Open Access

Germline EGFR mutations in lung cancer (Review)

  • Authors:
    • Minghui Liu
    • Xiaoyu Niu
    • Hongyu Liu
    • Jun Chen
  • View Affiliations

  • Published online on: May 16, 2023     https://doi.org/10.3892/ol.2023.13868
  • Article Number: 282
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung cancer is the leading cause of cancer-related death and familial lung cancer is a potential contributing factor. Epidermal growth factor receptor (EGFR) mutations are important events in carcinogenesis. The present study summarized the common germline mutations of EGFR, including T790M, V843I, R776H and P848L, and provided detailed information regarding each mutation site and potential treatment strategies. Individuals with germline mutations may develop lung cancer upon exposure to environmental stimuli such as smoking, air pollution or radiological contamination, or due to the occurrence of another somatic mutation. The present study recommends regular physical examinations as well as population-wide germline mutation screening for early detection and diagnosis of lung cancer.
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July-2023
Volume 26 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liu M, Niu X, Liu H and Chen J: Germline EGFR mutations in lung cancer (Review). Oncol Lett 26: 282, 2023
APA
Liu, M., Niu, X., Liu, H., & Chen, J. (2023). Germline EGFR mutations in lung cancer (Review). Oncology Letters, 26, 282. https://doi.org/10.3892/ol.2023.13868
MLA
Liu, M., Niu, X., Liu, H., Chen, J."Germline EGFR mutations in lung cancer (Review)". Oncology Letters 26.1 (2023): 282.
Chicago
Liu, M., Niu, X., Liu, H., Chen, J."Germline EGFR mutations in lung cancer (Review)". Oncology Letters 26, no. 1 (2023): 282. https://doi.org/10.3892/ol.2023.13868