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Article Open Access

Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis

  • Authors:
    • Xuan Meng
    • Runfu Cao
    • Xiaoqiang Liu
    • Bin Fu
    • Lianmin Luo
    • Meichun Jiang
    • Kaihong Wang
    • Yifu Liu
    • Qiqi Zhu
    • Chao Yang
    • Libo Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Meng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 172
    |
    Published online on: March 14, 2023
       https://doi.org/10.3892/ol.2023.13758
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Abstract

Bladder urothelial carcinoma (BLCA) accounts for 95% of all cases of bladder cancer worldwide, with a high incidence and poor prognosis. Chromobox (CBX) proteins play a key role in numerous malignant tumors; however, the role of CBX in BLCA remains unknown. Herein, the present study found that, compared with in normal bladder tissues, the expression levels of CBX1, CBX2, CBX3, CBX4 and CBX8 were markedly increased in BLCA tissues, as determined by Tumor Immune Estimation Resource, UALCAN and ONCOMINE analyses, whereas CBX6 and CBX7 were decreased in BLCA tissues. Furthermore, evident hypomethylation in the promoters of CBX1, and CBX2, as well as significant hypermethylation in the promoters of CBX5, CBX6 and CBX7, was detected in BLCA tissues compared with in normal bladder tissues. The expression of CBX1, CBX2 and CBX7 was involved in the prognosis of patients with BLCA. Low CBX7 expression was strongly associated with poorer overall survival in patients with BLCA, whereas high CBX1 and CBX2 expression was associated with poorer progression‑free survival. Besides, significant associations were determined between the expression of CBXs and immune cell infiltration, including dendritic cells, neutrophils, macrophages, CD4+ T cells, CD8+ T cells and B cells. Overall, the current results may provide a rationale for developing new targets and prognostic markers for BLCA therapy.
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View References

1 

Richters A, Aben KKH and Kiemeney LALM: The global burden of urinary bladder cancer: An update. World J Urol. 38:1895–1904. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Lenis AT, Lec PM, Chamie K and Mshs MD: Bladder cancer: A review. JAMA. 324:1980–1991. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Patel VG, Oh WK and Galsky MD: Treatment of muscle-invasive and advanced bladder cancer in 2020. CA Cancer J Clin. 70:404–423. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Seidl C: Targets for therapy of bladder cancer. Semin Nucl Med. 50:162–170. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Kobatake K, Ikeda KI, Nakata Y, Yamasaki N, Ueda T, Kanai A, Sentani K, Sera Y, Hayashi T, Koizumi M, et al: Kdm6a deficiency activates inflammatory pathways, promotes M2 macrophage polarization, and causes bladder cancer in cooperation with p53 dysfunction. Clin Cancer Res. 26:2065–2079. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Tao L, Mu X, Chen H, Jin D, Zhang R, Zhao Y, Fan J, Cao M and Zhou Z: FTO modifies the m6A level of MALAT and promotes bladder cancer progression. Clin Transl Med. 11:e3102021. View Article : Google Scholar : PubMed/NCBI

7 

Zhou Z, Zhang Z, Chen H, Bao W, Kuang X, Zhou P, Gao Z, Li D, Xie X, Yang C, et al: SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3 signalling. Br J Cancer. 127:211–222. 2022. View Article : Google Scholar : PubMed/NCBI

8 

Gil J and O'Loghlen A: PRC1 complex diversity: Where is it taking us? Trends Cell Biol. 24:632–641. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Wotton D and Merrill JC: Pc2 and SUMOylation. Biochem Soc Trans. 35:1401–1404. 2007. View Article : Google Scholar : PubMed/NCBI

10 

van Wijnen AJ, Bagheri L, Badreldin AA, Larson AN, Dudakovic A, Thaler R, Paradise CR and Wu Z: Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development. Bone. 143:1156592021. View Article : Google Scholar : PubMed/NCBI

11 

Zhou H, Xiong Y, Liu Z, Hou S and Zhou T: Expression and prognostic significance of CBX2 in colorectal cancer: Database mining for CBX family members in malignancies and vitro analyses. Cancer Cell Int. 21:4022021. View Article : Google Scholar : PubMed/NCBI

12 

Li J, Xu Y, Long XD, Wang W, Jiao HK, Mei Z, Yin QQ, Ma LN, Zhou AW, Wang LS, et al: Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity. Cancer Cell. 25:118–131. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Huang Z, Yan Y, Zhu Z, Liu J, He X, Dalangood S, Li M, Tan M, Cai J, Tang P, et al: CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling. Cell Death Dis. 12:5372021. View Article : Google Scholar : PubMed/NCBI

14 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Chandrashekar DS, Karthikeyan SK, Korla PK, Patel H, Shovon AR, Athar M, Netto GJ, Qin ZS, Kumar S, Manne U, et al: UALCAN: An update to the integrated cancer data analysis platform. Neoplasia. 25:18–27. 2022. View Article : Google Scholar : PubMed/NCBI

16 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Asplund A, Edqvist PHD, Schwenk JM and Pontén F: Antibodies for profiling the human proteome-the human protein atlas as a resource for cancer research. Proteomics. 12:2067–2077. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Survplot. URL. http://www.cbs.dtu.dk/~eklund/survplot2021 07 07

20 

BeeSwarm. URL. http://www.cbs.dtu.dk/~eklund/beeswarm/2021 07 07

21 

Therneau TM and Grambsch PM: Modeling survival data: Extending the Cox model. New York, NY: Springer-Verlag; 2000, View Article : Google Scholar

22 

Wickham H: ggplot2. Elegant graphics for data analysis. New York: Springer-Verlag; 2009

23 

Wu W, Jia G, Chen L, Liu H and Xia S: Analysis of the expression and prognostic value of annexin family proteins in bladder cancer. Front Genet. 12:7316252021. View Article : Google Scholar : PubMed/NCBI

24 

Lánczky A and Győrffy B: Web-based survival analysis tool tailored for medical research (KMplot): Development and implementation. J Med Internet Res. 23:e276332021. View Article : Google Scholar : PubMed/NCBI

25 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45((W1)): W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C and Chanda SK: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 10:15232019. View Article : Google Scholar : PubMed/NCBI

27 

Chatr-Aryamontri A, Oughtred R, Boucher L, Rust J, Chang C, Kolas NK, O'Donnell L, Oster S, Theesfeld C, Sellam A, et al: The BioGRID interaction database: 2017 Update. Nucleic Acids Res. 45(D1): D369–D379. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Bader GD and Hogue CWV: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

29 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

31 

Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, Li B and Liu XS: TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 77:e108–e110. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Thy S, Hommel A, Meneceur S, Bartkowiak AL, Schulz WA, Niegisch G and Hoffmann MJ: Epigenetic treatment of urothelial carcinoma cells sensitizes to cisplatin chemotherapy and PARP inhibitor treatment. Cancers (Basel). 13:13762021. View Article : Google Scholar : PubMed/NCBI

33 

Harsanyi S, Novakova ZV, Bevizova K, Danisovic L and Ziaran S: Biomarkers of bladder cancer: Cell-free DNA, epigenetic modifications and non-coding RNAs. Int J Mol Sci. 23:132062022. View Article : Google Scholar : PubMed/NCBI

34 

He M, Yue L, Wang H, Yu F, Yu M, Ni P, Zhang K, Chen S, Duan G and Zhang R: Evaluation of the prognostic value of CBXs in gastric cancer patients. Sci Rep. 11:123752021. View Article : Google Scholar : PubMed/NCBI

35 

Shiota M, Song Y, Yokomizo A, Tada Y, Kuroiwa K, Eto M, Oda Y, Inokuchi J, Uchiumi T, Fujimoto N, et al: Human heterochromatin protein 1 isoform HP1beta enhances androgen receptor activity and is implicated in prostate cancer growth. Endocr Relat Cancer. 17:455–467. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Yang YF, Pan YH, Tian QH, Wu DC and Su SG: CBX1 indicates poor outcomes and exerts oncogenic activity in hepatocellular carcinoma. Transl Oncol. 11:1110–1118. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Hu K, Yao L, Xu Z, Yan Y and Li J: Prognostic value and therapeutic potential of CBX family members in ovarian cancer. Front Cell Dev Biol. 10:8323542022. View Article : Google Scholar : PubMed/NCBI

38 

Hu A, Zhang Y, Zhao X, Li J and Ying Y: CBX1 is a direct target of miR-205-5p and contributes to the progression of pituitary tumor. Pharmazie. 74:154–156. 2019.PubMed/NCBI

39 

Zhu Y, Pu Z, Li Z, Lin Y, Li N and Peng F: Comprehensive analysis of the expression and prognosis value of chromobox family members in clear cell renal cell carcinoma. Front Oncol. 11:7005282021. View Article : Google Scholar : PubMed/NCBI

40 

Clermont PL, Sun L, Crea F, Thu KL, Zhang A, Parolia A, Lam WL and Helgason CD: Genotranscriptomic meta-analysis of the polycomb gene CBX2 in human cancers: Initial evidence of an oncogenic role. Br J Cancer. 111:1663–1672. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Hu FF, Chen H, Duan Y, Lan B, Liu CJ, Hu H, Dong X, Zhang Q, Cheng YM, Liu M, et al: CBX2 and EZH2 cooperatively promote the growth and metastasis of lung adenocarcinoma. Mol Ther Nucleic Acids. 27:670–684. 2022. View Article : Google Scholar : PubMed/NCBI

42 

Zheng S, Lv P, Su J, Miao K, Xu H and Li M: Overexpression of CBX2 in breast cancer promotes tumor progression through the PI3K/AKT signaling pathway. Am J Transl Res. 11:1668–1682. 2019.PubMed/NCBI

43 

Huo W, Tan D and Chen Q: CASC9 facilitates cell proliferation in bladder cancer by regulating CBX2 expression. Nephron. 144:388–399. 2020. View Article : Google Scholar : PubMed/NCBI

44 

Chen LY, Cheng CS, Qu C, Wang P, Chen H, Meng ZQ and Chen Z: Overexpression of CBX3 in pancreatic adenocarcinoma promotes cell cycle transition-associated tumor progression. Int J Mol Sci. 19:17682018. View Article : Google Scholar : PubMed/NCBI

45 

Lin H, Lian J, Xia L, Guan G and You J: CBX3 promotes gastric cancer progression and affects factors related to immunotherapeutic responses. Cancer Manag Res. 12:10113–10125. 2020. View Article : Google Scholar : PubMed/NCBI

46 

Alam H, Li N, Dhar SS, Wu SJ, Lv J, Chen K, Flores ER, Baseler L and Lee MG: HP1γ promotes lung adenocarcinoma by downregulating the transcription-repressive regulators NCOR2 and ZBTB7A. Cancer Res. 78:3834–3848. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Jin X, Zhang B, Zhang H and Yu H: Smoking-associated upregulation of CBX3 suppresses ARHGAP24 expression to activate Rac1 signaling and promote tumor progression in lung adenocarcinoma. Oncogene. 41:538–549. 2022. View Article : Google Scholar : PubMed/NCBI

48 

Huang Y, Lin Y, Song X and Wu D: LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma. Carcinogenesis. 42:733–741. 2021. View Article : Google Scholar : PubMed/NCBI

49 

Cai H, Yu Y, Ni X, Li C, Hu Y, Wang J, Chen F, Xi S and Chen Z: LncRNA LINC00998 inhibits the malignant glioma phenotype via the CBX3-mediated c-Met/Akt/mTOR axis. Cell Death Dis. 11:10322020. View Article : Google Scholar : PubMed/NCBI

50 

Wang X, Qin G, Liang X, Wang W, Wang Z, Liao D, Zhong L, Zhang R, Zeng YX, Wu Y and Kang T: Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma. Nat Commun. 11:11412020. View Article : Google Scholar : PubMed/NCBI

51 

Hu C, Zhang Q, Tang Q, Zhou H, Liu W, Huang J, Liu Y, Wang Q, Zhang J, Zhou M, et al: CBX4 promotes the proliferation and metastasis via regulating BMI-1 in lung cancer. J Cell Mol Med. 24:618–631. 2020. View Article : Google Scholar : PubMed/NCBI

52 

Zeng JS, Zhang ZD, Pei L, Bai ZZ, Yang Y, Yang H and Tian QH: CBX4 exhibits oncogenic activities in breast cancer via Notch1 signaling. Int J Biochem Cell Biol. 95:1–8. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Wang X, Li L, Wu Y, Zhang R, Zhang M, Liao D, Wang G, Qin G, Xu RH and Kang T: CBX4 suppresses metastasis via recruitment of HDAC3 to the Runx2 promoter in colorectal carcinoma. Cancer Res. 76:7277–7289. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Wu C and Zhang J: Long non-conding RNA LOXL1-AS1 sponges miR-589-5p to up-regulate CBX5 expression in renal cell carcinoma. Biosci Rep. 40:BSR202002122020. View Article : Google Scholar : PubMed/NCBI

55 

Sun Y, Wang X and Bu X: LINC02381 contributes to cell proliferation and hinders cell apoptosis in glioma by transcriptionally enhancing CBX5. Brain Res Bull. 176:121–129. 2021. View Article : Google Scholar : PubMed/NCBI

56 

Zheng H, Jiang WH, Tian T, Tan HS, Chen Y, Qiao GL, Han J, Huang SY, Yang Y, Li S, et al: CBX6 overexpression contributes to tumor progression and is predictive of a poor prognosis in hepatocellular carcinoma. Oncotarget. 8:18872–18884. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Deng H, Guan X, Gong L, Zeng J, Zhang H, Chen MY and Li G: CBX6 is negatively regulated by EZH2 and plays a potential tumor suppressor role in breast cancer. Sci Rep. 9:1972019. View Article : Google Scholar : PubMed/NCBI

58 

Sakai K, Nishiuchi T, Tange S, Suzuki Y, Yano S, Terashima M, Suzuki T and Matsumoto K: Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion. Sci Rep. 10:166782020. View Article : Google Scholar : PubMed/NCBI

59 

Pallante P, Forzati F, Federico A, Arra C and Fusco A: Polycomb protein family member CBX7 plays a critical role in cancer progression. Am J Cancer Res. 5:1594–1601. 2015.PubMed/NCBI

60 

Li J, Ouyang T, Li M, Hong T, Alriashy M, Meng W and Zhang N: CBX7 is dualistic in cancer progression based on its function and molecular interactions. Front Genet. 12:7407942021. View Article : Google Scholar : PubMed/NCBI

61 

Huang Z, Liu J, Yang J, Yan Y, Yang C, He X, Huang R, Tan M, Wu D, Yan J and Shen B: PDE4B induces epithelial-to-mesenchymal transition in bladder cancer cells and is transcriptionally suppressed by CBX7. Front Cell Dev Biol. 9:7830502021. View Article : Google Scholar : PubMed/NCBI

62 

Li R, Yan Q, Tian P, Wang Y, Wang J, Tao N, Ning L, Lin X, Ding L, Liu J and Ma C: CBX7 inhibits cell growth and motility and induces apoptosis in cervical cancer cells. Mol Ther Oncolytics. 15:108–116. 2019. View Article : Google Scholar : PubMed/NCBI

63 

Pallante P, Terracciano L, Carafa V, Schneider S, Zlobec I, Lugli A, Bianco M, Ferraro A, Sacchetti S, Troncone G, et al: The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients. Eur J Cancer. 46:2304–2313. 2010. View Article : Google Scholar : PubMed/NCBI

64 

Gong L, Tang Y, Jiang L, Tang W and Luo S: Regulation of circGOLPH3 and its binding protein CBX7 on the proliferation and apoptosis of prostate cancer cells. Biosci Rep. 40:BSR202009362020. View Article : Google Scholar : PubMed/NCBI

65 

Shinjo K, Yamashita Y, Yamamoto E, Akatsuka S, Uno N, Kamiya A, Niimi K, Sakaguchi Y, Nagasaka T, Takahashi T, et al: Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. Int J Cancer. 135:308–318. 2014. View Article : Google Scholar : PubMed/NCBI

66 

Zhang CZ, Chen SL, Wang CH, He YF, Yang X, Xie D and Yun JP: CBX8 exhibits oncogenic activity via AKT/β-catenin activation in hepatocellular carcinoma. Cancer Res. 78:51–63. 2018. View Article : Google Scholar : PubMed/NCBI

67 

Zeng F, Luo L, Li D, Guo J and Guo M: KPNA2 interaction with CBX8 contributes to the development and progression of bladder cancer by mediating the PRDM1/c-FOS pathway. J Transl Med. 19:1122021. View Article : Google Scholar : PubMed/NCBI

68 

Baci D, Bosi A, Gallazzi M, Rizzi M, Noonan DM, Poggi A, Bruno A and Mortara L: The Ovarian cancer tumor immune microenvironment (TIME) as target for therapy: A focus on innate immunity cells as therapeutic effectors. Int J Mol Sci. 21:31252020. View Article : Google Scholar : PubMed/NCBI

69 

Rohaan MW, van den Berg JH, Kvistborg P and Haanen JBAG: Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: A viable treatment option. J Immunother Cancer. 6:1022018. View Article : Google Scholar : PubMed/NCBI

70 

Okła K, Farber DL and Zou W: Tissue-resident memory T cells in tumor immunity and immunotherapy. J Exp Med. 218:e202016052021. View Article : Google Scholar : PubMed/NCBI

71 

Li B, Severson E, Pignon JC, Zhao H, Li T, Novak J, Jiang P, Shen H, Aster JC, Rodig S, et al: Comprehensive analyses of tumor immunity: Implications for cancer immunotherapy. Genome Biol. 17:1742016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Meng X, Cao R, Liu X, Fu B, Luo L, Jiang M, Wang K, Liu Y, Zhu Q, Yang C, Yang C, et al: Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis. Oncol Lett 25: 172, 2023.
APA
Meng, X., Cao, R., Liu, X., Fu, B., Luo, L., Jiang, M. ... Zhou, L. (2023). Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis. Oncology Letters, 25, 172. https://doi.org/10.3892/ol.2023.13758
MLA
Meng, X., Cao, R., Liu, X., Fu, B., Luo, L., Jiang, M., Wang, K., Liu, Y., Zhu, Q., Yang, C., Zhou, L."Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis". Oncology Letters 25.4 (2023): 172.
Chicago
Meng, X., Cao, R., Liu, X., Fu, B., Luo, L., Jiang, M., Wang, K., Liu, Y., Zhu, Q., Yang, C., Zhou, L."Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis". Oncology Letters 25, no. 4 (2023): 172. https://doi.org/10.3892/ol.2023.13758
Copy and paste a formatted citation
x
Spandidos Publications style
Meng X, Cao R, Liu X, Fu B, Luo L, Jiang M, Wang K, Liu Y, Zhu Q, Yang C, Yang C, et al: Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis. Oncol Lett 25: 172, 2023.
APA
Meng, X., Cao, R., Liu, X., Fu, B., Luo, L., Jiang, M. ... Zhou, L. (2023). Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis. Oncology Letters, 25, 172. https://doi.org/10.3892/ol.2023.13758
MLA
Meng, X., Cao, R., Liu, X., Fu, B., Luo, L., Jiang, M., Wang, K., Liu, Y., Zhu, Q., Yang, C., Zhou, L."Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis". Oncology Letters 25.4 (2023): 172.
Chicago
Meng, X., Cao, R., Liu, X., Fu, B., Luo, L., Jiang, M., Wang, K., Liu, Y., Zhu, Q., Yang, C., Zhou, L."Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis". Oncology Letters 25, no. 4 (2023): 172. https://doi.org/10.3892/ol.2023.13758
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