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Case Report Open Access

Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report

  • Authors:
    • Elena Lygina
    • Daria Morgacheva
    • Avinash Khadela
    • Humzah Postwala
    • Yesha Shah
    • Yulia Dinikina
  • View Affiliations / Copyright

    Affiliations: Department of Chemotherapy for Hematologic Diseases and Bone Marrow Transplantation for Children, Almazov National Medical Research Centre, St. Petersburg 197341, Russia, Department of Pharmacology, L.M. College of Pharmacy, Navrangpura, Ahmedabad, Gujarat 380009, India, Pharm D Section, L.M. College of Pharmacy, Navrangpura, Ahmedabad, Gujarat 380009, India
    Copyright: © Lygina et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 194
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    Published online on: March 30, 2023
       https://doi.org/10.3892/ol.2023.13780
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Abstract

Medulloblastoma (MB) is one of the most common pediatric malignant tumors arising from the central nervous system with an unknown etiology and variable prognosis. Relapsed or refractory MB in pediatric patients after intensive anticancer therapy (chemo‑, radiotherapy) is associated with treatment resistance and poor survival prognosis. Metronomic chemotherapy in combination with mTOR inhibitors may have advantages due to an alternate mechanism of cytotoxicity and a favourable adverse effects profile. Furthermore, it is considered to be a prospective anticancer regimen regardless of the presence/absence of molecular targets. The present study reported a successful result of this treatment option with optimal tolerability in relapsed MB in a pediatric male patient and highlighted the advantages for a selected group of patients.
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1 

Johnston DL, Keene D, Strother D, Taneva M, Lafay-Cousin L, Fryer C, Scheinemann K, Carret AS, Fleming A, Afzal S, et al: Survival following tumor recurrence in children with medulloblastoma. J Pediatr Hematol Oncol. 40:e159–e163. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Board PDQPTE, . Childhood medulloblastoma and other central nervous system embryonal tumors treatment (PDQ®). PDQ Cancer Information Summaries. National Cancer Institute; Bethesda, MD: 2008

3 

Khattab A and Monga DK: Turcot syndrome. StatPearls. StatPearls Publishing; Treasure Island, FL: 2022

4 

Onodera S, Nakamura Y and Azuma T: Gorlin syndrome: Recent advances in genetic testing and molecular and cellular biological research. Int J Mol Sci. 21:75592020. View Article : Google Scholar : PubMed/NCBI

5 

Ostrom QT, Gittleman H, Truitt G, Boscia A, Kruchko C and Barnholtz-Sloan JS: CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2011–2015. Neuro Oncol. 20 (Suppl 4):iv1–iv86. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Zapletalová D, André N, Deak L, Kyr M, Bajciova V, Mudry P, Dubska L, Demlova R, Pavelka Z, Zitterbart K, et al: Metronomic chemotherapy with the COMBAT regimen in advanced pediatric malignancies: A multicenter experience. Oncology. 82:249–260. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Panigrahy D, Kaipainen A, Butterfield CE, Chaponis DM, Laforme AM, Folkman J and Kieran MW: Inhibition of tumor angiogenesis by oral etoposide. Exp Ther Med. 1:739–746. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Pasquier E, Kavallaris M and André N: Metronomic chemotherapy: New rationale for new directions. Nat Rev Clin Oncol. 7:455–465. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Eckerdt F, Clymer J, Bell JB, Beauchamp EM, Blyth GT, Goldman S and Platanias LC: Pharmacological mTOR targeting enhances the antineoplastic effects of selective PI3Kα inhibition in medulloblastoma. Sci Rep. 9:128222019. View Article : Google Scholar : PubMed/NCBI

10 

Chaturvedi NK, Kling MJ, Coulter DW, McGuire TR, Ray S, Kesherwani V, Joshi SS and Sharp JG: Improved therapy for medulloblastoma: Targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy. Oncotarget. 9:16619–16633. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Borders EB, Binova C and Medina PJ: Mammalian target of rapamycin: Biological function and target for novel anticancer agents. Am J Health Syst Pharm. 67:2095–2106. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Brown RE, Tan D, Taylor JS, Miller M, Prichard JW and Kott MM: Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kappaB pathways in high risk neuro-blastoma, with cell cycle and protein analyte correlates. Ann Clin Lab Sci. 37:141–147. 2007.PubMed/NCBI

13 

Zenali MJ, Zhang PL, Bendel AE and Brown RE: Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kappaB pathways in Ewing family of tumors. Ann Clin Lab Sci. 39:160–166. 2009.PubMed/NCBI

14 

Mateo-Lozano S, Gokhale PC, Soldatenkov VA, Dritschilo A, Tirado OM and Notario V: Combined transcriptional and translational targeting of EWS/FLI-1 in Ewing's sarcoma. Clin Cancer Res. 12:6781–6790. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Houghton PJ, Morton CL, Kolb EA, Gorlick R, Lock R, Carol H, Reynolds CP, Maris JM, Keir ST, Billups CA and Smith MA: Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program. Pediatr Blood Cancer. 50:799–805. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Johnsen JI, Segerström L, Orrego A, Elfman L, Henriksson M, Kågedal B, Eksborg S, Sveinbjörnsson B and Kogner P: Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo. Oncogene. 27:2910–2922. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Vo KT, Karski EE, Nasholm NM, Allen S, Hollinger F, Gustafson WC, Long-Boyle JR, Shiboski S, Matthay KK and DuBois SG: Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors. Oncotarget. 8:23851–23861. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Houghton PJ, Morton CL, Gorlick R, Lock RB, Carol H, Reynolds CP, Kang MH, Maris JM, Keir ST, Kolb EA, et al: Stage 2 combination testing of rapamycin with cytotoxic agents by the pediatric preclinical testing program. Mol Cancer Ther. 9:101–112. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Semela D, Piguet AC, Kolev M, Schmitter K, Hlushchuk R, Djonov V, Stoupis C and Dufour JF: Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J Hepatol. 46:840–848. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, Bruns CJ, Zuelke C, Farkas S, Anthuber M, et al: Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor. Nat Med. 8:128–135. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Qayed M, Cash T, Tighiouart M, MacDonald T, Goldsmith KC, KeanPatty Church LS and Katzenstein HM: A phase I study of sirolimus in combination with metronomic therapy in children with recurrent and refractory solid/CNS tumors. J Clin Oncol. May 20–2015.(Epub ahead of print). View Article : Google Scholar

22 

Morgenstern DA, Marzouki M, Bartels U, Irwin MS, Sholler GL, Gammon J, Yankanah R, Wu B, Samson Y and Baruchel S: Phase I study of vinblastine and sirolimus in pediatric patients with recurrent or refractory solid tumors. Pediatr Blood Cancer. 61:128–133. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Cash T: Sirolimus in combination with metronomic chemotherapy in children with recurrent and/or refractory solid and CNS tumors (AflacST1502). ClinicalTrials.govIdentifier: NCT02574728. 2022.

24 

Putnam AR and Wallentine JC: Diagnostic Pathology: Pediatric Neoplasms. Salt Lake City, UT: pp. pp9842012

25 

Ole Juhnke B, Mynarek M, von Hoff K, Klagges S, Kortmann RD and Rutkowski S: HIT-MED guidance for patients with newly diagnosed medulloblastoma ependymoma CNS embryonal tumour and pineoblastoma. Version 4.0-02. 2017.

26 

Alammar H, Nassani R, Alshehri MM, Aljohani AA and Alrfaei BM: Deficiency in the treatment description of mTOR inhibitor resistance in medulloblastoma, a systematic review. Int J Mol Sci. 23:4642021. View Article : Google Scholar : PubMed/NCBI

27 

Bergers G and Benjamin LE: Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 3:401–410. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Wen J and Hadden MK: Medulloblastoma drugs in development: Current leads, trials and drawbacks. Eur J Med Chem. 215:1132682021. View Article : Google Scholar : PubMed/NCBI

29 

Kumar V, Kumar V, McGuire T, Coulter DW, Sharp JG and Mahato RI: Challenges and recent advances in medulloblastoma therapy. Trends Pharmacol Sci. 38:1061–1084. 2017. View Article : Google Scholar : PubMed/NCBI

30 

von Bueren AO, von Hoff K, Pietsch T, Gerber NU, Warmuth-Metz M, Deinlein F, Zwiener I, Faldum A, Fleischhack G, Benesch M, et al: Treatment of young children with localized medulloblastoma by chemotherapy alone: Results of the prospective, multicenter trial HIT 2000 confirming the prognostic impact of histology. Neuro Oncol. 13:669–679. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Bahl A and Bakhshi S: Metronomic chemotherapy in progressive pediatric malignancies: Old drugs in new package. Indian J Pediatr. 79:1617–1622. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Bowers DC, Aquino VM, Leavey PJ, Bash RO, Journeycake JM, Tomlinson G, Mulne AF, Haynes HJ and Winick NJ: Phase I study of oral cyclophosphamide and oral topotecan for children with recurrent or refractory solid tumors. Pediatr Blood Cancer. 42:93–98. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Sterba J, Pavelka Z, Andre N, Ventruba J, Skotakova J, Bajciova V, Bronisova D, Dubska L and Valik D: Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy. Pediatr Blood Cancer. 54:616–617. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Peyrl A, Chocholous M, Kieran MW, Azizi AA, Prucker C, Czech T, Dieckmann K, Schmook MT, Haberler C, Leiss U and Slavc I: Antiangiogenic metronomic therapy for children with recurrent embryonal brain tumors. Pediatr Blood Cancer. 59:511–517. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Yoshida S, Amano H, Hayashi I, Kitasato H, Kamata M, Inukai M, Yoshimura H and Majima M: COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo. Lab Invest. 83:1385–1394. 2003. View Article : Google Scholar : PubMed/NCBI

36 

D'Amato RJ, Loughnan MS, Flynn E and Folkman J: Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA. 91:4082–4085. 1994. View Article : Google Scholar : PubMed/NCBI

37 

Carcamo B and Francia G: Cyclic metronomic chemotherapy for pediatric tumors: Six case reports and a review of the literature. J Clin Med. 11:28492022. View Article : Google Scholar : PubMed/NCBI

38 

Slavc I, Peyrl A, Gojo J, Holm S, Blomgren K, Sehested AM, Leblond P and Czech T: MBCL-43. Reccurent medulloblastoma-long-term survival with a ‘MEMMAT’ based antiangiogenic approach. Neuro Oncol. 22 (Suppl 3):iii3972020. View Article : Google Scholar

39 

Simsek C, Esin E and Yalcin S: Metronomic chemotherapy: A systematic review of the literature and clinical experience. J Oncol. 2019:54837912019. View Article : Google Scholar : PubMed/NCBI

40 

Stempak D, Gammon J, Halton J, Moghrabi A, Koren G and Baruchel S: A pilot pharmacokinetic and antiangiogenic biomarker study of celecoxib and low-dose metronomic vinblastine or cyclophosphamide in pediatric recurrent solid tumors. J Pediatr Hematol Oncol. 28:720–728. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Sterba J, Valik D, Mudry P, Kepak T, Pavelka Z, Bajciova V, Zitterbart K, Kadlecova V and Mazanek P: Combined biodifferentiating and antiangiogenic oral metronomic therapy is feasible and effective in relapsed solid tumors in children: Single-center pilot study. Onkologie. 29:308–313. 2006.PubMed/NCBI

42 

Allen CE, Laetsch TW, Mody R, Irwin MS, Lim MS, Adamson PC, Seibel NL, Parsons DW, Cho YJ and Janeway K; Pediatric MATCH Target and Agent Prioritization Committee, . Target and agent prioritization for the children's oncology group-national cancer institute pediatric MATCH trial. J Natl Cancer Inst. 109:djw2742017. View Article : Google Scholar : PubMed/NCBI

43 

De Vita S, De Matteis S, Laurenti L, Chiusolo P, Reddiconto G, Fiorini A, Leone G and Sica S: Secondary Ph+ acute lymphoblastic leukemia after temozolomide. Ann Hematol. 84:760–762. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lygina E, Morgacheva D, Khadela A, Postwala H, Shah Y and Dinikina Y: Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report. Oncol Lett 25: 194, 2023.
APA
Lygina, E., Morgacheva, D., Khadela, A., Postwala, H., Shah, Y., & Dinikina, Y. (2023). Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report. Oncology Letters, 25, 194. https://doi.org/10.3892/ol.2023.13780
MLA
Lygina, E., Morgacheva, D., Khadela, A., Postwala, H., Shah, Y., Dinikina, Y."Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report". Oncology Letters 25.5 (2023): 194.
Chicago
Lygina, E., Morgacheva, D., Khadela, A., Postwala, H., Shah, Y., Dinikina, Y."Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report". Oncology Letters 25, no. 5 (2023): 194. https://doi.org/10.3892/ol.2023.13780
Copy and paste a formatted citation
x
Spandidos Publications style
Lygina E, Morgacheva D, Khadela A, Postwala H, Shah Y and Dinikina Y: Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report. Oncol Lett 25: 194, 2023.
APA
Lygina, E., Morgacheva, D., Khadela, A., Postwala, H., Shah, Y., & Dinikina, Y. (2023). Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report. Oncology Letters, 25, 194. https://doi.org/10.3892/ol.2023.13780
MLA
Lygina, E., Morgacheva, D., Khadela, A., Postwala, H., Shah, Y., Dinikina, Y."Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report". Oncology Letters 25.5 (2023): 194.
Chicago
Lygina, E., Morgacheva, D., Khadela, A., Postwala, H., Shah, Y., Dinikina, Y."Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report". Oncology Letters 25, no. 5 (2023): 194. https://doi.org/10.3892/ol.2023.13780
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