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Article

Levels of NT‑proBNP in patients with cancer

  • Authors:
    • Jozef Chovanec Jr
    • Jozef Chovanec Sr
    • Michal Chovanec
    • Michal Mego
  • View Affiliations / Copyright

    Affiliations: 2nd Department of Oncology, Faculty of Medicine, Comenius University and National Cancer Institute, 83310 Bratislava, Slovak Republic, Oncological Department, Hospital St. Jacob Bardejov, 08501 Bardejov, Slovak Republic
  • Article Number: 280
    |
    Published online on: May 16, 2023
       https://doi.org/10.3892/ol.2023.13866
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Abstract

At present, it is well known that natriuretic peptides may be produced by cancer cells. Stimulation of N‑terminal pro B‑type natriuretic peptide (NT‑proBNP) synthesis may be a reaction to activity of several proinflammatory cytokines. NT‑proBNP is also a marker of myocardial damage during cardiotoxic chemotherapy by anthracyclines. The present study aimed to analyze the association between NT‑proBNP and patient/disease characteristics in patients without cardiac symptoms. The present clinical study included 112 patients with cancer who were undergoing anticancer therapy between December 2017 and December 2021. From each patient, peripheral blood was obtained for detection of NT‑proBNP before any therapy, after therapy and 1 year after the first sample. NT‑proBNP was examined using an immunochemical method. The mean ± SEM value of NT‑pro‑BNP in the first, second and third sample was 561.0±75.1, 1,565.4±461.1 and 1,940.7±581.1 ng/l. A total of 15 (13.4%), 27 (24.1%) and 25 (30.1%) patients had elevated levels of NT‑pro‑BNP in the first, second and third sample above the normal value adjusted to age. It was observed that NT‑proBNP was increased in older patients and in patients with progressive metastatic disease with poor prognosis. Patients with non‑elevated NT‑proBNP in the second and third sample had significantly improved OS compared with patients with elevated NT‑proBNP [hazard ratio (HR), 0.47; 95% CI, 0.26‑0.85; P=0.002 for the second sample; and HR, 0.29; 95% CI, 0.14‑0.60; P=0.0000007, for the third sample]. The baseline NT‑proBNP value was not prognostic for OS (HR, 0.98; 95% CI, 0.50‑1.92; P=0.96). The present results suggest that the level of NT‑proBNP was associated with the extent of oncologic disease. Higher levels were associated with progression of metastatic disease and shorter overall survival.
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1 

Poprach A, Petráková K, Vyskocil J, Lakomý R, Nemecek R, Kocák I, Kocáková I and Vyzula R: Cardiotoxicity of drugs used in oncology. Klin Onkol. 21:288–293. 2008.(In Czech). PubMed/NCBI

2 

Kinova S, Hulin I, et al: Internal medicine. Prolitera, ISBN:. 9788097025397:2802013.

3 

Bando S, Soeki T, Matsuura T, Tobiume T, Ise T, Kusunose K, Yamaguchi K, Yagi S, Fukuda D, Iwase T, et al: Plasma brain natriuretic peptide levels are elevated in patients with cancer. PLoS One. 12:e01786072012. View Article : Google Scholar

4 

Mladosievicova B, et al: Cardiooncology. Grada, ISBN:. 9788024748382:1332014.

5 

Goncalvescová E: Merit of natriuretic peptides for diagnosis, prognosis, management and therapy of heart failure. Int Med Practice. 10:428–431. 2006.

6 

Pudil R, Mueller C, Čelutkienė J, Henriksen PA, Lenihan D, Dent S, Barac A, Stanway S, Moslehi J, Suter TM, et al: Role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies: A position statement from the cardio-oncology study group of the heart failure association and the cardio-oncology council of the European society of cardiology. Eur J Heart Fail. 22:1966–1983. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Oral I: Brain natriuretic peptide as prognostic marker of two-year survival in patients with heart failure in a long-term dialysis programme. Interventional Cardiology. 3:112–115. 2006.

8 

Kamai T, Tokura Y, Uematsu T, Sakamoto K, Suzuki I, Takei K, Narimatsu T, Kambara T, Yuki H, Betsunoh H, et al: Elevated serum levels of cardiovascular biomarkers are associated with progression of renal cancer. Open Heart. 5:e0006662018. View Article : Google Scholar : PubMed/NCBI

9 

Aujolett N, Meyer M, Cailliod R, Combier F, Coignet Y, Campard S, Facy O, Bernard A and Girard C: High N-terminal Pro-B type natriuretic peptide: A biomarker of lung cancer? Clin Lung Cancer. 11:341–345. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Pavo N, Raderer M, Hülsmann M, Neuhold S, Adlbrecht C, Strunk G, Goliasch G, Gisslinger H, Steger GG, Hejna M, et al: Cardiovascular biomarkers in pacients with cancer and their association with all-cause mortality. Heart. 101:1874–1880. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Popat J, Rivero A, Pratap P and Guglin M: What is causing extremely elevated amino terminal brain natriuretic peptide in cancer patients. Congest Heart Fail. 19:143–148. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Manimala NJ, Frost CD, Lane ML, Higuera M, Beg R and Vesely DL: Cardiac hormones target nuclear oncogenes c-Fos and c-Jun in carcinoma cells. Eur J Clin Invest. 43:1156–1162. 2013.PubMed/NCBI

13 

Tuňón J, Higueras J, Tarín N, Cristóbal C, Lorenzo O, Blanco-Colio L, Martín-Ventura JL, Huelmos A, Alonso J, Aceña A, et al: N-terminal pro-brain natriuretic peptide is associated with a future diagnosis of cancer in patients with coronary artery disease. PLoS One. 10:e01267412015. View Article : Google Scholar : PubMed/NCBI

14 

Zhang J, Zhao Z, Zu C, Hu H, Shen H, Zhang M and Wang J: Atrial natriuretic peptide modulates the proliferation of human gastric cancer cells via KCNQ1 expression. Oncol Lett. 6:407–414. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Advani P, Hoyne J, Moreno–Aspita A, Dubin M, Brock S, Harlow C, Chumsri S, Suter T and Blackshear JL: High-senzitive troponin T and NT-proBNP kinetics in breast cancer chemotherapy. Chemotherapy. 62:334–338. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Mladosievicova B, Urbanova D, Radvanska E, Slavkovsky P and Simkova I: Role of NT-proBNP in detection of myocardial damage in childhood leukemia survivors treated with and without anthracyclines. J Exp Clin Cancer Res. 31:862012. View Article : Google Scholar : PubMed/NCBI

17 

Michel L, Rassaf T and Totzeck M: Biomarkers for detection of apparent and subclinical cancer therapy-related cardiotoxicity. J Thorac Dis. 10:S4282–S4295. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Cao Z, Jia Y and Zhu B: BNP and NT-proBNP as diagnostic biomarkers for cardiac dysfunction in both clinical and forensic medicine. Int J Mol Sci. 20:18202019. View Article : Google Scholar : PubMed/NCBI

19 

Cingelová S: Cardiotoxicity of breast cancer adjuvant treatment. Klinicka onkologie J. 20:330–334. 2007.

20 

Romano S, Fratini S, Ricevuto E, Procaccini V, Stifano G, Mancini M, Di Mauro M, Ficorella C and Penco M: NT-proBNP and antracycline-induced cardiotoxicity. Br J Cancer. 105:1663–1668. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Papazisis K, Kontovinis LF, Papandreou CN, Kouvatseas G, Lafaras C, Antonakis E, Christopoulou M, Andreadis C, Mouratidou D and Kortsaris AH: Brain natriuretic peptic precursor (NT-proBNP) level predict for clinical benefit to sunitinib treatment in patients with metastatic renal cell carcinoma. BMC Cancer. 10:4892010. View Article : Google Scholar : PubMed/NCBI

22 

Rossner D, Knobloch K, Lichtinghagen R, Lichtenberg A, Kuehnle H and Lück HJ: NT-proBNP and Ca 125 as potential markers of mortality during long-term immunotherapy with trastuzumab in HER-2-possitive metastatic breast cancer. J Clin Oncol. 22:804. 2014. View Article : Google Scholar

23 

Ruggieri F, Noris A, Beretta L, Mortini P and Gemma M: Serum B-type natriuretic peptide is affected by neoplastic edema in patients with brain tumor. World Neurosurg. 85:193–196. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Bunevicius A, Deltuva V, Laws ER, Iervasi G, Tamsauskas A and Bunevicius R: Preoperative N-terminal pro-B-type natriuretic peptide concentration and prognosis of brain tumor patients: A 5-year follow up study. Sci Rep. 7:147752017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chovanec Jr J, Chovanec Sr J, Chovanec M and Mego M: Levels of NT‑proBNP in patients with cancer. Oncol Lett 26: 280, 2023.
APA
Chovanec Jr, J., Chovanec Sr, J., Chovanec, M., & Mego, M. (2023). Levels of NT‑proBNP in patients with cancer. Oncology Letters, 26, 280. https://doi.org/10.3892/ol.2023.13866
MLA
Chovanec Jr, J., Chovanec Sr, J., Chovanec, M., Mego, M."Levels of NT‑proBNP in patients with cancer". Oncology Letters 26.1 (2023): 280.
Chicago
Chovanec Jr, J., Chovanec Sr, J., Chovanec, M., Mego, M."Levels of NT‑proBNP in patients with cancer". Oncology Letters 26, no. 1 (2023): 280. https://doi.org/10.3892/ol.2023.13866
Copy and paste a formatted citation
x
Spandidos Publications style
Chovanec Jr J, Chovanec Sr J, Chovanec M and Mego M: Levels of NT‑proBNP in patients with cancer. Oncol Lett 26: 280, 2023.
APA
Chovanec Jr, J., Chovanec Sr, J., Chovanec, M., & Mego, M. (2023). Levels of NT‑proBNP in patients with cancer. Oncology Letters, 26, 280. https://doi.org/10.3892/ol.2023.13866
MLA
Chovanec Jr, J., Chovanec Sr, J., Chovanec, M., Mego, M."Levels of NT‑proBNP in patients with cancer". Oncology Letters 26.1 (2023): 280.
Chicago
Chovanec Jr, J., Chovanec Sr, J., Chovanec, M., Mego, M."Levels of NT‑proBNP in patients with cancer". Oncology Letters 26, no. 1 (2023): 280. https://doi.org/10.3892/ol.2023.13866
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