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Histologic re‑evaluation of a population‑based series of renal cell carcinomas from The Netherlands Cohort Study according to the 2022 ISUP/WHO classification

  • Authors:
    • Selena Odeh
    • Iryna V. Samarska
    • Andres Matoso
    • Jeroen A.A. Van De Pol
    • Marcella M.L.L. Baldewijns
    • Christina A. Hulsbergen-Van De Kaa
    • Jaleesa Van Der Meer
    • Guido Roemen
    • Erik Geelkens
    • Manon Van Engeland
    • Axel Zur Hausen
    • Leo J. Schouten
    • Kim M. Smits
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School for Oncology and Reproduction (GROW), Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands, Department of Pathology, Johns Hopkins University, Baltimore, MD 21218, USA, Department of Epidemiology, School for Oncology and Reproduction (GROW), Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands, Department of Pathology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands
    Copyright: © Odeh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 174
    |
    Published online on: March 15, 2023
       https://doi.org/10.3892/ol.2023.13760
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Abstract

The aim of the present study was to re‑evaluate 457 renal cell carcinoma (RCC) cases from the Netherlands Cohort Study on Diet and Cancer (NLCS), a large population‑based cohort, according to the new 2022 ISUP, Genitourinary Pathology Society and World Health Organisation (WHO) classifications to assess whether newly recognized subtypes of RCC could be found among these cases. These cases were initially evaluated according to the 2004 WHO classification, the Fuhrman grading system and the 3rd version of the Tumor‑Node‑Metastasis (TNM). Data on tumor size, laterality and date of diagnosis, among other clinicopathological characteristics, were obtained through record linkage with the Netherlands Cancer Registry and the Pathologisch‑Anatomisch Landelijk Geautomatiseerd Archief. Digital slides from the NLCS were reviewed by two urogenital pathologists according to the new ISUP grading and the 2022 WHO classification (5th edition). Immunohistochemistry staining for carbonic anhydrase IX was performed on cases with ambiguous morphology. A total of 373 cases of clear cell RCC (ccRCC), 61 cases of papillary RCC (pRCC), 13 cases of chromophobe RCC, 3 cases of collecting duct carcinoma and 4 cases of oncocytoma were identified. The subtyping showed no discrepancy with the previous diagnoses. A comparison of the WHO/ISUP grading to the original Fuhrman grading showed a similar grading in 245 (56.5%) cases of the total ccRCC and pRCC cases. The staging according to the novel TNM classification 8th edition showed a restaging in 286 cases (65.5%). Lymphovascular (microvascular) invasion (LVI) and tumor necrosis (TN) were present in 14.4% and 33.5% of the total number of cases, respectively. Furthermore, the presence of sarcomatoid differentiation in 5.1% and rhabdoid differentiation in 4.2% of the cases was observed. In conclusion, none of the newly accepted and emerging/provisional RCC entities were identified in the NLCS cases, which could be attributed to the high mean age (71.4 years) at diagnosis of the patients included in the present study. A restaging of the NLCS cases using the TNM 8th edition and regrading using ISUP grading was performed, which showed that it is possible to report on newer features, such as sarcomatoid differentiation and LVI, even in an old sample collection.
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Copy and paste a formatted citation
Spandidos Publications style
Odeh S, Samarska IV, Matoso A, Van De Pol JA, Baldewijns MM, Hulsbergen-Van De Kaa CA, Van Der Meer J, Roemen G, Geelkens E, Van Engeland M, Van Engeland M, et al: Histologic re‑evaluation of a population‑based series of renal cell carcinomas from The Netherlands Cohort Study according to the 2022 ISUP/WHO classification. Oncol Lett 25: 174, 2023.
APA
Odeh, S., Samarska, I.V., Matoso, A., Van De Pol, J.A., Baldewijns, M.M., Hulsbergen-Van De Kaa, C.A. ... Smits, K.M. (2023). Histologic re‑evaluation of a population‑based series of renal cell carcinomas from The Netherlands Cohort Study according to the 2022 ISUP/WHO classification. Oncology Letters, 25, 174. https://doi.org/10.3892/ol.2023.13760
MLA
Odeh, S., Samarska, I. V., Matoso, A., Van De Pol, J. A., Baldewijns, M. M., Hulsbergen-Van De Kaa, C. A., Van Der Meer, J., Roemen, G., Geelkens, E., Van Engeland, M., Zur Hausen, A., Schouten, L. J., Smits, K. M."Histologic re‑evaluation of a population‑based series of renal cell carcinomas from The Netherlands Cohort Study according to the 2022 ISUP/WHO classification". Oncology Letters 25.5 (2023): 174.
Chicago
Odeh, S., Samarska, I. V., Matoso, A., Van De Pol, J. A., Baldewijns, M. M., Hulsbergen-Van De Kaa, C. A., Van Der Meer, J., Roemen, G., Geelkens, E., Van Engeland, M., Zur Hausen, A., Schouten, L. J., Smits, K. M."Histologic re‑evaluation of a population‑based series of renal cell carcinomas from The Netherlands Cohort Study according to the 2022 ISUP/WHO classification". Oncology Letters 25, no. 5 (2023): 174. https://doi.org/10.3892/ol.2023.13760
Copy and paste a formatted citation
x
Spandidos Publications style
Odeh S, Samarska IV, Matoso A, Van De Pol JA, Baldewijns MM, Hulsbergen-Van De Kaa CA, Van Der Meer J, Roemen G, Geelkens E, Van Engeland M, Van Engeland M, et al: Histologic re‑evaluation of a population‑based series of renal cell carcinomas from The Netherlands Cohort Study according to the 2022 ISUP/WHO classification. Oncol Lett 25: 174, 2023.
APA
Odeh, S., Samarska, I.V., Matoso, A., Van De Pol, J.A., Baldewijns, M.M., Hulsbergen-Van De Kaa, C.A. ... Smits, K.M. (2023). Histologic re‑evaluation of a population‑based series of renal cell carcinomas from The Netherlands Cohort Study according to the 2022 ISUP/WHO classification. Oncology Letters, 25, 174. https://doi.org/10.3892/ol.2023.13760
MLA
Odeh, S., Samarska, I. V., Matoso, A., Van De Pol, J. A., Baldewijns, M. M., Hulsbergen-Van De Kaa, C. A., Van Der Meer, J., Roemen, G., Geelkens, E., Van Engeland, M., Zur Hausen, A., Schouten, L. J., Smits, K. M."Histologic re‑evaluation of a population‑based series of renal cell carcinomas from The Netherlands Cohort Study according to the 2022 ISUP/WHO classification". Oncology Letters 25.5 (2023): 174.
Chicago
Odeh, S., Samarska, I. V., Matoso, A., Van De Pol, J. A., Baldewijns, M. M., Hulsbergen-Van De Kaa, C. A., Van Der Meer, J., Roemen, G., Geelkens, E., Van Engeland, M., Zur Hausen, A., Schouten, L. J., Smits, K. M."Histologic re‑evaluation of a population‑based series of renal cell carcinomas from The Netherlands Cohort Study according to the 2022 ISUP/WHO classification". Oncology Letters 25, no. 5 (2023): 174. https://doi.org/10.3892/ol.2023.13760
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