Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Vaginal and tumor microbiomes in gynecological cancer (Review)

  • Authors:
    • Mengzhen Han
    • Na Wang
    • Wenjie Han
    • Meng Ban
    • Tao Sun
    • Junnan Xu
  • View Affiliations / Copyright

    Affiliations: Department of Breast Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, Liaoning 110000, P.R. China, Department of Breast Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, Liaoning 110000, P.R. China, Liaoning Microhealth Biotechnology Co., Ltd., Shenyang, Liaoning 110000, P.R. China, Department of Breast Medicine, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital, Shenyang, Liaoning 110000, P.R. China, Department of Breast Medicine, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital, Shenyang, Liaoning 110000, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 153
    |
    Published online on: March 3, 2023
       https://doi.org/10.3892/ol.2023.13739
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cervical, ovarian and endometrial cancer are the three most common types of gynecologic cancer. As a hub, the vagina connects the site of gynecological cancer with the external environment. Lactobacilli participate in the formation of a healthy vaginal microenvironment as the first line of defense against pathogen invasion; a dysbiotic vaginal microenvironment loses its original protective function and is associated with the onset, metastasis, poor efficacy and poor prognosis of gynecological cancer. The early diagnosis of cancer is the key to improve the survival time of patients with cancer. The screening of Porphyromonas, Sneathia and Atopobium vaginae, and other microbial markers, can assist the diagnosis of gynecological cancer, and screen out the high‑risk population as early as possible. With the in‑depth study of the microbes in tumor tissues, reasearchers have analyzed the immunological associations of microorganisms in tumor tissues. Due to the structural‑functional interconnection between the organ of gynecological tumorigenesis and the vagina, the present study aims to review the relationship between vaginal and tumor microorganisms and gynecological cancer in terms of occurrence, screening, treatment and prognosis.
View Figures

Figure 1

View References

1 

Johnson JS, Spakowicz DJ, Hong BY, Petersen LM, Demkowicz P, Chen L, Leopold SR, Hanson BM, Agresta HO, Gerstein M, et al: Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis. Nat Commun. 10:50292019. View Article : Google Scholar : PubMed/NCBI

2 

Rinninella E, Raoul P, Cintoni M, Franceschi F, Miggiano GAD, Gasbarrini A and Mele MC: What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms. 7:142019. View Article : Google Scholar : PubMed/NCBI

3 

Einstein MH, Levine NF and Nevadunsky NS: Menopause and cancers. Endocrinol Metab Clin North Am. 44:603–617. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Wu Y, Sun W, Liu H and Zhang D: Age at menopause and risk of developing endometrial cancer: A meta-analysis. Biomed Res Int. 2019:85841302019.PubMed/NCBI

5 

Liang Y, Chen M, Qin L, Wan B and Wang H: A meta-analysis of the relationship between vaginal microecology, human papillomavirus infection and cervical intraepithelial neoplasia. Infect Agent Cancer. 14:292019. View Article : Google Scholar : PubMed/NCBI

6 

Gillet E, Meys JF, Verstraelen H, Verhelst R, De Sutter P, Temmerman M and Vanden Broeck D: Association between bacterial vaginosis and cervical intraepithelial neoplasia: Systematic review and meta-analysis. PLoS One. 7:e452012012. View Article : Google Scholar : PubMed/NCBI

7 

Sepich-Poore GD, Zitvogel L, Straussman R, Hasty J, Wargo JA and Knight R: The microbiome and human cancer. Science. 371:eabc45522021. View Article : Google Scholar : PubMed/NCBI

8 

Poore GD, Kopylova E, Zhu Q, Carpenter C, Fraraccio S, Wandro S, Kosciolek T, Janssen S, Metcalf J, Song SJ, et al: Microbiome analyses of blood and tissues suggest cancer diagnostic approach. Nature. 579:567–574. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Witkin SS, Linhares IM and Giraldo P: Bacterial flora of the female genital tract: function and immune regulation. Best Pract Res Clin Obstet Gynaecol. 21:347–354. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Lidbeck A and Nord CE: Lactobacilli and the normal human anaerobic microflora. Clin Infect Dis. 16 (Suppl 4):S181–S187. 1993. View Article : Google Scholar : PubMed/NCBI

11 

Chee WJY, Chew SY and Than LTL: Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health. Microb Cell Fact. 19:2032020. View Article : Google Scholar : PubMed/NCBI

12 

Wilson JD, Lee RA, Balen AH and Rutherford AJ: Bacterial vaginal flora in relation to changing oestrogen levels. Int J Std Aids. 18:308–311. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Barrientos-Duran A, Fuentes-Lopez A, de Salazar A, Plaza-Diaz J and Garcia F: Reviewing the composition of vaginal microbiota: Inclusion of nutrition and probiotic factors in the maintenance of eubiosis. Nutrients. 12:4192020. View Article : Google Scholar : PubMed/NCBI

14 

Ravel J, Gajer P, Abdo Z, Schneider GM, Koenig SS, McCulle SL, Karlebach S, Gorle R, Russell J, Tacket CO, et al: Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA. 108 Suppl 1 (Suppl 1):S4680–S4687. 2011. View Article : Google Scholar

15 

Gajer P, Brotman RM, Bai G, Sakamoto J, Schutte UM, Zhong X, Koenig SS, Fu L, Ma ZS, Zhou X, et al: Temporal dynamics of the human vaginal microbiota. Sci Transl Med. 4:132ra522012. View Article : Google Scholar : PubMed/NCBI

16 

De Gregorio PR, Parolin C, Abruzzo A, Luppi B, Protti M, Mercolini L, Silva JA, Giordani B, Marangoni A, Nader-Macías MEF and Vitali B: Biosurfactant from vaginal Lactobacillus crispatus BC1 as a promising agent to interfere with Candida adhesion. Microb Cell Fact. 19:1332020. View Article : Google Scholar : PubMed/NCBI

17 

Jung H, Ehlers MM, Peters RPH, Lombaard H, Redelinghuys MJ, Bezuidenhoudt JE and Kock MM: Growth forms of Gardnerella spp. and Lactobacillus spp. On vaginal cells. Front Cell Infect Microbiol. 10:712020. View Article : Google Scholar : PubMed/NCBI

18 

Aldunate M, Tyssen D, Johnson A, Zakir T, Sonza S, Moench T, Cone R and Tachedjian G: Vaginal concentrations of lactic acid potently inactivate HIV. J Antimicrob Chemother. 68:2015–2025. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Tamarelle J, Thiebaut ACM, de Barbeyrac B, Bebear C, Ravel J and Delarocque-Astagneau E: The vaginal microbiota and its association with human papillomavirus, Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections: A systematic review and meta-analysis. Clin Microbiol Infect. 25:35–47. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Witkin SS and Linhares IM: Why do lactobacilli dominate the human vaginal microbiota? BJOG. 124:606–611. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Kyrgiou M, Mitra A and Moscicki AB: Does the vaginal microbiota play a role in the development of cervical cancer? Transl Res. 179:168–182. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Ilhan ZE, Laniewski P, Thomas N, Roe DJ, Chase DM and Herbst-Kralovetz MM: Deciphering the complex interplay between microbiota, HPV, inflammation and cancer through cervicovaginal metabolic profiling. EBioMedicine. 44:675–690. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Vornhagen J, Armistead B, Santana-Ufret V, Gendrin C, Merillat S, Coleman M, Quach P, Boldenow E, Alishetti V, Leonhard-Melief C, et al: Group B streptococcus exploits vaginal epithelial exfoliation for ascending infection. J Clin Invest. 128:1985–1999. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Scillato M, Spitale A, Mongelli G, Privitera GF, Mangano K, Cianci A, Stefani S and Santagati M: Antimicrobial properties of Lactobacillus cell-free supernatants against multidrug-resistant urogenital pathogens. Microbiologyopen. 10:e11732021. View Article : Google Scholar : PubMed/NCBI

25 

Chen Y, Qiu X, Wang W, Li D, Wu A, Hong Z, Di W and Qiu L: Human papillomavirus infection and cervical intraepithelial neoplasia progression are associated with increased vaginal microbiome diversity in a Chinese cohort. BMC Infect Dis. 20:6292020. View Article : Google Scholar : PubMed/NCBI

26 

Mitra A, MacIntyre DA, Marchesi JR, Lee YS, Bennett PR and Kyrgiou M: The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next? Microbiome. 4:582016. View Article : Google Scholar : PubMed/NCBI

27 

Onderdonk AB, Delaney ML and Fichorova RN: The human microbiome during Bacterial Vaginosis. Clin Microbiol Rev. 29:223–238. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Mitchell C and Marrazzo J: Bacterial vaginosis and the cervicovaginal immune response. Am J Reprod Immunol. 71:555–563. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Doerflinger SY, Throop AL and Herbst-Kralovetz MM: Bacteria in the vaginal microbiome alter the innate immune response and barrier properties of the human vaginal epithelia in a species-specific manner. J Infect Dis. 209:1989–1999. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Wang Z, Xiao R, Huang J, Qin X, Hu D, Guo E, Liu C, Lu F, You L, Sun C and Chen G: The diversity of vaginal microbiota predicts neoadjuvant chemotherapy responsiveness in locally advanced cervical cancer. Microb Ecol. 84:302–313. 2022. View Article : Google Scholar : PubMed/NCBI

31 

Klatt NR, Cheu R, Birse K, Zevin AS, Perner M, Noël-Romas L, Grobler A, Westmacott G, Xie IY, Butler J, et al: Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women. Science. 356:938–945. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Wang KD, Xu DJ, Wang BY, Yan DH, Lv Z and Su JR: Inhibitory effect of vaginal Lactobacillus supernatants on cervical cancer cells. Probiotics Antimicrob Proteins. 10:236–242. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Motevaseli E, Shirzad M, Akrami SM, Mousavi AS, Mirsalehian A and Modarressi MH: Normal and tumour cervical cells respond differently to vaginal lactobacilli, independent of pH and lactate. J Med Microbiol. 62((Pt 7)): 1065–1072. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Sungur T, Aslim B, Karaaslan C and Aktas B: Impact of Exopolysaccharides (EPSs) of Lactobacillus gasseri strains isolated from human vagina on cervical tumor cells (HeLa). Anaerobe. 47:137–144. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Palma E, Recine N, Domenici L, Giorgini M, Pierangeli A and Panici PB: Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem: A promising solution against HPV-infection. BMC Infect Dis. 18:132018. View Article : Google Scholar : PubMed/NCBI

36 

Gosmann C, Anahtar MN, Handley SA, Farcasanu M, Abu-Ali G, Bowman BA, Padavattan N, Desai C, Droit L, Moodley A, et al: Lactobacillus-Deficient cervicovaginal bacterial communities are associated with increased HIV Acquisition in Young South African Women. Immunity. 46:29–37. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Kalia N, Singh J and Kaur M: Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: A critical review. Ann Clin Microbiol Antimicrob. 19:52020. View Article : Google Scholar : PubMed/NCBI

38 

Borgogna JC, Shardell MD, Santori EK, Nelson TM, Rath JM, Glover ED, Ravel J, Gravitt PE, Yeoman CJ and Brotman RM: The vaginal metabolome and microbiota of cervical HPV-positive and HPV-negative women: A cross-sectional analysis. BJOG. 127:182–192. 2020. View Article : Google Scholar : PubMed/NCBI

39 

Wei ZT, Chen HL, Wang CF, Yang GL, Han SM and Zhang SL: Depiction of vaginal microbiota in women with high-risk human papillomavirus infection. Front Public Health. 8:5872982021. View Article : Google Scholar : PubMed/NCBI

40 

Uttley L, Whiteman BL, Woods HB, Harnan S, Philips ST and Cree IA; Early Cancer Detection Consortium, : Building the evidence base of blood-based biomarkers for early detection of cancer: A rapid systematic mapping review. EBioMedicine. 10:164–173. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Papageorgis P, Ozturk S, Lambert AW, Neophytou CM, Tzatsos A, Wong CK, Thiagalingam S and Constantinou AI: Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis. Breast Cancer Res. 17:982015. View Article : Google Scholar : PubMed/NCBI

42 

Fang L, Lu W, Choi HH, Yeung SC, Tung JY, Hsiao CD, Fuentes-Mattei E, Menter D, Chen C, Wang L, et al: ERK2-Dependent phosphorylation of CSN6 is critical in colorectal cancer development. Cancer Cell. 28:183–197. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Laniewski P, Cui H, Roe DJ, Barnes D, Goulder A, Monk BJ, Greenspan DL, Chase DM and Herbst-Kralovetz MM: Features of the cervicovaginal microenvironment drive cancer biomarker signatures in patients across cervical carcinogenesis. Sci Rep. 9:73332019. View Article : Google Scholar : PubMed/NCBI

44 

De Seta F, Campisciano G, Zanotta N, Ricci G and Comar M: The vaginal community state types microbiome-immune network as key factor for bacterial vaginosis and aerobic vaginitis. Front Microbiol. 10:24512019. View Article : Google Scholar : PubMed/NCBI

45 

Recine N, Palma E, Domenici L, Giorgini M, Imperiale L, Sassu C, Musella A, Marchetti C, Muzii L and Benedetti Panici P: Restoring vaginal microbiota: Biological control of bacterial vaginosis. A prospective case-control study using Lactobacillus rhamnosus BMX 54 as adjuvant treatment against bacterial vaginosis. Arch Gynecol Obstet. 293:101–107. 2016. View Article : Google Scholar : PubMed/NCBI

46 

De Alberti D, Russo R, Terruzzi F, Nobile V and Ouwehand AC: Lactobacilli vaginal colonisation after oral consumption of Respecta((R)) complex: A randomised controlled pilot study. Arch Gynecol Obstet. 292:861–867. 2015. View Article : Google Scholar : PubMed/NCBI

47 

de Vrese M, Laue C, Papazova E, Petricevic L and Schrezenmeir J: Impact of oral administration of four Lactobacillus strains on Nugent score-systematic review and meta-analysis. Benef Microbes. 10:483–496. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Lev-Sagie A, Goldman-Wohl D, Cohen Y, Dori-Bachash M, Leshem A, Mor U, Strahilevitz J, Moses AE, Shapiro H, Yagel S and Elinav E: Vaginal microbiome transplantation in women with intractable bacterial vaginosis. Nat Med. 25:1500–1504. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Molijn A, Jenkins D, Chen W, Zhang X, Pirog E, Enqi W, Liu B, Schmidt J, Cui J, Qiao Y, et al: The complex relationship between human papillomavirus and cervical adenocarcinoma. Int J Cancer. 138:409–416. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Ho GY, Bierman R, Beardsley L, Chang CJ and Burk RD: Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med. 338:423–428. 1998. View Article : Google Scholar : PubMed/NCBI

51 

Holly EA: Cervical intraepithelial neoplasia, cervical cancer, and HPV. Annu Rev Public Health. 17:69–84. 1996. View Article : Google Scholar : PubMed/NCBI

52 

Norenhag J, Du J, Olovsson M, Verstraelen H, Engstrand L and Brusselaers N: The vaginal microbiota, human papillomavirus and cervical dysplasia: A systematic review and network meta-analysis. BJOG. 127:171–180. 2020. View Article : Google Scholar : PubMed/NCBI

53 

Lee JE, Lee S, Lee H, Song YM, Lee K, Han MJ, Sung J and Ko G: Association of the vaginal microbiota with human papillomavirus infection in a Korean twin cohort. PLoS One. 8:e635142013. View Article : Google Scholar : PubMed/NCBI

54 

Yang Q, Wang Y, Wei X, Zhu J, Wang X, Xie X and Lu W: The alterations of vaginal microbiome in HPV16 infection as identified by shotgun metagenomic sequencing. Front Cell Infect Microbiol. 10:2862020. View Article : Google Scholar : PubMed/NCBI

55 

Zhang Z, Li T, Zhang D, Zong X, Bai H, Bi H and Liu Z: Distinction between vaginal and cervical microbiota in high-risk human papilloma virus-infected women in China. BMC Microbiol. 21:902021. View Article : Google Scholar : PubMed/NCBI

56 

Egawa N and Doorbar J: The low-risk papillomaviruses. Virus Res. 231:119–127. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Vanska S, Luostarinen T, Lagheden C, Eklund C, Kleppe SN, Andrae B, Sparén P, Sundström K, Lehtinen M and Dillner J: Differing age-specific cervical cancer incidence between different types of human papillomavirus: Implications for predicting the impact of elimination programs. Am J Epidemiol. 190:506–514. 2021. View Article : Google Scholar : PubMed/NCBI

58 

Huang X, Li C, Li F, Zhao J, Wan X and Wang K: Cervicovaginal microbiota composition correlates with the acquisition of high-risk human papillomavirus types. Int J Cancer. 143:621–634. 2018. View Article : Google Scholar : PubMed/NCBI

59 

Brotman RM, Shardell MD, Gajer P, Tracy JK, Zenilman JM, Ravel J and Gravitt PE: Interplay between the temporal dynamics of the vaginal microbiota and human papillomavirus detection. J Infect Dis. 210:1723–1733. 2014. View Article : Google Scholar : PubMed/NCBI

60 

Di Paola M, Sani C, Clemente AM, Iossa A, Perissi E, Castronovo G, Tanturli M, Rivero D, Cozzolino F, Cavalieri D, et al: Characterization of cervico-vaginal microbiota in women developing persistent high-risk Human Papillomavirus infection. Sci Rep. 7:102002017. View Article : Google Scholar : PubMed/NCBI

61 

Mei L, Wang T, Chen Y, Wei D, Zhang Y, Cui T, Meng J, Zhang X, Liu Y, Ding L and Niu X: Dysbiosis of vaginal microbiota associated with persistent high-risk human papilloma virus infection. J Transl Med. 20:122022. View Article : Google Scholar : PubMed/NCBI

62 

Lv P, Zhao F, Xu X, Xu J, Wang Q and Zhao Z: Correlation between common lower genital tract microbes and high-risk human papillomavirus infection. Can J Infect Dis Med Microbiol. 2019:96781042019. View Article : Google Scholar : PubMed/NCBI

63 

Torcia MG: Interplay among vaginal microbiome, immune response and sexually transmitted viral infections. Int J Mol Sci. 20:2262019. View Article : Google Scholar

64 

Mitra A, MacIntyre DA, Lee YS, Smith A, Marchesi JR, Lehne B, Bhatia R, Lyons D, Paraskevaidis E, Li JV, et al: Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity. Sci Rep. 5:168652015. View Article : Google Scholar : PubMed/NCBI

65 

Mitra A, MacIntyre DA, Ntritsos G, Smith A, Tsilidis KK, Marchesi JR, Bennett PR, Moscicki AB and Kyrgiou M: The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions. Nat Commun. 11:19992020. View Article : Google Scholar : PubMed/NCBI

66 

Tango CN, Seo SS, Kwon M, Lee DO, Chang HK and Kim MK: Taxonomic and functional differences in cervical microbiome associated with cervical cancer development. Sci Rep. 10:97202020. View Article : Google Scholar : PubMed/NCBI

67 

Wu S, Ding X, Kong Y, Acharya S, Wu H, Huang C, Liang Y, Nong X and Chen H: The feature of cervical microbiota associated with the progression of cervical cancer among reproductive females. Gynecol Oncol. 163:348–357. 2021. View Article : Google Scholar : PubMed/NCBI

68 

Łaniewski P, Barnes D, Goulder A, Cui H, Roe DJ, Chase DM and Herbst-Kralovetz MM: Linking cervicovaginal immune signatures, HPV and microbiota composition in cervical carcinogenesis in non-Hispanic and Hispanic women. Sci Rep. 8:75932018. View Article : Google Scholar : PubMed/NCBI

69 

Mitra A, MacIntyre DA, Paraskevaidi M, Moscicki AB, Mahajan V, Smith A, Lee YS, Lyons D, Paraskevaidis E, Marchesi JR, et al: The vaginal microbiota and innate immunity after local excisional treatment for cervical intraepithelial neoplasia. Genome Med. 13:1762021. View Article : Google Scholar : PubMed/NCBI

70 

Zhang H, Lu J, Lu Y, Cai Q, Liu H and Xu C: Cervical microbiome is altered in cervical intraepithelial neoplasia after loop electrosurgical excision procedure in China. Sci Rep. 8:49232018. View Article : Google Scholar : PubMed/NCBI

71 

Parkin DM, Bray F, Ferlay J and Pisani P: Global Cancer Statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

72 

Audirac-Chalifour A, Torres-Poveda K, Bahena-Roman M, Tellez-Sosa J, Martinez-Barnetche J, Cortina-Ceballos B, López-Estrada G, Delgado-Romero K, Burguete-García AI, Cantú D, et al: Cervical microbiome and cytokine profile at various stages of cervical cancer: A pilot study. PLoS One. 11:e01532742016. View Article : Google Scholar : PubMed/NCBI

73 

Kang GU, Jung DR, Lee YH, Jeon SY, Han HS, Chong GO and Shin JH: Potential association between vaginal microbiota and cervical carcinogenesis in Korean Women: A cohort study. Microorganisms. 9:2942021. View Article : Google Scholar : PubMed/NCBI

74 

Carlson KJ, Skates SJ and Singer DE: Screening for ovarian cancer. Ann Intern Med. 121:124–132. 1994. View Article : Google Scholar : PubMed/NCBI

75 

Coburn SB, Bray F, Sherman ME and Trabert B: International patterns and trends in ovarian cancer incidence, overall and by histologic subtype. Int J Cancer. 140:2451–2460. 2017. View Article : Google Scholar : PubMed/NCBI

76 

Nené NR, Reisel D, Leimbach A, Franchi D, Jones A, Evans I, Knapp S, Ryan A, Ghazali S, Timms JF, et al: Association between the cervicovaginal microbiome, BRCA1 mutation status, and risk of ovarian cancer: A case-control study. Lancet Oncol. 20:1171–1182. 2019. View Article : Google Scholar : PubMed/NCBI

77 

Morikawa A, Kawabata A, Shirahige K, Akiyama T, Okamoto A and Sutani T: Altered cervicovaginal microbiota in premenopausal ovarian cancer patients. Gene. 811:1460832022. View Article : Google Scholar : PubMed/NCBI

78 

Ely LK and Truong M: The role of opportunistic bilateral salpingectomy vs tubal occlusion or ligation for ovarian cancer prophylaxis. J Minim Invasive Gynecol. 24:371–378. 2017. View Article : Google Scholar : PubMed/NCBI

79 

Cibula D, Widschwendter M, Majek O and Dusek L: Tubal ligation and the risk of ovarian cancer: Review and meta-analysis. Hum Reprod Update. 17:55–67. 2011. View Article : Google Scholar : PubMed/NCBI

80 

Yoon SH, Kim SN, Shim SH, Kang SB and Lee SJ: Bilateral salpingectomy can reduce the risk of ovarian cancer in the general population: A meta-analysis. Eur J Cancer. 55:38–46. 2016. View Article : Google Scholar : PubMed/NCBI

81 

Jacobson D, Moore K, Gunderson C, Rowland M, Austin R, Honap TP, Xu J and Warinner C: Shifts in gut and vaginal microbiomes are associated with cancer recurrence time in women with ovarian cancer. PeerJ. 9:e115742021. View Article : Google Scholar : PubMed/NCBI

82 

Wong-Rolle A, Wei HK, Zhao C and Jin C: Unexpected guests in the tumor microenvironment: Microbiome in cancer. Protein Cell. 12:426–435. 2021. View Article : Google Scholar : PubMed/NCBI

83 

Amant F, Moerman P, Neven P, Timmerman D, Van Limbergen E and Vergote I: Endometrial cancer. Lancet Oncol. 366:491–505. 2005. View Article : Google Scholar : PubMed/NCBI

84 

Kim S, Seo H, Rahim MA, Lee S, Kim YS and Song HY: Changes in the microbiome of vaginal fluid after menopause in Korean Women. J Microbiol Biotechnol. 31:1490–1500. 2021. View Article : Google Scholar : PubMed/NCBI

85 

Shardell M, Gravitt PE, Burke AE, Ravel J and Brotman RM: Association of vaginal microbiota with signs and symptoms of the genitourinary syndrome of menopause across reproductive stages. J Gerontol A Biol Sci Med Sci. 76:1542–1550. 2021. View Article : Google Scholar : PubMed/NCBI

86 

Brotman RM, Shardell MD, Gajer P, Fadrosh D, Chang K, Silver MI, Viscidi RP, Burke AE, Ravel J and Gravitt PE: Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy. Menopause. 21:450–458. 2014. View Article : Google Scholar : PubMed/NCBI

87 

Suarez SS and Pacey AA: Sperm transport in the female reproductive tract. Hum Reprod Update. 12:23–37. 2006. View Article : Google Scholar : PubMed/NCBI

88 

Hansen LK, Becher N, Bastholm S, Glavind J, Ramsing M, Kim CJ, Romero R, Jensen JS and Uldbjerg N: The cervical mucus plug inhibits, but does not block, the passage of ascending bacteria from the vagina during pregnancy. Acta Obstet Gynecol Scand. 93:102–108. 2014. View Article : Google Scholar : PubMed/NCBI

89 

Zervomanolakis I, Ott HW, Hadziomerovic D, Mattle V, Seeber BE, Virgolini I, Heute D, Kissler S, Leyendecker G and Wildt L: Physiology of upward transport in the human female genital tract. Ann N Y Acad Sci. 1101:1–20. 2007. View Article : Google Scholar : PubMed/NCBI

90 

Garcia-Grau I, Simon C and Moreno I: Uterine microbiome-low biomass and high expectationsdagger. Biol Reprod. 101:1102–1114. 2019. View Article : Google Scholar : PubMed/NCBI

91 

Mitchell CM, Haick A, Nkwopara E, Garcia R, Rendi M, Agnew K, Fredricks DN and Eschenbach D: Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women. Am J Obstet Gynecol. 212:611e1–9. 2015. View Article : Google Scholar : PubMed/NCBI

92 

Chen C, Song X, Wei W, Zhong H, Dai J, Lan Z, Li F, Yu X, Feng Q, Wang Z, et al: The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nat Commun. 8:8752017. View Article : Google Scholar : PubMed/NCBI

93 

Furukawa T, Jisaki F, Sakamuro D, Takegami T and Murayama T: Detection of human cytomegalovirus genome in uterus tissue. Arch Viro. 135:265–277. 1994. View Article : Google Scholar : PubMed/NCBI

94 

Tobiasch E, Rabreau M, Geletneky K, Laruë-Charlus S, Severin F, Becker N and Schlehofer JR: Detection of adeno-associated virus DNA in human genital tissue and in material from spontaneous abortion. J Med Viro. 44:215–222. 1994. View Article : Google Scholar : PubMed/NCBI

95 

Komaroff AL, Rizzo R and Ecker JL: Human Herpesviruses 6A and 6B in reproductive diseases. Front Immunol. 12:6489452021. View Article : Google Scholar : PubMed/NCBI

96 

Callan T, Woodcock S and Huston WM: Ascension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection. PLoS Comput Biol. 17:e10093652021. View Article : Google Scholar : PubMed/NCBI

97 

Paavonen J, Aine R, Teisala K, Heinonen PK, Punnonen R, Lehtinen M, Miettinen A and Grönroos P: Chlamydial endometritis. J Clin Pathol. 38:726–732. 1985. View Article : Google Scholar : PubMed/NCBI

98 

Moreno I, Cicinelli E, Garcia-Grau I, Gonzalez-Monfort M, Bau D, Vilella F, De Ziegler D, Resta L, Valbuena D and Simon C: The diagnosis of chronic endometritis in infertile asymptomatic women: A comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology. Am J Obstet Gynecol. 218:602e1–e16. 2018. View Article : Google Scholar : PubMed/NCBI

99 

Smith JR, Wells C, Jolly M, Shah P, Savage M, Reginald P and Kitchen VS: Is endometrial infection with Candida albicans a cause of recurrent vaginal thrush? Genitourin Med. 69:295–296. 1993.PubMed/NCBI

100 

Walther-António MR, Chen J, Multinu F, Hokenstad A, Distad TJ, Cheek EH, Keeney GL, Creedon DJ, Nelson H, Mariani A and Chia N: Potential contribution of the uterine microbiome in the development of endometrial cancer. Genome Med. 8:1222016. View Article : Google Scholar : PubMed/NCBI

101 

Walsh DM, Hokenstad AN, Chen J, Sung J, Jenkins GD, Chia N, Nelson H, Mariani A and Walther-António MRS: Postmenopause as a key factor in the composition of the endometrial cancer microbiome (ECbiome). Sci Rep. 9:192132019. View Article : Google Scholar : PubMed/NCBI

102 

Milde-Langosch K, Becker G and Löning T: Human papillomavirus and c-myc/c-erbB2 in uterine and vulvar lesions. Virchows Arch A Pathol Anat Histopathol. 419:479–485. 1991. View Article : Google Scholar : PubMed/NCBI

103 

Yang HJ, Liu VW, Tsang PC, Yip AM, Ng TY, Cheung AN and Ngan HY: Comparison of human papillomavirus DNA levels in gynecological cancers: Implication for cancer development. Tumour Biol. 24:310–316. 2003. View Article : Google Scholar : PubMed/NCBI

104 

Olesen TB, Svahn MF, Faber MT, Duun-Henriksen AK, Junge J, Norrild B and Kjaer SK: Prevalence of human papillomavirus in endometrial cancer: A systematic review and meta-analysis. Gynecol Oncol. 134:206–215. 2014. View Article : Google Scholar : PubMed/NCBI

105 

Abu-Lubad MA, Jarajreh DA, Helaly GF, Alzoubi HM, Haddadin WJ, Dabobash MD, Albataineh EM, Aqel AA and Alnawaiseh NA: Human papillomavirus as an independent risk factor of invasive cervical and endometrial carcinomas in Jordan. J Infect Public Health. 13:613–618. 2020. View Article : Google Scholar : PubMed/NCBI

106 

Jiang XF, Tang QL, Zou Y, Xu L, Zeng H, Chi C, Jiang JR and Zhang BZ: Does HBV infection increase risk of endometrial carcinoma? Asian Pac J Cancer Prev. 15:713–716. 2014. View Article : Google Scholar : PubMed/NCBI

107 

Benharroch D, Klinkovich I, Piura B, Shaco-Levy R and Gopas J: Evidence of measles virus antigens and RNA in endometrial cancer. Eur J Obstet Gynecol Reprod Biol. 147:206–209. 2009. View Article : Google Scholar : PubMed/NCBI

108 

Tsementzi D, Pena-Gonzalez A, Bai J, Hu YJ, Patel P, Shelton J, Dolan M, Arluck J, Khanna N, Conrad L, et al: Comparison of vaginal microbiota in gynecologic cancer patients pre- and post-radiation therapy and healthy women. Cancer Med. 9:3714–3724. 2020. View Article : Google Scholar : PubMed/NCBI

109 

Nejman D, Livyatan I, Fuks G, Gavert N, Zwang Y, Geller LT, Rotter-Maskowitz A, Weiser R, Mallel G, Gigi E, et al: The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science. 368:973–980. 2020. View Article : Google Scholar : PubMed/NCBI

110 

Tzeng A, Sangwan N, Jia M, Liu CC, Keslar KS, Downs-Kelly E, Fairchild RL, Al-Hilli Z, Grobmyer SR and Eng C: Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer. Genome Med. 13:602021. View Article : Google Scholar : PubMed/NCBI

111 

Ma J, Gnanasekar A, Lee A, Li WT, Haas M, Wang-Rodriguez J, Chang EY, Rajasekaran M and Ongkeko WM: Influence of intratumor microbiome on clinical outcome and immune processes in prostate cancer. Cancers (Basel). 12:25242020. View Article : Google Scholar : PubMed/NCBI

112 

Pushalkar S, Hundeyin M, Daley D, Zambirinis CP, Kurz E, Mishra A, Mohan N, Aykut B, Usyk M, Torres LE, et al: The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression. Cancer Discov. 8:403–416. 2018. View Article : Google Scholar : PubMed/NCBI

113 

Gnanasekar A, Castaneda G, Iyangar A, Magesh S, Perez D, Chakladar J, Li WT, Bouvet M, Chang EY and Ongkeko WM: The intratumor microbiome predicts prognosis across gender and subtypes in papillary thyroid carcinoma. Comput Struct Biotechnol J. 19:1986–1997. 2021. View Article : Google Scholar : PubMed/NCBI

114 

Kostic AD, Gevers D, Pedamallu CS, Michaud M, Duke F, Earl AM, Ojesina AI, Jung J, Bass AJ, Tabernero J, et al: Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 22:292–298. 2012. View Article : Google Scholar : PubMed/NCBI

115 

Del Castillo E, Meier R, Chung M, Koestler DC, Chen T, Paster BJ, Charpentier KP, Kelsey KT, Izard J and Michaud DS: The microbiomes of pancreatic and duodenum tissue overlap and are highly subject specific but differ between pancreatic cancer and noncancer subjects. Cancer Epidemiol Biomarkers Prev. 28:370–383. 2019. View Article : Google Scholar : PubMed/NCBI

116 

Banerjee S, Tian T, Wei Z, Shih N, Feldman MD, Alwine JC, Coukos G and Robertson ES: The ovarian cancer oncobiome. Oncotarget. 8:36225–36245. 2017. View Article : Google Scholar : PubMed/NCBI

117 

Zhang PP, Zhou L, Cao JS, Li YP, Zeng Z, Sun N, Shen L, Zhu HY, Ruan Y, Zha WT, et al: Possible epithelial ovarian cancer association with HPV18 or HPV33 Infection. Asian Pac J Cancer Prev. 17:2959–2964. 2016.PubMed/NCBI

118 

Hassan ZK, Hafez MM, Kamel MM and Zekri AR: Human papillomavirus genotypes and methylation of CADM1, PAX1, MAL and ADCYAP1 genes in epithelial ovarian cancer patients. Asian Pac J Cancer Prev. 18:169–176. 2017.PubMed/NCBI

119 

Shanmughapriya S, Senthilkumar G, Vinodhini K, Das BC, Vasanthi N and Natarajaseenivasan K: Viral and bacterial aetiologies of epithelial ovarian cancer. Eur J Clin Microbiol Infect Dis. 31:2311–2317. 2012. View Article : Google Scholar : PubMed/NCBI

120 

Jonsson S, Oda H, Lundin E, Olsson J and Idahl A: Chlamydia trachomatis, Chlamydial heat shock protein 60 and anti-chlamydial antibodies in women with epithelial ovarian tumors. Transl Oncol. 11:546–551. 2018. View Article : Google Scholar : PubMed/NCBI

121 

Idahl A, Lundin E, Elgh F, Jurstrand M, Moller JK, Marklund I, Lindgren P and Ottander U: Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, human papillomavirus, and polyomavirus are not detectable in human tissue with epithelial ovarian cancer, borderline tumor, or benign conditions. Am J Obstet Gynecol. 202:71e1–6. 2010. View Article : Google Scholar : PubMed/NCBI

122 

Zhou B, Sun C, Huang J, Xia M, Guo E, Li N, Lu H, Shan W, Wu Y, Li Y, et al: The biodiversity composition of microbiome in ovarian carcinoma patients. Sci Rep. 9:16912019. View Article : Google Scholar : PubMed/NCBI

123 

Wang Q, Zhao L, Han L, Fu G, Tuo X, Ma S, Li Q, Wang Y, Liang D, Tang M, et al: The differential distribution of bacteria between cancerous and noncancerous ovarian tissues in situ. J Ovarian Res. 13:82020. View Article : Google Scholar : PubMed/NCBI

124 

Brewster WR, Burkett WC, Ko EM, Bae-Jump V, Nicole McCoy A and Keku TO: An evaluation of the microbiota of the upper reproductive tract of women with and without epithelial ovarian cancer. Gynecol Oncol Rep. 42:1010172022. View Article : Google Scholar : PubMed/NCBI

125 

Moreno I, Codoñer FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazán J, Alonso R, Alamá P, Remohí J, Pellicer A, et al: Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol. 216:684–703. 2016. View Article : Google Scholar : PubMed/NCBI

126 

Kyono K, Hashimoto T, Nagai Y and Sakuraba Y: Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single-center pilot study. Reprod Med Biol. 17:297–306. 2018. View Article : Google Scholar : PubMed/NCBI

127 

Wang L, Yang J, Su H, Shi L, Chen B and Zhang S: Endometrial microbiota from endometrial cancer and paired pericancer tissues in postmenopausal women: Differences and clinical relevance. Menopause. 29:1168–1175. 2022. View Article : Google Scholar : PubMed/NCBI

128 

Lu W, He F, Lin Z, Liu S, Tang L, Huang Y and Hu Z: Dysbiosis of the endometrial microbiota and its association with inflammatory cytokines in endometrial cancer. Int J Cancer. 148:1708–1716. 2021. View Article : Google Scholar : PubMed/NCBI

129 

Caselli E, Soffritti I, D'Accolti M, Piva I, Greco P and Bonaccorsi G: Atopobium vaginae and porphyromonas somerae induce proinflammatory cytokines expression in endometrial cells: A possible implication for endometrial cancer? Cancer Manag Res. 11:8571–8575. 2019. View Article : Google Scholar : PubMed/NCBI

130 

Deligdisch L, Marin T, Lee AT, Etkind P, Holland JF, Melana S and Pogo BG: Human mammary tumor virus (HMTV) in endometrial carcinoma. Int J Gynecol Cancer. 23:1423–1428. 2013. View Article : Google Scholar : PubMed/NCBI

131 

Li C, Gu Y, He Q, Huang J, Song Y, Wan X and Li Y: Integrated analysis of microbiome and transcriptome data reveals the interplay between commensal bacteria and fibrin degradation in endometrial cancer. Front Cell Infect Microbiol. 11:7485582021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Han M, Wang N, Han W, Ban M, Sun T and Xu J: Vaginal and tumor microbiomes in gynecological cancer (Review). Oncol Lett 25: 153, 2023.
APA
Han, M., Wang, N., Han, W., Ban, M., Sun, T., & Xu, J. (2023). Vaginal and tumor microbiomes in gynecological cancer (Review). Oncology Letters, 25, 153. https://doi.org/10.3892/ol.2023.13739
MLA
Han, M., Wang, N., Han, W., Ban, M., Sun, T., Xu, J."Vaginal and tumor microbiomes in gynecological cancer (Review)". Oncology Letters 25.4 (2023): 153.
Chicago
Han, M., Wang, N., Han, W., Ban, M., Sun, T., Xu, J."Vaginal and tumor microbiomes in gynecological cancer (Review)". Oncology Letters 25, no. 4 (2023): 153. https://doi.org/10.3892/ol.2023.13739
Copy and paste a formatted citation
x
Spandidos Publications style
Han M, Wang N, Han W, Ban M, Sun T and Xu J: Vaginal and tumor microbiomes in gynecological cancer (Review). Oncol Lett 25: 153, 2023.
APA
Han, M., Wang, N., Han, W., Ban, M., Sun, T., & Xu, J. (2023). Vaginal and tumor microbiomes in gynecological cancer (Review). Oncology Letters, 25, 153. https://doi.org/10.3892/ol.2023.13739
MLA
Han, M., Wang, N., Han, W., Ban, M., Sun, T., Xu, J."Vaginal and tumor microbiomes in gynecological cancer (Review)". Oncology Letters 25.4 (2023): 153.
Chicago
Han, M., Wang, N., Han, W., Ban, M., Sun, T., Xu, J."Vaginal and tumor microbiomes in gynecological cancer (Review)". Oncology Letters 25, no. 4 (2023): 153. https://doi.org/10.3892/ol.2023.13739
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team