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Prognostic value of circWWC3 as a novel survival‑related biomarker for clear cell renal cell carcinoma

  • Authors:
    • Haoyuan Wang
    • Xiaopeng Ma
    • Sijie Li
    • Xiaochen Ni
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, School of Basic Medical Sciences, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 196
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    Published online on: April 3, 2023
       https://doi.org/10.3892/ol.2023.13782
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Abstract

The aim of the present study was to assess the prognostic value of circular RNA WW and C2 domain‑containing protein 3 (circWWC3) in patients with clear cell renal cell carcinoma (ccRCC). The clinicopathological data were collected for patients with ccRCC treated between January 1, 2012, and February 31, 2014, at The Fourth Hospital of Hebei Medical University Hospital (Shijiazhuang, China). A total of 150 patients who underwent nephrectomy were included in the study. Analysis of stored tissues and long‑term follow‑up data was performed. Fluorescence in situ hybridization was used to detect the relative circWWC3 expression in fresh‑frozen cancerous and adjacent para‑cancerous tissue samples from patients with ccRCC. A χ2 test was used to analyze the association between circWWC3 expression levels and the clinicopathological parameters of the patients. A Cox proportional risk regression model was used to analyze the clinical factors affecting patient prognosis. The survival curve was plotted using the Kaplan‑Meier method, and the association between circWWC3 expression levels and patient survival status was tested using the log‑rank test. circWWC3 expression in cancerous tissues was higher than that in the adjacent normal tissues. Additionally, circWWC3 expression was significantly associated with T stage (P=0.005) and pathological grade (P=0.033). Univariate Cox regression analysis showed that overall survival (OS) was associated with T stage, pathological Fuhrman grade and circWWC3 expression levels (all P<0.05). Multivariate Cox regression analysis also yielded similar results in patients with ccRCC (P<0.05). Moreover, the OS time of patients with high circWWC3 expression was significantly shorter than that of patients with low circWWC3 expression. In conclusion, high circWWC3 expression is an independent risk factor affecting patient prognosis, and is expected to be an important prognostic biomarker and novel therapeutic target for patients with ccRCC.
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1 

Yicong Y, Wang Y, Denglong W and Baoying H: Increased CDC6 expression associated with poor prognosis in patients with clear cell renal cell carcinoma. Front Oncol. 11:6664182021. View Article : Google Scholar : PubMed/NCBI

2 

Jing J, Zhao X, Wang J and Li T: Potential diagnostic and prognostic value and regulatory relationship of long noncoding RNA CCAT1 and miR-130a-3p in clear cell renal cell carcinoma. Cancer Cell Int. 21:682021. View Article : Google Scholar : PubMed/NCBI

3 

Cao C, Ma Q, Huang X, Li A, Liu J, Ye J and Gui Y: Targeted demethylation of the PLOD2 mRNA inhibits the proliferation and migration of renal cell carcinoma. Front Mol Biosci. 8:6756832021. View Article : Google Scholar : PubMed/NCBI

4 

Wu G, Wang Q, Xu Y, Li J, Zhang H, Qi G and Xia Q: Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: Agonist or inverse agonist? Cell Death Dis. 10:4162019. View Article : Google Scholar : PubMed/NCBI

5 

Cui C, Yang J, Li X, Liu D, Fu L and Wang X: Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance. Mol Cancer. 19:582020. View Article : Google Scholar : PubMed/NCBI

6 

Yao B, Zhang Q, Yang Z, An F, Nie H, Wang H, Yang C, Sun J, Chen K, Zhou J, et al: CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A-modified CREB1 mRNA. Mol Cancer. 21:1402022. View Article : Google Scholar : PubMed/NCBI

7 

Zhang Z, Yang T and Xiao J: Circular RNAs: Promising biomarkers for human diseases. EBioMedicine. 34:267–274. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Wei W, Ji L, Duan W and Zhu J: Circular RNA circ_0081001 knockdown enhances methotrexate sensitivity in osteosarcoma cells by regulating miR-494-3p/TGM2 axis. J Orthop Surg Res. 16:502021. View Article : Google Scholar : PubMed/NCBI

9 

Zhang J, Chou X, Zhuang M, Zhu C, Hu Y, Cheng D and Liu Z: circKMT2D contributes to H2O2-attenuated osteosarcoma progression via the miR-210/autophagy pathway. Exp Ther Med. 20:652020. View Article : Google Scholar : PubMed/NCBI

10 

Beilerli A, Gareev I, Beylerli O, Yang G, Pavlov V, Aliev G and Ahmad A: Circular RNAs as biomarkers and therapeutic targets in cancer. Semin Cancer Biol. 83:242–252. 2022. View Article : Google Scholar : PubMed/NCBI

11 

Wu Y, Xie Z, Chen J, Chen J, Ni W, Ma Y, Huang K, Wang G, Wang J, Ma J, et al: Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression. Mol Cancer. 18:732019. View Article : Google Scholar : PubMed/NCBI

12 

Rong X, Han Q, Lin X, Kremerskothen J and Wang E: FRMPD1 activates the Hippo pathway via interaction with WWC3 to suppress the proliferation and invasiveness of lung cancer cells. Cancer Manag Res. 11:3395–3410. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Han Q, Rong X, Wang E and Liu S: WW and C2 domain-containing protein-3 promoted EBSS-induced apoptosis through inhibiting autophagy in non-small cell lung cancer cells. J Thorac Dis. 12:4205–4215. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Liu S, Zhang J, Zheng T, Mou X and Xin W: Circ_WWC3 overexpression decelerates the progression of osteosarcoma by regulating miR-421/PDE7B axis. Open Life Sci. 16:229–241. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Li C and Li X: Antitumor Activity of lncRNA NBAT-1 via Inhibition of miR-4504 to Target to WWC3 in oxaliplatin-resistant colorectal carcinoma. J Healthc Eng. 2022:91215542022. View Article : Google Scholar : PubMed/NCBI

16 

Wang Y, Jiang M, Yao Y and Cai Z: WWC3 inhibits glioma cell proliferation through suppressing the Wnt/β-catenin signaling pathway. DNA Cell Biol. 37:31–37. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Meng L, Liu S, Liu F and Sang M, Ju Y, Fan X, Gu L, Li Z, Geng C and Sang M: ZEB1-mediated transcriptional upregulation of circWWC3 promotes breast cancer progression through activating Ras signaling pathway. Mol Ther Nucleic Acids. 22:124–137. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Zhou F, Wang D, Wei W, Chen H, Shi H, Zhou N, Wu L and Peng R: Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. BMC Cancer. 20:402020. View Article : Google Scholar : PubMed/NCBI

19 

Wang Y, Zhang Y, Wang P, Fu X and Lin W: Circular RNAs in renal cell carcinoma: implications for tumorigenesis, diagnosis, and therapy. Mol Cancer. 19:1492020. View Article : Google Scholar : PubMed/NCBI

20 

Yang L, Zou X, Zou J and Zhang G: Functions of circular RNAs in bladder, prostate and renal cell cancer (Review). Mol Med Rep. 23:3072021. View Article : Google Scholar : PubMed/NCBI

21 

Ma C, Qin J, Zhang J, Wang X, Wu D and Li X: Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma. Mol Med Rep. 21:141–150. 2020.PubMed/NCBI

22 

Feng W, Guo R, Zhang D and Zhang R: Circ-ABCB10 knockdown inhibits the malignant progression of cervical cancer through microRNA-128-3p/ZEB1 axis. Biol Proced Online. 23:172021. View Article : Google Scholar : PubMed/NCBI

23 

Erdoğan F, Demirel A and Polat O: Prognostic significance of morphologic parameters in renal cell carcinoma. Int J Clin Pract. 58:333–336. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Delahunt B, Eble JN, Egevad L and Samaratunga H: Grading of renal cell carcinoma. Histopathology. 74:4–17. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Liu S, Deng X and Zhang J: Identification of dysregulated serum miR-508-3p and miR-885-5p as potential diagnostic biomarkers of clear cell renal carcinoma. Mol Med Rep. 20:5075–5083. 2019.PubMed/NCBI

26 

El-Deiry WS, Taylor B and Neal JW: Tumor evolution, heterogeneity, and therapy for our patients with advanced cancer: How far have we come? Am Soc Clin Oncol Educ Book. 37:e8–e15. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Gui CP, Liao B, Luo CG, Chen YH, Tan L, Tang YM, Li JY, Hou Y, Song HD, Lin HS, et al: circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis. Mol Cancer. 20:1692021. View Article : Google Scholar : PubMed/NCBI

28 

Zhang MX, Wang JL, Mo CQ, Mao XP, Feng ZH, Li JY, Lin HS, Song HD, Xu QH, Wang YH, et al: CircME1 promotes aerobic glycolysis and sunitinib resistance of clear cell renal cell carcinoma through cis-regulation of ME1. Oncogene. 41:3979–3990. 2022. View Article : Google Scholar : PubMed/NCBI

29 

Wang Y, Zhang Y, Su X, Qiu Q, Yuan Y, Weng C, Zou S, Tian Y, Han W, Liu P, et al: Circular RNA circDVL1 inhibits clear cell renal cell carcinoma progression through the miR-412-3p/PCDH7 axis. Int J Biol Sci. 18:1491–1507. 2022. View Article : Google Scholar : PubMed/NCBI

30 

Downs TM, Schultzel M, Shi H, Sanders C, Tahir Z and Sadler GR: Renal cell carcinoma: Risk assessment and prognostic factors for newly diagnosed patients. Crit Rev Oncol Hematol. 70:59–70. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Miller K, Bergmann L, Doehn C, Grünwald V, Gschwend JE, Ivanyi P and Kuczyk MA: Interdisciplinary recommendations for the treatment of advanced renal cell carcinoma. Aktuel Urol. 53:403–415. 2022.(In German). PubMed/NCBI

32 

Babin L, Andraos E, Fuchs S, Pyronnet S, Brunet E and Meggetto F: From circRNAs to fusion circRNAs in hematological malignancies. JCI Insight. 6:e1515132021. View Article : Google Scholar : PubMed/NCBI

33 

Huang G, Liang M, Liu H, Huang J, Li P, Wang C, Zhang Y, Lin Y and Jiang X: CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway. Cell Death Dis. 11:10652020. View Article : Google Scholar : PubMed/NCBI

34 

Zheng X, Huang M, Xing L, Yang R, Wang X, Jiang R, Zhang L and Chen J: The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer. Mol Cancer. 19:732020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Ma X, Li S and Ni X: Prognostic value of circWWC3 as a novel survival‑related biomarker for clear cell renal cell carcinoma. Oncol Lett 25: 196, 2023.
APA
Wang, H., Ma, X., Li, S., & Ni, X. (2023). Prognostic value of circWWC3 as a novel survival‑related biomarker for clear cell renal cell carcinoma. Oncology Letters, 25, 196. https://doi.org/10.3892/ol.2023.13782
MLA
Wang, H., Ma, X., Li, S., Ni, X."Prognostic value of circWWC3 as a novel survival‑related biomarker for clear cell renal cell carcinoma". Oncology Letters 25.5 (2023): 196.
Chicago
Wang, H., Ma, X., Li, S., Ni, X."Prognostic value of circWWC3 as a novel survival‑related biomarker for clear cell renal cell carcinoma". Oncology Letters 25, no. 5 (2023): 196. https://doi.org/10.3892/ol.2023.13782
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Ma X, Li S and Ni X: Prognostic value of circWWC3 as a novel survival‑related biomarker for clear cell renal cell carcinoma. Oncol Lett 25: 196, 2023.
APA
Wang, H., Ma, X., Li, S., & Ni, X. (2023). Prognostic value of circWWC3 as a novel survival‑related biomarker for clear cell renal cell carcinoma. Oncology Letters, 25, 196. https://doi.org/10.3892/ol.2023.13782
MLA
Wang, H., Ma, X., Li, S., Ni, X."Prognostic value of circWWC3 as a novel survival‑related biomarker for clear cell renal cell carcinoma". Oncology Letters 25.5 (2023): 196.
Chicago
Wang, H., Ma, X., Li, S., Ni, X."Prognostic value of circWWC3 as a novel survival‑related biomarker for clear cell renal cell carcinoma". Oncology Letters 25, no. 5 (2023): 196. https://doi.org/10.3892/ol.2023.13782
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