: Helicobacter pylori infection, gastric cancer and gastropanel. Rom J Intern Med. 54:151–156. 2016.PubMed/NCBI

24 

Plummer M, Franceschi S, Vignat J, Forman D and de Martel C: Global burden of gastric cancer attributable to Helicobacter pylori. Int J Cancer. 136:487–490. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Outlioua A, Badre W, Desterke C, Echarki Z, El Hammani N, Rabhi M, Riyad M, Karkouri M, Arnoult D, Khalil A and Akarid K: Gastric IL-1β, IL-8, and IL-17A expression in Moroccan patients infected with Helicobacter pylori may be a predictive signature of severe pathological stages. Cytokine. 126:1548932020. View Article : Google Scholar : PubMed/NCBI

26 

Rasool KH, Alubadi AE and Al-Bayati IFI: The role of serum interleukin-4 and interleukin-6 in Helicobacter pylori-infected patients. Microb Pathog. 162:1053622022. View Article : Google Scholar : PubMed/NCBI

27 

Gonciarz W, Krupa A, Hinc K, Obuchowski M, Moran AP, Gajewski A and Chmiela M: The effect of Helicobacter pylori infection and different H. pylori components on the proliferation and apoptosis of gastric epithelial cells and fibroblasts. PLoS One. 14:e02206362019. View Article : Google Scholar : PubMed/NCBI

28 

Mera RM, Bravo LE, Camargo MC, Bravo JC, Delgado AG, Romero-Gallo J, Yepez MC, Realpe JL, Schneider BG, Morgan DR, et al: Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Gut. 67:1239–1246. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Ernst PB, Peura DA and Crowe SE: The translation of Helicobacter pylori basic research to patient care. Gastroenterology. 130:188–206. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Infection with Helicobacter pylori. IARC Monogr Eval Carcinog Risks Hum. 61:177–240. 1994.PubMed/NCBI

31 

Battaglin F, Naseem M, Puccini A and Lenz HJ: Molecular biomarkers in gastro-esophageal cancer: Recent developments, current trends and future directions. Cancer Cell Int. 18:992018. View Article : Google Scholar : PubMed/NCBI

32 

Dina C, Meyre D, Gallina S, Durand E, Körner A, Jacobson P, Carlsson LMS, Kiess W, Vatin V, Lecoeur C, et al: Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet. 39:724–726. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Chen J and Du B: Novel positioning from obesity to cancer: FTO, an m(6)A RNA demethylase, regulates tumour progression. J Cancer Res Clin Oncol. 145:19–29. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Zou D, Dong L, Li C, Yin Z, Rao S and Zhou Q: The m(6)A eraser FTO facilitates proliferation and migration of human cervical cancer cells. Cancer Cell Int. 19:3212019. View Article : Google Scholar : PubMed/NCBI

35 

Deng X, Su R, Stanford S and Chen J: Critical enzymatic functions of FTO in obesity and cancer. Front Endocrinol (Lausanne). 9:3962018. View Article : Google Scholar : PubMed/NCBI

36 

Zhang L, Wan Y, Zhang Z, Jiang Y, Lang J, Cheng W and Zhu L: FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway. RNA Biol. 18:1265–1278. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Tang X, Liu S, Chen D, Zhao Z and Zhou J: The role of the fat mass and obesity-associated protein in the proliferation of pancreatic cancer cells. Oncol Lett. 17:2473–2478. 2019.PubMed/NCBI

38 

Chen D, Li C, Zhao Y, Zhou J, Wang Q and Xie Y: 2021. Bioinformatics analysis for the identification of differentially expressed genes and related signaling pathways in H. pylori-CagA transfected gastric cancer cells. PeerJ. 9:e112032021. View Article : Google Scholar : PubMed/NCBI

39 

Hou S, Shan M, Gao C, Feng X, Yang Y, Zhang R, He Y, Zhang G and Zhang L: PCDHGB7 increases chemosensitivity to carboplatin by inhibiting HSPA9 via inducing apoptosis in breast cancer. Dis Markers. 2019:61315482019. View Article : Google Scholar : PubMed/NCBI

40 

Chen Y, Zhou Y, Han F, Zhao Y, Tu M, Wang Y, Huang C, Fan S, Chen P, Yao X, et al: A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis. Theranostics. 10:7193–7210. 2020. View Article : Google Scholar : PubMed/NCBI

41 

Wang S and Huo X: Comprehensive analysis of ESRRA in endometrial cancer. Technol Cancer Res Treat. 20:15330338219920832021.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gui S, Wang Q, Bao L, He X, Wang Z, Liu L, Wu L, Zhao Y, Zhou J, Xie Y, Xie Y, et al: Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer. Oncol Lett 25: 143, 2023.
APA
Gui, S., Wang, Q., Bao, L., He, X., Wang, Z., Liu, L. ... Xie, Y. (2023). Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer. Oncology Letters, 25, 143. https://doi.org/10.3892/ol.2023.13729
MLA
Gui, S., Wang, Q., Bao, L., He, X., Wang, Z., Liu, L., Wu, L., Zhao, Y., Zhou, J., Xie, Y."Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer". Oncology Letters 25.4 (2023): 143.
Chicago
Gui, S., Wang, Q., Bao, L., He, X., Wang, Z., Liu, L., Wu, L., Zhao, Y., Zhou, J., Xie, Y."Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer". Oncology Letters 25, no. 4 (2023): 143. https://doi.org/10.3892/ol.2023.13729
Copy and paste a formatted citation
x
Spandidos Publications style
Gui S, Wang Q, Bao L, He X, Wang Z, Liu L, Wu L, Zhao Y, Zhou J, Xie Y, Xie Y, et al: Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer. Oncol Lett 25: 143, 2023.
APA
Gui, S., Wang, Q., Bao, L., He, X., Wang, Z., Liu, L. ... Xie, Y. (2023). Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer. Oncology Letters, 25, 143. https://doi.org/10.3892/ol.2023.13729
MLA
Gui, S., Wang, Q., Bao, L., He, X., Wang, Z., Liu, L., Wu, L., Zhao, Y., Zhou, J., Xie, Y."Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer". Oncology Letters 25.4 (2023): 143.
Chicago
Gui, S., Wang, Q., Bao, L., He, X., Wang, Z., Liu, L., Wu, L., Zhao, Y., Zhou, J., Xie, Y."Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer". Oncology Letters 25, no. 4 (2023): 143. https://doi.org/10.3892/ol.2023.13729
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team