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The ‘double‑track sign’: A novel CT finding suggestive of the diagnosis of T1a gastric cancer

  • Authors:
    • Pan Liang
    • Dongbo Lv
    • Xiu-Chun Ren
    • Ming Cheng
    • Zhi-Wei Hu
    • Liu-Liang Yong
    • Bing-Bing Zhu
    • Meng-Ru Liu
    • Jian-Bo Gao

  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 286
    |
    Published online on: May 19, 2023
       https://doi.org/10.3892/ol.2023.13872
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Abstract

Effective identification of T1a stage cancer is crucial for planning endoscopic resection for early gastric cancers. The present study aimed to determine the diagnostic value of the double‑track sign in patients with T1a gastric cancer using computed tomography (CT) imaging. A total of 152 patients diagnosed with pathologically proven T1a gastric cancer at The First Affiliated Hospital of Zhengzhou University (Zhengzhou, China) between July 2011 and August 2021 were retrospectively reviewed. The control group consisted of 2,926 patients with gastritis. Clinical data, including patient characteristics and preoperative CT imaging findings with gastric morphological features, were reviewed and analyzed. Out of 51 patients with T1a gastric cancer finally included, 31 (60.8%) exhibited local double‑track enhancement changes of the stomach, referred to as the ‘double‑track sign’, on CT images. In addition, four patients (7.8%) had well‑enhanced mucosal thickening of the gastric wall. Of the 2,926 control subjects, none had any double‑track sign and six patients (0.2%) had local gastric wall thickening with abnormally strengthened enhancement. In conclusion, a double‑track sign on CT images is beneficial in the diagnostic differentiation of T1a gastric cancer.
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1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Thrift AP and El-Serag HB: Burden of gastric cancer. Clin Gastroenterol Hepatol. 18:534–542. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Niu PH, Zhao LL, Wu HL, Zhao DB and Chen YT: Artificial intelligence in gastric cancer: Application and future perspectives. World J Gastroenterol. 26:5408–5419. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Ye Z, Zeng Y, Wei S, Wang Y, Lin Z, Chen S, Wang Z, Chen S and Chen L: Short-term survival and safety of apatinib combined with oxaliplatin and S-1 in the conversion therapy of unresectable gastric cancer. BMC Cancer. 21:7022021. View Article : Google Scholar : PubMed/NCBI

5 

Yoshida N, Doyama H, Yano T, Horimatsu T, Uedo N, Yamamoto Y, Kakushima N, Kanzaki H, Hori S, Yao K, et al: Early gastric cancer detection in high-risk patients: A multicentre randomised controlled trial on the effect of second-generation narrow band imaging. Gut. 70:67–75. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Lee IJ, Lee JM, Kim SH, Shin CI, Lee JY, Kim SH, Han JK and Choi BI: Diagnostic performance of 64-channel multidetector CT in the evaluation of gastric cancer: Differentiation of mucosal cancer (T1a) from submucosal involvement (T1b and T2). Radiology. 255:805–814. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Yuan Y, Ren S, Wang T, Shen F, Hao Q and Lu J: Differentiating T1a-T1b from T2 in gastric cancer lesions with three different measurement approaches based on contrast-enhanced T1W imaging at 3.0 T. BMC Med Imaging. 21:1402021. View Article : Google Scholar : PubMed/NCBI

8 

Wang ZL, Li YL, Tang L, Li XT, Bu ZD and Sun YS: Utility of the gastric window in computed tomography for differentiation of early gastric cancer (T1 stage) from muscularis involvement (T2 stage). Abdom Radiol (NY). 46:1478–1486. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Patel TH and Cecchini M: Targeted therapies in advanced gastric cancer. Curr Treat Options Oncol. 21:702020. View Article : Google Scholar : PubMed/NCBI

10 

Everett SM and Axon AT: Early gastric cancer in Europe. Gut. 41:142–150. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Machlowska J, Baj J, Sitarz M, Maciejewski R and Sitarz R: Gastric cancer: Epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int J Mol Sci. 21:40122020. View Article : Google Scholar : PubMed/NCBI

12 

Lin Z, Bian H, Chen C, Chen W and Li Q: Application of serum pepsinogen and carbohydrate antigen 72-4 (CA72-4) combined with gastrin-17 (G-17) detection in the screening, diagnosis, and evaluation of early gastric cancer. J Gastrointest Oncol. 12:1042–1048. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Zhong H and Luo X: Serum dihydropyrimidinase-like 3 concentration in patients with gastric cancer and its diagnostic value. Iran J Public Health. 50:1789–1795. 2021.PubMed/NCBI

14 

Park KJ, Lee MW, Koo JH, Park Y, Kim H, Choi D and Lee SJ: Detection of early gastric cancer using hydro-stomach CT: Blinded vs unblinded analysis. World J Gastroenterol. 17:1051–1057. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Kim TU, Kim S, Lee JW, Lee NK, Jeon TY and Park DY: MDCT features in the differentiation of T4a gastric cancer from less-advanced gastric cancer: Significance of the hyperattenuating serosa sign. Br J Radiol. 86:201302902013. View Article : Google Scholar : PubMed/NCBI

16 

Chen Y, Jia Y, Peng Z and Wang G: The prognostic role of tumor size in stage T1 gastric cancer. World J Surg Oncol. 20:1352022. View Article : Google Scholar : PubMed/NCBI

17 

Ahn HS, Lee HJ, Yoo MW, Kim SG, Im JP, Kim SH, Kim WH, Lee KU and Yang HK: Diagnostic accuracy of T and N stages with endoscopy, stomach protocol CT, and endoscopic ultrasonography in early gastric cancer. J Surg Oncol. 99:20–27. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Kim YN, Choi D, Kim SH, Kim MJ, Lee SJ, Lee WJ, Kim S and Kim JJ: Gastric cancer staging at isotropic MDCT including coronal and sagittal MPR images: Endoscopically diagnosed early vs. advanced gastric cancer. Abdom Imaging. 34:26–34. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liang P, Lv D, Ren X, Cheng M, Hu Z, Yong L, Zhu B, Liu M and Gao J: The ‘double‑track sign’: A novel CT finding suggestive of the diagnosis of T1a gastric cancer. Oncol Lett 26: 286, 2023.
APA
Liang, P., Lv, D., Ren, X., Cheng, M., Hu, Z., Yong, L. ... Gao, J. (2023). The ‘double‑track sign’: A novel CT finding suggestive of the diagnosis of T1a gastric cancer. Oncology Letters, 26, 286. https://doi.org/10.3892/ol.2023.13872
MLA
Liang, P., Lv, D., Ren, X., Cheng, M., Hu, Z., Yong, L., Zhu, B., Liu, M., Gao, J."The ‘double‑track sign’: A novel CT finding suggestive of the diagnosis of T1a gastric cancer". Oncology Letters 26.1 (2023): 286.
Chicago
Liang, P., Lv, D., Ren, X., Cheng, M., Hu, Z., Yong, L., Zhu, B., Liu, M., Gao, J."The ‘double‑track sign’: A novel CT finding suggestive of the diagnosis of T1a gastric cancer". Oncology Letters 26, no. 1 (2023): 286. https://doi.org/10.3892/ol.2023.13872
Copy and paste a formatted citation
x
Spandidos Publications style
Liang P, Lv D, Ren X, Cheng M, Hu Z, Yong L, Zhu B, Liu M and Gao J: The ‘double‑track sign’: A novel CT finding suggestive of the diagnosis of T1a gastric cancer. Oncol Lett 26: 286, 2023.
APA
Liang, P., Lv, D., Ren, X., Cheng, M., Hu, Z., Yong, L. ... Gao, J. (2023). The ‘double‑track sign’: A novel CT finding suggestive of the diagnosis of T1a gastric cancer. Oncology Letters, 26, 286. https://doi.org/10.3892/ol.2023.13872
MLA
Liang, P., Lv, D., Ren, X., Cheng, M., Hu, Z., Yong, L., Zhu, B., Liu, M., Gao, J."The ‘double‑track sign’: A novel CT finding suggestive of the diagnosis of T1a gastric cancer". Oncology Letters 26.1 (2023): 286.
Chicago
Liang, P., Lv, D., Ren, X., Cheng, M., Hu, Z., Yong, L., Zhu, B., Liu, M., Gao, J."The ‘double‑track sign’: A novel CT finding suggestive of the diagnosis of T1a gastric cancer". Oncology Letters 26, no. 1 (2023): 286. https://doi.org/10.3892/ol.2023.13872
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