Open Access

Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report

  • Authors:
    • Elena Lygina
    • Daria Morgacheva
    • Avinash Khadela
    • Humzah Postwala
    • Yesha Shah
    • Yulia Dinikina
  • View Affiliations

  • Published online on: March 30, 2023     https://doi.org/10.3892/ol.2023.13780
  • Article Number: 194
  • Copyright: © Lygina et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Medulloblastoma (MB) is one of the most common pediatric malignant tumors arising from the central nervous system with an unknown etiology and variable prognosis. Relapsed or refractory MB in pediatric patients after intensive anticancer therapy (chemo‑, radiotherapy) is associated with treatment resistance and poor survival prognosis. Metronomic chemotherapy in combination with mTOR inhibitors may have advantages due to an alternate mechanism of cytotoxicity and a favourable adverse effects profile. Furthermore, it is considered to be a prospective anticancer regimen regardless of the presence/absence of molecular targets. The present study reported a successful result of this treatment option with optimal tolerability in relapsed MB in a pediatric male patient and highlighted the advantages for a selected group of patients.
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May-2023
Volume 25 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Lygina E, Morgacheva D, Khadela A, Postwala H, Shah Y and Dinikina Y: Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report. Oncol Lett 25: 194, 2023
APA
Lygina, E., Morgacheva, D., Khadela, A., Postwala, H., Shah, Y., & Dinikina, Y. (2023). Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report. Oncology Letters, 25, 194. https://doi.org/10.3892/ol.2023.13780
MLA
Lygina, E., Morgacheva, D., Khadela, A., Postwala, H., Shah, Y., Dinikina, Y."Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report". Oncology Letters 25.5 (2023): 194.
Chicago
Lygina, E., Morgacheva, D., Khadela, A., Postwala, H., Shah, Y., Dinikina, Y."Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report". Oncology Letters 25, no. 5 (2023): 194. https://doi.org/10.3892/ol.2023.13780