Open Access

Combination of CAR‑T cell therapy and radiotherapy: Opportunities and challenges in solid tumors (Review)

  • Authors:
    • Liqiang Zhong
    • Yi Li
    • Tobias Achu Muluh
    • Yongsheng Wang
  • View Affiliations

  • Published online on: May 16, 2023     https://doi.org/10.3892/ol.2023.13867
  • Article Number: 281
  • Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chimeric antigen receptor (CAR) T cell therapy has emerged as a new and breakthrough cancer immunotherapy. Although CAR‑T cell therapy has made significant progress clinically in patients with refractory or drug‑resistant hematological malignancies, there are numerous challenges in its application to solid tumor therapy, including antigen escape, severe toxic reactions, abnormal vascularization, tumor hypoxia, insufficient infiltration of CAR‑T cells and immunosuppression. As a conventional mode of anti‑tumor therapy, radiotherapy has shown promising effects in combination with CAR‑T cell therapy by enhancing the specific immunity of endogenous target antigens, which promoted the infiltration and expansion of CAR‑T cells and improved the hypoxic tumor microenvironment. This review focuses on the obstacles to the application of CAR‑T technology in solid tumor therapy, the potential opportunities and challenges of combined radiotherapy and CAR‑T cell therapy, and the review of recent literature to evaluate the best combination for the treatment of solid tumors.
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July-2023
Volume 26 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhong L, Li Y, Muluh TA and Wang Y: Combination of CAR‑T cell therapy and radiotherapy: Opportunities and challenges in solid tumors (Review). Oncol Lett 26: 281, 2023
APA
Zhong, L., Li, Y., Muluh, T.A., & Wang, Y. (2023). Combination of CAR‑T cell therapy and radiotherapy: Opportunities and challenges in solid tumors (Review). Oncology Letters, 26, 281. https://doi.org/10.3892/ol.2023.13867
MLA
Zhong, L., Li, Y., Muluh, T. A., Wang, Y."Combination of CAR‑T cell therapy and radiotherapy: Opportunities and challenges in solid tumors (Review)". Oncology Letters 26.1 (2023): 281.
Chicago
Zhong, L., Li, Y., Muluh, T. A., Wang, Y."Combination of CAR‑T cell therapy and radiotherapy: Opportunities and challenges in solid tumors (Review)". Oncology Letters 26, no. 1 (2023): 281. https://doi.org/10.3892/ol.2023.13867