Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2023 Volume 26 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2023 Volume 26 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Soluble NKG2D ligands impair CD8+ T cell antitumor function dependent of NKG2D downregulation in neuroblastoma

  • Authors:
    • Yi Zhang
    • Feifei Luo
    • Kuiran Dong
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai 201102, P.R. China, Biotherapy Research Center, Fudan University, Shanghai 200040, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 297
    |
    Published online on: May 24, 2023
       https://doi.org/10.3892/ol.2023.13883
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

T cell‑based immunotherapy has achieved remarkable beneficial clinical outcomes. Tumor‑derived NKG2D ligands (NKG2DL) allow tumors to escape immunologic surveillance. However, the mechanism underlying NKG2DL‑mediated immune escape in neuroblastoma (NB) remains incompletely understood. In the present study, first soluble NKG2DL, soluble major histocompatibility complex (MHC) class‑I‑related chain A and soluble UL‑16 binding proteins expression levels were determined in both the serum from patients with NB and in NB cell line culture supernatants. NB cell‑derived sNKG2DL was initially cleaved by ADAM10 and ADAM17. Furthermore, sNKG2DL expression levels were positively correlated with the immunosuppressive microenvironment and poor prognosis. Tumor‑derived sNKG2DL induced degradation of NKG2D on CD8+ T cells and impaired CD8+ T cell proliferation, IFN‑γ production, and CD107a translocation. More importantly, blockage of sNKG2DL increased the antitumor activity of CD8+ T cells. Thus, the results showed that NB‑induced immunosuppression was achieved through tumor‑derived sMICA and sULBP‑2, and blockage of the tumor‑derived sNKG2DLs with sNKG2DL neutralizing antibodies was a novel strategy to recover T‑cell function and enhance antitumor immunotherapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Maris JM: Recent advances in neuroblastoma. N Engl J Med. 362:2202–2211. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Park JA and Cheung NKV: Targets and antibody formats for immunotherapy of neuroblastoma. J Clin Oncol. 38:1836–1848. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Janoueix-Lerosey I, Schleiermacher G and Delattre O: Molecular pathogenesis of peripheral neuroblastic tumors. Oncogene. 29:1566–1579. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Sylvain NJ, Salman MM, Pushie MJ, Hou H, Meher V, Herlo R, Peeling L and Kelly ME: The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse model. Biochim Biophys Acta Biomembr. 1863:1835732021. View Article : Google Scholar : PubMed/NCBI

5 

Salman MM, Kitchen P, Woodroofe MN, Bill RM, Conner AC, Heath PR and Conner MT: Transcriptome analysis of gene expression provides new insights into the effect of mild therapeutic hypothermia on primary human cortical astrocytes cultured under hypoxia. Front Cell Neurosci. 11:3862017. View Article : Google Scholar : PubMed/NCBI

6 

Ndunge OB, Kilian N and Salman MM: Cerebral malaria and neuronal implications of plasmodium falciparum infection: From mechanisms to advanced models. Adv Sci (Weinh). 9:e22029442022. View Article : Google Scholar : PubMed/NCBI

7 

Salman MM, Kitchen P, Yool AJ and Bill RM: Recent breakthroughs and future directions in drugging aquaporins. Trends Pharmacol Sci. 43:30–42. 2022. View Article : Google Scholar : PubMed/NCBI

8 

López-Soto A, Huergo-Zapico L, Acebes-Huerta A, Villa-Alvarez M and Gonzalez S: NKG2D signaling in cancer immunosurveillance. Int J Cancer. 136:1741–1750. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Chiossone L, Dumas PY, Vienne M and Vivier E: Natural killer cells and other innate lymphoid cells in cancer. Nat Rev Immunol. 18:671–688. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL and Spies T: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 285:727–729. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Prajapati K, Perez C, Rojas LBP, Burke B and Guevara-Patino JA: Functions of NKG2D in CD8+ T cells: An opportunity for immunotherapy. Cell Mol Immunol. 15:470–479. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Mujal AM, Delconte RB and Sun JC: Natural killer cells: From innate to adaptive features. Annu Rev Immunol. 39:417–447. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Zloza A, Kohlhapp FJ, Lyons GE, Schenkel JM, Moore TV, Lacek AT, O'Sullivan JA, Varanasi V, Williams JW, Jagoda MC, et al: NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses. Nat Med. 18:422–428. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Raulet DH: Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol. 3:781–790. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Liu H, Wang S, Xin J, Wang J, Yao C and Zhang Z: Role of NKG2D and its ligands in cancer immunotherapy. Am J Cancer Res. 9:2064–2078. 2019.PubMed/NCBI

16 

Salih HR, Rammensee HG and Steinle A: Cutting edge: Down-regulation of MICA on human tumors by proteolytic shedding. J Immunol. 169:4098–4102. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Groh V, Wu J, Yee C and Spies T: Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature. 419:734–738. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Pistoia V, Morandi F, Bianchi G, Pezzolo A, Prigione I and Raffaghello L: Immunosuppressive microenvironment in neuroblastoma. Front Oncol. 3:1672013. View Article : Google Scholar : PubMed/NCBI

19 

Fuertes MB, Domaica CI and Zwirner NW: Leveraging NKG2D ligands in immuno-oncology. Front Immunol. 12:7131582021. View Article : Google Scholar : PubMed/NCBI

20 

Morandi F, Sabatini F, Podestà M and Airoldi I: Immunotherapeutic strategies for Neuroblastoma: Present, past and future. Vaccines (Basel). 9:432021. View Article : Google Scholar : PubMed/NCBI

21 

Park JR, Digiusto DL, Slovak M, Wright C, Naranjo A, Wagner J, Meechoovet HB, Bautista C, Chang WC, Ostberg JR and Jensen MC: Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. Mol Ther. 15:825–833. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Pule MA, Savoldo B, Myers GD, Rossig C, Russell HV, Dotti G, Huls MH, Liu E, Gee AP, Mei Z, et al: Virus-specific T cells engineered to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma. Nat Med. 14:1264–1270. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Kailayangiri S, Altvater B, Spurny C, Jamitzky S, Schelhaas S, Jacobs AH, Wiek C, Roellecke K, Hanenberg H, Hartmann W, et al: Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G. Oncoimmunology. 6:e12500502017. View Article : Google Scholar : PubMed/NCBI

24 

Pathania AS, Prathipati P, Olwenyi OA, Chava S, Smith OV, Gupta SC, Chaturvedi NK, Byrareddy SN, Coulter DW and Challagundla KB: miR-15a and miR-15b modulate natural killer and CD8+T-cell activation and anti-tumor immune response by targeting PD-L1 in neuroblastoma. Mol Ther Oncolytics. 25:308–329. 2022. View Article : Google Scholar : PubMed/NCBI

25 

Zhen Z, Yang K, Ye L, You Z, Chen R, Liu Y and He Y: HLA-E inhibitor enhances the killing of neuroblastoma stem cells by co-cultured dendritic cells and cytokine-induced killer cells loaded with membrane-based microparticles. Am J Cancer Res. 7:334–345. 2017.PubMed/NCBI

26 

Brandetti E, Veneziani I, Melaiu O, Pezzolo A, Castellano A, Boldrini R, Ferretti E, Fruci D, Moretta L, Pistoia V, et al: MYCN is an immunosuppressive oncogene dampening the expression of ligands for NK-cell-activating receptors in human high-risk neuroblastoma. Oncoimmunology. 6:e13164392017. View Article : Google Scholar : PubMed/NCBI

27 

Yan X, Johnson BD and Orentas RJ: Murine CD8 lymphocyte expansion in vitro by artificial antigen-presenting cells expressing CD137L (4-1BBL) is superior to CD28, and CD137L expressed on neuroblastoma expands CD8 tumour-reactive effector cells in vivo. Immunology. 112:105–116. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Zingoni A, Molfetta R, Fionda C, Soriani A, Paolini R, Cippitelli M, Cerboni C and Santoni A: NKG2D and its ligands: ‘One for All, All for One’. Front Immunol. 9:4762018. View Article : Google Scholar : PubMed/NCBI

29 

Diefenbach A, Tomasello E, Lucas M, Jamieson AM, Hsia JK, Vivier E and Raulet DH: Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat Immunol. 3:1142–1149. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Raffaghello L, Prigione I, Airoldi I, Camoriano M, Levreri I, Gambini C, Pende D, Steinle A, Ferrone S and Pistoia V: Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma. Neoplasia. 6:558–568. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Paschen A, Sucker A, Hill B, Moll I, Zapatka M, Nguyen XD, Sim GC, Gutmann I, Hassel J, Becker JC, et al: Differential clinical significance of individual NKG2D ligands in melanoma: Soluble ULBP2 as an indicator of poor prognosis superior to S100B. Clin Cancer Res. 15:5208–5215. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Zingoni A, Vulpis E, Loconte L and Santoni A: NKG2D ligand shedding in response to stress: Role of ADAM10. Front Immunol. 11:4472020. View Article : Google Scholar : PubMed/NCBI

33 

Hsia HE, Tüshaus J, Brummer T, Zheng Y, Scilabra SD and Lichtenthaler SF: Functions of ‘A disintegrin and metalloproteases (ADAMs)’ in the mammalian nervous system. Cell Mol Life Sci. 76:3055–3081. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Zheng X, Jiang F, Katakowski M, Zhang ZG, Lu QE and Chopp M: ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation. Cancer Biol Ther. 8:1045–1054. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Guo W, Huang J, Lei P, Guo L and Li X: LncRNA SNHG1 promoted HGC-27 cell growth and migration via the miR-140/ADAM10 axis. Int J Biol Macromol. 122:817–823. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Waldhauer I and Steinle A: Proteolytic release of soluble UL16-binding protein 2 from tumor cells. Cancer Res. 66:2520–2526. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Waldhauer I, Goehlsdorf D, Gieseke F, Weinschenk T, Wittenbrink M, Ludwig A, Stevanovic S, Rammensee HG and Steinle A: Tumor-associated MICA is shed by ADAM proteases. Cancer Res. 68:6368–6376. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Wolpert F, Tritschler I, Steinle A, Weller M and Eisele G: A disintegrin and metalloproteinases 10 and 17 modulate the immunogenicity of glioblastoma-initiating cells. Neuro Oncol. 16:382–391. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Tosetti F, Venè R, Camodeca C, Nuti E, Rossello A, D'Arrigo C, Galante D, Ferrari N, Poggi A and Zocchi MR: Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells. Oncoimmunology. 7:e14218892018. View Article : Google Scholar : PubMed/NCBI

40 

Buchanan PC, Boylan KLM, Walcheck B, Heinze R, Geller MA, Argenta PA and Skubitz APN: Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17. J Biol Chem. 292:6339–6351. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Yang J, LeBlanc ME, Cano I, Saez-Torres KL, Saint-Geniez M, Ng YS and D'Amore PA: ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface. J Biol Chem. 295:6641–6651. 2020. View Article : Google Scholar : PubMed/NCBI

42 

Liu G, Lu S, Wang X, Page ST, Higano CS, Plymate SR, Greenberg NM, Sun S, Li Z and Wu JD: Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis. J Clin Invest. 123:4410–4422. 2013. View Article : Google Scholar : PubMed/NCBI

43 

de Andrade LF, Tay RE, Pan D, Luoma AM, Ito Y, Badrinath S, Tsoucas D, Franz B, May KF Jr, Harvey CJ, et al: Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity. Science. 359:1537–1542. 2018. View Article : Google Scholar

44 

Zhang J, Liu D, Li G, Staveley-O'Carroll KF, Graff JN, Li Z and Wu JD: Antibody-mediated neutralization of soluble MIC significantly enhances CTLA4 blockade therapy. Sci Adv. 3:e16021332017. View Article : Google Scholar : PubMed/NCBI

45 

Xiao G, Wang X, Sheng J, Lu S, Yu X and Wu JD: Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype. J Hematol Oncol. 8:132015. View Article : Google Scholar : PubMed/NCBI

46 

André MC, Sigurdardottir D, Kuttruff S, Pömmerl B, Handgretinger R, Rammensee HG and Steinle A: Impaired tumor rejection by memory CD8 T cells in mice with NKG2D dysfunction. Int J Cancer. 131:1601–1610. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Perez C, Prajapati K, Burke B, Plaza-Rojas L, Zeleznik-Le NJ and Guevara-Patino JA: NKG2D signaling certifies effector CD8 T cells for memory formation. J Immunother Cancer. 7:482019. View Article : Google Scholar : PubMed/NCBI

48 

Quamine AE, Olsen MR, Cho MM and Capitini CM: Approaches to enhance natural killer cell-based immunotherapy for pediatric solid tumors. Cancers (Basel). 13:27962021. View Article : Google Scholar : PubMed/NCBI

49 

Liu S, Galat V, Galat Y, Lee YKA, Wainwright D and Wu J: NK cell-based cancer immunotherapy: From basic biology to clinical development. J Hematol Oncol. 14:72021. View Article : Google Scholar : PubMed/NCBI

50 

Basher F, Dhar P, Wang X, Wainwright DA, Zhang B, Sosman J, Ji Z and Wu JD: Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy. J Hematol Oncol. 13:742020. View Article : Google Scholar : PubMed/NCBI

51 

Ullrich E, Koch J, Cerwenka A and Steinle A: New prospects on the NKG2D/NKG2DL system for oncology. Oncoimmunology. 2:e260972013. View Article : Google Scholar : PubMed/NCBI

52 

Kloess S, Huenecke S, Piechulek D, Esser R, Koch J, Brehm C, Soerensen J, Gardlowski T, Brinkmann A, Bader P, et al: IL-2-activated haploidentical NK cells restore NKG2D-mediated NK-cell cytotoxicity in neuroblastoma patients by scavenging of plasma MICA. Eur J Immunol. 40:3255–3267. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Mastronuzzi A, Colafati GS, Carai A, D'Egidio M, Fabozzi F, Bufalo FD, Villani MF, Baldo GD, Vennarini S, Canino C, et al: Central nervous system metastasis in neuroblastoma: From three decades clinical experience to new considerations in the immunotherapy era. Cancers (Basel). 14:62492022. View Article : Google Scholar : PubMed/NCBI

54 

Salman MM, Kitchen P, Halsey A, Wang MX, Törnroth-Horsefield S, Conner AC, Badaut J, Iliff JJ and Bill RM: Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis. Brain. 145:64–75. 2022. View Article : Google Scholar : PubMed/NCBI

55 

Kitchen P, Salman MM, Halsey AM, Clarke-Bland C, MacDonald JA, Ishida H, Vogel HJ, Almutiri S, Logan A, Kreida S, et al: Targeting aquaporin-4 subcellular localization to treat central nervous system edema. Cell. 181:784–799.e19. 2020. View Article : Google Scholar : PubMed/NCBI

56 

Salman MM, Al-Obaidi Z, Kitchen P, Loreto A, Bill RM and Wade-Martins R: Advances in applying computer-aided drug design for neurodegenerative diseases. Int J Mol Sci. 22:46882021. View Article : Google Scholar : PubMed/NCBI

57 

Aldewachi H, Al-Zidan RN, Conner MT and Salman MM: High-throughput screening platforms in the discovery of novel drugs for neurodegenerative diseases. Bioengineering (Basel). 8:302021. View Article : Google Scholar : PubMed/NCBI

58 

Wagner K, Unger L, Salman MM, Kitchen P, Bill RM and Yool AJ: Signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease. Int J Mol Sci. 23:13882022. View Article : Google Scholar : PubMed/NCBI

59 

Markou A, Unger L, Abir-Awan M, Saadallah A, Halsey A, Balklava Z, Conner M, Törnroth-Horsefield S, Greenhill SD, Conner A, et al: Molecular mechanisms governing aquaporin relocalisation. Biochim Biophys Acta Biomembr. 1864:1838532022. View Article : Google Scholar : PubMed/NCBI

60 

Papaspyropoulos A, Tsolaki M, Foroglou N and Pantazaki AA: Modeling and targeting Alzheimer's disease With Organoids. Front Pharmacol. 11:3962020. View Article : Google Scholar : PubMed/NCBI

61 

Salman MM, Marsh G, Kusters I, Delincé M, Di Caprio G, Upadhyayula S, de Nola G, Hunt R, Ohashi KG, Gray T, et al: Design and validation of a human brain endothelial microvessel-on-a-chip open microfluidic model enabling advanced optical imaging. Front Bioeng Biotechnol. 8:5737752020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Luo F and Dong K: Soluble NKG2D ligands impair CD8<sup>+</sup> T cell antitumor function dependent of NKG2D downregulation in neuroblastoma. Oncol Lett 26: 297, 2023.
APA
Zhang, Y., Luo, F., & Dong, K. (2023). Soluble NKG2D ligands impair CD8<sup>+</sup> T cell antitumor function dependent of NKG2D downregulation in neuroblastoma. Oncology Letters, 26, 297. https://doi.org/10.3892/ol.2023.13883
MLA
Zhang, Y., Luo, F., Dong, K."Soluble NKG2D ligands impair CD8<sup>+</sup> T cell antitumor function dependent of NKG2D downregulation in neuroblastoma". Oncology Letters 26.1 (2023): 297.
Chicago
Zhang, Y., Luo, F., Dong, K."Soluble NKG2D ligands impair CD8<sup>+</sup> T cell antitumor function dependent of NKG2D downregulation in neuroblastoma". Oncology Letters 26, no. 1 (2023): 297. https://doi.org/10.3892/ol.2023.13883
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Luo F and Dong K: Soluble NKG2D ligands impair CD8<sup>+</sup> T cell antitumor function dependent of NKG2D downregulation in neuroblastoma. Oncol Lett 26: 297, 2023.
APA
Zhang, Y., Luo, F., & Dong, K. (2023). Soluble NKG2D ligands impair CD8<sup>+</sup> T cell antitumor function dependent of NKG2D downregulation in neuroblastoma. Oncology Letters, 26, 297. https://doi.org/10.3892/ol.2023.13883
MLA
Zhang, Y., Luo, F., Dong, K."Soluble NKG2D ligands impair CD8<sup>+</sup> T cell antitumor function dependent of NKG2D downregulation in neuroblastoma". Oncology Letters 26.1 (2023): 297.
Chicago
Zhang, Y., Luo, F., Dong, K."Soluble NKG2D ligands impair CD8<sup>+</sup> T cell antitumor function dependent of NKG2D downregulation in neuroblastoma". Oncology Letters 26, no. 1 (2023): 297. https://doi.org/10.3892/ol.2023.13883
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team