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Analysis and validation of the potential of the MYO1E gene in pancreatic adenocarcinoma based on a bioinformatics approach

  • Authors:
    • Songbai Liu
    • Peng Liu
    • Xiaobin Fei
    • Changhao Zhu
    • Junyi Hou
    • Xing Wang
    • Yaozhen Pan

  • View Affiliations

  • Published online on: May 19, 2023     https://doi.org/10.3892/ol.2023.13871
  • Article Number: 285

  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic adenocarcinoma (PAAD) is a common digestive cancer, and its prognosis is poor. Myosin 1E (MYO1E) is a class I myosin family member whose expression and function have not been reported in PAAD. In the present study, bioinformatics analysis was used to explore the expression levels of MYO1E in PAAD and its prognostic value, and the immunological role of MYO1E in PAAD was analyzed. The study revealed that a variety of malignancies have substantially increased MYO1E expression. Further investigation demonstrated that PAAD tissues exhibited greater levels of MYO1E mRNA and protein expression than normal tissues. High MYO1E expression is associated with poor prognosis in patients with PAAD. MYO1E expression was also associated with pathological stage in patients with PAAD. Functional enrichment analysis demonstrated that MYO1E was linked to multiple tumor‑related mechanisms in PAAD. The pancreatic adenocarcinoma tumor microenvironment (TME) was analyzed and it was revealed that MYO1E expression was positively associated with tumor immune cell infiltration. In addition, MYO1E was closely associated with some tumor chemokines/receptors and immune checkpoints. In vitro experiments revealed that the suppression of MYO1E expression could inhibit pancreatic adenocarcinoma cell proliferation, invasion and migration. Through preliminary analysis, the present study evaluated the potential function of MYO1E in PAAD and its function in TME, and MYO1E may become a potential biomarker for PAAD.
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July-2023
Volume 26 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu S, Liu P, Fei X, Zhu C, Hou J, Wang X and Pan Y: Analysis and validation of the potential of the MYO1E gene in pancreatic adenocarcinoma based on a bioinformatics approach. Oncol Lett 26: 285, 2023
APA
Liu, S., Liu, P., Fei, X., Zhu, C., Hou, J., Wang, X., & Pan, Y. (2023). Analysis and validation of the potential of the MYO1E gene in pancreatic adenocarcinoma based on a bioinformatics approach. Oncology Letters, 26, 285. https://doi.org/10.3892/ol.2023.13871
MLA
Liu, S., Liu, P., Fei, X., Zhu, C., Hou, J., Wang, X., Pan, Y."Analysis and validation of the potential of the MYO1E gene in pancreatic adenocarcinoma based on a bioinformatics approach". Oncology Letters 26.1 (2023): 285.
Chicago
Liu, S., Liu, P., Fei, X., Zhu, C., Hou, J., Wang, X., Pan, Y."Analysis and validation of the potential of the MYO1E gene in pancreatic adenocarcinoma based on a bioinformatics approach". Oncology Letters 26, no. 1 (2023): 285. https://doi.org/10.3892/ol.2023.13871