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Cetuximab or nimotuzumab in combination with chemotherapy for treating recurrent/metastatic nasopharyngeal carcinoma: A meta‑analysis and systemic review

  • Authors:
    • Xiaoling Ni
    • Junqi Zhang
    • De Zhu
    • Qing Du
    • Jun Yang
    • Hong Cheng Yue
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Bazhong Central Hospital, Bazhong, Sichuan 636000, P.R. China
    Copyright: © Ni et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 204
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    Published online on: April 5, 2023
       https://doi.org/10.3892/ol.2023.13790
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Abstract

The present study aimed to evaluate the effectiveness and safety of cetuximab (CTX) or nimotuzumab (NTZ) in combination with chemotherapy for patients with recurrent and/or metastatic nasopharyngeal carcinoma (RM‑NPC), and for this purpose, a single‑group rate meta‑analysis was performed. A systematic search of the Cochrane library, Pubmed, EMBASE, Chwina National Knowledge Infrastructure and WanFang databases for studies published until February 15, 2022 was performed. The 1‑, 2‑, 3‑ and 5‑year overall survival (OS) rates were the primary endpoints. Complete response, partial response, stable disease, objective response rate, disease control rate and grade ≥3 toxicities were considered secondary endpoints. Cochran Q test and I2 statistics were performed to assess the heterogeneity among studies. A total of nine studies comprising 435 patients were included in the analysis. The pooled 1‑, 2‑, 3‑ and 5‑year OS rates were 81.0% [95% confidence interval (CI): 65.0‑90.7%], 49.9% (95% CI: 35.3‑64.5%), 46.3% (95% CI: 31.4‑61.8%) and 31.0% (95% CI: 20.8‑43.4%), respectively. The pooled disease control rate and objective response rate were 88.7% (95% CI: 78.4‑94.5%) and 55.6% (95% CI: 39.9‑70.1%), respectively. In addition, all grade 3‑4 adverse events from the included studies were gathered. In conclusion, the use of CTX or NTZ in combination with chemotherapy may be a feasible and safe option for treating RM‑NPC.
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Copy and paste a formatted citation
Spandidos Publications style
Ni X, Zhang J, Zhu D, Du Q, Yang J and Yue HC: Cetuximab or nimotuzumab in combination with chemotherapy for treating recurrent/metastatic nasopharyngeal carcinoma: A meta‑analysis and systemic review. Oncol Lett 25: 204, 2023.
APA
Ni, X., Zhang, J., Zhu, D., Du, Q., Yang, J., & Yue, H.C. (2023). Cetuximab or nimotuzumab in combination with chemotherapy for treating recurrent/metastatic nasopharyngeal carcinoma: A meta‑analysis and systemic review. Oncology Letters, 25, 204. https://doi.org/10.3892/ol.2023.13790
MLA
Ni, X., Zhang, J., Zhu, D., Du, Q., Yang, J., Yue, H. C."Cetuximab or nimotuzumab in combination with chemotherapy for treating recurrent/metastatic nasopharyngeal carcinoma: A meta‑analysis and systemic review". Oncology Letters 25.5 (2023): 204.
Chicago
Ni, X., Zhang, J., Zhu, D., Du, Q., Yang, J., Yue, H. C."Cetuximab or nimotuzumab in combination with chemotherapy for treating recurrent/metastatic nasopharyngeal carcinoma: A meta‑analysis and systemic review". Oncology Letters 25, no. 5 (2023): 204. https://doi.org/10.3892/ol.2023.13790
Copy and paste a formatted citation
x
Spandidos Publications style
Ni X, Zhang J, Zhu D, Du Q, Yang J and Yue HC: Cetuximab or nimotuzumab in combination with chemotherapy for treating recurrent/metastatic nasopharyngeal carcinoma: A meta‑analysis and systemic review. Oncol Lett 25: 204, 2023.
APA
Ni, X., Zhang, J., Zhu, D., Du, Q., Yang, J., & Yue, H.C. (2023). Cetuximab or nimotuzumab in combination with chemotherapy for treating recurrent/metastatic nasopharyngeal carcinoma: A meta‑analysis and systemic review. Oncology Letters, 25, 204. https://doi.org/10.3892/ol.2023.13790
MLA
Ni, X., Zhang, J., Zhu, D., Du, Q., Yang, J., Yue, H. C."Cetuximab or nimotuzumab in combination with chemotherapy for treating recurrent/metastatic nasopharyngeal carcinoma: A meta‑analysis and systemic review". Oncology Letters 25.5 (2023): 204.
Chicago
Ni, X., Zhang, J., Zhu, D., Du, Q., Yang, J., Yue, H. C."Cetuximab or nimotuzumab in combination with chemotherapy for treating recurrent/metastatic nasopharyngeal carcinoma: A meta‑analysis and systemic review". Oncology Letters 25, no. 5 (2023): 204. https://doi.org/10.3892/ol.2023.13790
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